Tuesday, December 15, 2009

Vol. 15, No. 24

TRIGGER
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 15, No. 24  December 15, 2009
(The next issue will be on January 4, 2010)
__________________________________________________________
TRIGGER is also available by RSS Feed:
http://feeds.feedburner.com/blogspot/glro
and BLOG:
http://trigger-tf7.blogspot.com/
__________________________________________________________
ANNOUNCEMENTS
Best wishes to all our colleagues for a peaceful, prosperous and happy New Year!
-Jim, Genie & Pierre
________________________________________________________
PAPERS IN PRESS
None submitted for this issue.
__________________________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI
Papers are culled from NLM MedLine (PubMed). Titles in square brackets indicate that the paper was not published in English. References that lack volume or page numbers are typically electronic pre-publications (E-pubs) ahead of the print publication; if so, the final citation with volume and page numbers may or may not appear in a future issue of Trigger.
THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1VAkznzBjyyuPqdThubrwXr/

Antonijoan RM, Rico S, Martinez-Gonzalez J, Borrell M, Valcarcel D, Fontcuberta J, and Barbanoj MJ (2009) Comparative pharmacodynamic time-course of bemiparin and enoxaparin in healthy volunteers. Int J Clin Pharmacol Ther Volume 47:726-732.
http://www.ncbi.nlm.nih.gov/pubmed/19954711

Breitenstein A, Tanner FC, and Luscher TF (2009) Tissue factor and cardiovascular disease. Circ J
http://www.ncbi.nlm.nih.gov/pubmed/19996531

Cugno M, Marzano AV, Asero R, and Tedeschi A (2009) Activation of blood coagulation in chronic urticaria: Pathophysiological and clinical implications. Intern Emerg Med
http://www.ncbi.nlm.nih.gov/pubmed/19949893

Di Minno G, Coppola A, Di Minno MN, and Poon MC (2009) Glanzmann's thrombasthenia (defective platelet integrin alphaIIb-beta3): Proposals for management between evidence and open issues. Thromb Haemost 102:1157-1164.
http://www.ncbi.nlm.nih.gov/pubmed/19967146

Dickneite G, Dorr B, Kaspereit F, and Tanaka KA (2009) Prothrombin complex concentrate versus recombinant factor VIIa for reversal of hemodilutional coagulopathy in a porcine trauma model. J Trauma
http://www.ncbi.nlm.nih.gov/pubmed/19996804

Diringer MN, Skolnick BE, Mayer SA, Steiner T, Davis SM, Brun NC, and Broderick JP (2009) Thromboembolic events with recombinant activated factor VII in spontaneous intracerebral hemorrhage. Results from the factor seven for acute hemorrhagic stroke (FAST) trial. Stroke
http://www.ncbi.nlm.nih.gov/pubmed/19959538

Franchini M, Favaloro EJ, and Lippi G (2009) Mild hemophilia A. J Thromb Haemost
http://www.ncbi.nlm.nih.gov/pubmed/19995408

Gessler F, Voss V, Dutzmann S, Seifert V, Gerlach R, and Kogel D (2009) Inhibition of tissue factor/protease-activated receptor-2 signaling limits proliferation, migration and invasion of malignant glioma cells. Neuroscience
http://www.ncbi.nlm.nih.gov/pubmed/19958818

Holbrook LM, Watkins NA, Simmonds AD, Jones CI, Ouwehand WH, and Gibbins JM (2009) Platelets release novel thiol isomerase enzymes which are recruited to the cell surface following activation. Br J Haematol
http://www.ncbi.nlm.nih.gov/pubmed/19995400

Hoppensteadt DA, Neville B, Schultz C, Jeske W, Raake W, and Fareed J (2009) Comparative studies on the topical administration of mucopolysaccharide and heparin ointments in nonhuman primates. Clin Appl Thromb Hemost
http://www.ncbi.nlm.nih.gov/pubmed/19959490

Howes JL, Smith RS, Helmer SD, and Taylor SM (2009) Complications of recombinant activated human coagulation factor VII. Am J Surg 198:895-899.
http://www.ncbi.nlm.nih.gov/pubmed/19969148

Huang H, Jia S, Chen S, Sha Y, Ma A, Ma X, Zhang J, Bai X, and He L (2009) [The coagulation factor VII gene polymorphisms in patients with myocardial infarction in Ningxia Hui and Han populations.]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 26:653-658.
http://www.ncbi.nlm.nih.gov/pubmed/19953488

Kanse SM and Etscheid M (2009) Factor VII activating protease (FSAP): Caught in the cross fire between polycations and polyanions. J Thromb Haemost
http://www.ncbi.nlm.nih.gov/pubmed/19995407

Khan MM, Liu Y, Khan ME, Gilman ML, Khan ST, Bromberg ME, and Colman RW (2009) Upregulation of tissue factor in monocytes by cleaved high molecular weight kininogen is dependent on TNF{alpha} and IL-1{beta}. Am J Physiol Heart Circ Physiol
http://www.ncbi.nlm.nih.gov/pubmed/19966052

Klymiuk N, Aigner B, Brem G, and Wolf E (2009) Genetic modification of pigs as organ donors for xenotransplantation. Mol Reprod Dev
http://www.ncbi.nlm.nih.gov/pubmed/19998476

Knesek MJ, Litinas E, Adiguzel C, Hopkinson W, Hoppensteadt D, Lassen M, and Fareed J (2009) Inflammatory biomarker profiling in elderly patients with acute hip fracture treated with heparins. Clin Appl Thromb Hemost
http://www.ncbi.nlm.nih.gov/pubmed/19959493

Koizume S, Yokota N, Miyagi E, Hirahara F, Nakamura Y, Sakuma Y, Yoshida A, Kameda Y, Tsuchiya E, Ruf W, and Miyagi Y (2009) Hepatocyte nuclear factor-4-independent synthesis of coagulation factor VII in breast cancer cells and its inhibition by targeting selective histone acetyltransferases. Mol Cancer Res
http://www.ncbi.nlm.nih.gov/pubmed/19996301

Krudysz-Amblo J, Jennings ME, Mann KG, and Butenas S (2009) Carbohydrates and activity of natural and recombinant tissue factor. J Biol Chem
http://www.ncbi.nlm.nih.gov/pubmed/19955571

Li Q, Zhang J, Li WM, and Zou P (2009) [Pathogenetic role of tissue factor in endothelial-injury in graft-versus-host disease.]. Zhonghua Xue Ye Xue Za Zhi 30:610-614.
http://www.ncbi.nlm.nih.gov/pubmed/19954621

Mihara M, Aihara KI, Ikeda Y, Yoshida S, Kinouchi M, Kurahashi K, Fujinaka Y, Akaike M, and Matsumoto T (2009) Inhibition of thrombin action ameliorates insulin resistance in type 2 diabetic db/db mice. Endocrinology
http://www.ncbi.nlm.nih.gov/pubmed/19966184

Millan C, Quintana B, Rodriguez A, Iglesias M, Barranco M, and Navia J (2009) [Efficacy of recombinant activated factor VII for massive bleeding after cardiac surgery: Experience with 32 patients]. Rev Esp Anestesiol Reanim 56:485-492.
http://www.ncbi.nlm.nih.gov/pubmed/19994617

Puetz J, Darling G, McCormick KA, and Wofford JD (2009) Fresh frozen plasma and recombinant factor VIIa use in neonates. J Pediatr Hematol Oncol 31:901-906.
http://www.ncbi.nlm.nih.gov/pubmed/19956022

Rollin J, Regina S, and Gruel Y (2009) Tumour expression of alternatively spliced tissue factor is a prognostic marker in non-small cell lung cancer. J Thromb Haemost
http://www.ncbi.nlm.nih.gov/pubmed/19995406

Shi WX, Zhou H, Li N, Huang HL, and Zhou BC (2009) [Investigation of the mechanisms of coagulation factor VIIa-induced colon cancer SW620 cell proliferation and migration]. Zhonghua Zhong Liu Za Zhi 31:485-489.
http://www.ncbi.nlm.nih.gov/pubmed/19950693

Yin W, Shanmugavelayudam SK, and Rubenstein DA (2009) 3D numerical simulation of coronary blood flow and its effect on endothelial cell activation. Conf Proc IEEE Eng Med Biol Soc 1:4003-4006.
http://www.ncbi.nlm.nih.gov/pubmed/19964091
____________________________________________________
ABOUT TRIGGER
TRIGGER is edited by Jim Morrissey and Pierre Neuenschwander, with editorial assistance by Genie Morrissey. It includes Abstracts of Papers in Press, Meeting Announcements, Positions Sought/Available,or any other pertinent item that subscribers may want to share with their colleagues. To submit an item for publication in Trigger, e-mail us. To request or cancel a subscription,or for more information about TRIGGER or the biology of tissue factor and factor VII, visit our web site. You can also contact us by mail: J.H. Morrissey, University of Illinois College of Medicine, 417 Med Sci Bldg MC-714, 506 S. Mathews Ave., Urbana, IL 61801, USA.

