TRIGGER
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 16, No. 24 December 15, 2010
(The next issue will be on January 3, 2011)
__________________________________________________________
TRIGGER is also available by RSS Feed:
http://feeds.feedburner.com/blogspot/glro
and BLOG:
http://trigger-tf7.blogspot.com/
__________________________________________________________
ANNOUNCEMENTS
Best wishes to all our colleagues for a wonderful holiday season, and for a happy, healthy and prosperous New Year!
-Jim, Genie & Pierre for TRIGGER
__________________________________________________________
PAPERS IN PRESS
None submitted for this issue.
__________________________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI
Papers are culled from NLM MedLine (PubMed). Titles in square brackets indicate that the paper was not published in English. References that lack volume or page numbers are typically electronic pre-publications (E-pubs) ahead of the print publication; if so, the final citation with volume and page numbers may or may not appear in a future issue of Trigger.
THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/12GV77p667dUoeBLddghjh6/
Boadas A, Fernandez-Palazzi F, De Bosch NB, Cedeno M, Ruiz-Saez A (2010) Elective surgery in patients with congenital coagulopathies and inhibitors: experience of the National Haemophilia Centre of Venezuela. Haemophilia.
http://www.ncbi.nlm.nih.gov/pubmed/21118333
Camera M, Brambilla M, Toschi V, Tremoli E (2010) Tissue factor expression on platelets is a dynamic event. Blood 116:5076-5077.
http://www.ncbi.nlm.nih.gov/pubmed/21127189
Disse J, Petersen HH, Larsen KS, Persson E, Esmon N, Esmon CT, . . .Ruf W (2010) The endothelial protein c receptor supports tissue factor ternary coagulation initiation complex signaling through protease-activated receptors. J Biol Chem.
http://www.ncbi.nlm.nih.gov/pubmed/21149441
Dong X, Song L, Zhu D, Zhang H, Liu L, Leng X (2010) Tissue factor pathway inhibitor suppresses the growth of human vascular smooth muscle cells through regulating cell cycle. Mol Biol Rep.
http://www.ncbi.nlm.nih.gov/pubmed/21132373
Ge C, You Y, Zou P (2010) [Preliminary study on role of endothelial cells and tissue factor in graft-versus-host disease]. Zhongguo Shi Yan Xue Ye Xue Za Zhi 18:1278-1281.
http://www.ncbi.nlm.nih.gov/pubmed/21129276
Illanes S, Zhou W, Schwarting S, Heiland S, Veltkamp R (2010) Comparative Effectiveness of Hemostatic Therapy in Experimental Warfarin-Associated Intracerebral Hemorrhage. Stroke.
http://www.ncbi.nlm.nih.gov/pubmed/21127298
Krysiak R, Okopien B (2010) Hemostatic effects of simvastatin in subjects with impaired glucose tolerance. Intern Med J.
http://www.ncbi.nlm.nih.gov/pubmed/21118403
Ma YY, He XJ, Wang HJ, Xia YJ, Wang SL, Ye ZY, Tao HQ (2010) Interaction of coagulation factors and tumor-associated macrophages mediates migration and invasion of gastric cancer. Cancer Sci.
http://www.ncbi.nlm.nih.gov/pubmed/21134074
Martinez-Martinez I, Ordonez A, Pedersen S, de la Morena-Barrio ME, Navarro-Fernandez J, Kristensen SR, . . . Corral J (2010) Heparin affinity of factor VIIa: Implications on the physiological inhibition by antithrombin and clearance of recombinant factor VIIa. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/21126754
Otero L, Alonso D, Castro M, Cinat G, Gabri M, Gomez D (2010) Tissue factor as a novel marker for detection of circulating cancer cells. Biomarkers.
http://www.ncbi.nlm.nih.gov/pubmed/21128872
Romay-Penabad Z, Aguilar-Valenzuela R, Urbanus RT, Derksen RH, Pennings MT, Papalardo E, . . . Pierangeli SS (2010) Apolipoprotein E receptor 2 is involved in the thrombotic complications in a murine model of the antiphospholipid syndrome. Blood.
http://www.ncbi.nlm.nih.gov/pubmed/21119114
Sen P, Komissarov AA, Florova G, Idell S, Pendurthi UR, Rao LV (2010) Plasminogen activator inhibitor-1 inhibits factor VIIa bound to tissue factor. J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/21143380
Smid M, Dielis AW, Winkens M, Spronk HM, Van Oerle R, Hamulyak K, . . .Ten Cate H (2010) Thrombin generation in patients with a first acute myocardial infarction. J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/21143375
Witmer CM, Huang YS, Lynch K, Raffini LJ, Shah SS (2010) Off-Label Recombinant Factor VIIa Use and Thrombosis in Children: A Multi-center Cohort Study. J Pediatr.
http://www.ncbi.nlm.nih.gov/pubmed/21146180
Zhou B, Zhou H, Ling S, Guo D, Yan Y, Zhou F, Wu Y (2010) Activation of PAR2 or/and TLR4 promotes SW620 cell proliferation and migration via phosphorylation of ERK1/2. Oncol Rep.
http://www.ncbi.nlm.nih.gov/pubmed/21152870
Zhou XG (2010) Characterization of the anticoagulant protein Rhipilin-1 from the Rhipicephalus haemaphysaloides tick. J Insect Physiol.
http://www.ncbi.nlm.nih.gov/pubmed/21147114
__________________________________________________________
ABOUT TRIGGER
TRIGGER is edited by Jim Morrissey and Pierre Neuenschwander, with editorial assistance by Genie Morrissey. It includes Abstracts of Papers in Press, Meeting Announcements, Positions Sought/Available,or any other pertinent item that subscribers may want to share with their colleagues. To submit an item for publication in Trigger, e-mail us. To request or cancel a subscription,or for more information about TRIGGER or the biology of tissue factor and factor VII, visit our web site. You can also contact us by mail: J.H. Morrissey, University of Illinois College of Medicine, 417 Med Sci Bldg MC-714, 506 S. Mathews Ave., Urbana, IL 61801, USA.
DISCLAIMER: TRIGGER is provided "as is" for information purposes only and without warranty of any kind, express or implied. Users shall assume the entire risk as to the accuracy and usefulness of information in TRIGGER. Opinions expressed here are not necessarily those of the editors or their employers. You may share TRIGGER with your scientific colleagues but you are not permitted to use it or its contents for commercial purposes.
__________________________________________________________
Thursday, December 16, 2010
Wednesday, December 1, 2010
Vol. 16, No. 23
TRIGGER
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 16, No. 23 December 1, 2010
(The next issue will be on December 15, 2010)
__________________________________________________________
TRIGGER is also available by RSS Feed:
http://feeds.feedburner.com/blogspot/glro
and BLOG:
http://trigger-tf7.blogspot.com/
__________________________________________________________
PAPERS IN PRESS
AUTHORS: Cho Y, Cao X, Shen DF, Tuo J, Parver LM, Rickles FR and Chan C-C.
TITLE: Evidence for enhanced tissue factor expression in age-related macular degeneration
JOURNAL: Laboratory Investigation
ABSTRACT: Tissue factor (TF) is the primary initiator of blood coagulation. In addition to hemostasis, TF can initiate intracellular signaling and promote inflammation and angiogenesis, the key processes underlying the pathogenesis of age-related macular degeneration (AMD). AMD, the leading cause of irreversible blindness among the elderly, involves many genetic and environmental risk factors, including oxidative stress and inflammation. In this study, TF expression was examined in human AMD tissue and in the eyes of a model of AMD, the Ccl2-/-/Cx3cr1-/-(DKO) mouse, as well as in the ARPE-19 cell line after lipopolysaccharide (LPS) and H2O2 stimulation. Total RNA was extracted from tissue samples and further analyzed by real-time RT-PCR. Immunohistochemistry was performed to evaluate TF protein expression. In the human retina, a 32-fold increase of TF mRNA expression was detected in AMD macular lesions compared with normal maculae. TF protein expression was also enhanced in human AMD maculae. Similarly, TF transcript and protein expression were moderately increased in retinal lesions, neuroretinal tissue, and cultured RPE cells of DKO mice compared with age-matched wild-type mice. TF expression level correlated with age in both wild-type and DKO mice. In order to better understand how AMD might lead to enhanced TF expression, 1, 5, and 10 mg/ml LPS as well as 100 and 200 mM H2O2 were used to stimulate ARPE-19 cells for 24 and 2 h, respectively. LPS treatment consistently increased TF transcript and protein expression. H2O2 alone or in combination with LPS also moderately enhanced TF expression. These results indicate that upregulated TF expression may be associated with AMD, and inflammatory and oxidative stress may contribute to TF expression in AMD eyes.
SUBMITTED BY: Frederick R. Rickles, M.D. (frickles AT mfa DOT gwu DOT edu)
__________________________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI
Papers are culled from NLM MedLine (PubMed). Titles in square brackets indicate that the paper was not published in English. References that lack volume or page numbers are typically electronic pre-publications (E-pubs) ahead of the print publication; if so, the final citation with volume and page numbers may or may not appear in a future issue of Trigger.
THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1Dqm8edJ8YqLi_hLPqyFAcv/
Agerso H, Brophy DF, Pelzer H, Martin EJ, Carr M, Hedner U, Ezban M (2010) Recombinant human factor VIIa (rFVIIa) cleared principally by antithrombin following IV administration in haemophilia patients. J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/21114621
Bajaj MS, Ogueli GI, Kumar Y, Vadivel K, Lawson G, Shanker S, . . . Bajaj SP (2010) Engineering Kunitz domain 1 (KD1) of human tissue factor pathway inhibitor-2 to selectively inhibit fibrinolysis: properties of KD1-L17R variant. J Biol Chem.
http://www.ncbi.nlm.nih.gov/pubmed/21115497
Celi A, Cianchetti S, Dell'omo G, Pedrinelli R (2010) Angiotensin II, tissue factor and the thrombotic paradox of hypertension. Expert Rev Cardiovasc Ther 8:1723-1729.
http://www.ncbi.nlm.nih.gov/pubmed/21108554
Dries DJ (2010) The contemporary role of blood products and components used in trauma resuscitation. Scand J Trauma Resusc Emerg Med 18:63.
http://www.ncbi.nlm.nih.gov/pubmed/21106098
Dusse LM, Carvalho MG, Cooper AJ, Lwaleed BA (2010) Plasma factor VII: A potential marker of pre-eclampsia. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/21094984
Girolami A, Berti de Marinis G, Bonamigo E, Sartori R, Vettore S (2010) Ox Brain versus Rabbit Brain Thromboplastin Assays Are the Best Tool for a Preliminary Diagnosis of the Arg304Gln Factor VII Defect (FVII Padua). Acta Haematol 124:229-234.
http://www.ncbi.nlm.nih.gov/pubmed/21099211
Jacob M, Chappell D, Stoeckelhuber M, Welsch U, Rehm M, Bruegger D, . . . Becker BF (2010) Perspectives in Microvascular Fluid Handling: Does the Distribution of Coagulation Factors in Human Myocardium Comply with Plasma Extravasation in Venular Coronary Segments? J Vasc Res 48:219-226.
http://www.ncbi.nlm.nih.gov/pubmed/21088428
Knudson MM, Cohen MJ, Reidy R, Jaeger S, Bacchetti P, Jin C, . . . Holcomb JB (2010) Trauma, Transfusions, and Use of Recombinant Factor VIIa: A Multicenter Case Registry Report of 380 Patients from the Western Trauma Association. J Am Coll Surg.
http://www.ncbi.nlm.nih.gov/pubmed/21115374
Lin Y, Stanworth S, Birchall J, Doree C, Hyde C (2010) Use of recombinant factor VIIa for the prevention and treatment of bleeding in patients without hemophilia: a systematic review and meta-analysis. CMAJ.
http://www.ncbi.nlm.nih.gov/pubmed/21078742
Liu X, Nie J, Guo SW (2010) Elevated immunoreactivity to tissue factor and its association with dysmenorrhea severity and the amount of menses in adenomyosis. Hum Reprod.
http://www.ncbi.nlm.nih.gov/pubmed/21115504
Owen BA, Xue A, Heit JA, Owen WG (2010) Procoagulant activity, but not number, of microparticles increases with age and in individuals after a single venous thromboembolism. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/21106230
Petersen LC, Karpf DM, Agerso H, Hermit MB, Pelzer H, Persson E, . . . Ezban M (2010) Intravascular inhibition of factor VIIa and the analogue NN1731 by antithrombin. Br J Haematol.
http://www.ncbi.nlm.nih.gov/pubmed/21083658
Scher C, Narine V, Chien D (2010) Recombinant factor VIIa in trauma patients without coagulation disorders. Anesthesiol Clin 28:681-690.
http://www.ncbi.nlm.nih.gov/pubmed/21074745
Shetty S, Bhave M, Ghosh K (2010) Acquired hemophilia A : diagnosis, aetiology, clinical spectrum and treatment options. Autoimmun Rev.
http://www.ncbi.nlm.nih.gov/pubmed/21115138
Temma T, Ogawa Y, Kuge Y, Ishino S, Takai N, Nishigori K, . . . Saji H (2010) Tissue factor detection for selectively discriminating unstable plaques in an atherosclerotic rabbit model. J Nucl Med 51:1979-1986.
http://www.ncbi.nlm.nih.gov/pubmed/21078793
Zakai NA, Lange L, Longstreth WT, O'Meara ES, Kelley JL, Fornage M, . . . Reiner AP (2010) Association of coagulation and inflammation related genes and factor VIIc levels with stroke: the cardiovascular health study. J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/21114618
Zhou H, Yan Y, Xu G, Zhou B, Wen H, Guo D, . . . Wang H (2010) Toll-like receptor (TLR)-4 mediates anti-beta(2) GPI/beta(2) GPI-induced tissue factor expression in THP-1 cells. Clin Exp Immunol.
http://www.ncbi.nlm.nih.gov/pubmed/21091668
__________________________________________________________
ABOUT TRIGGER
TRIGGER is edited by Jim Morrissey and Pierre Neuenschwander, with editorial assistance by Genie Morrissey. It includes Abstracts of Papers in Press, Meeting Announcements, Positions Sought/Available,or any other pertinent item that subscribers may want to share with their colleagues. To submit an item for publication in Trigger, e-mail us. To request or cancel a subscription,or for more information about TRIGGER or the biology of tissue factor and factor VII, visit our web site. You can also contact us by mail: J.H. Morrissey, University of Illinois College of Medicine, 417 Med Sci Bldg MC-714, 506 S. Mathews Ave., Urbana, IL 61801, USA.
DISCLAIMER: TRIGGER is provided "as is" for information purposes only and without warranty of any kind, express or implied. Users shall assume the entire risk as to the accuracy and usefulness of information in TRIGGER. Opinions expressed here are not necessarily those of the editors or their employers. You may share TRIGGER with your scientific colleagues but you are not permitted to use it or its contents for commercial purposes.
__________________________________________________________
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 16, No. 23 December 1, 2010
(The next issue will be on December 15, 2010)
__________________________________________________________
TRIGGER is also available by RSS Feed:
http://feeds.feedburner.com/blogspot/glro
and BLOG:
http://trigger-tf7.blogspot.com/
__________________________________________________________
PAPERS IN PRESS
AUTHORS: Cho Y, Cao X, Shen DF, Tuo J, Parver LM, Rickles FR and Chan C-C.
TITLE: Evidence for enhanced tissue factor expression in age-related macular degeneration
JOURNAL: Laboratory Investigation
ABSTRACT: Tissue factor (TF) is the primary initiator of blood coagulation. In addition to hemostasis, TF can initiate intracellular signaling and promote inflammation and angiogenesis, the key processes underlying the pathogenesis of age-related macular degeneration (AMD). AMD, the leading cause of irreversible blindness among the elderly, involves many genetic and environmental risk factors, including oxidative stress and inflammation. In this study, TF expression was examined in human AMD tissue and in the eyes of a model of AMD, the Ccl2-/-/Cx3cr1-/-(DKO) mouse, as well as in the ARPE-19 cell line after lipopolysaccharide (LPS) and H2O2 stimulation. Total RNA was extracted from tissue samples and further analyzed by real-time RT-PCR. Immunohistochemistry was performed to evaluate TF protein expression. In the human retina, a 32-fold increase of TF mRNA expression was detected in AMD macular lesions compared with normal maculae. TF protein expression was also enhanced in human AMD maculae. Similarly, TF transcript and protein expression were moderately increased in retinal lesions, neuroretinal tissue, and cultured RPE cells of DKO mice compared with age-matched wild-type mice. TF expression level correlated with age in both wild-type and DKO mice. In order to better understand how AMD might lead to enhanced TF expression, 1, 5, and 10 mg/ml LPS as well as 100 and 200 mM H2O2 were used to stimulate ARPE-19 cells for 24 and 2 h, respectively. LPS treatment consistently increased TF transcript and protein expression. H2O2 alone or in combination with LPS also moderately enhanced TF expression. These results indicate that upregulated TF expression may be associated with AMD, and inflammatory and oxidative stress may contribute to TF expression in AMD eyes.
SUBMITTED BY: Frederick R. Rickles, M.D. (frickles AT mfa DOT gwu DOT edu)
__________________________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI
Papers are culled from NLM MedLine (PubMed). Titles in square brackets indicate that the paper was not published in English. References that lack volume or page numbers are typically electronic pre-publications (E-pubs) ahead of the print publication; if so, the final citation with volume and page numbers may or may not appear in a future issue of Trigger.
THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1Dqm8edJ8YqLi_hLPqyFAcv/
Agerso H, Brophy DF, Pelzer H, Martin EJ, Carr M, Hedner U, Ezban M (2010) Recombinant human factor VIIa (rFVIIa) cleared principally by antithrombin following IV administration in haemophilia patients. J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/21114621
Bajaj MS, Ogueli GI, Kumar Y, Vadivel K, Lawson G, Shanker S, . . . Bajaj SP (2010) Engineering Kunitz domain 1 (KD1) of human tissue factor pathway inhibitor-2 to selectively inhibit fibrinolysis: properties of KD1-L17R variant. J Biol Chem.
http://www.ncbi.nlm.nih.gov/pubmed/21115497
Celi A, Cianchetti S, Dell'omo G, Pedrinelli R (2010) Angiotensin II, tissue factor and the thrombotic paradox of hypertension. Expert Rev Cardiovasc Ther 8:1723-1729.
http://www.ncbi.nlm.nih.gov/pubmed/21108554
Dries DJ (2010) The contemporary role of blood products and components used in trauma resuscitation. Scand J Trauma Resusc Emerg Med 18:63.
http://www.ncbi.nlm.nih.gov/pubmed/21106098
Dusse LM, Carvalho MG, Cooper AJ, Lwaleed BA (2010) Plasma factor VII: A potential marker of pre-eclampsia. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/21094984
Girolami A, Berti de Marinis G, Bonamigo E, Sartori R, Vettore S (2010) Ox Brain versus Rabbit Brain Thromboplastin Assays Are the Best Tool for a Preliminary Diagnosis of the Arg304Gln Factor VII Defect (FVII Padua). Acta Haematol 124:229-234.
http://www.ncbi.nlm.nih.gov/pubmed/21099211
Jacob M, Chappell D, Stoeckelhuber M, Welsch U, Rehm M, Bruegger D, . . . Becker BF (2010) Perspectives in Microvascular Fluid Handling: Does the Distribution of Coagulation Factors in Human Myocardium Comply with Plasma Extravasation in Venular Coronary Segments? J Vasc Res 48:219-226.
http://www.ncbi.nlm.nih.gov/pubmed/21088428
Knudson MM, Cohen MJ, Reidy R, Jaeger S, Bacchetti P, Jin C, . . . Holcomb JB (2010) Trauma, Transfusions, and Use of Recombinant Factor VIIa: A Multicenter Case Registry Report of 380 Patients from the Western Trauma Association. J Am Coll Surg.
http://www.ncbi.nlm.nih.gov/pubmed/21115374
Lin Y, Stanworth S, Birchall J, Doree C, Hyde C (2010) Use of recombinant factor VIIa for the prevention and treatment of bleeding in patients without hemophilia: a systematic review and meta-analysis. CMAJ.
http://www.ncbi.nlm.nih.gov/pubmed/21078742
Liu X, Nie J, Guo SW (2010) Elevated immunoreactivity to tissue factor and its association with dysmenorrhea severity and the amount of menses in adenomyosis. Hum Reprod.
http://www.ncbi.nlm.nih.gov/pubmed/21115504
Owen BA, Xue A, Heit JA, Owen WG (2010) Procoagulant activity, but not number, of microparticles increases with age and in individuals after a single venous thromboembolism. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/21106230
Petersen LC, Karpf DM, Agerso H, Hermit MB, Pelzer H, Persson E, . . . Ezban M (2010) Intravascular inhibition of factor VIIa and the analogue NN1731 by antithrombin. Br J Haematol.
http://www.ncbi.nlm.nih.gov/pubmed/21083658
Scher C, Narine V, Chien D (2010) Recombinant factor VIIa in trauma patients without coagulation disorders. Anesthesiol Clin 28:681-690.
http://www.ncbi.nlm.nih.gov/pubmed/21074745
Shetty S, Bhave M, Ghosh K (2010) Acquired hemophilia A : diagnosis, aetiology, clinical spectrum and treatment options. Autoimmun Rev.
http://www.ncbi.nlm.nih.gov/pubmed/21115138
Temma T, Ogawa Y, Kuge Y, Ishino S, Takai N, Nishigori K, . . . Saji H (2010) Tissue factor detection for selectively discriminating unstable plaques in an atherosclerotic rabbit model. J Nucl Med 51:1979-1986.
http://www.ncbi.nlm.nih.gov/pubmed/21078793
Zakai NA, Lange L, Longstreth WT, O'Meara ES, Kelley JL, Fornage M, . . . Reiner AP (2010) Association of coagulation and inflammation related genes and factor VIIc levels with stroke: the cardiovascular health study. J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/21114618
Zhou H, Yan Y, Xu G, Zhou B, Wen H, Guo D, . . . Wang H (2010) Toll-like receptor (TLR)-4 mediates anti-beta(2) GPI/beta(2) GPI-induced tissue factor expression in THP-1 cells. Clin Exp Immunol.
http://www.ncbi.nlm.nih.gov/pubmed/21091668
__________________________________________________________
ABOUT TRIGGER
TRIGGER is edited by Jim Morrissey and Pierre Neuenschwander, with editorial assistance by Genie Morrissey. It includes Abstracts of Papers in Press, Meeting Announcements, Positions Sought/Available,or any other pertinent item that subscribers may want to share with their colleagues. To submit an item for publication in Trigger, e-mail us. To request or cancel a subscription,or for more information about TRIGGER or the biology of tissue factor and factor VII, visit our web site. You can also contact us by mail: J.H. Morrissey, University of Illinois College of Medicine, 417 Med Sci Bldg MC-714, 506 S. Mathews Ave., Urbana, IL 61801, USA.
DISCLAIMER: TRIGGER is provided "as is" for information purposes only and without warranty of any kind, express or implied. Users shall assume the entire risk as to the accuracy and usefulness of information in TRIGGER. Opinions expressed here are not necessarily those of the editors or their employers. You may share TRIGGER with your scientific colleagues but you are not permitted to use it or its contents for commercial purposes.
__________________________________________________________
Monday, November 15, 2010
Vol. 16, No. 22
TRIGGER
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 16, No. 22 November 15, 2010
(The next issue will be on December 1, 2010)
__________________________________________________________
TRIGGER is also available by RSS Feed:
http://feeds.feedburner.com/blogspot/glro
and BLOG:
http://trigger-tf7.blogspot.com/
__________________________________________________________
PAPERS IN PRESS
None submitted for this issue.
__________________________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI
Papers are culled from NLM MedLine (PubMed). Titles in square brackets indicate that the paper was not published in English. References that lack volume or page numbers are typically electronic pre-publications (E-pubs) ahead of the print publication; if so, the final citation with volume and page numbers may or may not appear in a future issue of Trigger.
THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/16c3jUjlhfW-MitLtvE01jx/
Aledort LM (2010) Off-label use of recombinant activated factor VII--safe or not safe? N Engl J Med 363:1853-1854.
http://www.ncbi.nlm.nih.gov/pubmed/21047230
Alesci S, Krekeler S, Miesbach W (2010) Successful treatment of an injury bleeding on a patient suffering from mild von Willebrand's disease and predisposition to allergic diseases, with recombinant factor VIIA. Haemophilia.
http://www.ncbi.nlm.nih.gov/pubmed/21070492
Auwerda JJ, Yuana Y, Osanto S, de Maat MP, Sonneveld P, Bertina RM, Leebeek FW (2010) Microparticle-associated tissue factor activity and venous thrombosis in multiple myeloma. Thromb Haemost 105.
http://www.ncbi.nlm.nih.gov/pubmed/21057704
Casey BJ, Behrens AM, Hess JR, Wu ZJ, Griffith BP, Kofinas P (2010) FVII Dependent Coagulation Activation in Citrated Plasma by Polymer Hydrogels. Biomacromolecules.
http://www.ncbi.nlm.nih.gov/pubmed/21058718
Davizon P, Munday AD, Lopez JA (2010) Tissue factor, lipid rafts, and microparticles. Semin Thromb Hemost 36:857-864.
http://www.ncbi.nlm.nih.gov/pubmed/21049386
Girardi G (2010) Role of tissue factor in feto-maternal development: a xiphos. J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/21070593
Han B, Haitsma JJ, Zhang Y, Bai X, Rubacha M, Keshavjee S, . . . Liu M (2010) Long pentraxin PTX3 deficiency worsens LPS-induced acute lung injury. Intensive Care Med.
http://www.ncbi.nlm.nih.gov/pubmed/21072499
Hong I, Stachnik J (2010) Unlabeled uses of factor VIIa (recombinant) in pediatric patients. Am J Health Syst Pharm 67:1909-1919.
http://www.ncbi.nlm.nih.gov/pubmed/21048207
Kacka K, Kacki W, Merak J, Bleka A (2010) Use of recombinant activated factor VII for reduction of perioperative blood loss during elective surgical correction of spine deformity in a Jehovah's Witness. Case repor. Ortop Traumatol Rehabil 12:448-458.
http://www.ncbi.nlm.nih.gov/pubmed/21057153
Key NS, Mackman N (2010) Tissue factor and its measurement in whole blood, plasma, and microparticles. Semin Thromb Hemost 36:865-875.
http://www.ncbi.nlm.nih.gov/pubmed/21049387
Killary AM, Balasenthil S, Chen N, Lott ST, Chen J, Carter J, . . .Sen S (2010) A Migration Signature and Plasma Biomarker Panel for Pancreatic Adenocarcinoma. Cancer Prev Res (Phila).
http://www.ncbi.nlm.nih.gov/pubmed/21071578
Levi M, Levy JH, Andersen HF, Truloff D (2010) Safety of recombinant activated factor VII in randomized clinical trials. N Engl J Med 363:1791-1800.
http://www.ncbi.nlm.nih.gov/pubmed/21047223
Luyendyk JP, Flanagan KC, Williams CD, Jaeschke H, Slusser JG, Mackman N, Cantor GH (2010) Tissue factor contributes to neutrophil CD11b expression in alpha-naphthylisothiocyanate-treated mice.
