TRIGGER
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 20, No. 2 January 15, 2014
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TRIGGER is also available by RSS Feed:
and BLOG:
http://trigger-tf7.blogspot.com/
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UPCOMING MEETINGS EVENTS
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 20, No. 2 January 15, 2014
(The next issue will be on February 3, 2014)
TRIGGER is also available by RSS Feed:
and BLOG:
http://trigger-tf7.blogspot.com/
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ANNOUNCEMENTS
None Submitted for this issue.
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As we have done for the past few years, the individual
PubMed "collections" of the papers appearing in each issue of TRIGGER
for 2013 have now been consolidated into a single collection. (The individual PubMed collections for each
TRIGGER issue in 2013 have, accordingly, been deleted.) Here are the links to the consolidated
collections for the past five years:
2009 (301 references):
2010 (531 references):
2011 (612 references):
2012 (976 references):
2013 (848 references):
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PAPERS IN PRESSNone Submitted for this issue.
UPCOMING MEETINGS EVENTS
7th Symposium on Hemostasis: Old System, New Players, New
Directions May 15-17, 2014 at the Carolina Inn, Chapel Hill, NC, USA The focus
will include the latest findings related to tissue factor, coagulation
proteases and their role in hemostasis and thrombosis, as well as interplay
between coagulation and inflammation. Important new research on novel
approaches for treating bleeding in hemophilia and trauma induced coagulopathy,
animal models of bleeding and thrombosis and activation of coagulation in disease
will also be presented.
Invited faculty are the world's formost basic scientists
and clinicians working in the field of tissue factor biology, coagulation and
hemostasis.
Registration is now OPEN:
General info on upcoming meetings of interest:
http://tf7.org/meetings.htm
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI
ISTH also maintains a list of upcoming meetings of
interest:
POSITIONS SOUGHT/AVAILABLE
A postdoctoral position is offered as part of the Novo
Nordisk R&D STAR Programme (Science, Talent, Attraction and Recruitment).
This program supports the brightest graduate students in biotechnology, life,
medical and engineering sciences, who want to pursue a career in pharmaceutical
R&D.
About the department:
Translational Haemophilia Pharmacology is offering an international
Postdoc fellowship to a highly motivated and ambitious candidate. Translational
Haemophilia Pharmacology is a research unit focusing on research and
development of drug candidates for the treatment of haemophilia; we support the
Novo Nordisk haemophilia portfolio with knowledge generated in animal models of
haemophilia.
The Job: The project
will first focus on optimizing and validating a thrombin generation assay for
use with samples from dogs, prior to and after therapeutic intervention.
Subsequently the assay will be used to predicting the bleeding phenotype and
response to treatment in dogs with haemophilia A and B as a model for human
haemophilia. The project is conducted in close collaboration with leading
researchers from the University of North Carolina at Chapel Hill.
The starting date is February 1, 2014 or later, and the
position is on a temporary contract. Part of the PostDoc project will take
place at Translational Haemophilia Pharmacology in Måløv, Denmark and the other
part in the lab of Dr. Tim Nichols in close collaboration with Dr. Alisa
Wolberg at the University of North Carolina, Chapel Hill. Travel expenses
between the US and Denmark will be reimbursed by Novo Nordisk.
The candidate will become part of two laboratories located in high impact centers of excellence
within haemophilia and thus exposed to world class science and in addition
serve as a liaison between the University of Chapel Hill and Novo Nordisk A/S.
Qualifications:
You hold a PhD in medicine, veterinary medicine, pharmacology, biology
or related disciplines. Solid knowledge on in vivo research in general and
haemostasis research in particular is desirable. Experience with haemophilia
research is considered an advantage. We require very good communication skills in English.
At Novo Nordisk your skills, dedication, and ambition
help us change lives for the better. In exchange we offer you an opportunity to
work with extraordinary talent and benefit from a range of possibilities for
professional and personal development.
For further information, please call Bo Wiinberg on +45
3075 3030.
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Papers are culled from NLM MedLine (PubMed). Titles in square brackets indicate that the paper was not published in English. References that lack volume or page numbers are typically electronic pre-publications (E-pubs) ahead of the print publication; if so, the final citation with volume and page numbers may or may not appear in a future issue of Trigger.
THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":
Blatny J, Mathew P, Monagle P, Ovesna P, Fiamoli V (2014)
Safety and efficacy of recombinant activated factor VII in nonhemophilia
children with severe or life-threatening bleeding: a report from the SeveNBleeP
registry. Blood Coagul Fibrinolysis.
Boknas N, Faxalv L, Lindahl TL, Ramstrom S (2014) Contact
activation - important to consider when measuring the contribution of tissue
factor-bearing microparticles to thrombin generation using
phospholipid-containing reagents. J Thromb Haemost.
