TRIGGER
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 20, No. 1 January 2, 2014
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TRIGGER is also available by RSS Feed:
and BLOG:
http://trigger-tf7.blogspot.com/
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UPCOMING MEETINGS EVENTS
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 20, No. 1 January 2, 2014
(The next issue will be on January 15, 2014)
TRIGGER is also available by RSS Feed:
and BLOG:
http://trigger-tf7.blogspot.com/
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PAPERS IN PRESS
None Submitted for this issue.
__________________________________________________________None Submitted for this issue.
UPCOMING MEETINGS EVENTS
General info on upcoming meetings of interest:
http://tf7.org/meetings.htm
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RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI
ISTH also maintains a list of upcoming meetings of
interest:
POSITIONS SOUGHT/AVAILABLE
We are seeking a highly qualified and motivated individual
for one Postdoctoral Position in the Division of Hematology at The Children's
Hospital of Philadelphia in the laboratory of Dr. Paris Margaritis.
The research will be devoted to studying the biological
and therapeutic effects of blood coagulation factor expression in vitro or in
vivo in appropriate models. Applicants should have a strong background in
molecular biology and have experience working with transgenic/gene targeted
mouse and rat models. Those with experience in coagulation protein biochemistry
and tissue culture are strongly encouraged to apply. Candidates should have
successfully earned an advanced degree (M.D. or Ph.D.), have excellent
communications skills and are willing to work on a multidisciplinary team.
Highly competitive salary and benefits are offered. Curriculum vitae and the
names of three referees should be sent to: Dr. Paris Margaritis, The Children's
Hospital of Philadelphia, Division of Hematology, Colket Translational Research
Building, Rm 5024, 3501 Civic Center Blvd., Philadelphia, PA 19104 U.S.A.
Email: margaritis AT email DOT chop DOT edu
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RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI
Papers are culled from NLM MedLine (PubMed). Titles in square brackets indicate that the paper was not published in English. References that lack volume or page numbers are typically electronic pre-publications (E-pubs) ahead of the print publication; if so, the final citation with volume and page numbers may or may not appear in a future issue of Trigger.
THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":
Aberg M, Eriksson O, Mokhtari D, Siegbahn A (2013) Tissue
factor/factor VIIa induces cell survival and gene transcription by
transactivation of the insulin-like growth factor 1 receptor. Thromb Haemost
111.
Aberg M, Siegbahn A (2013) Tissue factor non-coagulant
signaling - molecular mechanisms and biological consequences with a focus on
cell migration and apoptosis. J Thromb Haemost 11:817-825.
Agarwal V, Okonta KE, Lal PS (2012) Recombinant-activated
factor VII in the paediatric cardiac surgery: single unit experience. Afr J
Paediatr Surg 9:193-197.
Ankeny RF, Hinds MT, Nerem RM (2013) Dynamic shear stress
regulation of inflammatory and thrombotic pathways in baboon endothelial
outgrowth cells. Tissue Eng Part A 19:1573-1582.
Bind MA, Lepeule J, Zanobetti A, Gasparini A, Baccarelli
A, Coull BA, . . . Schwartz J (2014) Air pollution and gene-specific
methylation in the Normative Aging Study: Association, effect modification, and
mediation analysis. Epigenetics 9.
Bladbjerg EM, Larsen TM, Due A, Jespersen J, Stender S,
Astrup A (2013) Postprandial coagulation activation in overweight
individuals after weight loss: Acute and long-term effects of a
high-monounsaturated fat diet and a low-fat diet. Thromb Res.
Bouchard BA, Gissel MT, Whelihan MF, Mann KG, Butenas S
(2013) Platelets do not express the oxidized or reduced forms of tissue factor.
Biochim Biophys Acta.
Breij EC, de Goeij BE, Verploegen S, Schuurhuis DH,
Amirkhosravi A, Francis JL, . . . Parren PW (2013) An antibody-drug conjugate
that targets tissue factor exhibits potent therapeutic activity against a broad
range of solid tumors. Cancer Res.