Toxicol Appl Pharmacol.
http://www.ncbi.nlm.nih.gov/pubmed/21070799
Martinez-Sales V, Vila V, Ferrando M, Reganon E (2010) Atorvastatin neutralises the thrombin-induced tissue factor expresion in endothelial cells via geranylgeranyl pyrophosphate. Cytotechnology.
http://www.ncbi.nlm.nih.gov/pubmed/21052830
Martinez-Sales V, Vila V, Mico L, Contreras MT, Escandell A, Reganon E (2010) [Circulating endothelial cells and circulating microparticles in patients with antiphospholipid antibodies.]. Med Clin (Barc).
http://www.ncbi.nlm.nih.gov/pubmed/21051055
Mitroulis I, Kambas K, Anyfanti P, Doumas M, Ritis K (2010) The multivalent activity of the tissue factor-thrombin pathway in thrombotic and non-thrombotic disorders as a target for therapeutic intervention. Expert Opin Ther Targets.
http://www.ncbi.nlm.nih.gov/pubmed/21062231
Natorska J, Marek G, Hlawaty M, Sadowski J, Tracz W, Undas A (2010) Fibrin presence within aortic valves in patients with aortic stenosis: Association with in vivo thrombin generation and fibrin clot properties. Thromb Haemost 105.
http://www.ncbi.nlm.nih.gov/pubmed/21057695
Tardy-Poncet B, Piot M, Chapelle C, Berger C, Tardy B (2010) Difference in TFPI levels between haemophilia A and B patients. Haemophilia.
http://www.ncbi.nlm.nih.gov/pubmed/21070483
Wang S, Xiao X, Zhou X, Huang T, Du C, Yu N, . . . Zhang Z (2010) TFPI-2 is a putative tumor suppressor gene frequently inactivated by promoter hypermethylation in nasopharyngeal carcinoma. BMC Cancer 10:617.
http://www.ncbi.nlm.nih.gov/pubmed/21062455
Zhang X, Yu H, Lou JR, Zheng J, Zhu H, Popescu NI, . . . Ding WQ (2010) microRNA-19 (miR-19) regulates tissue factor expression in breast cancer cells. J Biol Chem.
http://www.ncbi.nlm.nih.gov/pubmed/21059650
__________________________________________________________
ABOUT TRIGGER
TRIGGER is edited by Jim Morrissey and Pierre Neuenschwander, with editorial assistance by Genie Morrissey. It includes Abstracts of Papers in Press, Meeting Announcements, Positions Sought/Available,or any other pertinent item that subscribers may want to share with their colleagues. To submit an item for publication in Trigger, e-mail us. To request or cancel a subscription,or for more information about TRIGGER or the biology of tissue factor and factor VII, visit our web site. You can also contact us by mail: J.H. Morrissey, University of Illinois College of Medicine, 417 Med Sci Bldg MC-714, 506 S. Mathews Ave., Urbana, IL 61801, USA.
DISCLAIMER: TRIGGER is provided "as is" for information purposes only and without warranty of any kind, express or implied. Users shall assume the entire risk as to the accuracy and usefulness of information in TRIGGER. Opinions expressed here are not necessarily those of the editors or their employers. You may share TRIGGER with your scientific colleagues but you are not permitted to use it or its contents for commercial purposes.
__________________________________________________________
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 16, No. 22 November 15, 2010
(The next issue will be on December 1, 2010)
__________________________________________________________
TRIGGER is also available by RSS Feed:
http://feeds.feedburner.com/blogspot/glro
and BLOG:
http://trigger-tf7.blogspot.com/
__________________________________________________________
PAPERS IN PRESS
None submitted for this issue.
__________________________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI
Papers are culled from NLM MedLine (PubMed). Titles in square brackets indicate that the paper was not published in English. References that lack volume or page numbers are typically electronic pre-publications (E-pubs) ahead of the print publication; if so, the final citation with volume and page numbers may or may not appear in a future issue of Trigger.
THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/16c3jUjlhfW-MitLtvE01jx/
Aledort LM (2010) Off-label use of recombinant activated factor VII--safe or not safe? N Engl J Med 363:1853-1854.
http://www.ncbi.nlm.nih.gov/pubmed/21047230
Alesci S, Krekeler S, Miesbach W (2010) Successful treatment of an injury bleeding on a patient suffering from mild von Willebrand's disease and predisposition to allergic diseases, with recombinant factor VIIA. Haemophilia.
http://www.ncbi.nlm.nih.gov/pubmed/21070492
Auwerda JJ, Yuana Y, Osanto S, de Maat MP, Sonneveld P, Bertina RM, Leebeek FW (2010) Microparticle-associated tissue factor activity and venous thrombosis in multiple myeloma. Thromb Haemost 105.
http://www.ncbi.nlm.nih.gov/pubmed/21057704
Casey BJ, Behrens AM, Hess JR, Wu ZJ, Griffith BP, Kofinas P (2010) FVII Dependent Coagulation Activation in Citrated Plasma by Polymer Hydrogels. Biomacromolecules.
http://www.ncbi.nlm.nih.gov/pubmed/21058718
Davizon P, Munday AD, Lopez JA (2010) Tissue factor, lipid rafts, and microparticles. Semin Thromb Hemost 36:857-864.
http://www.ncbi.nlm.nih.gov/pubmed/21049386
Girardi G (2010) Role of tissue factor in feto-maternal development: a xiphos. J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/21070593
Han B, Haitsma JJ, Zhang Y, Bai X, Rubacha M, Keshavjee S, . . . Liu M (2010) Long pentraxin PTX3 deficiency worsens LPS-induced acute lung injury. Intensive Care Med.
http://www.ncbi.nlm.nih.gov/pubmed/21072499
Hong I, Stachnik J (2010) Unlabeled uses of factor VIIa (recombinant) in pediatric patients. Am J Health Syst Pharm 67:1909-1919.
http://www.ncbi.nlm.nih.gov/pubmed/21048207
Kacka K, Kacki W, Merak J, Bleka A (2010) Use of recombinant activated factor VII for reduction of perioperative blood loss during elective surgical correction of spine deformity in a Jehovah's Witness. Case repor. Ortop Traumatol Rehabil 12:448-458.
http://www.ncbi.nlm.nih.gov/pubmed/21057153
Key NS, Mackman N (2010) Tissue factor and its measurement in whole blood, plasma, and microparticles. Semin Thromb Hemost 36:865-875.
http://www.ncbi.nlm.nih.gov/pubmed/21049387
Killary AM, Balasenthil S, Chen N, Lott ST, Chen J, Carter J, . . .Sen S (2010) A Migration Signature and Plasma Biomarker Panel for Pancreatic Adenocarcinoma. Cancer Prev Res (Phila).
http://www.ncbi.nlm.nih.gov/pubmed/21071578
Levi M, Levy JH, Andersen HF, Truloff D (2010) Safety of recombinant activated factor VII in randomized clinical trials. N Engl J Med 363:1791-1800.
http://www.ncbi.nlm.nih.gov/pubmed/21047223
Luyendyk JP, Flanagan KC, Williams CD, Jaeschke H, Slusser JG, Mackman N, Cantor GH (2010) Tissue factor contributes to neutrophil CD11b expression in alpha-naphthylisothiocyanate-treated mice.
Toxicol Appl Pharmacol.
http://www.ncbi.nlm.nih.gov/pubmed/21070799
Martinez-Sales V, Vila V, Ferrando M, Reganon E (2010) Atorvastatin neutralises the thrombin-induced tissue factor expresion in endothelial cells via geranylgeranyl pyrophosphate. Cytotechnology.
http://www.ncbi.nlm.nih.gov/pubmed/21052830
Martinez-Sales V, Vila V, Mico L, Contreras MT, Escandell A, Reganon E (2010) [Circulating endothelial cells and circulating microparticles in patients with antiphospholipid antibodies.]. Med Clin (Barc).
http://www.ncbi.nlm.nih.gov/pubmed/21051055
Mitroulis I, Kambas K, Anyfanti P, Doumas M, Ritis K (2010) The multivalent activity of the tissue factor-thrombin pathway in thrombotic and non-thrombotic disorders as a target for therapeutic intervention. Expert Opin Ther Targets.
http://www.ncbi.nlm.nih.gov/pubmed/21062231
Natorska J, Marek G, Hlawaty M, Sadowski J, Tracz W, Undas A (2010) Fibrin presence within aortic valves in patients with aortic stenosis: Association with in vivo thrombin generation and fibrin clot properties. Thromb Haemost 105.
http://www.ncbi.nlm.nih.gov/pubmed/21057695
Tardy-Poncet B, Piot M, Chapelle C, Berger C, Tardy B (2010) Difference in TFPI levels between haemophilia A and B patients. Haemophilia.
http://www.ncbi.nlm.nih.gov/pubmed/21070483
Wang S, Xiao X, Zhou X, Huang T, Du C, Yu N, . . . Zhang Z (2010) TFPI-2 is a putative tumor suppressor gene frequently inactivated by promoter hypermethylation in nasopharyngeal carcinoma. BMC Cancer 10:617.
http://www.ncbi.nlm.nih.gov/pubmed/21062455
Zhang X, Yu H, Lou JR, Zheng J, Zhu H, Popescu NI, . . . Ding WQ (2010) microRNA-19 (miR-19) regulates tissue factor expression in breast cancer cells. J Biol Chem.
http://www.ncbi.nlm.nih.gov/pubmed/21059650
__________________________________________________________
ABOUT TRIGGER
TRIGGER is edited by Jim Morrissey and Pierre Neuenschwander, with editorial assistance by Genie Morrissey. It includes Abstracts of Papers in Press, Meeting Announcements, Positions Sought/Available,or any other pertinent item that subscribers may want to share with their colleagues. To submit an item for publication in Trigger, e-mail us. To request or cancel a subscription,or for more information about TRIGGER or the biology of tissue factor and factor VII, visit our web site. You can also contact us by mail: J.H. Morrissey, University of Illinois College of Medicine, 417 Med Sci Bldg MC-714, 506 S. Mathews Ave., Urbana, IL 61801, USA.
