Thursday, December 15, 2011

Vol. 17, No. 24

TRIGGER
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 17, No. 24 December 15, 2011
(The next issue will be on January 2, 2012)
__________________________________________________________
TRIGGER is also available by RSS Feed:
and BLOG:
http://trigger-tf7.blogspot.com/
__________________________________________________________
ANNOUNCEMENTS
Our best holiday wishes to all the TRIGGER subscribers for a happy, healthy and prosperous New Year!

-Jim & Genie Morrissey and Pierre Neuenschwander
__________________________________________________________
PAPERS IN PRESS
None submitted for this issue.
__________________________________________________________
UPCOMING MEETINGS & EVENTS
The meeting brochure and online registration for the upcoming "6th Symposium on Hemostasis with Special Focus on Tissue Factor, Factor VIIa and Tissue Factor Pathway Inhibitor-- Hemostasis and Beyond" are now available at:
http://medicine.med.unc.edu/hemonc/tf2012
The meeting will be held on 3-5 May 2012, at the Carolina Inn, Chapel Hill NC, USA.
__________________________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI
Papers are culled from NLM MedLine (PubMed). Titles in square brackets indicate that the paper was not published in English. References that lack volume or page numbers are typically electronic pre-publications (E-pubs) ahead of the print publication; if so, the final citation with volume and page numbers may or may not appear in a future issue of Trigger.
THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1jme8kBYm8u5kkri2b58UN-/

Binny C, McIntosh J, Della Peruta M, Kymalainen H, Tuddenham EG, Buckley SM, . . . Nathwani AC (2011) AAV-mediated gene transfer in the perinatal period results in expression of FVII at levels that protect against fatal spontaneous haemorrhage. Blood.
http://www.ncbi.nlm.nih.gov/pubmed/22134170

Brophy DF, Martin EJ, Barrett JC, Nolte ME, Kuhn JG, Hedner U, Ezban M (2011) Overcoming delayed in-vitro response to rFVIIa: effects of rFVIIa and rFVIIa analogue (vatreptacog alfa) concentration escalation in whole blood assays. Blood Coagul Fibrinolysis 22:541-546.
http://www.ncbi.nlm.nih.gov/pubmed/21681082

Brophy DF, Martin EJ, Christian Barrett J, Nolte ME, Kuhn JG, Gerk PM, . . . Hedner U (2011) Monitoring rFVIIa 90 mug kg(1) dosing in haemophiliacs: comparing laboratory response using various whole blood assays over 6 h. Haemophilia 17:e949-957.
http://www.ncbi.nlm.nih.gov/pubmed/21362113

Camire RM (2011) A new look at blood coagulation factor V. Curr Opin Hematol 18:338-342.
http://www.ncbi.nlm.nih.gov/pubmed/21730834

Carlsson K, Persson E, Lindgren M, Carlsson U, Svensson M (2011) Effects on the conformation of FVIIa by sTF and Ca(2) binding: studies of fluorescence resonance energy transfer and quenching. Biochem Biophys Res Commun 413:545-549.
http://www.ncbi.nlm.nih.gov/pubmed/21924243

Chavez-Tapia NC, Alfaro-Lara R, Tellez-Avila F, Barrientos-Gutierrez T, Gonzalez-Chon O, Mendez-Sanchez N, Uribe M (2011) Prophylactic activated recombinant factor VII in liver resection and liver transplantation: systematic review and meta-analysis. PLoS One 6:e22581.
http://www.ncbi.nlm.nih.gov/pubmed/21818342

Cocco E, Varughese J, Buza N, Bellone S, Lin KY, Bellone M, . . . Santin AD (2011) Tissue factor expression in ovarian cancer: implications for immunotherapy with hI-con1, a factor VII-IgGF(c) chimeric protein targeting tissue factor. Clin Exp Metastasis 28:689-700.
http://www.ncbi.nlm.nih.gov/pubmed/21725665

Collins PW (2011) Management of acquired haemophilia A. J Thromb Haemost 9 Suppl 1:226-235.
http://www.ncbi.nlm.nih.gov/pubmed/21781259

Cui MZ (2011) Lysophosphatidic acid effects on atherosclerosis and thrombosis. Clin Lipidol 6:413-426.
http://www.ncbi.nlm.nih.gov/pubmed/22162980

Egorina EM, Sovershaev MA, Hansen JB (2011) The role of tissue factor in systemic inflammatory response syndrome. Blood Coagul Fibrinolysis 22:451-456.
http://www.ncbi.nlm.nih.gov/pubmed/21597365