Brouwers HB, Greenberg SM (2013) Hematoma expansion
following acute intracerebral hemorrhage. Cerebrovasc Dis 35:195-201.
Broze GJ, Jr., Girard TJ (2013) Factor V, tissue factor
pathway inhibitor, and east Texas bleeding disorder. J Clin Invest
123:3710-3712.
Buzby JS, Williams SA, Imfeld KL, Kunicki TJ, Nugent DJ
(2014) Tissue factor inflammatory response regulated by promoter genotype and
p38 MAPK in neonatal vs. adult microvascular endothelial cells. Inflamm Res.
Cao Y, Zhang Z, Xu J, Yuan W, Wang J, Huang X, . . . Du J
(2013) The association of idiopathic recurrent pregnancy loss with
polymorphisms in hemostasis-related genes. Gene 530:248-252.
Carrieri C, Milella RA, Incampo F, Crupi P, Antonacci D,
Semeraro N, Colucci M (2013) Antithrombotic activity of 12 table grape
varieties. Relationship with polyphenolic profile. Food Chem
140:647-653.
Chen C, Liao D, Wang J, Liang Z, Yao Q (2013) Anti-human
protein S antibody induces tissue factor expression through a direct
interaction with platelet phosphofructokinase. Thromb Res.
Chen D, Ma L, Tham EL, Maresh S, Lechler RI, McVey JH,
Dorling A (2013) Fibrocytes mediate intimal hyperplasia
post-vascular injury and are regulated by two tissue factor-dependent
mechanisms. J Thromb Haemost 11:963-974.
Chen J, Zhang B, Pan C, Ren L, Chen Y (2013) [Effects of
monocyte chemotactic protein-3 on ICAM-1, VCAM-1, TF, and TFPI expression and
apoptosis in human umbilical vein endothelial cells]. Nan Fang Yi Ke Da Xue Xue
Bao 33:86-92.
Chung YM, Goyette J, Tedla N, Hsu K, Geczy CL (2013)
S100A12 suppresses pro-inflammatory, but not pro-thrombotic functions of serum
amyloid A. PLoS One 8:e62372.
Clark KB, Kon ND, Hammon JW, Jr., MacGregor DA, Kincaid
EH, Reichert MG (2013) Factor IX complex for the treatment of severe bleeding
after cardiac surgery. J Cardiovasc Pharmacol 62:67-71.
Coppola A, Tagliaferri A, Calizzani G, Candura F,
Franchini M, Ruosi C, . . . Di Minno G (2013) Clinical use and the Italian
demand for activated prothrombin complex and activated recombinant factor VII
concentrates. Blood Transfus 11 Suppl 4:s101-109.
Cornet AD, Hofstra JJ, Vlaar AP, Tuinman PR, Levi M,
Girbes AR, . . .Beishuizen A (2013) Activated protein C attenuates
pulmonary coagulopathy in patients with acute respiratory distress syndrome. J
Thromb Haemost 11:894-901.
Demissie A, Shahani L, Khan A, Desai M (2013) Acquired
haemophilia A initially diagnosed as angioedema. BMJ Case Rep 2013.
Dutra LA, Braga-Neto P, Pedroso JL, Barsottini OG (2012)
Sneddon's syndrome: case report and review of its relationship with
antiphospholipid syndrome. Einstein (Sao Paulo) 10:230-232.
Ebo DG, Faber M, Sabato V, Leysen J, Gadisseur A, Bridts
CH, De Clerck LS (2013) Sensitization to the mammalian oligosaccharide
galactose-alpha-1,3-galactose (alpha-gal): experience in a Flemish case series.
Acta Clin Belg 68:206-209.
El Makarem MA, Eslam M, Sayed D, Shawkat M, Idriss NK,
Soliman EM, . . . Elheney S (2013) Diabetes worsening of hepatitis C
cirrhosis: Are alterations in monocytic tissue factor (CD 142) is the cause?
Ann Hepatol 13:27-37.
Engelbrecht S, Wood EM, Cole-Sinclair MF (2013) Clinical
transfusion practice update: haemovigilance, complications, patient blood
management and national standards. Med J Aust 199:397-401.