DISCLAIMER: TRIGGER is provided "as is" for information purposes only and without warranty of any kind, express or implied. Users shall assume the entire risk as to the accuracy and usefulness of information in TRIGGER. Opinions expressed here are not necessarily those of the editors or their employers. You may share TRIGGER with your scientific colleagues but you are not permitted to use it or its contents for commercial purposes.
__________________________________________________________
Thursday, November 4, 2010
Vol. 16, No. 21
TRIGGER
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 16, No. 21 November 4, 2010
(The next issue will be on November 15, 2010)
__________________________________________________________
TRIGGER is also available by RSS Feed:
http://feeds.feedburner.com/blogspot/glro
and BLOG:
http://trigger-tf7.blogspot.com/
__________________________________________________________
ANNOUNCEMENTS
ISTH Travel Awards for U.S. New Investigators - December 3 application deadline for U.S. New Investigators Travel Awards. These travel awards,to attend the ISTH Congress in Kyoto in July 2011, are anticipated to be $2,000, and will support Fellows and Junior Faculty at US laboratories. To be considered, applicants must submit an abstract and an NIH-style biosketch (2 pages). Applicants must also submit their abstracts in original or modified form to the Kyoto Congress abstract selection committee. ISTH 2011 Congress abstract instructions can be found at: http://www.isth2011.com/
Award selection will be announced by January 7, 2011. Receipt of the awards, which will be made on site at the Kyoto meeting, will also depend upon abstract acceptance by the Kyoto Congress. Candidates may go to the following web site by December 3 to submit their applications: http://www.kyototravelawards.org/
For questions about the awards, please email Dr. Kenneth Mann (Kenneth DOT Mann AT uvm DOT edu).
__________________________________________________________
PAPERS IN PRESS
AUTHORS: Choi SH, Collins JNR, Smith SA, Davis-Harrison RL, Rienstra CM, and Morrissey JH.
TITLE: Phosphoramidate end labeling of inorganic polyphosphates: Facile manipulation of polyphosphate for investigating and modulating its biological activities.
JOURNAL: Biochemistry, In Press.
ABSTRACT: Polyphosphates, linear polymers of inorganic phosphates linked by phosphoanhydride bonds, are widely present among organisms and play diverse roles in biology, including functioning as potent natural modulators of the human blood clotting system. However, studies of protein-polyphosphate interactions are hampered by a dearth of methods for derivatizing polyphosphate or immobilizing it onto solid supports. We now report that EDAC (1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide) efficiently promotes the covalent attachment of a variety of primary amine-containing labels and probes to the terminal phosphates of polyphosphates via stable phosphoramidate linkages. Using 31P NMR, we confirmed that EDAC-mediated reactions between primary amines and polyphosphate result in phosphoramidate linkages with the terminal phosphate groups. We show that polyphosphate can be biotinylated, labeled with fluorophores, and immobilized onto solid supports, that immobilized polyphosphate can be readily used to quantify protein binding affinities, that covalently derivatized or immobilized polyphosphate retains its ability to trigger blood clotting, and that derivatizing the ends of polyphosphate with spermidine protects it from exopolyphosphatase degradation. Our findings open up essentially the entire armamentarium of protein chemistry to modifying polyphosphate, which should greatly facilitate studies of its biological roles.
PREPRINT: http://pubs.acs.org/doi/abs/10.1021/bi1014437
SUBMITTED BY: Jim Morrissey (jhmorris AT illinois DOT edu)
__________________________________________________________
UPCOMING MEETINGS & EVENTS
Abstract Submission is now open for the Arteriosclerosis, Thrombosis and Vascular Biology 2011 Scientific Sessions, April 28-30, 2011 in Chicago Illinois, USA. Submission Deadline: Wednesday January 19, 2011. For more information:
http://www.americanheart.org/presenter.jhtml?identifier=3057022
__________________________________________________________
POSITIONS SOUGHT/AVAILABLE
Ph.D. and Technician Positions Available –
Are you a skilled protein biochemist looking for a new opportunity? Have you ever thought about moving to Vermont? If so, get your resume together and send it along! We're looking for technicians and a PhD level scientist experienced in protein biochemistry to add to our distinguished team at our facility in Essex Junction, Vermont USA. Experience working with blood coagulation proteins is preferred. Industry experience for both positions preferred. Check out the job postings here: http://www.haemtech.com/news.htm
Please, no phone calls. We're looking forward to hearing from you!
Robert Myers, Director, Business and Marketing Haematologic Technologies, Inc.
E-mail: rmyers AT haemtech DOT net
__________________________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI
Papers are culled from NLM MedLine (PubMed). Titles in square brackets indicate that the paper was not published in English. References that lack volume or page numbers are typically electronic pre-publications (E-pubs) ahead of the print publication; if so, the final citation with volume and page numbers may or may not appear in a future issue of Trigger.
THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1l51ojfq19nZSniwlaVFaMi/
Agmon-Levin N, Blank M, Zandman-Goddard G, Orbach H, Meroni PL, Tincani A, . . . Shoenfeld Y (2010) Vitamin D: an instrumental factor in the anti-phospholipid syndrome by inhibition of tissue factor expression. Ann Rheum Dis.
http://www.ncbi.nlm.nih.gov/pubmed/20980705
Alonso A, Tang W, Agarwal SK, Soliman EZ, Chamberlain AM, Folsom AR (2010) Hemostatic markers are associated with the risk and prognosis of atrial fibrillation: The ARIC study. Int J Cardiol.
http://www.ncbi.nlm.nih.gov/pubmed/20965585
Borensztajn K, Bresser P, van der Loos C, Bot I, van den Blink B, den Bakker MA, . . . Spek CA (2010) Protease-Activated Receptor-2 Induces Myofibroblast Differentiation and Tissue Factor Up-Regulation during Bleomycin-Induced Lung Injury. Potential Role in Pulmonary Fibrosis. Am J Pathol.
http://www.ncbi.nlm.nih.gov/pubmed/20971733
Breitenstein A, Stein S, Holy EW, Camici GG, Lohmann C, Akhmedov A, . . . Tanner FC (2010) Sirt1 inhibition promotes in vivo arterial thrombosis and tissue factor expression in stimulated cells. Cardiovasc Res.
http://www.ncbi.nlm.nih.gov/pubmed/20978007
Cho Y, Cao X, Shen D, Tuo J, Parver LM, Rickles FR, Chan CC (2010) Evidence for enhanced tissue factor expression in age-related macular degeneration. Lab Invest.
http://www.ncbi.nlm.nih.gov/pubmed/21042291
D'Angelo MR, Dutton RP (2010) Management of trauma-induced coagulopathy: trends and practices. AANA J 78:35-40.
http://www.ncbi.nlm.nih.gov/pubmed/20977127
Dreischaluck J, Schwoppe C, Spieker T, Kessler T, Tiemann K, Liersch R, . . . Berdel WE (2010) Vascular infarction by subcutaneous application of tissue factor targeted to tumor vessels with NGR-peptides: Activity and toxicity profile. Int J Oncol 37:1389-1397.
http://www.ncbi.nlm.nih.gov/pubmed/21042706
Girolami A, Bonamigo E, Vettore S (2010) The lack of ties between north-eastern Italy and African-Americans suggest a multi-founder effect for FVII Padua (Arg304Gln) disorder. Blood Coagul Fibrinolysis 21:775-776.
http://www.ncbi.nlm.nih.gov/pubmed/21042058
Girolami A, De Marinis GB, Bonamigo E, Allemand E (2010) Worldwide diffusion of FVII Arg304Gln coagulation defect (FVII Padua)((1)). Eur J Haematol.
http://www.ncbi.nlm.nih.gov/pubmed/20958793
Hillarp A, Baghaei F, Blixter IF, Gustafsson KM, Stigendal L, Sten-Linder M, . . . Lindahl TL (2010) Effects of the oral, direct factor Xa inhibitor rivaroxaban on commonly used coagulation assays. J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/20946166
Ittel A, Bretelle F, Gris JC, Chau C, Sebahoun G, Boubli L, Arnoux D (2010) Increased risk of gestational vascular complications in women with low free tissue factor pathway inhibitor plasma levels out of pregnancy. Thromb Haemost 105.
http://www.ncbi.nlm.nih.gov/pubmed/20978710
Kasthuri RS, Glover SL, Boles J, Mackman N (2010) Tissue factor and tissue factor pathway inhibitor as key regulators of global hemostasis: measurement of their levels in coagulation assays. Semin Thromb Hemost 36:764-771.