DISCLAIMER: TRIGGER is provided "as is" for information purposes only and without warranty of any kind, express or implied. Users shall assume the entire risk as to the accuracy and usefulness of information in TRIGGER. Opinions expressed here are not necessarily those of the editors or their employers. You may share TRIGGER with your scientific colleagues but you are not permitted to use it or its contents for commercial purposes.
__________________________________________________________

Tuesday, December 1, 2009

Vol. 15, No. 23

TRIGGER
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 15, No. 23  December 1, 2009
(The next issue will be on December 15, 2009)
__________________________________________________________
TRIGGER is also available by RSS Feed:
http://feeds.feedburner.com/blogspot/glro
and BLOG:
http://trigger-tf7.blogspot.com/
__________________________________________________________
PAPERS IN PRESS
None submitted for this issue.
__________________________________________________________
UPCOMING MEETINGS & EVENTS
The XXXIII World Congress of the International Society of Hematology will take place in Jerusalem, Israel, October 10-13, 2010. For more information, go to:
http://www.kenes.com/ish2010

The 20th Congress of the International Society for Fibrinolysis and Proteolysis will be held in Amsterdam on August 24-28, 2010. For more information, go to:
http://www.isfp2010.org/
__________________________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI
Papers are culled from NLM MedLine (PubMed). Titles in square brackets indicate that the paper was not published in English. References that lack volume or page numbers are typically electronic pre-publications (E-pubs) ahead of the print publication; if so, the final citation with volume and page numbers may or may not appear in a future issue of Trigger.
THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1BwfadP5culEmKrmixp0KSI/

Beppu S, Nakajima Y, Shibasaki M, Kageyama K, Mizobe T, Shime N, and Matsuda N (2009) Phosphodiesterase 3 inhibition reduces platelet activation and monocyte tissue factor expression in knee arthroplasty patients. Anesthesiology 111:1227-1237.
http://www.ncbi.nlm.nih.gov/pubmed/19934866

Bilic E, Rajic L, Femenic R, Konja J, Vucic K, Novak M, Cvitkovic M, Galic S, and Krmek N (2009) Recombinant activated factor VII controls chemotherapy-related hemorrhage in patients with solid intra-abdominal tumors: A report of three pediatric cases. Acta Clin Croat 48:161-166.
http://www.ncbi.nlm.nih.gov/pubmed/19928415

Forest A, Pautas E, Ray P, Bonnet D, Verny M, Amabile N, Boulanger C, Riou B, Tedgui A, Mallat Z, and Boddaert J (2009) Circulating microparticles and procoagulant activity in elderly patients. J Gerontol A Biol Sci Med Sci
http://www.ncbi.nlm.nih.gov/pubmed/19942591

Fu Y, Zhang GG, Cao Y, Liu Y, Yu JF, and Yin XH (2009) [Effect of adenovirus-mediated tissue factor pathway inhibitor gene transfer on apoptosis of rat vascular smooth muscle cells]. Zhonghua Xin Xue Guan Bing Za Zhi 37:542-547.
http://www.ncbi.nlm.nih.gov/pubmed/19927638

Girardi G (2009) Role of tissue factor in the maternal immunological attack of the embryo in the antiphospholipid syndrome. Clin Rev Allergy Immunol
http://www.ncbi.nlm.nih.gov/pubmed/19921475

Gopalakrishnan R, Hedner U, Ghosh S, Nayak R, Allen TC, Pendurthi UR, and Rao LV (2009) Bio-distribution of pharmacologically administered rFVIIa. J Thromb Haemost
http://www.ncbi.nlm.nih.gov/pubmed/19943873

He X, Han B, Bai X, Zhang Y, Cypel M, Mura M, Keshavjee S, and Liu M (2009) PTX3 as a potential biomarker of acute lung injury: Supporting evidence from animal experimentation. Intensive Care Med
http://www.ncbi.nlm.nih.gov/pubmed/19921147

Iakhiaev MA and Iakhiaev AV (2009) Graph-theoretical comparison of protein surfaces reveals potential determinants of cross-reactivity and the molecular mimicry. Mol Immunol
http://www.ncbi.nlm.nih.gov/pubmed/19939450

Jing Y and Jian-Xiong Y (2009) Human tissue factor pathway inhibitor-2 suppresses the wound-healing activities of human Tenon's capsule fibroblasts in vitro. Mol Vis 15:2306-2312.
http://www.ncbi.nlm.nih.gov/pubmed/19936309

Leduc D, Senikas V, Lalonde AB, Ballerman C, Biringer A, et al. (2009) Active management of the third stage of labour: Prevention and treatment of postpartum hemorrhage. J Obstet Gynaecol Can 31:980-993.
http://www.ncbi.nlm.nih.gov/pubmed/19941729

Mackman N and Taubman M (2009) Tissue factor: Past, present, and future. Arterioscler Thromb Vasc Biol 29:1986-1988.
http://www.ncbi.nlm.nih.gov/pubmed/19923557

Mahnel R, Bassus S, and Kirchmaier CM (2009) [Bleeding complications due to anticoagulatoric therapy.]. Internist (Berl)
http://www.ncbi.nlm.nih.gov/pubmed/19924389

Ming XF, Rajapakse AG, Carvas JM, Ruffieux J, and Yang Z (2009) Opposing and uncoupling effects of mTOR and S6K1 in the regulation of endothelial tissue factor expression. FEBS Lett
http://www.ncbi.nlm.nih.gov/pubmed/19914247

Mobarrez F, Antovic J, Egberg N, Hansson M, Jorneskog G, Hultenby K, and Wallen H (2009) A multicolor flow cytometric assay for measurement of platelet-derived microparticles. Thromb Res
http://www.ncbi.nlm.nih.gov/pubmed/19939440

Nielsen VG, Kirklin JK, and George JF (2009) Carbon monoxide releasing molecule-2 increases the velocity of thrombus growth and strength in hemophilia A, hemophilia B and factor VII-deficient plasmas. Blood Coagul Fibrinolysis
http://www.ncbi.nlm.nih.gov/pubmed/19923981

Phillips LE, McLintock C, Pollock W, Gatt S, Popham P, Jankelowitz G, Ogle R, and Cameron PA (2009) Recombinant activated factor VII in obstetric hemorrhage: Experiences from the Australian and New Zealand Haemostasis Registry. Anesth Analg 109:1908-1915.
http://www.ncbi.nlm.nih.gov/pubmed/19923520

Provencal M, Berger-Thibault N, Labbe D, Veitch R, Boivin D, Rivard GE, Gingras D, and Beliveau R (2009) Tissue factor mediates the HGF/Met-induced anti-apoptotic pathway in DAOY medulloblastoma cells. J Neurooncol
http://www.ncbi.nlm.nih.gov/pubmed/19921488

Takedani H, Kawahara H, and Kajiwara M (2009) Major orthopaedic surgeries for haemophilia with inhibitors using rFVIIa. Haemophilia
http://www.ncbi.nlm.nih.gov/pubmed/19925628

Tatopoulos A, Herbain D, Kazmierczak C, Bollaert PE, and Gibot S (2009) Parenteral use of recombinant activated factor VII during diffuse alveolar hemorrhage secondary to leptospirosis. Intensive Care Med
http://www.ncbi.nlm.nih.gov/pubmed/19924396

Wang HJ, Lo WY, Lu TL, and Huang H (2009) (-)-Epigallocatechin-3-gallate decreases thrombin/paclitaxel-induced endothelial tissue factor expression via the inhibition of c-Jun terminal NH2 kinase phosphorylation. Biochem Biophys Res Commun
http://www.ncbi.nlm.nih.gov/pubmed/19944065
____________________________________________________
ABOUT TRIGGER
TRIGGER is edited by Jim Morrissey and Pierre Neuenschwander, with editorial assistance by Genie Morrissey. It includes Abstracts of Papers in Press, Meeting Announcements, Positions Sought/Available,or any other pertinent item that subscribers may want to share with their colleagues. To submit an item for publication in Trigger, e-mail us. To request or cancel a subscription,or for more information about TRIGGER or the biology of tissue factor and factor VII, visit our web site. You can also contact us by mail: J.H. Morrissey, University of Illinois College of Medicine, 417 Med Sci Bldg MC-714, 506 S. Mathews Ave., Urbana, IL 61801, USA.

DISCLAIMER: TRIGGER is provided "as is" for information purposes only and without warranty of any kind, express or implied. Users shall assume the entire risk as to the accuracy and usefulness of information in TRIGGER. Opinions expressed here are not necessarily those of the editors or their employers. You may share TRIGGER with your scientific colleagues but you are not permitted to use it or its contents for commercial purposes.
__________________________________________________________

Monday, November 16, 2009

Vol. 15, No. 22

TRIGGER
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 15, No. 22  November 16, 2009
(The next issue will be on December 1, 2009)
__________________________________________________________
TRIGGER is also available by RSS Feed:
http://feeds.feedburner.com/blogspot/glro
and BLOG:
http://trigger-tf7.blogspot.com/
__________________________________________________________
PAPERS IN PRESS
The December issue of ATVB will have a series of reviews devoted to tissue factor. Here are the titles & authors:

Tissue Factor: Past, Present, and Future—ATVB In Focus
Nigel Mackman, Mark Taubman

Tissue Factor in Coagulation: Which? Where? When?—ATVB In Focus
Saulius Butenas, Thomas Orfeo, Kenneth G. Mann

What Is Wrong With the Allosteric Disulfide Bond Hypothesis?—ATVB In Focus
Ronald R. Bach, Dougald Monroe

Tissue Factor and PAR2 Signaling in the Tumor Microenvironment—ATVB In Focus
Florence Schaffner, Wolfram Ruf

Tissue Factor and Cancer Stem Cells: Is There a Linkage?—ATVB In Focus
Chloe Milsom, Nathalie Magnus, Brian Meehan, Khalid Al-Nedawi, Delphine Garnier, Janusz Rak