Esmon CT, Xu J, Lupu F (2011) Innate immunity and coagulation. J Thromb Haemost 9 Suppl 1:182-188.
http://www.ncbi.nlm.nih.gov/pubmed/21781254

Girard TJ, Tuley E, Broze GJ, Jr. (2011) TFPIbeta is the GPI-anchored TFPI isoform on human endothelial cells and placental microsomes. Blood.
http://www.ncbi.nlm.nih.gov/pubmed/22144186

Gurusamy KS, Pissanou T, Pikhart H, Vaughan J, Burroughs AK, Davidson BR (2011) Methods to decrease blood loss and transfusion requirements for liver transplantation. Cochrane Database Syst Rev 12:CD009052.
http://www.ncbi.nlm.nih.gov/pubmed/22161443

Hay JW, Zhou ZY (2011) Economical comparison of APCC vs. rFVIIa for mild-to-moderate bleeding episodes in haemophilia patients with inhibitors. Haemophilia 17:e969-974.
http://www.ncbi.nlm.nih.gov/pubmed/21649802

Hibi K, Goto T, Shirahata A, Saito M, Kigawa G, Nemoto H, Sanada Y (2011) Detection of TFPI2 methylation in the serum of colorectal cancer patients. Cancer Lett 311:96-100.
http://www.ncbi.nlm.nih.gov/pubmed/21820798

Hoshi A, Matsumoto A, Chung J, Isozumi Y, Koyama T (2011) Activation of coagulation by a thalidomide-based regimen. Blood Coagul Fibrinolysis 22:532-540.
http://www.ncbi.nlm.nih.gov/pubmed/21670663

Hwang SM, Kim JE, Han KS, Kim HK (2011) Thrombomodulin phenotype of a distinct monocyte subtype is an independent prognostic marker for disseminated intravascular coagulation. Crit Care 15:R113.
http://www.ncbi.nlm.nih.gov/pubmed/21489300

Ingerslev J, Sorensen B (2011) Parallel use of by-passing agents in haemophilia with inhibitors: a critical review. Br J Haematol 155:256-262.
http://www.ncbi.nlm.nih.gov/pubmed/21895627

Kakko T, Jaakkola U, Raitakari OT, Kallio J (2011) Inflammatory effects of blood leukocytes: association with vascular function in neuropeptide Y proline 7-genotyped type 2 diabetes patients. Diab Vasc Dis Res 8:221-228.
http://www.ncbi.nlm.nih.gov/pubmed/21746772

Kayem G, Kurinczuk JJ, Alfirevic Z, Spark P, Brocklehurst P, Knight M (2011) Specific second-line therapies for postpartum haemorrhage: a national cohort study. BJOG 118:856-864.
http://www.ncbi.nlm.nih.gov/pubmed/21392247

Kim WJ, Oh JY, Son HJ, Chin JH, Choi DK, Lee EH, . . . Choi IC (2011) The prophylactic use of recombinant factor VIIa in a patient with DeBakey type III aortic dissection -A case report. Korean J Anesthesiol 61:431-434.
http://www.ncbi.nlm.nih.gov/pubmed/22148094

Knudsen T, Kjalke M, Tranholm M, Nichols TC, Jensen AL, Kristensen AT (2011) Development of a flow cytometric assay for detection of coated platelets in dogs and evaluation of binding of coated platelets to recombinant human coagulation factor VIIa. Am J Vet Res 72:1007-1014.
http://www.ncbi.nlm.nih.gov/pubmed/21801056

Kobayashi T, Nakabayashi M, Yoshioka A, Maeda M, Ikenoue T (2011) Recombinant activated factor VII (rFVIIa/NovoSeven((R))) in the management of severe postpartum haemorrhage: initial report of a multicentre case series in Japan. Int J Hematol.
http://www.ncbi.nlm.nih.gov/pubmed/22160834

Krijnen PA, Hahn NE, Kholova I, Baylan U, Sipkens JA, van Alphen FP, . . . Niessen HW (2012) Loss of DPP4 activity is related to a prothrombogenic status of endothelial cells: implications for the coronary microvasculature of myocardial infarction patients. Basic Res Cardiol 107:1-13.
http://www.ncbi.nlm.nih.gov/pubmed/22167343

Kruthika-Vinod TP, Nagaraja D, Christopher R (2011) Coagulation factor VII R353Q polymorphism and the risk of puerperal cerebral venous thrombosis. J Clin Neurosci.
http://www.ncbi.nlm.nih.gov/pubmed/22136731