http://www.ncbi.nlm.nih.gov/pubmed/20978997
Klintman J, Astermark J, Berntorp E (2010) Combination of FVIII and by-passing agent potentiates in vitro thrombin production in haemophilia A inhibitor plasma. Br J Haematol 151:381-386.
http://www.ncbi.nlm.nih.gov/pubmed/20977448
Lehr EJ, Alford TJ, Wang SH (2010) Recombinant activated factor VII for postoperative hemorrhage following repair of acute type A aortic dissection. Heart Surg Forum 13:E275-279.
http://www.ncbi.nlm.nih.gov/pubmed/20961825
Matsuda S, Yamashita A, Sato Y, Kitajima S, Koike T, Sugita C, . . . Asada Y (2010) Human C-reactive protein enhances thrombus formation after neointimal balloon injury in transgenic rabbits. J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/21029360
Milligan C, Higginson I, Smith JE (2010) Emergency department staff knowledge of massive transfusion for trauma: the need for an evidence based protocol. Emerg Med J.
http://www.ncbi.nlm.nih.gov/pubmed/21030544
Schweintzger S, Schlagenhauf A, Rinner B, Bernhard H, Novak M, Leschnik B, Muntean W (2010) High microparticle concentration in cord plasma. Hamostaseologie 30:S122-125.
http://www.ncbi.nlm.nih.gov/pubmed/21042669
Sullivan BP, Weinreb PH, Violette SM, Luyendyk JP (2010) The Coagulation System Contributes to {alpha}V{beta}6 Integrin Expression and Liver Fibrosis Induced by Cholestasis. Am J Pathol.
http://www.ncbi.nlm.nih.gov/pubmed/21037076
Van Den Boogaard FE, Brands X, Schultz MJ, Levi M, Roelofs JJ, Van't Veer C, Van Der Poll T (2010) Recombinant Human Tissue Factor Pathway Inhibitor exerts anticoagulant, anti-inflammatory and antimicrobial effects in murine pneumococcal pneumonia. J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/21029363
Zhang M, Sun L (2010) The tissue factor pathway inhibitor 1 of Sciaenops ocellatus possesses antimicrobial activity and is involved in the immune response against bacterial infection. Dev Comp Immunol.
http://www.ncbi.nlm.nih.gov/pubmed/20970444
Zhang M, Xiao ZZ, Sun L (2010) Identification and analysis of the tissue factor pathway inhibitor 2 of Sciaenops ocellatus. Fish Shellfish Immunol.
http://www.ncbi.nlm.nih.gov/pubmed/20970505
__________________________________________________________
ABOUT TRIGGER
TRIGGER is edited by Jim Morrissey and Pierre Neuenschwander, with editorial assistance by Genie Morrissey. It includes Abstracts of Papers in Press, Meeting Announcements, Positions Sought/Available,or any other pertinent item that subscribers may want to share with their colleagues. To submit an item for publication in Trigger, e-mail us. To request or cancel a subscription,or for more information about TRIGGER or the biology of tissue factor and factor VII, visit our web site. You can also contact us by mail: J.H. Morrissey, University of Illinois College of Medicine, 417 Med Sci Bldg MC-714, 506 S. Mathews Ave., Urbana, IL 61801, USA.
DISCLAIMER: TRIGGER is provided "as is" for information purposes only and without warranty of any kind, express or implied. Users shall assume the entire risk as to the accuracy and usefulness of information in TRIGGER. Opinions expressed here are not necessarily those of the editors or their employers. You may share TRIGGER with your scientific colleagues but you are not permitted to use it or its contents for commercial purposes.
__________________________________________________________
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 16, No. 21 November 4, 2010
(The next issue will be on November 15, 2010)
__________________________________________________________
TRIGGER is also available by RSS Feed:
http://feeds.feedburner.com/blogspot/glro
and BLOG:
http://trigger-tf7.blogspot.com/
__________________________________________________________
ANNOUNCEMENTS
ISTH Travel Awards for U.S. New Investigators - December 3 application deadline for U.S. New Investigators Travel Awards. These travel awards,to attend the ISTH Congress in Kyoto in July 2011, are anticipated to be $2,000, and will support Fellows and Junior Faculty at US laboratories. To be considered, applicants must submit an abstract and an NIH-style biosketch (2 pages). Applicants must also submit their abstracts in original or modified form to the Kyoto Congress abstract selection committee. ISTH 2011 Congress abstract instructions can be found at: http://www.isth2011.com/
Award selection will be announced by January 7, 2011. Receipt of the awards, which will be made on site at the Kyoto meeting, will also depend upon abstract acceptance by the Kyoto Congress. Candidates may go to the following web site by December 3 to submit their applications: http://www.kyototravelawards.org/
For questions about the awards, please email Dr. Kenneth Mann (Kenneth DOT Mann AT uvm DOT edu).
__________________________________________________________
PAPERS IN PRESS
AUTHORS: Choi SH, Collins JNR, Smith SA, Davis-Harrison RL, Rienstra CM, and Morrissey JH.
TITLE: Phosphoramidate end labeling of inorganic polyphosphates: Facile manipulation of polyphosphate for investigating and modulating its biological activities.
JOURNAL: Biochemistry, In Press.
ABSTRACT: Polyphosphates, linear polymers of inorganic phosphates linked by phosphoanhydride bonds, are widely present among organisms and play diverse roles in biology, including functioning as potent natural modulators of the human blood clotting system. However, studies of protein-polyphosphate interactions are hampered by a dearth of methods for derivatizing polyphosphate or immobilizing it onto solid supports. We now report that EDAC (1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide) efficiently promotes the covalent attachment of a variety of primary amine-containing labels and probes to the terminal phosphates of polyphosphates via stable phosphoramidate linkages. Using 31P NMR, we confirmed that EDAC-mediated reactions between primary amines and polyphosphate result in phosphoramidate linkages with the terminal phosphate groups. We show that polyphosphate can be biotinylated, labeled with fluorophores, and immobilized onto solid supports, that immobilized polyphosphate can be readily used to quantify protein binding affinities, that covalently derivatized or immobilized polyphosphate retains its ability to trigger blood clotting, and that derivatizing the ends of polyphosphate with spermidine protects it from exopolyphosphatase degradation. Our findings open up essentially the entire armamentarium of protein chemistry to modifying polyphosphate, which should greatly facilitate studies of its biological roles.
PREPRINT: http://pubs.acs.org/doi/abs/10.1021/bi1014437
SUBMITTED BY: Jim Morrissey (jhmorris AT illinois DOT edu)
__________________________________________________________
UPCOMING MEETINGS & EVENTS
Abstract Submission is now open for the Arteriosclerosis, Thrombosis and Vascular Biology 2011 Scientific Sessions, April 28-30, 2011 in Chicago Illinois, USA. Submission Deadline: Wednesday January 19, 2011. For more information:
http://www.americanheart.org/presenter.jhtml?identifier=3057022
__________________________________________________________
POSITIONS SOUGHT/AVAILABLE
Ph.D. and Technician Positions Available –
Are you a skilled protein biochemist looking for a new opportunity? Have you ever thought about moving to Vermont? If so, get your resume together and send it along! We're looking for technicians and a PhD level scientist experienced in protein biochemistry to add to our distinguished team at our facility in Essex Junction, Vermont USA. Experience working with blood coagulation proteins is preferred. Industry experience for both positions preferred. Check out the job postings here: http://www.haemtech.com/news.htm
Please, no phone calls. We're looking forward to hearing from you!
Robert Myers, Director, Business and Marketing Haematologic Technologies, Inc.
E-mail: rmyers AT haemtech DOT net
__________________________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI
Papers are culled from NLM MedLine (PubMed). Titles in square brackets indicate that the paper was not published in English. References that lack volume or page numbers are typically electronic pre-publications (E-pubs) ahead of the print publication; if so, the final citation with volume and page numbers may or may not appear in a future issue of Trigger.
THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1l51ojfq19nZSniwlaVFaMi/
Agmon-Levin N, Blank M, Zandman-Goddard G, Orbach H, Meroni PL, Tincani A, . . . Shoenfeld Y (2010) Vitamin D: an instrumental factor in the anti-phospholipid syndrome by inhibition of tissue factor expression. Ann Rheum Dis.
http://www.ncbi.nlm.nih.gov/pubmed/20980705
Alonso A, Tang W, Agarwal SK, Soliman EZ, Chamberlain AM, Folsom AR (2010) Hemostatic markers are associated with the risk and prognosis of atrial fibrillation: The ARIC study. Int J Cardiol.
http://www.ncbi.nlm.nih.gov/pubmed/20965585
Borensztajn K, Bresser P, van der Loos C, Bot I, van den Blink B, den Bakker MA, . . . Spek CA (2010) Protease-Activated Receptor-2 Induces Myofibroblast Differentiation and Tissue Factor Up-Regulation during Bleomycin-Induced Lung Injury. Potential Role in Pulmonary Fibrosis. Am J Pathol.
http://www.ncbi.nlm.nih.gov/pubmed/20971733
Breitenstein A, Stein S, Holy EW, Camici GG, Lohmann C, Akhmedov A, . . . Tanner FC (2010) Sirt1 inhibition promotes in vivo arterial thrombosis and tissue factor expression in stimulated cells. Cardiovasc Res.
http://www.ncbi.nlm.nih.gov/pubmed/20978007
Cho Y, Cao X, Shen D, Tuo J, Parver LM, Rickles FR, Chan CC (2010) Evidence for enhanced tissue factor expression in age-related macular degeneration. Lab Invest.
http://www.ncbi.nlm.nih.gov/pubmed/21042291
D'Angelo MR, Dutton RP (2010) Management of trauma-induced coagulopathy: trends and practices. AANA J 78:35-40.
http://www.ncbi.nlm.nih.gov/pubmed/20977127
Dreischaluck J, Schwoppe C, Spieker T, Kessler T, Tiemann K, Liersch R, . . . Berdel WE (2010) Vascular infarction by subcutaneous application of tissue factor targeted to tumor vessels with NGR-peptides: Activity and toxicity profile. Int J Oncol 37:1389-1397.
http://www.ncbi.nlm.nih.gov/pubmed/21042706
Girolami A, Bonamigo E, Vettore S (2010) The lack of ties between north-eastern Italy and African-Americans suggest a multi-founder effect for FVII Padua (Arg304Gln) disorder. Blood Coagul Fibrinolysis 21:775-776.
http://www.ncbi.nlm.nih.gov/pubmed/21042058
Girolami A, De Marinis GB, Bonamigo E, Allemand E (2010) Worldwide diffusion of FVII Arg304Gln coagulation defect (FVII Padua)((1)). Eur J Haematol.
http://www.ncbi.nlm.nih.gov/pubmed/20958793
Hillarp A, Baghaei F, Blixter IF, Gustafsson KM, Stigendal L, Sten-Linder M, . . . Lindahl TL (2010) Effects of the oral, direct factor Xa inhibitor rivaroxaban on commonly used coagulation assays. J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/20946166
Ittel A, Bretelle F, Gris JC, Chau C, Sebahoun G, Boubli L, Arnoux D (2010) Increased risk of gestational vascular complications in women with low free tissue factor pathway inhibitor plasma levels out of pregnancy. Thromb Haemost 105.
http://www.ncbi.nlm.nih.gov/pubmed/20978710
Kasthuri RS, Glover SL, Boles J, Mackman N (2010) Tissue factor and tissue factor pathway inhibitor as key regulators of global hemostasis: measurement of their levels in coagulation assays. Semin Thromb Hemost 36:764-771.
http://www.ncbi.nlm.nih.gov/pubmed/20978997
Klintman J, Astermark J, Berntorp E (2010) Combination of FVIII and by-passing agent potentiates in vitro thrombin production in haemophilia A inhibitor plasma. Br J Haematol 151:381-386.
http://www.ncbi.nlm.nih.gov/pubmed/20977448
Lehr EJ, Alford TJ, Wang SH (2010) Recombinant activated factor VII for postoperative hemorrhage following repair of acute type A aortic dissection. Heart Surg Forum 13:E275-279.
http://www.ncbi.nlm.nih.gov/pubmed/20961825
Matsuda S, Yamashita A, Sato Y, Kitajima S, Koike T, Sugita C, . . . Asada Y (2010) Human C-reactive protein enhances thrombus formation after neointimal balloon injury in transgenic rabbits. J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/21029360
Milligan C, Higginson I, Smith JE (2010) Emergency department staff knowledge of massive transfusion for trauma: the need for an evidence based protocol. Emerg Med J.
http://www.ncbi.nlm.nih.gov/pubmed/21030544
Schweintzger S, Schlagenhauf A, Rinner B, Bernhard H, Novak M, Leschnik B, Muntean W (2010) High microparticle concentration in cord plasma. Hamostaseologie 30:S122-125.
http://www.ncbi.nlm.nih.gov/pubmed/21042669
Sullivan BP, Weinreb PH, Violette SM, Luyendyk JP (2010) The Coagulation System Contributes to {alpha}V{beta}6 Integrin Expression and Liver Fibrosis Induced by Cholestasis. Am J Pathol.
http://www.ncbi.nlm.nih.gov/pubmed/21037076
Van Den Boogaard FE, Brands X, Schultz MJ, Levi M, Roelofs JJ, Van't Veer C, Van Der Poll T (2010) Recombinant Human Tissue Factor Pathway Inhibitor exerts anticoagulant, anti-inflammatory and antimicrobial effects in murine pneumococcal pneumonia. J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/21029363
Zhang M, Sun L (2010) The tissue factor pathway inhibitor 1 of Sciaenops ocellatus possesses antimicrobial activity and is involved in the immune response against bacterial infection. Dev Comp Immunol.
http://www.ncbi.nlm.nih.gov/pubmed/20970444
Zhang M, Xiao ZZ, Sun L (2010) Identification and analysis of the tissue factor pathway inhibitor 2 of Sciaenops ocellatus. Fish Shellfish Immunol.
http://www.ncbi.nlm.nih.gov/pubmed/20970505
__________________________________________________________
ABOUT TRIGGER
TRIGGER is edited by Jim Morrissey and Pierre Neuenschwander, with editorial assistance by Genie Morrissey. It includes Abstracts of Papers in Press, Meeting Announcements, Positions Sought/Available,or any other pertinent item that subscribers may want to share with their colleagues. To submit an item for publication in Trigger, e-mail us. To request or cancel a subscription,or for more information about TRIGGER or the biology of tissue factor and factor VII, visit our web site. You can also contact us by mail: J.H. Morrissey, University of Illinois College of Medicine, 417 Med Sci Bldg MC-714, 506 S. Mathews Ave., Urbana, IL 61801, USA.
DISCLAIMER: TRIGGER is provided "as is" for information purposes only and without warranty of any kind, express or implied. Users shall assume the entire risk as to the accuracy and usefulness of information in TRIGGER. Opinions expressed here are not necessarily those of the editors or their employers. You may share TRIGGER with your scientific colleagues but you are not permitted to use it or its contents for commercial purposes.
__________________________________________________________
Saturday, October 16, 2010
Vol. 16, No. 20
TRIGGER
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 16, No. 20 October 15, 2010
(The next issue will be on November 1, 2010)
__________________________________________________________
TRIGGER is also available by RSS Feed:
http://feeds.feedburner.com/blogspot/glro
and BLOG:
http://trigger-tf7.blogspot.com/
__________________________________________________________
PAPERS IN PRESS
None submitted for this issue.
__________________________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI
Papers are culled from NLM MedLine (PubMed). Titles in square brackets indicate that the paper was not published in English. References that lack volume or page numbers are typically electronic pre-publications (E-pubs) ahead of the print publication; if so, the final citation with volume and page numbers may or may not appear in a future issue of Trigger.
THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1611bQFR-xUAymamGxJvvi2/
Chatterjee MS, Denney WS, Jing H, Diamond SL (2010) Systems biology of coagulation initiation: kinetics of thrombin generation in resting and activated human blood. PLoS Comput Biol 6.
http://www.ncbi.nlm.nih.gov/pubmed/20941387
Davidson SJ, Turner N, Tillyer L (2010) Anticoagulation of a patient with hypertrophic cardiomyopathy and factor VII deficiency. Blood Coagulation and Fibrinolysis 21:707-708.
http://www.ncbi.nlm.nih.gov/pubmed/20885134
Ezzat WH, Dahl JP, Luginbuhl A, Gordin E, Krein H, Heffelfinger RN (2010) Recombinant human tissue factor pathway inhibitor prevents thrombosis in a venous tuck model. Laryngoscope.
http://www.ncbi.nlm.nih.gov/pubmed/20939073
Grottke O, Braunschweig T, Zimmermann L, et al. (2010) Recombinant factor VIIa reduces bleeding after blunt liver injury in coagulopathic, hypofibrinogenaemic pigs. British Journal of Anaesthesia.
http://www.ncbi.nlm.nih.gov/pubmed/20926476
Holy EW, Tanner FC (2010) Tissue factor in cardiovascular disease pathophysiology and pharmacological intervention. Advances in Pharmacology 59:259-292.
http://www.ncbi.nlm.nih.gov/pubmed/20933205
Hu Z, Li J (2010) Natural killer cells are crucial for the efficacy of Icon (factor VII/human IgG1 Fc) immunotherapy in human tongue cancer. BMC Immunol 11:49.
http://www.ncbi.nlm.nih.gov/pubmed/20939894
Monte AA, Bodmer M, Schaeffer TH (2010) Low-Molecular-Weight Heparin Overdose: Management by Observation (November). Annals of Pharmacotherapy.
http://www.ncbi.nlm.nih.gov/pubmed/20923945
Moyssakis I, Vlahodimitris IE, Kanakis MA, Kapsimali V, Tsoucala C, Vaiopoulos GA (2010) Behavior of coagulation factors and normal inhibitors of coagulation during the acute phase of myocardial infarction. Blood Coagulation and Fibrinolysis 21:670-673.
http://www.ncbi.nlm.nih.gov/pubmed/20885133
Nadir Y, Kenig Y, Drugan A, Zcharia E, Brenner B (2010) Involvement of heparanase in vaginal and cesarean section deliveries. Thrombosis Research.