Protein S as Cofactor for TFPI—ATVB In Focus
Tilman M. Hackeng, Jan Rosing __________________________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI
Papers are culled from NLM MedLine (PubMed). Titles in square brackets indicate that the paper was not published in English. References that lack volume or page numbers are typically electronic pre-publications (E-pubs) ahead of the print publication; if so, the final citation with volume and page numbers may or may not appear in a future issue of Trigger.
THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1piZFxp1cZ4dirm0AXCNOYT/

Agledahl I, Brodin E, Svartberg J, and Hansen JB (2009) Impact of long-term testosterone treatment on plasma levels of free TFPI and TF-induced thrombin generation ex vivo in elderly men with low testosterone levels. Thromb Haemost 102:945-950.
http://www.ncbi.nlm.nih.gov/pubmed/19888533

Back J, Sanchez J, Elgue G, Ekdahl KN, and Nilsson B (2009) Activated human platelets induce factor XIIa-mediated contact activation. Biochem Biophys Res Commun
http://www.ncbi.nlm.nih.gov/pubmed/19878657

Chinni E, Colaizzo D, Tiscia GL, Martinelli P, Maruotti GM, Matteo M, Margaglione M, and Grandone E (2009) Markers of haemostasis and angiogenesis in placentae from gestational vascular complications: Impairment of mechanisms involved in maintaining intervillous blood flow. Thromb Res
http://www.ncbi.nlm.nih.gov/pubmed/19887303

Chu AJ (2009) Blood coagulation as an intrinsic pathway for proinflammation: A mini review. Inflamm Allergy Drug Targets
http://www.ncbi.nlm.nih.gov/pubmed/19906010

Conde-Agudelo A and Romero R (2009) Amniotic fluid embolism: An evidence-based review. Am J Obstet Gynecol 201:445-13.
http://www.ncbi.nlm.nih.gov/pubmed/19879393

Cugno M, Tedeschi A, Asero R, Meroni PL, and Marzano AV (2009) Skin autoimmunity and blood coagulation. Autoimmunity
http://www.ncbi.nlm.nih.gov/pubmed/19883336

Erez O, Romero R, Vaisbuch E, Kusanovic JP, Mazaki-Tovi S, et al. (2009) High tissue factor activity and low tissue factor pathway inhibitor concentrations in patients with preterm labor. J Matern Fetal Neonatal Med
http://www.ncbi.nlm.nih.gov/pubmed/19883261

Girolami A, Allemand E, Tezza F, Pellati D, and Scandellari R (2009) Rectus muscle sheath haematoma in a patient with congenital FX deficiency and in another with congenital FVII deficiency. Haemophilia
http://www.ncbi.nlm.nih.gov/pubmed/19878333

Klintman J, Berntorp E, and Astermark J (2009) Thrombin generation in vitro in the presence of by-passing agents in siblings with severe haemophilia A. Haemophilia
http://www.ncbi.nlm.nih.gov/pubmed/19878339

Lekhal S, Borvik T, Brodin E, Nordoy A, and Hansen JB (2009) Tissue factor-induced thrombin generation in the fasting and postprandial state among elderly survivors of myocardial infarction. Thromb Res
http://www.ncbi.nlm.nih.gov/pubmed/19880163

Machlus KR, Colby EA, Wu JR, Koch GG, Key NS, and Wolberg AS (2009) Effects of tissue factor, thrombomodulin and elevated clotting factor levels on thrombin generation in the calibrated automated thrombogram. Thromb Haemost 102:936-944.
http://www.ncbi.nlm.nih.gov/pubmed/19888532

Schuepbach RA and Riewald M (2009) Coagulation factor Xa cleaves PAR1 and mediates signaling dependent on binding to the endothelial protein C receptor. J Thromb Haemost
http://www.ncbi.nlm.nih.gov/pubmed/19895674

Shantsila E and Lip GY (2009) The role of monocytes in thrombotic disorders. Insights from tissue factor, monocyte-platelet aggregates and novel mechanisms. Thromb Haemost 102:916-924.
http://www.ncbi.nlm.nih.gov/pubmed/19888530

Todd T and Perry J (2009) A review of long-term prophylaxis in the rare inherited coagulation factor deficiencies. Haemophilia
http://www.ncbi.nlm.nih.gov/pubmed/19906159

Willis C, Bird R, Mullany D, Cameron P, and Phillips L (2009) Use of rFVIIa for critical bleeding in cardiac surgery: Dose variation and patient outcomes. Vox Sang
http://www.ncbi.nlm.nih.gov/pubmed/19878495

Xue Y, Liu X, and Sun J (2009) PU/PTFE-stimulated monocyte-derived soluble factors induced inflammatory activation in endothelial cells. Toxicol In Vitro
http://www.ncbi.nlm.nih.gov/pubmed/19895882

Yamabe H, Shimada M, Nakamura N, Murakami R, Shimaya Y, Fujita T, Okumura K, and Kaizuka M(2009) Tissue factor pathway inhibitor (TFPI) production by human podocyte in culture. Thromb Res
http://www.ncbi.nlm.nih.gov/pubmed/19906409

Yokota N, Koizume S, Miyagi E, Hirahara F, Nakamura Y, Kikuchi K, Ruf W, Sakuma Y, Tsuchiya E, and Miyagi Y (2009) Self-production of tissue factor-coagulation factor VII complex by ovarian cancer cells. Br J Cancer
http://www.ncbi.nlm.nih.gov/pubmed/19904262

Zhu L, Wang J, Mu J, Wang H, Zhang C, Wang J, Liu X, Yan X, Dai L, and Ma D (2009) Expression and characterization of Kunitz domain 3 and C-terminal of human tissue factor pathway inhibitor-2. Acta Biochim Biophys Sin (Shanghai) 41:948-954.
http://www.ncbi.nlm.nih.gov/pubmed/19902129
____________________________________________________
ABOUT TRIGGER
TRIGGER is edited by Jim Morrissey and Pierre Neuenschwander, with editorial assistance by Genie Morrissey. It includes Abstracts of Papers in Press, Meeting Announcements, Positions Sought/Available,or any other pertinent item that subscribers may want to share with their colleagues. To submit an item for publication in Trigger, e-mail us. To request or cancel a subscription,or for more information about TRIGGER or the biology of tissue factor and factor VII, visit our web site. You can also contact us by mail: J.H. Morrissey, University of Illinois College of Medicine, 417 Med Sci Bldg MC-714, 506 S. Mathews Ave., Urbana, IL 61801, USA.

DISCLAIMER: TRIGGER is provided "as is" for information purposes only and without warranty of any kind, express or implied. Users shall assume the entire risk as to the accuracy and usefulness of information in TRIGGER. Opinions expressed here are not necessarily those of the editors or their employers. You may share TRIGGER with your scientific colleagues but you are not permitted to use it or its contents for commercial purposes.
__________________________________________________________

Monday, November 2, 2009

Vol. 15, No. 21

TRIGGER
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 15, No. 21  November 2, 2009
(The next issue will be on November 16, 2009)
__________________________________________________________
TRIGGER is also available by RSS Feed:
http://feeds.feedburner.com/blogspot/glro
and BLOG:
http://trigger-tf7.blogspot.com/
__________________________________________________________
PAPERS IN PRESS
None submitted for this issue.
__________________________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI
Papers are culled from NLM MedLine (PubMed). Titles in square brackets indicate that the paper was not published in English. References that lack volume or page numbers are typically electronic pre-publications (E-pubs) ahead of the print publication; if so, the final citation with volume and page numbers may or may not appear in a future issue of Trigger.
THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1piZFxp1cZ4dirm0AXCNOYT/

Al-Ruzzeh S and Navia JL (2009) The "off-label" role of recombinant factor VIIa in surgery: Is the problem deficient evidence or defective concept? J Am Coll Surg 209:659-667.
http://www.ncbi.nlm.nih.gov/pubmed/19854409

Ames PR, Margaglione M, Mackie S, and Alves JD (2009) Eosinophilia and thrombophilia in Churg Strauss syndrome: A clinical and pathogenetic overview. Clin Appl Thromb Hemost
http://www.ncbi.nlm.nih.gov/pubmed/19833618

Ames PR, Aloj G, and Gentile F (2009) Eosinophilia and thrombosis in parasitic diseases: An overview. Clin Appl Thromb Hemost
http://www.ncbi.nlm.nih.gov/pubmed/19833625

Bohgaki M, Matsumoto M, Atsumi T, Kondo T, Yasuda S, Horita T, Nakayama KI, Okumura F, Hatakeyama S, and Koike T (2009) Plasma gelsolin facilitates interaction between beta(2) glycoprotein I and alpha5beta1 integrin. J Cell Mol Med
http://www.ncbi.nlm.nih.gov/pubmed/19840195

Breitenstein A, Camici GG, and Tanner FC (2010) Tissue factor: Beyond coagulation in the cardiovascular system. Clin Sci (Lond) 118:159-172.
http://www.ncbi.nlm.nih.gov/pubmed/19845509

Chandradas S, Deikus G, Tardos JG, and Bogdanov VY (2009) Antagonistic roles of four SR proteins in the biosynthesis of alternatively spliced tissue factor transcripts in monocytic cells. J Leukoc Biol
http://www.ncbi.nlm.nih.gov/pubmed/19843576