Fisher MJ (2013) Brain regulation of thrombosis and
hemostasis: from theory to practice. Stroke 44:3275-3285.
Francischetti IM, Assumpcao TC, Ma D, Li Y, Vicente EC,
Uieda W, Ribeiro JM (2013) The "Vampirome": Transcriptome and
proteome analysis of the principal and accessory submaxillary glands of the
vampire bat Desmodus rotundus, a vector of human rabies. J Proteomics
82:288-319.
Franz C, Boing AN, Hau CM, Montag M, Strowitzki T,
Nieuwland R, Toth B (2013) Procoagulant tissue factor-exposing vesicles in
human seminal fluid. J Reprod Immunol 98:45-51.
Girolami A, Sambado L, Bonamigo E, Ferrari S, Lombardi AM
(2013) Pathogenetic Role of Factor VII Deficiency and Thrombosis in
Cross-Reactive Material Positive Patients. Lab Hematol 19:17-21.
Grabowski EF, Kushak RI, Liu B, Ingelfinger JR (2013)
Shiga toxin downregulates tissue factor pathway inhibitor, modulating an
increase in the expression of functional tissue factor on endothelium. Thromb
Res 131:521-528.
Haku J, Nogami K, Matsumoto T, Ogiwara K, Shima M (2013)
Optimal monitoring of bypass-therapy in hemophilia A patients with inhibitor
using clot waveform analysis. J Thromb Haemost.
Han J, Gerstenhaber JA, Lazarovici P, Lelkes PI (2013)
Tissue factor activity and ECM-related gene expression in human aortic
endothelial cells grown on electrospun biohybrid scaffolds. Biomacromolecules
14:1338-1348.
Hayakawa M, Gando S, Ieko M, Honma Y, Homma T, Yanagida
Y, . . .Asakura H (2013) Massive amounts of tissue factor induce
fibrinogenolysis without tissue hypoperfusion in rats. Shock 39:514-519.
Herrmann R, Thom J, Wood A, Phillips M, Muhammad S, Baker
R (2013) Thrombin generation using the calibrated automated thrombinoscope to
assess reversibility of dabigatran and rivaroxaban. Thromb Haemost 111.
Hill AM, Stewart PW, Fung MK, Kris-Etherton PM, Ginsberg
HN, Tracy RP, . . . Ershow AG (2014) Monthly hemostatic factor variability in
women and men. Eur J Clin Invest.
Holster IL, Hunfeld NG, Kuipers EJ, Kruip MJ, Tjwa ET
(2013) On the treatment of new oral anticoagulant-associated gastrointestinal
hemorrhage. J Gastrointestin Liver Dis 22:229-231.
Holy EW, Jakob P, Eickner T, Camici GG, Beer JH, Akhmedov
A, . . .Tanner FC (2013) PI3K/p110alpha inhibition selectively
interferes with arterial thrombosis and neointima formation, but not re-endothelialization: potential implications for
drug-eluting stent design. Eur Heart J.
Hu L, Xia L, Zhou H, Wu B, Mu Y, Wu Y, Yan J (2013)
TF/FVIIa/PAR2 promotes cell proliferation and migration via PKCalpha and
ERK-dependent c-Jun/AP-1 pathway in colon cancer cell line SW620. Tumour Biol 34:2573-2581.
Hus I, Sokolowska B, Walter-Croneck A, Chrapko M,
Nowaczynska A, Dmoszynska A (2013) Assessment of plasma prothrombotic factors
in patients with Buerger's disease. Blood Coagul Fibrinolysis 24:133-139.
Irons EE, Flatt JW, Doronin K, Fox TL, Acchione M,
Stewart PL, Shayakhmetov DM (2013) Coagulation factor binding orientation and
dimerization may influence infectivity of adenovirus-coagulation factor
complexes. J Virol 87:9610-9619.
Isozumi Y, Arai R, Fujimoto K, Koyama T (2013) Activation
of coagulation by lenalidomide-based regimens for the treatment of multiple
myeloma. PLoS One 8:e64369.