Krysiak R, Gdula-Dymek A, Okopien B (2011) Hemostatic effects of bezafibrate and omega-3 fatty acids in isolated hypertriglyceridemic patients. Pharmacol Rep 63:763-771.
http://www.ncbi.nlm.nih.gov/pubmed/21857087

Latchamsetty R, Gautam S, Bhakta D, Chugh A, John RM, Epstein LM, . . . Jongnarangsin K (2011) Management and outcomes of cardiac tamponade during atrial fibrillation ablation in the presence of therapeutic anticoagulation with warfarin. Heart Rhythm 8:805-808.
http://www.ncbi.nlm.nih.gov/pubmed/21236362

Lemon SJ, Jr., Crannage AJ (2011) Pharmacologic anticoagulation reversal in the emergency department. Adv Emerg Nurs J 33:212-223; quiz 224-215.
http://www.ncbi.nlm.nih.gov/pubmed/21836448

Li J, Liu Y, Yin W, Zhang C, Huang J, Liao C, . . . Xiao P (2011) Alterations of the preoperative coagulation profile in patients with acute appendicitis. Clin Chem Lab Med 49:1333-1339.
http://www.ncbi.nlm.nih.gov/pubmed/21663567

Lisman T, Porte RJ (2011) Recombinant factor VIIa to treat severe bleeding in patients with liver disease: pitfalls and possibilities. J Hepatol 55:950-951.
http://www.ncbi.nlm.nih.gov/pubmed/21925325

Liu Y, Jiang P, Capkova K, Xue D, Ye L, Sinha SC, . . . Liu C (2011) Tissue factor-activated coagulation cascade in the tumor microenvironment is critical for tumor progression and an effective target for therapy. Cancer Res 71:6492-6502.
http://www.ncbi.nlm.nih.gov/pubmed/21880589

Luszczak J, Undas A, Gissel M, Olszowska M, Butenas S (2011) Activated factor XI and tissue factor in aortic stenosis: links with thrombin generation. Blood Coagul Fibrinolysis 22:473-479.
http://www.ncbi.nlm.nih.gov/pubmed/21519234

Mayne E, Funderburg NT, Sieg SF, Asaad R, Kalinowska M, Rodriguez B, . . . Lederman MM (2011) Increased platelet and microparticle activation in HIV infection: upregulation of P-selectin and tissue factor expression. J Acquir Immune Defic Syndr.
http://www.ncbi.nlm.nih.gov/pubmed/22156911

Meisel SR, Xu XP, Edgington TS, Cercek B, Ong J, Kaul S, Shah PK (2011) Dose-dependent modulation of tissue factor protein and procoagulant activity in human monocyte-derived macrophages by oxidized low density lipoprotein. J Atheroscler Thromb 18:596-603.
http://www.ncbi.nlm.nih.gov/pubmed/21467727

Milligan C, Higginson I, Smith JE (2011) Emergency department staff knowledge of massive transfusion for trauma: the need for an evidence based protocol. Emerg Med J 28:870-872.
http://www.ncbi.nlm.nih.gov/pubmed/21030544

Paluszkiewicz P, Mayzner-Zawadzka E, Baranowski W, Breborowicz GH, Brzezinski M, Durek G, . . . Wujtewicz M (2011) Recommendations for the management of trauma or surgery-related massive blood loss. Pol Przegl Chir 83:465-476.
http://www.ncbi.nlm.nih.gov/pubmed/22166722

Park JB, Kim BK, Kwon YW, Muller DN, Lee HC, Youn SW, . . . Kim HS (2011) Peroxisome proliferator-activated receptor-gamma agonists suppress tissue factor overexpression in rat balloon injury model with Paclitaxel infusion. PLoS One 6:e28327.
http://www.ncbi.nlm.nih.gov/pubmed/22140576

Patanwala AE, Acquisto NM, Erstad BL (2011) Prothrombin complex concentrate for critical bleeding. Ann Pharmacother 45:990-999.
http://www.ncbi.nlm.nih.gov/pubmed/21730276

Peled E, Rovitsky A, Axelman E, Norman D, Brenner B, Nadir Y (2011) Increased heparanase level and procoagulant activity in orthopedic surgery patients receiving prophylactic dose of enoxaparin. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/22154361