Duckers C, Simioni P, Spiezia L, Radu C, Dabrilli P, Gavasso S, Rosing J, and Castoldi E (2009) Residual platelet factor V ensures thrombin generation in patients with severe congenital factor V deficiency and mild bleeding symptoms. Blood
http://www.ncbi.nlm.nih.gov/pubmed/19861681

Erem C, Ucuncu O, Yilmaz M, Kocak M, Nuhoglu I, and Ersoz HO (2009) Increased thrombin-activatable fibrinolysis inhibitor and decreased tissue factor pathway inhibitor in patients with hyperthyroidism. Endocrine
http://www.ncbi.nlm.nih.gov/pubmed/19859836

Funderburg NT, Mayne E, Sieg SF, Asaad R, Jiang W, et al. (2009) Increased tissue factor expression on circulating monocytes in chronic HIV infection: Relationship to in vivo coagulation and immune activation. Blood
http://www.ncbi.nlm.nih.gov/pubmed/19828697

Jarosz K, Czuprynska M, Andrzejewska J, Wasilewicz MP, Post M, Lubikowski J, Wojcicki M, and Milkiewicz P (2009) Administration of a recombinant factor Vlla in patients undergoing liver transplantation for fulminant hepatic failure. Transplant Proc 41:3088-3090.
http://www.ncbi.nlm.nih.gov/pubmed/19857684

Liu N, Aldea S, Francois D, Cherqui-Michel M, Giansily-Blaizot M, and Fischler M (2009) Recombinant activated factor VII for a patient with factor VII deficiency undergoing urgent intracerebral haematoma evacuation with underlying cavernous angioma. Br J Anaesth
http://www.ncbi.nlm.nih.gov/pubmed/19846405

Manly DA, Wang J, Glover SL, Kasthuri R, Liebman HA, Key NS, and Mackman N (2009) Increased microparticle tissue factor activity in cancer patients with Venous Thromboembolism. Thromb Res
http://www.ncbi.nlm.nih.gov/pubmed/19854471

Natorska J, Marek G, Hlawaty M, Sobczyk D, Sadowski J, Tracz W, and Undas A (2009) Evidence for tissue factor expression in aortic valves in patients with aortic stenosis. Pol Arch Med Wewn 119:636-643.
http://www.ncbi.nlm.nih.gov/pubmed/19847139

Poralla C, Hertfelder HJ, Oldenburg J, Muller A, Bartmann P, and Heep A (2009) Treatment of acute pulmonary haemorrhage in extremely preterm infants with recombinant activated factor VII. Acta Paediatr
http://www.ncbi.nlm.nih.gov/pubmed/19839953

Potaczek DP, Owczarek D, Cibor D, Nishiyama C, Okumura K, Mach T, and Undas A (2009) Tissue factor -1208D>I polymorphism is associated with D-dimer levels in patients with inflammatory bowel disease. Inflamm Bowel Dis
http://www.ncbi.nlm.nih.gov/pubmed/19856410

Schneider P, Dreden PV, Rousseau A, Kassim Y, Legrand E, Vannier JP, and Vasse M (2009) Increased levels of tissue factor activity and procoagulant phospholipids during treatment of children with acute lymphoblastic leukaemia. Br J Haematol
http://www.ncbi.nlm.nih.gov/pubmed/19874310

Sen P, Ghosh S, Ezban M, Pendurthi UR, and Vijaya Mohan Rao L (2009) Effect of glycoPEGylation on factor VIIa binding and internalization. Haemophilia
http://www.ncbi.nlm.nih.gov/pubmed/19845776

Shen F, Pompano RR, Kastrup CJ, and Ismagilov RF (2009) Confinement regulates complex biochemical networks: Initiation of blood clotting by "diffusion acting". Biophys J 97:2137-2145.
http://www.ncbi.nlm.nih.gov/pubmed/19843446

Tang JQ, Fan Q, Wan YL, Liu YC, Wang X, Wu T, Pan YS, Wu WH, and Zhu J (2009) [Ectopic expression and clinical significance of tissue factor/coagulation factor VII complex in colorectal cancer.]. Beijing Da Xue Xue Bao 41:531-536.
http://www.ncbi.nlm.nih.gov/pubmed/19829668

van den Berg YW, van den Hengel LG, Myers HR, Ayachi O, Jordanova E, Ruf W, Spek CA, Reitsma PH, Bogdanov VY, and Versteeg HH (2009) Alternatively spliced tissue factor induces angiogenesis through integrin ligation. Proc Natl Acad Sci U S A
http://www.ncbi.nlm.nih.gov/pubmed/19875693

Zwicker JI, Liebman HA, Neuberg D, Lacroix R, Bauer KA, Furie BC, and Furie B (2009) Tumor-derived tissue factor-bearing microparticles are associated with venous thromboembolic events in malignancy. Clin Cancer Res
http://www.ncbi.nlm.nih.gov/pubmed/19861441
____________________________________________________
ABOUT TRIGGER
TRIGGER is edited by Jim Morrissey and Pierre Neuenschwander, with editorial assistance by Genie Morrissey. It includes Abstracts of Papers in Press, Meeting Announcements, Positions Sought/Available,or any other pertinent item that subscribers may want to share with their colleagues. To submit an item for publication in Trigger, e-mail us. To request or cancel a subscription,or for more information about TRIGGER or the biology of tissue factor and factor VII, visit our web site. You can also contact us by mail: J.H. Morrissey, University of Illinois College of Medicine, 417 Med Sci Bldg MC-714, 506 S. Mathews Ave., Urbana, IL 61801, USA.

DISCLAIMER: TRIGGER is provided "as is" for information purposes only and without warranty of any kind, express or implied. Users shall assume the entire risk as to the accuracy and usefulness of information in TRIGGER. Opinions expressed here are not necessarily those of the editors or their employers. You may share TRIGGER with your scientific colleagues but you are not permitted to use it or its contents for commercial purposes.
__________________________________________________________

Thursday, October 15, 2009

Vol. 15, No. 20

TRIGGER
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 15, No. 20  October 15, 2009
(The next issue will be on November 2, 2009)
__________________________________________________________
TRIGGER is also available by RSS Feed:
http://feeds.feedburner.com/blogspot/glro
and BLOG:
http://trigger-tf7.blogspot.com/
__________________________________________________________
PAPERS IN PRESS
None submitted for this issue.
__________________________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI
Papers are culled from NLM MedLine (PubMed). Titles in square brackets indicate that the paper was not published in English. References that lack volume or page numbers are typically electronic pre-publications (E-pubs) ahead of the print publication; if so, the final citation with volume and page numbers may or may not appear in a future issue of Trigger.
THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1X1DcQ8Vekf53snESdDxGh4/

Al-Shahi Salman R (2009) Haemostatic drug therapies for acute spontaneous intracerebral haemorrhage. Cochrane Database Syst Rev CD005951
http://www.ncbi.nlm.nih.gov/pubmed/19821350

Brandhorst H, Friberg A, Nilsson B, Andersson HH, Felldin M, Foss A, Salmela K, Tibell A, Tufveson G, Korsgren O, and Brandhorst D (2009) Large-scale comparison of liberase HI and collagenase NB1 utilized for human islet isolation. Cell Transplant
http://www.ncbi.nlm.nih.gov/pubmed/19818208

Camino-Lopez S, Badimon L, Gonzalez A, Canals D, Pena E, and Llorente-Cortes V (2009) Aggregated LDL induces tissue factor by inhibiting sphingomyelinase activity in human vascular smooth muscle cells. J Thromb Haemost
http://www.ncbi.nlm.nih.gov/pubmed/19817993

Campbell RA, Overmyer KA, Selzman CH, Sheridan BC, and Wolberg AS (2009) Contributions of extravascular and intravascular cells to fibrin network formation, structure, and stability. Blood
http://www.ncbi.nlm.nih.gov/pubmed/19797520

Gebhard C, Akhmedov A, Mocharla P, Angstenberger J, Sahbai S, Camici GG, Luscher TF, and Tanner FC (2009) PDGF-CC induces tissue factor expression: Role of PDGF receptor alpha/beta. Basic Res Cardiol
http://www.ncbi.nlm.nih.gov/pubmed/19795151

Gurusamy KS, Li J, Sharma D, and Davidson BR (2009) Pharmacological interventions to decrease blood loss and blood transfusion requirements for liver resection. Cochrane Database Syst Rev CD008085
http://www.ncbi.nlm.nih.gov/pubmed/19821442

He S, Ezban M, Bark N, Persson E, and Hedner U (2009) Fibrin gel structure obtained with a FVIIa analogue with enhanced FX-activating potential in haemophilia. Thromb Haemost 102:790-792.
http://www.ncbi.nlm.nih.gov/pubmed/19806268

Johnson GJ, Leis LA, and Bach RR (2009) Tissue factor activity of blood mononuclear cells is increased after total knee arthroplasty. Thromb Haemost 102:728-734.
http://www.ncbi.nlm.nih.gov/pubmed/19806259

Kentsis A, Bradwin G, Miller DT, and Trenor CC, III (2009) Venous thrombosis associated with gene deletion of tissue factor pathway inhibitor. Am J Hematol
http://www.ncbi.nlm.nih.gov/pubmed/19806663

Latella MC, de Gaetano M, Di Castelnuovo A, Napoleone E, Lorenzet R, Gattone M, Giannuzzi P, Rogus J, Huttner K, Donati MB, and Iacoviello L (2009) Interleukin 1 gene cluster, myocardial infarction at young age and inflammatory response of human mononuclear cells. Immunol Invest 38:203-219.
http://www.ncbi.nlm.nih.gov/pubmed/19811432