Jakubowski JA, Zhou C, Jurcevic S, Winters KJ, Lachno DR,
Frelinger AL, 3rd, . . . Mant TG (2013) A phase 1 study of prasugrel in
patients with sickle cell disease: Effects on biomarkers of platelet activation
and coagulation. Thromb Res.
Jialal I, Kaur H, Devaraj S (2013) Human C-reactive
protein accentuates macrophage activity in biobreeding diabetic rats. J
Diabetes Complications 27:23-28.
Kalus JS (2013) Pharmacologic interventions for reversing
the effects of oral anticoagulants. Am J Health Syst Pharm 70:S12-21.
Kim MS, Park SH, Han SY, Kim YH, Lee EJ, Yoon Park JH,
Kang YH (2013) Phloretin suppresses thrombin-mediated
leukocyte-platelet-endothelial interactions. Mol Nutr Food Res.
Klein OL, Okwuosa T, Chan C, Schreiner P, Kanaya AM, Liu
K, Green D (2013) Changes in procoagulants track longitudinally with
insulin resistance: findings from the Coronary Artery Risk
Development in Young Adults (CARDIA) study. Diabet Med.
Kohoutova D, Pecka M, Cihak M, Cyrany J, Maly J, Bures J
(2013) Prevalence of hypercoagulable disorders in inflammatory bowel disease.
Scand J Gastroenterol.
Korhonen TK, Haiko J, Laakkonen L, Jarvinen HM,
Westerlund-Wikstrom B (2013) Fibrinolytic and coagulative activities of
Yersinia pestis. Front Cell Infect Microbiol 3:35.
Kumar Y, Vadivel K, Schmidt AE, Ogueli GI, Ponnuraj SM,
Rannulu NS, . . . Bajaj SP (2014) Decoy Plasminogen Receptor Containing
a Selective Kunitz-Inhibitory Domain. Biochemistry.
Kyaw TZ, Jayaranee S, Bee PC, Chin EF (2013) Acquired
Factor VIII Inhibitors: Three Cases. Turk J Haematol 30:76-80.
Laurance S, Aghourian MN, Jiva Lila Z, Lemarie CA,
Blostein MD (2013) Gas6-induced tissue factor expression in endothelial cells
is mediated through caveolin-1-enriched microdomains. J Thromb Haemost.
Levi M, van der Poll T (2013) Disseminated intravascular
coagulation: a review for the internist. Intern Emerg Med 8:23-32.
Li B, Chen M, Liu X, Guo SW (2013) Constitutive and tumor
necrosis factor-alpha-induced activation of nuclear factor-kappaB in
adenomyosis and its inhibition by andrographolide. Fertil Steril 100:568-577.
Li M, Zheng F, Jin Y, Wang M, Zhu L, Yang L (2013) Double
heterozygous mutations Gln100Leu and His348Gln of the F7 gene in a patient with
factor VII deficiency. Blood Coagul Fibrinolysis 24:199-201.
Maroney SA, Ellery PE, Wood JP, Ferrel JP, Martinez ND,
Mast AE (2013) Comparison of the inhibitory activities of human
tissue factor pathway inhibitor (TFPI)alpha and TFPIbeta. J Thromb Haemost
11:911-918.
Mathieu C, Chevrier A, Lascau-Coman V, Rivard GE, Hoemann
CD (2013) Stereological analysis of subchondral angiogenesis induced by
chitosan and coagulation factors in microdrilled articular cartilage defects.
Osteoarthritis Cartilage 21:849-859.
Moriguchi T, Sumpio BE (2013) PECAM-1 phosphorylation and
tissue factor expression in HUVECs exposed to uniform and disturbed pulsatile
flow and chemical stimuli. J Vasc Surg.
Nagao A, Hanabusa H, Takedani H (2014) Continuous
infusion of rFVIIa during surgery in a FVII-deficient patient: a case report
from Japan. Haemophilia 20:e110-112.
Napolitano M, Giansily-Blaizot M, Dolce A, Schved JF,
Auerswald G, Ingerslev J, . . . Mariani G (2013) Prophylaxis in congenital
factor VII deficiency: indications, efficacy and safety. Results from the Seven
Treatment Evaluation Registry (STER). Haematologica 98:538-544.