Quezada M, Diaz J, Henriquez S, Bravo ML, Aranda E, Oliva B, . . . Owen GI (2010) 2-Methoxyestradiol inhibits progesterone-dependent tissue factor expression and activity in breast cancer cells. Horm Cancer 1:117-126.
http://www.ncbi.nlm.nih.gov/pubmed/21761355

Rasekh HR, Imani A, Karimi M, Golestani M (2011) Cost-utility analysis of immune tolerance induction therapy versus on-demand treatment with recombinant factor VII for hemophilia A with high titer inhibitors in Iran. Clinicoecon Outcomes Res 3:207-212.
http://www.ncbi.nlm.nih.gov/pubmed/22163168

Ruf W, Disse J, Carneiro-Lobo TC, Yokota N, Schaffner F (2011) Tissue factor and cell signalling in cancer progression and thrombosis. J Thromb Haemost 9 Suppl 1:306-315.
http://www.ncbi.nlm.nih.gov/pubmed/21781267

Saito Y, Hashimoto Y, Kuroda J, Yasunaga M, Koga Y, Takahashi A, Matsumura Y (2011) The inhibition of pancreatic cancer invasion-metastasis cascade in both cellular signal and blood coagulation cascade of tissue factor by its neutralisation antibody. Eur J Cancer 47:2230-2239.
http://www.ncbi.nlm.nih.gov/pubmed/21621407

Sangha N, Gonzales NR (2011) Treatment targets in intracerebral hemorrhage. Neurotherapeutics 8:374-387.
http://www.ncbi.nlm.nih.gov/pubmed/21732225

Sartori MT, Della Puppa A, Ballin A, Saggiorato G, Bernardi D, Padoan A, . . . Cella G (2011) Prothrombotic state in glioblastoma multiforme: an evaluation of the procoagulant activity of circulating microparticles. J Neurooncol 104:225-231.
http://www.ncbi.nlm.nih.gov/pubmed/21104297

Schmid D, Svoboda M, Sorgner A, Moravcevic I, Thalhammer T, Chiba P, Moslinger T (2011) Glibenclamide reduces proinflammatory cytokines in an ex vivo model of human endotoxinaemia under hypoxaemic conditions. Life Sci 89:725-734.
http://www.ncbi.nlm.nih.gov/pubmed/21925514

Schmid P, Mordasini A, Luginbuhl M, Regli B, Kohler HP, Zimmermann H, . . . Alberio L (2011) Low-dose recombinant factor VIIa for massive bleeding: a single centre observational cohort study with 73 patients. Swiss Med Wkly 141:w13213.
http://www.ncbi.nlm.nih.gov/pubmed/21735365

Shander A, Walsh CE, Cromwell C (2011) Acquired hemophilia: a rare but life-threatening potential cause of bleeding in the intensive care unit. Intensive Care Med 37:1240-1249.
http://www.ncbi.nlm.nih.gov/pubmed/21626430

Siddiq S, Clark A, Mumford A (2011) A systematic review of the management and outcomes of pregnancy in Glanzmann thrombasthenia. Haemophilia 17:e858-869.
http://www.ncbi.nlm.nih.gov/pubmed/21457404

Sie P, Samama CM, Godier A, Rosencher N, Steib A, Llau JV, . . . Albaladejo P (2011) Surgery and invasive procedures in patients on long-term treatment with direct oral anticoagulants: Thrombin or factor-Xa inhibitors. Recommendations of the Working Group on perioperative haemostasis and the French Study Group on thrombosis and haemostasis. Arch Cardiovasc Dis 104:669-676.
http://www.ncbi.nlm.nih.gov/pubmed/22152517

Sorour Y, Van Veen JJ, Makris M (2010) Recombinant factor VIIa for unlicensed indications--a definite No or a cautious Maybe in selected patients? Int J Clin Pract 64:1468-1471.
http://www.ncbi.nlm.nih.gov/pubmed/20722768

Stephan F, Hazelzet JA, Bulder I, Boermeester MA, van Till JO, van der Poll T, . . . Zeerleder S (2011) Activation of factor VII-activating protease in human inflammation: a sensor for cell death. Crit Care 15:R110.
http://www.ncbi.nlm.nih.gov/pubmed/21466697

Stokol T, Daddona JL, Mubayed LS, Trimpert J, Kang S (2011) Evaluation of tissue factor expression in canine tumor cells. Am J Vet Res 72:1097-1106.
http://www.ncbi.nlm.nih.gov/pubmed/21801068