Bosch YP, Al Dieri R, Ten Cate H, Nelemans PJ, Bloemen S,
de Laat B, . . . Mochtar B (2013) Measurement of thrombin generation
intra-operatively and its association with bleeding tendency after cardiac
surgery. Thromb Res.
Gebhard C, Stahli BE, Largiader S, Holy EW, Akhmedov A,
Camici GG, . . . Tanner FC (2013) Caffeic acid phenethyl ester inhibits
endothelial tissue factor expression. Biol Pharm Bull 36:1032-1035.
Hansen L, Petersen LC, Lauritzen B, Clausen JT, Grell SN,
Agerso H, . . . Almholt K (2013) Target-mediated clearance and bio-distribution
of a monoclonal antibody against the Kunitz-type protease inhibitor 2 domain of
Tissue Factor Pathway Inhibitor. Thromb Res.
Hilbert P, Hofmann GO, Teichmann J, Struck MF, Stuttmann
R (2013) The "coagulation box" and a new hemoglobin-driven algorithm
for bleeding control in patients with severe multiple traumas. Arch Trauma Res
2:3-10.
Holley AB, Petteys S, Mitchell JD, Holley PR, Collen JF
(2013) Thromboprophylaxis and VTE rates in soldiers wounded in Operation
Enduring Freedom and Operation Iraqi Freedom. Chest 144:966-973.
Kiessling AH, Nitsch J, Strouhal U, Kornberger A, Zierer
A, Moritz A (2013) Associated risk of recombinant activated factor VIIa
application. Heart Surg Forum 16:E132-136.
Magon N, Babu KM, Kapur K, Chopra S, Joneja GS (2013) Recombinant activated factor VII in post partum
haemorrhage. Niger Med J 54:289-294.
Menegatti M, Vangone A, Palla R, Milano G, Cavallo L,
Oliva R, . . . Peyvandi F (2013) A recurrent Gly43Asp substitution in
coagulation Factor X rigidifies its catalytic pocket and impairs catalytic
activity and intracellular trafficking. Thromb Res.
Osterud B, Olsen JO (2013) Pro- and anti-inflammatory effects of histamine on tissue factor
and TNFalpha expression in monocytes of human blood. Thromb Res.
Saeki N, Mochizuki S, Fujii T, Kawamoto M (2014)
Postsurgical coagulopathy in a hemophilia A patient with inhibitors: efficacy
of recombinant factor VIIa. J Anesth.
Wang GJ, Wang YB, Li DN, Li C, Deng BB (2014) Expression
of tissue factor pathway inhibitor-2 in gastric stromal tumor and its clinical
significance. Exp Ther Med 7:513-517.
Wood JP, Bunce MW, Maroney SA, Tracy PB, Camire RM, Mast
AE (2013) Tissue factor pathway inhibitor-alpha inhibits prothrombinase during
the initiation of blood coagulation. Proc Natl Acad Sci U S A 110:17838-17843.
Xiao W, Li CQ, Xiao XP, Lin FZ (2013) Expression and fast
preparation of biologically active recombinant human coagulation factor VII in CHO-K1 cells. Genet Mol Res 12:6813-6824.
Yu YH, Wu DS, Huang FF, Zhang Z, Liu LX, Zhang J, . . .
Chen FP (2013) MicroRNA-20b and ERK1/2 pathway independently regulate the
expression of tissue factor in hematopoietic and trophoblastic differentiation
of human embryonic stem cells. Stem Cell Res Ther 4:121.
Zelaya H, Tsukida K, Chiba E, Marranzino G, Alvarez S,
Kitazawa H, . . . Villena J (2014) Immunobiotic lactobacilli reduce
viral-associated pulmonary damage through the modulation of
inflammation-coagulation interactions. Int Immunopharmacol.
Zerrouqi A, Pyrzynska B, Brat DJ, Van Meir EG (2014) p14ARF suppresses tumor-induced thrombosis by
regulating the tissue factor pathway. Cancer Res.
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TRIGGER is edited by Jim Morrissey and Pierre Neuenschwander, with editorial assistance by Genie Morrissey. It includes Abstracts of Papers in Press, Meeting Announcements, Positions Sought/Available,or any other pertinent item that subscribers may want to share with their colleagues. To submit an item for publication in Trigger, e-mail us. To request or cancel a subscription,or for more information about TRIGGER or the biology of tissue factor and factor VII, visit our web site. You can also contact us by mail: J.H. Morrissey, University of Illinois College of Medicine, 417 Med Sci Bldg MC-714, 506 S. Mathews Ave., Urbana, IL 61801, USA.
DISCLAIMER: TRIGGER is provided "as is" for information purposes only and without warranty of any kind, express or implied. Users shall assume the entire risk as to the accuracy and usefulness of information in TRIGGER. Opinions expressed here are not necessarily those of the editors or their employers. You may share TRIGGER with your scientific colleagues but you are not permitted to use it or its contents for commercial purposes.
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