Ng HJ, Chee YL, Ponnudurai K, Lim LC, Tan D, Tay JC, . .
. Lee LH (2013) Consensus recommendations for preventing and
managing bleeding complications associated with novel oral anticoagulants in
singapore. Ann Acad Med Singapore 42:593-602.
Onasoga-Jarvis AA, Puls TJ, O'Brien SK, Kuang L, Liang
HJ, Neeves KB (2013) Thrombin generation and fibrin formation under
flow on biomimetic tissue factor rich surfaces. J Thromb Haemost.
Palmerini T, Tomasi L, Barozzi C, Della Riva D, Mariani
A, Taglieri N, . . . Ahamed J (2013) Detection of Tissue Factor Antigen and
Coagulation Activity in Coronary Artery Thrombi Isolated from Patients with
ST-Segment Elevation Acute Myocardial Infarction. PLoS One 8:e81501.
Palojarvi A, Andersson S, Langstrom S, Petaja J (2013)
Coordinated release of tissue factor and tissue factor pathway inhibitor in
VLBW infants. Acta Paediatr 102:584-589.
Papalexopoulou N, Attia RQ, Bapat VN (2013) Successful
surgical repair of acute type A aortic dissection without the use of blood
products. Ann R Coll Surg Engl 95:127-129.
Papareddy P, Kalle M, Sorensen OE, Malmsten M, Morgelin
M, Schmidtchen A (2013) The TFPI-2 Derived Peptide EDC34 Improves Outcome of
Gram-Negative Sepsis. PLoS Pathog 9:e1003803.
Pasqualoto KF, Balan A, Barreto SA, Simons SM,
Chudzinski-Tavassi AM (2013) Structural Findings and Molecular Modeling
Approach of a Tfpi-Like Inhibitor. Protein Pept Lett.
Pham HP, Shaz BH (2013) Update on massive transfusion. Br
J Anaesth 111 Suppl 1:i71-i82.
Rao AK (2013) Inherited platelet function disorders:
overview and disorders of granules, secretion, and signal transduction. Hematol
Oncol Clin North Am 27:585-611.
Romagnuolo I, Sticchi E, Fedi S, Cellai AP, Lami D,
Alessandrello A, . . . Fatini C (2013) Is tissue factor pathway inhibitor a
marker of procoagulable status in healthy infertile women undergoing ovarian
stimulation for assisted reproduction? Blood Coagul Fibrinolysis.
Ross B, Miller MA, Ditch K, Tran M (2014) Clinical
Experience of Life-Threatening Dabigatran-Related Bleeding at a Large, Tertiary
Care, Academic Medical Center: a Case Series. J Med Toxicol.
Salge-Bartels U, Heiden M, Gross N, Seitz R (2013)
Significance of platelet and monocyte activation for therapeutic
immunoglobulin-induced thromboembolism. Thromb Res.
Scheffert JL, Taber DJ, Pilch NA, McGillicuddy JW, Baliga
PK, Chavin KD (2013) Timing of factor VIIa in liver transplantation impacts
cost and clinical outcomes. Pharmacotherapy 33:483-488.
Schulte S (2013) Challenges for new haemophilia products
from a manufacturer's perspective. Thromb Res.
Shah K, Bayoumi R, Banerjee Y (2013) Protein
anticoagulants targeting factor VIIa-tissue factor complex: a comprehensive
review. Hematology 18:1-7.
Shapiro AD, Neufeld EJ, Blanchette V, Salaj P, Gut RZ,
Cooper DL (2014) Safety of recombinant activated factor VII
(rFVIIa) in patients with congenital haemophilia with inhibitors: overall
rFVIIa exposure and intervals following high (>240 mug kg(-1) ) rFVIIa doses
across clinical trials and registries. Haemophilia 20:e23-31.
Siegal DM, Garcia DA, Crowther MA (2014) How I treat:
target specific oral anticoagulant associated bleeding. Blood.