Maugeri N, Baldini M, Rovere-Querini P, Maseri A, Sabbadini MG, and Manfredi AA (2009) Leukocyte and platelet activation in patients with giant cell arteritis and polymyalgia rheumatica: A clue to thromboembolic risks? Autoimmunity 42:386-388.
http://www.ncbi.nlm.nih.gov/pubmed/19811309

Ryden L, Grabau D, Schaffner F, Jonsson PE, Ruf W, and Belting M (2009) Evidence for tissue factor phosphorylation and its correlation with protease activated receptor expression and the prognosis of primary breast cancer. Int J Cancer
http://www.ncbi.nlm.nih.gov/pubmed/19795460

Sun BW, Shi GS, Zhang P, Zou XQ, and Chen X (2009) [Inhibitive effect of exogenous carbon monoxide-releasing molecules 2 on tissue factor expression in sepsis]. Zhonghua Shao Shang Za Zhi 25:111-114.
http://www.ncbi.nlm.nih.gov/pubmed/19799035

Tanaka R, Nakashima D, Suzuki A, Miyawaki Y, Fujimori Y, et al. (2009) Impaired secretion of carboxyl-terminal truncated factor VII due to an F7 nonsense mutation associated with FVII deficiency. Thromb Res
http://www.ncbi.nlm.nih.gov/pubmed/19822353

van Nispen Tot Pannerden HE, van Dijk SM, Du V, and Heijnen HF (2009) Platelet protein disulfide isomerase is localized in the dense tubular system and does not become surface expressed after activation. Blood
http://www.ncbi.nlm.nih.gov/pubmed/19805615

Van Dreden P, Rousseau A, Savoure A, Lenormand B, Fontaine S, and Vasse M (2009) Plasma thrombomodulin activity, tissue factor activity and high levels of circulating procoagulant phospholipid as prognostic factors for acute myocardial infarction. Blood Coagul Fibrinolysis
http://www.ncbi.nlm.nih.gov/pubmed/19809306

Willis CD, Cameron PA, and Phillips LE (2009) Clinical guidelines and off-licence Recombinant Activated Factor VII (rFVIIa): Content, use and association with patient outcomes. J Thromb Haemost
http://www.ncbi.nlm.nih.gov/pubmed/19804534

Zaar M, Secher NH, Johansson PI, Vainer B, Ezban M, Agerso H, Madsen PL, Lomholt N, Hermit MB, and Lauritzen B (2009) Effects of a recombinant FVIIa analogue, NN1731, on blood loss and survival after liver trauma in the pig. Br J Anaesth
http://www.ncbi.nlm.nih.gov/pubmed/19808774
______________________________________________________
ABOUT TRIGGER
TRIGGER is edited by Jim Morrissey and Pierre Neuenschwander, with editorial assistance by Genie Morrissey. It includes Abstracts of Papers in Press, Meeting Announcements, Positions Sought/Available,or any other pertinent item that subscribers may want to share with their colleagues. To submit an item for publication in Trigger, e-mail us. To request or cancel a subscription,or for more information about TRIGGER or the biology of tissue factor and factor VII, visit our web site. You can also contact us by mail: J.H. Morrissey, University of Illinois College of Medicine, 417 Med Sci Bldg MC-714, 506 S. Mathews Ave., Urbana, IL 61801, USA.

DISCLAIMER: TRIGGER is provided "as is" for information purposes only and without warranty of any kind, express or implied. Users shall assume the entire risk as to the accuracy and usefulness of information in TRIGGER. Opinions expressed here are not necessarily those of the editors or their employers. You may share TRIGGER with your scientific colleagues but you are not permitted to use it or its contents for commercial purposes.
__________________________________________________________

Thursday, October 1, 2009

Vol. 15, No. 19

TRIGGER
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 15, No. 19  October 1, 2009
(The next issue will be on October 15, 2009)
__________________________________________________________
TRIGGER is also available by RSS Feed:
http://feeds.feedburner.com/blogspot/glro
and BLOG:
http://trigger-tf7.blogspot.com/
__________________________________________________________
ANNOUNCEMENTS
In response to our previous request for feedback, Prof. Leon Poller made the interesting suggestion that brief reviews of important published reports in the area of TF, FVII or TFPI biology would be nice to see. Perhaps even just some quick comments about interesting recent papers in this area would be useful. The trick, of course, is to find the time to do this! So, if anyone would like, at any time, to submit such a brief review, highlight, or even just a quick comment about a paper or papers recently been published in this area, we would be happy to include your comments/contributions in TRIGGER.

-Jim Morrissey
__________________________________________________________
PAPERS IN PRESS
None submitted for this issue.
__________________________________________________________
UPCOMING MEETINGS & EVENTS
The 5th International Conference on Thrombosis and Hemostasis: Issues in Cancer will take place in Stresa, Italy, on April 23-25, 2010. Deadline for abstract submission is December 1, 2009. For more information, go to: http://www.icthic.com/
__________________________________________________________
POSITIONS SOUGHT/AVAILABLE
The University of Texas Health Science Center at Tyler invites applications from outstanding scientists for state-funded faculty positions at all levels. Tyler is located midway between Dallas and Shreveport amidst the picturesque lakes and piney woods of East Texas. The mission of the basic and clinical research at the UT Health Science Center focuses on lung injury/repair, pulmonary infectious diseases, cardiovascular diseases, immunology and thoracic oncology, but applicants in other broadly-related fields are welcome. A complete listing and description of current faculty research interests can be found online via UTHSCT's website: http://www.uthct.edu/ResearchThe successful candidate will bring or establish a dynamic independent research program in a discipline related to the mission of UTHSCT. A strong track record of extramural funding and collaboration is required at the Associate and Full Professor levels and is recommended at the Assistant Professor level. Teaching requirements are minimal. Applicants should submit their curriculum vitae, a statement of future research plans and the names of three references to: Dr. Pierre F. Neuenschwander, Faculty Search Committee Chair, University of Texas Health Science Center at Tyler, 11937 US Highway 271, Tyler, Texas 75708-3154, or by email. (pierre DOT neuenschwander AT uthct DOT edu). Please use the subject line: Faculty Applicant.

UTHSCT is an EEO/AA Employer M/F/V/D. This position is security sensitive and subject to Texas Education Code 51.215 which authorizes the employer to obtain criminal history information.
__________________________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI
Papers are culled from NLM MedLine (PubMed). Titles in square brackets indicate that the paper was not published in English. References that lack volume or page numbers are typically electronic pre-publications (E-pubs) ahead of the print publication; if so, the final citation with volume and page numbers may or may not appear in a future issue of Trigger.
THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1j9AYf8_l-cI6qfkNrFPTGD/

Atac FB, Ince DA, Verdi H, Gokmen Z, Yazici AC, Gulcan H, Tarcan A, Taneri A, Sezgin E, and Ozbek N (2009) Lack of association between FXIII-Val34Leu, FVII-323 del/ins, and transforming growth factor
beta1 (915G/T) gene polymorphisms and bronchopulmonary dysplasia (A Single-Center study). DNA Cell Biol
http://www.ncbi.nlm.nih.gov/pubmed/19778283

Barillari G, Frigo MG, Casarotto M, Farnia A, Masse B, Wetzl R, Bianchin A, Rabi A, Malacarne P, Pasca S, and Bigotto E (2009) Use of recombinant activated factor VII in severe post-partum haemorrhage:
Data from the Italian Registry A multicentric observational retrospective study. Thromb Res
http://www.ncbi.nlm.nih.gov/pubmed/19783283

Bidet A, Boiteux-Vergnes C, and Mouton C (2009) [Acquired and repeated factor VII deficiency during infections outbreaks: Case-report.]. Ann Biol Clin (Paris) 67:587-589.
http://www.ncbi.nlm.nih.gov/pubmed/19789134

Chrusciel P, Goch A, Banach M, Mikhailidis DP, Rysz J, and Goch JH (2009) Circadian changes in the hemostatic system in healthy men and patients with cardiovascular diseases. Med Sci Monit 15:RA203-RA208
http://www.ncbi.nlm.nih.gov/pubmed/19789523

Clemens N, Frauenknecht K, Katzav A, Sommer C, and von Landenberg P (2009) In vitro effects of antiphospholipid syndrome-IgG fractions and human monoclonal antiphospholipid IgG antibody on human umbilical vein endothelial cells and monocytes. Ann N Y Acad Sci 1173:805-813.
http://www.ncbi.nlm.nih.gov/pubmed/19758232

De Rosa S, Cirillo P, Paglia A, Sasso L, Di Palma V, and Chiariello M (2010) Reactive oxygen species and antioxidants in the pathophysiology of cardiovascular disease: Does the actual knowledge justify a clinical approach? Curr Vasc Pharmacol
http://www.ncbi.nlm.nih.gov/pubmed/19758111

Jajoria P, Murthy V, Papalardo E, Romay-Penabad Z, Gleason C, and Pierangeli SS (2009) Statins for the treatment of antiphospholipid syndrome? Ann N Y Acad Sci 1173:736-745.
http://www.ncbi.nlm.nih.gov/pubmed/19758223

John R, Panch S, Hrabe J, Wei P, Solovey A, Joyce L, and Hebbel R (2009) Activation of endothelial and coagulation systems in left ventricular assist device recipients. Ann Thorac Surg 88:1171-1179.
http://www.ncbi.nlm.nih.gov/pubmed/19766802