Storgaard M, Henriksen ST, Zaragoza F, Peschke B, Tanner D (2011) Design, synthesis and biological activity of novel peptidyl benzyl ketone FVIIa inhibitors. Bioorg Med Chem Lett 21:3918-3922.
http://www.ncbi.nlm.nih.gov/pubmed/21641796

Takeuchi H, Fernandez-Valdivia RC, Caswell DS, Nita-Lazar A, Rana NA, Garner TP, . . . Haltiwanger RS (2011) Rumi functions as both a protein O-glucosyltransferase and a protein O-xylosyltransferase. Proc Natl Acad Sci U S A 108:16600-16605.
http://www.ncbi.nlm.nih.gov/pubmed/21949356

Tang JQ, Fan Q, Wu WH, Jia ZC, Li H, Yang YM, . . . Wan YL (2010) Extrahepatic synthesis of coagulation factor VII by colorectal cancer cells promotes tumor invasion and metastasis. Chin Med J (Engl) 123:3559-3565.
http://www.ncbi.nlm.nih.gov/pubmed/22166631

Tran HT, Tjonnfjord GE, Paus A, Holme PA (2011) rFVIIa administered by continuous infusion during surgery in patients with severe congenital FVII deficiency. Haemophilia 17:764-770.
http://www.ncbi.nlm.nih.gov/pubmed/21707871

van den Hengel LG, Kocaturk B, Reitsma PH, Ruf W, Versteeg HH (2011) Complete abolishment of coagulant activity in monomeric disulfide-deficient tissue factor. Blood 118:3446-3448.
http://www.ncbi.nlm.nih.gov/pubmed/21940832

Vang ML, Hvas AM, Ravn HB (2011) Urgent reversal of vitamin K antagonist therapy. Acta Anaesthesiol Scand 55:507-516.
http://www.ncbi.nlm.nih.gov/pubmed/21418150

Versteeg HH, Ruf W (2011) Thiol pathways in the regulation of tissue factor prothrombotic activity. Curr Opin Hematol 18:343-348.
http://www.ncbi.nlm.nih.gov/pubmed/21778880

Walsh M, Thomas SG, Howard JC, Evans E, Guyer K, Medvecz A, . . . Castellino FJ (2011) Blood component therapy in trauma guided with the utilization of the perfusionist and thromboelastography. J Extra Corpor Technol 43:162-167.
http://www.ncbi.nlm.nih.gov/pubmed/22164456

Weatherall J, Barnes N, Brown C, Preaud E (2011) Future characteristics of bypassing agents to improve care of hemophilia inhibitor patients: an economic and health-related quality of life perspective. Expert Rev Pharmacoecon Outcomes Res 11:411-414.
http://www.ncbi.nlm.nih.gov/pubmed/21831021

Wyckoff T, Reed EA, Desai ND, Augoustides JG (2011) Possible Anaphylaxis Due to Recombinant Factor VIIa Administration During Thoracic Aortic Surgery. J Cardiothorac Vasc Anesth.
http://www.ncbi.nlm.nih.gov/pubmed/22155168

Yamamoto E, Nishimura N, Okada K, Sekido C, Yamamichi S, Hasumi K (2011) Inhibitors of autoactivation of plasma hyaluronan-binding protein (factor VII activating protease). Biol Pharm Bull 34:462-470.
http://www.ncbi.nlm.nih.gov/pubmed/21467630

Young G, Auerswald G, Jimenez-Yuste V, Konkle BA, Lambert T, Morfini M, . . . Blanchette V (2011) When should prophylaxis therapy in inhibitor patients be considered? Haemophilia 17:e849-857.
http://www.ncbi.nlm.nih.gov/pubmed/21418444

Zhu J, Xie R, Piao X, Hou Y, Zhao C, Qiao G, . . . Lu Y (2011) Homocysteine enhances clot-promoting activity of endothelial cells via phosphatidylserine externalization and microparticles formation. Amino Acids.
http://www.ncbi.nlm.nih.gov/pubmed/22160264
__________________________________________________________
ABOUT TRIGGER
TRIGGER is edited by Jim Morrissey and Pierre Neuenschwander, with editorial assistance by Genie Morrissey. It includes Abstracts of Papers in Press, Meeting Announcements, Positions Sought/Available,or any other pertinent item that subscribers may want to share with their colleagues. To submit an item for publication in Trigger, e-mail us. To request or cancel a subscription,or for more information about TRIGGER or the biology of tissue factor and factor VII, visit our web site. You can also contact us by mail: J.H. Morrissey, University of Illinois College of Medicine, 417 Med Sci Bldg MC-714, 506 S. Mathews Ave., Urbana, IL 61801, USA.