Sui L, Liu GH, Izpisua Belmonte JC (2013) hESC-derived
pancreatic progenitors. Cell Res 23:592-594.
Tavoosi N, Smith SA, Davis-Harrison RL, Morrissey JH
(2013) Factor VII and protein C are phosphatidic acid-binding proteins. Biochemistry 52:5545-5552.
Trummer A, Werwitzke S, Wermes C, Ganser A, Birschmann I,
Budde U, Tiede A (2013) Addition of in-vitro generated endothelial
microparticles to von-Willebrand plasma improves primary and secondary
hemostasis. Thromb Res.
Unruh D, Turner K, Srinivasan R, Kocaturk B, Qi X, Chu Z,
. . .Bogdanov VY (2014) Alternatively spliced tissue factor
contributes to tumor spread and activation of coagulation in pancreatic ductal
adenocarcinoma. Int J Cancer 134:9-20.
Vincent LM, Tran S, Livaja R, Bensend TA, Milewicz DM,
Dahlback B (2013) Coagulation factor V(A2440G) causes east Texas
bleeding disorder via TFPIalpha. J Clin Invest 123:3777-3787.
Wafaisade A, Lefering R, Maegele M, Helm P, Braun M,
Paffrath T, Bouillon B (2013) [Recombinant factor VIIa for the treatment of
exsanguinating trauma patients: a matched-pair analysis from the Trauma
Registry of the German Society for Trauma Surgery]. Unfallchirurg 116:524-530.
Walenga JM, Jeske WP, Hoppensteadt D, Cunanan J, Khan H,
Escalante V, . . . Bakhos M (2013) Comparative studies on branded enoxaparin
and a US generic version of enoxaparin. Clin Appl Thromb Hemost 19:261-267.
Willemze R, Bradford RL, Mooberry MJ, Roubey RA, Key NS
(2013) Plasma Microparticle Tissue Factor Activity in Patients With
Antiphospholipid Antibodies With and Without Clinical Complications.
Thromb Res.
Wu X, Du Z, Yu J, Sun Y, Pei B, Lu X, . . . Hu J (2014)
Activity of factor VII in patients with isolated blunt traumatic brain injury: Association with coagulopathy and progressive hemorrhagic
injury. J Trauma Acute Care Surg 76:114-120.
Yada K, Nogami K, Ogiwara K, Shima M (2013) Activated
prothrombin complex concentrate (APCC)-mediated activation of factor (F)VIII in
mixtures of FVIII and APCC enhances hemostatic effectiveness. J Thromb Haemost
11:902-910.
Yamada Y, Fujimoto-Ibusuki K, Morikawa-Kubota K (2013)
Perioperative management of factor XI deficiency in a patient undergoing hip
arthroplasty. J Anesth.
Yang HP, Yue L, Jiang WW, Liu Q, Kou JP, Yu BY (2013)
Diosgenin inhibits tumor necrosis factor-induced tissue factor activity and
expression in THP-1 cells via down-regulation of the NF-kappaB, Akt, and MAPK
signaling pathways. Chin J Nat Med 11:608-615.
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TRIGGER is edited by Jim Morrissey and Pierre Neuenschwander, with editorial assistance by Genie Morrissey. It includes Abstracts of Papers in Press, Meeting Announcements, Positions Sought/Available,or any other pertinent item that subscribers may want to share with their colleagues. To submit an item for publication in Trigger, e-mail us. To request or cancel a subscription,or for more information about TRIGGER or the biology of tissue factor and factor VII, visit our web site. You can also contact us by mail: J.H. Morrissey, University of Illinois College of Medicine, 417 Med Sci Bldg MC-714, 506 S. Mathews Ave., Urbana, IL 61801, USA.
DISCLAIMER: TRIGGER is provided "as is" for information purposes only and without warranty of any kind, express or implied. Users shall assume the entire risk as to the accuracy and usefulness of information in TRIGGER. Opinions expressed here are not necessarily those of the editors or their employers. You may share TRIGGER with your scientific colleagues but you are not permitted to use it or its contents for commercial purposes.
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