Karatela RA and Sainani GS (2009) Interrelationships of factor VII activity and plasma leptin with insulin resistance in coronary heart disease. Atherosclerosis
http://www.ncbi.nlm.nih.gov/pubmed/19781705

Kubota T, Fukuya Y, Hashimoto R, Kanda T, Suzuki H, Okamura Y, Nanki T, Miyasaka N, and Umezawa K (2009) Possible involvement of chemokine-induced platelet activation in thrombophilic diathesis of antiphospholipid syndrome. Ann N Y Acad Sci 1173:137-145.
http://www.ncbi.nlm.nih.gov/pubmed/19758142

Lee JH, Lee HJ, Bin JH, Hahn SH, Kim SY, Kim HH, and Lee WB (2009) A novel homozygous missense mutation in the factor VII gene of severe factor VII deficiency in a newborn baby. Blood Coagul Fibrinolysis 20:161-164.
http://www.ncbi.nlm.nih.gov/pubmed/19786945

Mota L, Shetty S, Idicula-Thomas S, and Ghosh K (2009) Phenotypic and genotypic characterization of Factor VII deficiency patients from Western India. Clin Chim Acta
http://www.ncbi.nlm.nih.gov/pubmed/19751712

Piotrowski A, Dabrowska-Wojciak I, Mikinka M, Fendler W, Walas W, Sobala W, and Kuczkowski KM (2009) Coagulation abnormalities and severe intraventricular hemorrhage in extremely low birth weight infants. J Matern Fetal Neonatal Med 1-6.
http://www.ncbi.nlm.nih.gov/pubmed/19757338

Poovassery JS, Sarr D, Smith G, Nagy T, and Moore JM (2009) Malaria-induced murine pregnancy failure: Distinct roles for IFN-{gamma} and TNF. J Immunol
http://www.ncbi.nlm.nih.gov/pubmed/19783682

Stahl AL, Sartz L, Nelsson A, Bekassy ZD, and Karpman D (2009) Shiga toxin and lipopolysaccharide induce platelet-leukocyte aggregates and tissue factor release, a thrombotic mechanism in hemolytic uremic syndrome. PLoS ONE 4:e6990
http://www.ncbi.nlm.nih.gov/pubmed/19750223

Tang Z, Geng G, Huang Q, Xu G, Hu H, Chen J, and Li J (2009) Prognostic significance of tissue factor pathway inhibitor-2 in pancreatic carcinoma and its effect on tumor invasion and metastasis. Med Oncol
http://www.ncbi.nlm.nih.gov/pubmed/19763915

Vestergaard S, Nedergaard H, Jonasdottir O, Wagner KM, Mette NA, and Bjerre J (2009) Effect of X-ray radiation exposure on lyophilized recombinant activated factor VII (formulated for storage at room temperature). Curr Med Res Opin
http://www.ncbi.nlm.nih.gov/pubmed/19775196
______________________________________________________
ABOUT TRIGGER
TRIGGER is edited by Jim Morrissey and Pierre Neuenschwander, with editorial assistance by Genie Morrissey. It includes Abstracts of Papers in Press, Meeting Announcements, Positions Sought/Available,or any other pertinent item that subscribers may want to share with their colleagues. To submit an item for publication in Trigger, e-mail us. To request or cancel a subscription,or for more information about TRIGGER or the biology of tissue factor and factor VII, visit our web site. You can also contact us by mail: J.H. Morrissey, University of Illinois College of Medicine, 417 Med Sci Bldg MC-714, 506 S. Mathews Ave., Urbana, IL 61801, USA.

DISCLAIMER: TRIGGER is provided "as is" for information purposes only and without warranty of any kind, express or implied. Users shall assume the entire risk as to the accuracy and usefulness of information in TRIGGER. Opinions expressed here are not necessarily those of the editors or their employers. You may share TRIGGER with your scientific colleagues but you are not permitted to use it or its contents for commercial purposes.
__________________________________________________________

Wednesday, September 16, 2009

Vol. 15, No. 18

TRIGGER
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 15, No. 18 September 15, 2009
(The next issue will be on October 1, 2009)
__________________________________________________________
TRIGGER is also available by RSS Feed:
http://feeds.feedburner.com/blogspot/glro
and BLOG:
http://trigger-tf7.blogspot.com/
__________________________________________________________
ANNOUNCEMENTS
TRIGGER IS NOW AVAILABLE BY RSS FEED AND BLOG:
Beginning today, we are making each TRIGGER issue available on the Internet as an RSS feed and also posting the issue on a blog, both of which are maintained by Pierre Neuenschwander. This is in addition to the regularly e-mailed version you have all been receiving. Please note that anyone submitting an item for Trigger will be given the option of including it only in the e-mailed version. It is therefore possible that some items in the e-mailed version of Trigger might be missing from the RSS or blog versions. But this will probably be uncommon.
Here are the links.

TRIGGER RSS feed:
http://feeds.feedburner.com/blogspot/glro

TRIGGER blog entries:
http://trigger-tf7.blogspot.com/

-Pierre Neuenschwander and Jim Morrissey
__________________________________________________________
PAPERS IN PRESS
AUTHORS: Thomas H. Yun and James H. Morrissey
TITLE: Polyphosphate and omptins: novel bacterial procoagulant agent
JOURNAL: the Journal of Cellular and Molecular Medicine
ABSTRACT: Derangement of the blood clotting system contributes strongly to multiple organ failure in severe sepsis. In this review, we examine two microbial modulators of the clotting system: polyphosphates and omptins. Polyphosphates are linear polymers of inorganic phosphate that are abundant in the acidocalcisomes of prokaryotes and unicellular organisms as well as in the dense granules of human platelets. Polyphosphates modulate hemostasis by: 1) triggering clotting via the contact pathway; 2) accelerating the activation of coagulation factor V (a key cofactor in blood clotting); and 3) causing fibrin to form clots whose fibrils are thicker and more resistant to fibrinolysis. While polyphosphates are found in all prokaryotes, omptins have a more limited distribution among certain Gram-negative species. Omptins are outer membrane aspartyl proteases which were recently found to proteolytically inactivate tissue factor pathway inhibitor (TFPI), the main inhibitor of the initiation phase of blood clotting. Omptin activity against TFPI requires lipopolysaccharide without O-antigen (rough LPS) such as is found on the surface of Yersinia pestis, the etiologic agent of plague. Interestingly, expression of Pla, the Yersinia pestis omptin, has a demonstrated virulence role in converting plasminogen into the fibrinolytic enzyme plasmin, which would seemingly antagonize any procoagulant effect of TFPI inactivation. However, since the rate of TFPI inactivation is much higher than the rate of plasminogen activation, we hypothesize that Pla may have a dual function in supporting the bubonic form of plague which is unique to Yersinia pestis.
SUBMITTED BY: Jim Morrissey
__________________________________________________________
POSTDOCTORAL POSITION AVAILABLE

A Post-Doctoral Position is available in the Department of Pathology and Laboratory Medicine and the program in Hemostasis and Thrombosis at the University of North Carolina at Chapel Hill to study mechanisms contributing to hemostasis and thrombosis. Our group uses in vitro, ex vivo, and in vivo approaches to examine the effects of clotting factors, cellular activity, and flow on clot formation, structure and stability. The current position is to elucidate biochemical and physical mechanisms that promote fibrin stability. Highly motivated individuals with good communication skills and previous experience in coagulation research and/or fluid mechanics are encouraged to apply.
Applicants should possess a PhD or MD/PhD degree. Preference will be given to those individuals who provide a summary of how their interests might fit into the current focus areas of the lab.
Competitive salary and benefits are offered.

Please send CV, half-page description of research interests, and contact information for three references to: Dr. Alisa Wolberg. (alisa_wolberg AT med DOT unc DOT edu). Please use the subject line: Postdoc applicant.
UNC-CH is an equal opportunity employer.
_________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI
Papers are culled from NLM MedLine (PubMed). Titles in square brackets indicate that the paper was not published in English. References that lack volume or page numbers are typically electronic pre-publications (E-pubs) ahead of the print publication; if so, the final citation with volume and page numbers may or may not appear in a future issue of Trigger.
THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1dEUkTcNF0jLFxmiybSXM7q/

Blann A, Shantsila E, and Shantsila A (2009) Microparticles and arterial disease. Semin Thromb Hemost 35:488-496.
http://www.ncbi.nlm.nih.gov/pubmed/19739039

Borawski J, Gozdzikiewicz J, Dubowski M, Pawlak K, and Mysliwiec M (2009) Tissue factor pathway inhibitor release and depletion by sulodexide in humans. Adv Med Sci 54:32-36.
http://www.ncbi.nlm.nih.gov/pubmed/19731406

Cassinello Ogea C, Cotera Usua I, Cortes Franco S, and Felix Lucia J (2009) [Intraoperative use of activated recombinant factor VII in a patient with brain cancer]. Rev Esp Anestesiol Reanim 56:394-396.
http://www.ncbi.nlm.nih.gov/pubmed/19725350

Cheng CY, Sun Y, Wen ZB, He XF, Wang GF, Lin GQ, Jiang HH, Tian XM, and He SL (2009) [Effects of tetramethylpyrazine on thrombin-induced tissue factor expression in vascular endothelial cells.]. Nan Fang Yi Ke Da Xue Xue Bao 29:1743-1747.
http://www.ncbi.nlm.nih.gov/pubmed/19726327