DISCLAIMER: TRIGGER is provided "as is" for information purposes only and without warranty of any kind, express or implied. Users shall assume the entire risk as to the accuracy and usefulness of information in TRIGGER. Opinions expressed here are not necessarily those of the editors or their employers. You may share TRIGGER with your scientific colleagues but you are not permitted to use it or its contents for commercial purposes.
__________________________________________________________

Monday, December 12, 2011

Vol. 17, No. 23

TRIGGER
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 17, No. 23 December 1, 2011
(The next issue will be on December 15, 2011)
__________________________________________________________
TRIGGER is also available by RSS Feed:
and BLOG:
http://trigger-tf7.blogspot.com/
__________________________________________________________
POSITIONS SOUGHT/AVAILABLE
The UNC McAllister Heart Institute, in collaboration with the departments in the School of Medicine and across the entire University, seeks outstanding candidates for an open-rank position at all levels of basic/translational research. This recruitment seeks a research scientist/physician interested in cardiovascular disease, including but not limited to vascular development, angiogenesis, cardiac pathology, and thrombosis. Applicants should have a strong record of recent accomplishments as a post-doctoral fellow or sustained productivity as an established faculty member. Academic credentials and experience will determine rank, track, and salary in an appropriate academic department. Applications will be reviewed beginning November 10, 2011 and until the position is filled.

Applicants must submit a letter of interest, curriculum vitae, a description of research plans, and names of four references through UNC Chapel Hill's web-based system. PDF documents are preferred. The following link will direct you to the position:
http://jobs.unc.edu/2502018

UNC McAllister Heart Institute and the University of North Carolina is an Equal Opportunity Employer. Hiring is contingent upon eligibility to work in the United States. Women and minorities are encouraged to apply.
__________________________________________________________
PAPERS IN PRESS
None submitted for this issue.
__________________________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI
Papers are culled from NLM MedLine (PubMed). Titles in square brackets indicate that the paper was not published in English. References that lack volume or page numbers are typically electronic pre-publications (E-pubs) ahead of the print publication; if so, the final citation with volume and page numbers may or may not appear in a future issue of Trigger.
THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1felWqyBWcGWhnjhWiipypk/

Alstrom U, Levin LA, Stahle E, Svedjeholm R, Friberg O (2011) Cost analysis of re-exploration for bleeding after coronary artery bypass graft surgery. Br J Anaesth.
http://www.ncbi.nlm.nih.gov/pubmed/22113929

Bhananker SM, Ramaiah R (2011) Trends in trauma transfusion. Int J Crit Illn Inj Sci 1:51-56.
http://www.ncbi.nlm.nih.gov/pubmed/22096774

Bouchama A, Al-Mohanna F, Assad L, Baturcam E, Eldali A, Owaidah T, Dehbi M (2011) Tissue factor/factor VIIa pathway mediates coagulation activation in induced-heat stroke in the baboon. Crit Care Med.
http://www.ncbi.nlm.nih.gov/pubmed/22080642

Busch JD, Van Andel R, Cordova J, Colman RE, Keim P, Rocke TE, . . . Wagner DM (2011) Population Differences in Host Immune Factors May Influence Survival of Gunnison's Prairie Dogs (Cynomys gunnisoni) during Plague Outbreaks. J Wildl Dis 47:968-973.
http://www.ncbi.nlm.nih.gov/pubmed/22102668

Cerletti C, Tamburrelli C, Izzi B, Gianfagna F, de Gaetano G (2011) Platelet-leukocyte interactions in thrombosis. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/22075180

Cheng V, Kashyap SR, Schauer PR, Kirwan JP, McCrae KR (2011) Restoration of glycemic control in patients with type 2 diabetes mellitus after bariatric surgery is associated with reduction in microparticles. Surg Obes Relat Dis.
http://www.ncbi.nlm.nih.gov/pubmed/22093380

Christensen A, Jensen JT, Nohr AM, Cooper DL (2011) Room-Temperature-Stable Coagulation Factor VII Recombinant: Chemical and Microbiologic Stability Over 24 Hours During Continuous In VitroInfusion. Clin Ther.
http://www.ncbi.nlm.nih.gov/pubmed/22088413

Comes JF, Devignes J, Thiebaugeorges O, Briquel ME, Lecompte T (2011) Prophylactic use of a recombinant activated factor VII in delivery haemorrhage by caesarean in a woman with major factor VII deficiency: a case report. Ann Biol Clin (Paris) 69:713-719.
http://www.ncbi.nlm.nih.gov/pubmed/22123573

Corlan AD, Ross J (2011) Canalization effect in the coagulation cascade and the interindividual variability of oral anticoagulant response. a simulation Study. Theor Biol Med Model 8:37.
http://www.ncbi.nlm.nih.gov/pubmed/22082142

Dirkmann D, Gorlinger K, Gisbertz C, Dusse F, Peters J (2011) Factor XIII and Tranexamic Acid But Not Recombinant Factor VIIa Attenuate Tissue Plasminogen Activator-Induced Hyperfibrinolysis in Human Whole Blood. Anesth Analg.
http://www.ncbi.nlm.nih.gov/pubmed/22104068

Egorina EM, Sovershaev TA, Hansen JB, Sovershaev MA (2011) BMP-2 inhibits TF expression in human monocytes by shutting down MAPK signaling and AP-1 transcriptional activity. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/22119392

Fadzil F (2011) Recurrent intracranial haemorrhages in a patient with factor seven deficiency: a case report. Med J Malaysia 66:261-263.
http://www.ncbi.nlm.nih.gov/pubmed/22111455

Francischetti IM, Oliveira CJ, Ostera GR, Yager SB, Debierre-Grockiego F, Carregaro V, . . . Waisberg M (2011) Defibrotide Interferes With Several Steps of the Coagulation-Inflammation Cycle and Exhibits Therapeutic Potential to Treat Severe Malaria. Arterioscler Thromb Vasc Biol.
http://www.ncbi.nlm.nih.gov/pubmed/22116094

Fukushima T, Mikane T, Ono D, Oku S, Kobayashi H, Watanabe Y, . . . Tokioka H (2011) A case of acquired hemophilia A with massive hemothorax. J Anesth.
http://www.ncbi.nlm.nih.gov/pubmed/22086484

Graham EM, Atz AM, Gillis J, Desantis SM, Haney AL, Deardorff RL, . . . Spinale FG (2011) Differential effects of aprotinin and tranexamic acid on outcomes and cytokine profiles in neonates undergoing cardiac surgery. J Thorac Cardiovasc Surg.
http://www.ncbi.nlm.nih.gov/pubmed/22075061

Hay JW, Zhou ZY (2011) Systematic literature review of economics analysis on treatment of mild-to-moderate bleeds with aPCC versus rFVIIa. J Med Econ 14:516-525.
http://www.ncbi.nlm.nih.gov/pubmed/21699366

Henriquez S, Calderon C, Quezada M, Oliva B, Bravo ML, Aranda E, . . . Owen GI (2011) Progesterone utilizes distinct membrane pools of tissue factor to increase coagulation and invasion and these effects are inhibited by TFPI. J Cell Physiol 226:3278-3285.
http://www.ncbi.nlm.nih.gov/pubmed/21344386

Hibi K, Goto T, Shirahata A, Saito M, Kigawa G, Nemoto H, Sanada Y (2011) Detection of TFPI2 Methylation in the Serum of Gastric Cancer Patients. Anticancer Res 31:3835-3838.
http://www.ncbi.nlm.nih.gov/pubmed/22110206

Huang J, Liu XJ, Bao HR, Zhang Y, Tan EL, Liao JM (2011) [The relationship between coagulation/anticoagulation imbalance and oxidative stress in patients with chronic obstructive pulmonary disease]. Zhonghua Nei Ke Za Zhi 50:664-667.
http://www.ncbi.nlm.nih.gov/pubmed/22093558