Dutton RP, Hauser C, Boffard K, Dimsitts J, Bernard G, Holcomb J, Leppaniemi A, Tortella B, and Bouillon B (2009) Scientific and logistical challenges in designing the CONTROL trial: Recombinant factor VIIa in severe trauma patients with refractory bleeding. Clin Trials
http://www.ncbi.nlm.nih.gov/pubmed/19737846

Eisses MJ, Richards M, Joffe D, Geiduschek JM, and Chandler WL (2009) The response of hemostatic marker levels to activated factor VII in a neonate following cardiopulmonary bypass. Case Report Med 2009:420152
http://www.ncbi.nlm.nih.gov/pubmed/19730751

Ellis DJ, Usman MH, Milner PG, Canafax DM, and Ezekowitz MD (2009) The first evaluation of a novel vitamin K antagonist, Tecarfarin (ATI-5923), in patients with atrial fibrillation. Circulation
http://www.ncbi.nlm.nih.gov/pubmed/19738136

Erez O, Gotsch F, Mazaki-Tovi S, Vaisbuch E, Kusanovic JP, et al. (2009) Evidence of maternal platelet activation, excessive thrombin generation, and high amniotic fluid tissue factor immunoreactivity and functional activity in patients with fetal death. J Matern Fetal Neonatal Med 22:672-687.
http://www.ncbi.nlm.nih.gov/pubmed/19736615

Faust K, Troger B, Kahl F, Schumacher M, Gopel W, and Hartel C (2009) Successful use of recombinant factor VIIa in a preterm infant with life-threatening haematuria. Blood Coagul Fibrinolysis
http://www.ncbi.nlm.nih.gov/pubmed/19730247

Horstman LL, Jy W, Bidot CJ, Nordberg ML, Minagar A, Alexander JS, Kelley RE, and Ahn YS (2009) Potential roles of cell-derived microparticles in ischemic brain disease. Neurol Res 31:799-806.
http://www.ncbi.nlm.nih.gov/pubmed/19723448

Ingelmo Ingelmo I, Rama-Maceiras P, Fàbregas Julià N N, and Hernandez PJ (2009) [Use of activated recombinant factor VII in patients with brain injury or undergoing brain surgery]. Rev Esp Anestesiol Reanim 56:339-342.
http://www.ncbi.nlm.nih.gov/pubmed/19725340

Kasthuri RS, Taubman MB, and Mackman N (2009) Role of tissue factor in cancer. J Clin Oncol
http://www.ncbi.nlm.nih.gov/pubmed/19738116

Khorana AA and Connolly GC (2009) Assessing risk of venous thromboembolism in the cancer patient. J Clin Oncol
http://www.ncbi.nlm.nih.gov/pubmed/19720906

Kim JS, Park DW, Lee HK, Kim JR, and Baek SH (2009) Early growth response-1 is involved in foam cell formation and is upregulated by the TLR9-MyD88-ERK1/2 pathway. Biochem Biophys Res Commun
http://www.ncbi.nlm.nih.gov/pubmed/19737531

Liang W, Cheng J, Liu R, Wang JP, Mu JG, Wang QH, Wang HJ, and Ma D (2009) Peptide corresponding to the C terminus of tissue factor pathway inhibitor inhibits mesangial cell proliferation and activation in vivo. Peptides
http://www.ncbi.nlm.nih.gov/pubmed/19720104

Livnat T, Zivelin A, Tamarin I, Guetta V, and Salomon O (2009) Thrombin generation assay as a possible tool for assessment of reduced activity of clotting factors induced by antiphospholipid antibodies and in-vitro evaluation of treatment options. Blood Coagul Fibrinolysis
http://www.ncbi.nlm.nih.gov/pubmed/19730246

Lockwood CJ, Paidas M, Murk WK, Kayisli UA, Gopinath A, Huang SJ, Krikun G, and Schatz F (2009) Involvement of human decidual cell-expressed tissue factor in uterine hemostasis and abruption. Thromb Res
http://www.ncbi.nlm.nih.gov/pubmed/19720393

Lopez BR, Aeschlimann DN, Carvajal FC, and Lema FG (2009) [Recombinant activated factor VII for perioperative bleeding.]. Rev Med Chil 137:837-843.
http://www.ncbi.nlm.nih.gov/pubmed/19746288

Marzano AV, Tedeschi A, Spinelli D, Fanoni D, Crosti C, and Cugno M (2009) Coagulation activation in autoimmune bullous diseases. Clin Exp Immunol 158:31-36.
http://www.ncbi.nlm.nih.gov/pubmed/19737228

McMullan DM (2009) Relative risks of recombinant factor VII. Pediatr Crit Care Med 10:604-605.
http://www.ncbi.nlm.nih.gov/pubmed/19741450

Pawlak K, Mysliwiec M, and Pawlak D (2009) Haemostatic system, biochemical profiles, kynurenines and the prevalence of cardiovascular disease in peritoneally dialyzed patients. Thromb Res
http://www.ncbi.nlm.nih.gov/pubmed/19732942

Ray MJ, Juneja M, Bett N, and Walters DL (2009) A comparison of anticoagulation with bivalirudin and provisional GPIIb/IIIa inhibition with unfractionated heparin and mandatory GPIIb/IIIa inhibition during percutaneous coronary intervention in relation to platelet activation and the inhibition of coagulation. EuroIntervention 5:330-335.
http://www.ncbi.nlm.nih.gov/pubmed/19736157

Rousseau A, Robert A, Gerotziafas G, Torchin D, Zannad F, Lacut K, Libersa C, Dasque E, Demolis JL, Elalamy I, and Simon T (2009) Effect of two oral doses of 17beta-estradiol associated with dydrogesterone on thrombin generation in healthy menopausal women: A randomized double-blind placebo-controlled study. Fundam Clin Pharmacol
http://www.ncbi.nlm.nih.gov/pubmed/19719551

Satoh SI, Hitomi A, Ikegaki I, Kawasaki K, Nakazono O, Iwasaki M, Mohri M, and Asano T (2009) Amelioration of endothelial damage/dysfunction is a possible mechanism for the neuroprotective effects of Rho-kinase inhibitors against ischemic brain damage. Brain Res Bull
http://www.ncbi.nlm.nih.gov/pubmed/19723568

Sorensen B, Asvaldsdottir HS, Gudmundsdottir BR, and Onundarson PT (2009) The combination of recombinant factor VIIa and fibrinogen correct clotting ex vivo in patient samples obtained following cardiopulmonary bypass surgery. Thromb Res
http://www.ncbi.nlm.nih.gov/pubmed/19733387

Spivey MH and Duffy MR (2009) Traumatic haemorrhage: A role for recombinant factor VIIa? Anaesthesia 64:1141-1142.
http://www.ncbi.nlm.nih.gov/pubmed/19735409

Tang R, Long J, and Chen B (2009) [Expression of integrin alphavbeta3, tissue factor, and vascular endothelial growth factor in experimental choroidal neovascularization.]. Zhong Nan Da Xue Xue Bao Yi Xue Ban 34:762-767.
http://www.ncbi.nlm.nih.gov/pubmed/19734584

Yun TH and Morrissey JH (2009) Polyphosphate and omptins: Novel bacterial procoagulant agents. J Cell Mol Med
http://www.ncbi.nlm.nih.gov/pubmed/19725923

Zhou H, Wang H, Li N, Yu Y, Huang H, Yan Y, and Wang T (2009) Annexin A2 mediates anti-beta2GPI/beta2GPI-induced tissue factor expression on monocytes. Int J Mol Med 24:557-562.
http://www.ncbi.nlm.nih.gov/pubmed/19724897

Zou YN, Hou JB, Zhang Y, Nie HG, Liu HX, and Yu B (2009) [Ad-TFPI gene transfer attenuates intimal proliferation in rabbit carotid arteries after balloon injury]. Zhonghua Xin Xue Guan Bing Za Zhi 37:169-173.
http://www.ncbi.nlm.nih.gov/pubmed/19719999
______________________________________________________
ABOUT TRIGGER

TRIGGER is edited by Jim Morrissey and Pierre Neuenschwander, with editorial assistance by Genie Morrissey. It includes Abstracts of Papers in Press, Meeting Announcements, Positions Sought/Available,or any other pertinent item that subscribers may want to share with their colleagues. To submit an item for publication in Trigger, e-mail us. To request or cancel a subscription,or for more information about TRIGGER or the biology of tissue factor and factor VII, visit our web site. You can also contact us by mail: J.H. Morrissey, University of Illinois College of Medicine, 417 Med Sci Bldg MC-714, 506 S. Mathews Ave., Urbana, IL 61801, USA.