Jia ZC, Wan YL, Tang JQ, Dai Y, Liu YC, Wang X, Zhu J (2011) Tissue factor/activated factor VIIa induces matrix metalloproteinase-7 expression through activation of c-Fos via ERK1/2 and p38 MAPK signaling pathways in human colon cancer cell. Int J Colorectal Dis.
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Kanse SM, Declerck PJ, Ruf W, Broze G, Etscheid M (2011) Factor VII-Activating Protease Promotes the Proteolysis and Inhibition of Tissue Factor Pathway Inhibitor. Arterioscler Thromb Vasc Biol.
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Katgi A, Ataca P, Kahraman S, Piskin O, Ozcan MA, Demirkan F, . . . Undar B (2011) Ischemic stroke after recombinant factor VIIa treatment in acquired hemophilia A patient. Blood Coagul Fibrinolysis.
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Khan MM, Douglas SD, Benton TD (2011) Substance P-Neurokinin-1 receptor interaction upregulates monocyte tissue factor. J Neuroimmunol.
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Lee CW, Park CS, Hwang I, Lee H, Park DW, Kang SJ, . . . Park SJ (2011) Comparison of ruptured coronary plaques in patients with unstable and stable clinical presentation. J Thromb Thrombolysis 32:150-157.
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Lorenzet R, Napoleone E, Cutrone A, Donati MB (2011) Thrombosis and obesity: Cellular bases. Thromb Res.
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Machado GB, de Oliveira AV, Saliba AM, de Lima CD, Suassuna JH, Plotkowski MC (2011) Pseudomonas aeruginosa toxin ExoU induces a PAF-dependent impairment of alveolar fibrin turnover secondary to enhanced activation of coagulation and increased expression of plasminogen activator inhibitor-1 in the course of mice pneumosepsis. Respir Res 12:104.
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Mischke R (2011) Determination of canine coagulation factor VII. Vet J 190:305-306.
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Morse BC, Dente CJ, Hodgman EI, Shaz BH, Nicholas JM, Wyrzykowski AD, . . . Feliciano DV (2011) The effects of protocolized use of recombinant factor VIIa within a massive transfusion protocol in a civilian level I trauma center. Am Surg 77:1043-1049.
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Mu E, Chen S, Li X, Ma XC (2011) [The effect of factor VII activating protease treatment on proliferation and collagen synthesis of cultured human pulmonary fibroblasts]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 23:653-657.
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Nakagomi A, Sasaki M, Ishikawa Y, Shibui T, Kosugi M, Endoh Y, . . . Mizuno K (2011) Upregulation of monocyte tissue factor activity is significantly associated with carotid intima-media thickness in patients with metabolic syndrome. J Atheroscler Thromb 18:475-486.
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Orfeo T, Gissel M, Butenas S, Undas A, Brummel-Ziedins KE, Mann KG (2011) Anticoagulants and the propagation phase of thrombin generation. PLoS One 6:e27852.
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Poller L, Ibrahim S, Pattison A, Jespersen J (2011) INR derivation with the PT/INR Line simplified using a spreadsheet from the world wide web. J Clin Pathol 64:930-932.
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Poursafa P, Kelishadi R, Moattar F, Rafiee L, Amin MM, Lahijanzadeh A, Javanmard SH (2011) Genetic variation in the association of air pollutants with a biomarker of vascular injury in children and adolescents in Isfahan, Iran. J Res Med Sci 16:733-740.
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Sen P, Nayak R, Clark CA, Gopalakrishnan R, Esmon CT, Pendurthi UR, Rao LV (2011) Factor X binding to endothelial cell protein C receptor: comparison with factor VIIa and activated protein C. Blood 118:2635-2636.
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Sun Q, Chen L, Gao M, Jiang W, Shao F, Li J, . . . Yu B (2011) Ruscogenin inhibits lipopolysaccharide-induced acute lung injury in mice: Involvement of tissue factor, inducible NO synthase and nuclear factor (NF)-kappaB. Int Immunopharmacol.
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Tarzia V, Bottio T, Buratto E, Spiezia L, Simioni P, Gerosa G (2011) The hazard of comparing apples and oranges: The proper indication for the use of recombinant activated clotting factor VII in cardiac surgery. J Thorac Cardiovasc Surg 142:1588-1589.
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Zheng F, Jin Y, Wang M, Niu Z, Xu P, Xie H (2011) Congenital combined deficiency of factor VII and X in a patient due to accidental diphacinone intoxication. Thromb Haemost 106:180-181.
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Zhou F, Zhou H, Wang T, Mu Y, Wu B, Guo DL, . . . Wu Y (2011) Epigallocatechin-3-gallate inhibits proliferation and migration of human colon cancer SW620 cells in vitro. Acta Pharmacol Sin.
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ABOUT TRIGGER
TRIGGER is edited by Jim Morrissey and Pierre Neuenschwander, with editorial assistance by Genie Morrissey. It includes Abstracts of Papers in Press, Meeting Announcements, Positions Sought/Available,or any other pertinent item that subscribers may want to share with their colleagues. To submit an item for publication in Trigger, e-mail us. To request or cancel a subscription,or for more information about TRIGGER or the biology of tissue factor and factor VII, visit our web site. You can also contact us by mail: J.H. Morrissey, University of Illinois College of Medicine, 417 Med Sci Bldg MC-714, 506 S. Mathews Ave., Urbana, IL 61801, USA.

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