DISCLAIMER: TRIGGER is provided "as is" for information purposes only and without warranty of any kind, express or implied. Users shall assume the entire risk as to the accuracy and usefulness of information in TRIGGER. Opinions expressed here are not necessarily those of the editors or their employers. You may share TRIGGER with your scientific colleagues but you are not permitted to use it or its contents for commercial purposes.
__________________________________________________________

Tuesday, September 8, 2009

Vol. 15, No. 17

TRIGGER
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 15, No.17 September 1, 2009
(The next issue will be on September 15, 2009)
__________________________________________________________
PAPERS IN PRESS
None submitted for this issue.
__________________________________________________________
POSITIONS SOUGHT/AVAILABLE
Not available for this issue.
__________________________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI
Papers are culled from NLM MedLine (PubMed). Titles in square brackets indicate that the paper was not published in English. References that lack volume or page numbers are typically electronic pre-publications (E-pubs) ahead of the print publication; if so, the final citation with volume and page numbers may or may not appear in a future issue of Trigger.
THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1hMMEMxh76FScQ7Z9P7SeU6/

Aouba A, Dezamis E, Sermet A, Rothschild C, Hermine O, Lasne D, and Torchet MF (2009) Uncomplicated neurosurgical resection of amalignant glioneuronal tumour under haemostatic cover of rFVIIa in a severe haemophilia patient with a high-titre inhibitor: A case report and literature review of rFVIIa use in major surgeries. Haemophilia
http://www.ncbi.nlm.nih.gov/pubmed/19709314

Bastarache JA, Fremont RD, Kropski JA, Bossert FR, and Ware LB (2009) Procoagulant alveolar microparticles in the lungs of patients with acute respiratory distress syndrome. Am J Physiol Lung Cell Mol Physiol
http://www.ncbi.nlm.nih.gov/pubmed/19700643

Brims FJ, Chauhan AJ, Higgins BM, and Shute JK (2009) Coagulation factors in the airways in moderate and severe asthma and the effect of inhaled steroids. Thorax
http://www.ncbi.nlm.nih.gov/pubmed/19703828

Carlstrom LP, Jens JK, Dobyns ME, Passage M, Dickson PI, andEllinwood NM (2009) Inadvertent propagation of factor VII deficiencyin a canine mucopolysaccharidosis type I research breeding colony. Comp Med 59:378-382.
http://www.ncbi.nlm.nih.gov/pubmed/19712579

Culley CM, Guttendorf S, Coldren M, Skledar SJ, Gross PR, Spiro RM,Triulzi DJ, and Ragni MV (2009) Coagulation factor VIIa (recombinant) in nonhemophilic patients requiring neurosurgery. Am J Health SystPharm 66:1554-1559.
http://www.ncbi.nlm.nih.gov/pubmed/19710439

DelGiudice LA and White GA (2009) The role of tissue factor andtissue factor pathway inhibitor in health and disease states. J Vet Emerg Crit Care (San Antonio) 19:23-29.
http://www.ncbi.nlm.nih.gov/pubmed/19691583

Esmon CT (2009) Basic mechanisms and pathogenesis of venousthrombosis. Blood Rev 23:225-229.
http://www.ncbi.nlm.nih.gov/pubmed/19683659

Felten ML and Fischler M (2009) Intraoperative use of activated recombinant factor VII for refractory bleeding in complicated lung transplantations. J Cardiothorac Vasc Anesth
http://www.ncbi.nlm.nih.gov/pubmed/19695905

Holy EW, Stampfli SF, Akhmedov A, Holm N, Camici GG, Luscher TF, and Tanner FC (2009) Laminin receptor activation inhibits endothelial tissue factor expression. J Mol Cell Cardiol
http://www.ncbi.nlm.nih.gov/pubmed/19712679

Ireland HA, Cooper JA, Drenos F, Acharya J, Mitchell JP, Bauer KA, Morrissey JH, Esnouf MP, and Humphries SE (2009) FVII, FVIIa, and downstream markers of extrinsic pathway activation differ by EPCRSer219Gly variant in healthy men. Arterioscler Thromb Vasc Biol
http://www.ncbi.nlm.nih.gov/pubmed/19696402

Jayandharan GR, Nair SC, Poonnoose PM, Thomas R, John J, et al.(2009) Polymorphism in factor VII gene modifies phenotype of severe haemophilia. Haemophilia
http://www.ncbi.nlm.nih.gov/pubmed/19686262

Kjalke M, Runge M, Rojkjaer R, Steinbruchel D, and Johansson PI(2009) Influence of cardiopulmonary bypass on the interaction of recombinant factor VIIa with activated platelets. J Extra Corpor Technol 41:97-104.
http://www.ncbi.nlm.nih.gov/pubmed/19681308

Lai XW, Yang LH, Liu XE, Zhang Y, Feng JJ, and Chen JF (2009) [Correlation analysis of tissue factor promotor polymorphism -1208I/D and venous thromboembolism.]. Zhongguo Shi Yan Xue Ye Xue Za Zhi 17:1036-1039.
http://www.ncbi.nlm.nih.gov/pubmed/19698254

Lappegard KT, Christiansen D, Pharo A, Thorgersen EB, Hellerud BC, etal. (2009) Human genetic deficiencies reveal the roles of complement in the inflammatory network: Lessons from nature. Proc Natl Acad Sci U S A
http://www.ncbi.nlm.nih.gov/pubmed/19717455

Livnat T, Tamarin I, Mor Y, Winckler H, Horowitz Z, Korianski Y, Bar-Zakay B, Seligsohn U, and Salomon O (2009) Recombinant activated factor VII and tranexamic acid are haemostatically effective during major surgery in factor XI-deficient patients with inhibitor antibodies. Thromb Haemost 102:487-492.
http://www.ncbi.nlm.nih.gov/pubmed/19718468

Llorente-Cortes V, Estruch R, Mena MP, Ros E, Gonzalez MA, Fito M, Lamuela-Raventos RM, and Badimon L (2009) Effect of Mediterranean diet on the expression of pro-atherogenic genes in a population at high cardiovascular risk. Atherosclerosis
http://www.ncbi.nlm.nih.gov/pubmed/19712933

Macey MG, Wolf SI, Wheeler-Jones CP, and Lawson C (2009) Expression of blood coagulation factors on monocytes after exposure to TNF treated endothelium in a novel whole blood model of arterial flow. J Immunol Methods
http://www.ncbi.nlm.nih.gov/pubmed/19699743

Maciel EO, Carvalhal GF, Silva VD, Batista EL, Jr., and Garicochea B(2009) Increased Tissue Factor Expression and Poor Nephroblastoma Prognosis. J Urol
http://www.ncbi.nlm.nih.gov/pubmed/19683742

McEachron T and Mackman N (2009) Tumors, ticks and tissue factor. J Thromb Haemost
http://www.ncbi.nlm.nih.gov/pubmed/19694942

Mosad E, Elsayh KI, and Eltayeb AA (2009) Tissue Factor Pathway Inhibitor and P-Selectin as markers of sepsis-induced non-overt disseminated intravascular coagulopathy. Clin Appl Thromb Hemost
http://www.ncbi.nlm.nih.gov/pubmed/19689998

Pan S, White TA, Witt TA, Chiriac A, Mueske CS, and Simari RD (2009)Vascular-directed Tissue Factor Pathway Inhibitor overexpression regulates plasma cholesterol and reduces atherosclerotic plaque development. Circ Res
http://www.ncbi.nlm.nih.gov/pubmed/19713537

Phillips LE, Zatta AJ, Schembri NL, Noone AK, and Isbister J (2009) Uncontrolled bleeding in surgical patients: The role of recombinant activated factor VIIa. Curr Drug Targets 10:744-770.
http://www.ncbi.nlm.nih.gov/pubmed/19702522

Santagostino E, Morfini M, Auerswald GK, Benson GM, Salek SZ, LambertT, Salaj P, Jimenez-Yuste V, and Ljung RC (2009) Paediatric haemophilia with inhibitors: Existing management options, treatment gaps and unmet needs. Haemophilia 15:983-989.
http://www.ncbi.nlm.nih.gov/pubmed/19712172

Swiniarska J, Zekanowska E, Dancewicz M, Bella M, Szczesny TJ, and Kowalewski J (2009) Pneumonectomy due to lung cancer results in amore pronounced activation of coagulation system than lobectomy. Eur J Cardiothorac Surg
http://www.ncbi.nlm.nih.gov/pubmed/19692265

Weiss DR, Juchem G, Kemkes BM, Gansera B, and Nees S (2009) Extensive deendothelialization and thrombogenicity in routinely prepared vein grafts for coronary bypass operations: Facts and remedy. Int J Clin Exp Med 2:95-113.
http://www.ncbi.nlm.nih.gov/pubmed/19684884

Willis CD, Cameron PA, and Phillips L (2009) Variation in the use of Recombinant Activated Factor VII in critical bleeding. Intern Med J
http://www.ncbi.nlm.nih.gov/pubmed/19712199

Yang L, Manithody C, and Rezaie AR (2009) Functional role of O-linked and N-linked glycosylation sites present on the activation peptide of factor X. J Thromb Haemost
http://www.ncbi.nlm.nih.gov/pubmed/19691479
__________________________________________________________
ABOUT TRIGGER

TRIGGER is edited by Jim Morrissey and Pierre Neuenschwander, with editorial assistance by Genie Morrissey. It includes Abstracts of Papers in Press, Meeting Announcements, Positions Sought/Available,or any other pertinent item that subscribers may want to share with their colleagues. To submit an item for publication in Trigger, e-mail us. To request or cancel a subscription,or for more information about TRIGGER or the biology of tissue factor and factor VII, visit our web site. You can also contact us by mail: J.H. Morrissey, University of Illinois College ofMedicine, 417 Med Sci Bldg MC-714, 506 S. Mathews Ave., Urbana, IL 61801, USA.

DISCLAIMER: TRIGGER is provided "as is" for information purposes only and without warranty of any kind, express or implied. Users shall assume the entire risk as to the accuracy and usefulness of information in TRIGGER. Opinions expressed here are not necessarily those of the editors or their employers. You may share TRIGGER with your scientific colleagues but you are not permitted to use it or its contents for commercial purposes.
__________________________________________________________