http://www.ncbi.nlm.nih.gov/pubmed/20932554
Oberheiden T, Blahak C, Nguyen XD, et al. (2010) Activation of platelets and cellular coagulation in cerebral small-vessel disease. Blood Coagulation and Fibrinolysis.
http://www.ncbi.nlm.nih.gov/pubmed/20885295
Rajpathak SN, Xue X, Wassertheil-Smoller S, et al. (2010) Effect of long term low-fat dietary intervention on change in hemostatic factors: Results from the Women's Health Initiative. Nutr Metab Cardiovasc Dis.
http://www.ncbi.nlm.nih.gov/pubmed/20884191
Seested T, Nielsen HM, Christensen EI, Appa RS (2010) The unsialylated subpopulation of recombinant activated factor VII binds to the asialo-glycoprotein receptor (ASGPR) on primary rat hepatocytes. Thrombosis and Haemostasis 104.
http://www.ncbi.nlm.nih.gov/pubmed/20886190
Seidlova D, Blatny J, Penka M, et al. (2010) [Recombinant activated factor VII in the treatment of life threatening post-partum haemorrhage; registry UniSeven in the Czech Republic]. Ceska Gynekologie 75:297-305.
http://www.ncbi.nlm.nih.gov/pubmed/20925226
Seligsohn U (2010) [Inherited bleeding disorders common in Jews]. Harefuah 149:298-303, 335.
http://www.ncbi.nlm.nih.gov/pubmed/20929069
Stavik B, Skretting G, Sletten M, Sandset PM, Iversen N (2010) Overexpression of both TFPIalpha and TFPIbeta induces apoptosis and expression of genes involved in the death receptor pathway in breast
cancer cells. Molecular Carcinogenesis.
http://www.ncbi.nlm.nih.gov/pubmed/20886581
Tournier A, Wahl D, Chaouat A, et al. (2010) Calibrated automated thrombography demonstrates hypercoagulability in patients with idiopathic pulmonary arterial hypertension. Thrombosis Research.
http://www.ncbi.nlm.nih.gov/pubmed/20888030
Vidwan P, Pathak A, Sheth S, Huang J, Monroe DM, Stouffer GA (2010) Activation of Protease-Activated Receptors 3 and 4 Accelerates Tissue Factor-Induced Thrombin Generation on the Surface of Vascular Smooth Muscle Cells. Arteriosclerosis, Thrombosis, and Vascular Biology.
http://www.ncbi.nlm.nih.gov/pubmed/20930172
Zhou J, Wang Y, Xiong Y, Wang H, Feng Y, Chen J (2010) Delivery of TFPI-2 Using Ultrasound With a Microbubble Agent (Sonovue) Inhibits Intimal Hyperplasia after Balloon Injury in a Rabbit Carotid Artery Model. Ultrasound in Medicine and Biology.
http://www.ncbi.nlm.nih.gov/pubmed/20888684
__________________________________________________________
ABOUT TRIGGER
TRIGGER is edited by Jim Morrissey and Pierre Neuenschwander, with editorial assistance by Genie Morrissey. It includes Abstracts of Papers in Press, Meeting Announcements, Positions Sought/Available,or any other pertinent item that subscribers may want to share with their colleagues. To submit an item for publication in Trigger, e-mail us. To request or cancel a subscription,or for more information about TRIGGER or the biology of tissue factor and factor VII, visit our web site. You can also contact us by mail: J.H. Morrissey, University of Illinois College of Medicine, 417 Med Sci Bldg MC-714, 506 S. Mathews Ave., Urbana, IL 61801, USA.
DISCLAIMER: TRIGGER is provided "as is" for information purposes only and without warranty of any kind, express or implied. Users shall assume the entire risk as to the accuracy and usefulness of information in TRIGGER. Opinions expressed here are not necessarily those of the editors or their employers. You may share TRIGGER with your scientific colleagues but you are not permitted to use it or its contents for commercial purposes.
__________________________________________________________
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 16, No. 20 October 15, 2010
(The next issue will be on November 1, 2010)
__________________________________________________________
TRIGGER is also available by RSS Feed:
http://feeds.feedburner.com/blogspot/glro
and BLOG:
http://trigger-tf7.blogspot.com/
__________________________________________________________
PAPERS IN PRESS
None submitted for this issue.
__________________________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI
Papers are culled from NLM MedLine (PubMed). Titles in square brackets indicate that the paper was not published in English. References that lack volume or page numbers are typically electronic pre-publications (E-pubs) ahead of the print publication; if so, the final citation with volume and page numbers may or may not appear in a future issue of Trigger.
THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1611bQFR-xUAymamGxJvvi2/
Chatterjee MS, Denney WS, Jing H, Diamond SL (2010) Systems biology of coagulation initiation: kinetics of thrombin generation in resting and activated human blood. PLoS Comput Biol 6.
http://www.ncbi.nlm.nih.gov/pubmed/20941387
Davidson SJ, Turner N, Tillyer L (2010) Anticoagulation of a patient with hypertrophic cardiomyopathy and factor VII deficiency. Blood Coagulation and Fibrinolysis 21:707-708.
http://www.ncbi.nlm.nih.gov/pubmed/20885134
Ezzat WH, Dahl JP, Luginbuhl A, Gordin E, Krein H, Heffelfinger RN (2010) Recombinant human tissue factor pathway inhibitor prevents thrombosis in a venous tuck model. Laryngoscope.
http://www.ncbi.nlm.nih.gov/pubmed/20939073
Grottke O, Braunschweig T, Zimmermann L, et al. (2010) Recombinant factor VIIa reduces bleeding after blunt liver injury in coagulopathic, hypofibrinogenaemic pigs. British Journal of Anaesthesia.
http://www.ncbi.nlm.nih.gov/pubmed/20926476
Holy EW, Tanner FC (2010) Tissue factor in cardiovascular disease pathophysiology and pharmacological intervention. Advances in Pharmacology 59:259-292.
http://www.ncbi.nlm.nih.gov/pubmed/20933205
Hu Z, Li J (2010) Natural killer cells are crucial for the efficacy of Icon (factor VII/human IgG1 Fc) immunotherapy in human tongue cancer. BMC Immunol 11:49.
http://www.ncbi.nlm.nih.gov/pubmed/20939894
Monte AA, Bodmer M, Schaeffer TH (2010) Low-Molecular-Weight Heparin Overdose: Management by Observation (November). Annals of Pharmacotherapy.
http://www.ncbi.nlm.nih.gov/pubmed/20923945
Moyssakis I, Vlahodimitris IE, Kanakis MA, Kapsimali V, Tsoucala C, Vaiopoulos GA (2010) Behavior of coagulation factors and normal inhibitors of coagulation during the acute phase of myocardial infarction. Blood Coagulation and Fibrinolysis 21:670-673.
http://www.ncbi.nlm.nih.gov/pubmed/20885133
Nadir Y, Kenig Y, Drugan A, Zcharia E, Brenner B (2010) Involvement of heparanase in vaginal and cesarean section deliveries. Thrombosis Research.
http://www.ncbi.nlm.nih.gov/pubmed/20932554
Oberheiden T, Blahak C, Nguyen XD, et al. (2010) Activation of platelets and cellular coagulation in cerebral small-vessel disease. Blood Coagulation and Fibrinolysis.
http://www.ncbi.nlm.nih.gov/pubmed/20885295
Rajpathak SN, Xue X, Wassertheil-Smoller S, et al. (2010) Effect of long term low-fat dietary intervention on change in hemostatic factors: Results from the Women's Health Initiative. Nutr Metab Cardiovasc Dis.
http://www.ncbi.nlm.nih.gov/pubmed/20884191
Seested T, Nielsen HM, Christensen EI, Appa RS (2010) The unsialylated subpopulation of recombinant activated factor VII binds to the asialo-glycoprotein receptor (ASGPR) on primary rat hepatocytes. Thrombosis and Haemostasis 104.
http://www.ncbi.nlm.nih.gov/pubmed/20886190
Seidlova D, Blatny J, Penka M, et al. (2010) [Recombinant activated factor VII in the treatment of life threatening post-partum haemorrhage; registry UniSeven in the Czech Republic]. Ceska Gynekologie 75:297-305.
http://www.ncbi.nlm.nih.gov/pubmed/20925226
Seligsohn U (2010) [Inherited bleeding disorders common in Jews]. Harefuah 149:298-303, 335.
http://www.ncbi.nlm.nih.gov/pubmed/20929069
Stavik B, Skretting G, Sletten M, Sandset PM, Iversen N (2010) Overexpression of both TFPIalpha and TFPIbeta induces apoptosis and expression of genes involved in the death receptor pathway in breast
cancer cells. Molecular Carcinogenesis.
http://www.ncbi.nlm.nih.gov/pubmed/20886581
Tournier A, Wahl D, Chaouat A, et al. (2010) Calibrated automated thrombography demonstrates hypercoagulability in patients with idiopathic pulmonary arterial hypertension. Thrombosis Research.
http://www.ncbi.nlm.nih.gov/pubmed/20888030
Vidwan P, Pathak A, Sheth S, Huang J, Monroe DM, Stouffer GA (2010) Activation of Protease-Activated Receptors 3 and 4 Accelerates Tissue Factor-Induced Thrombin Generation on the Surface of Vascular Smooth Muscle Cells. Arteriosclerosis, Thrombosis, and Vascular Biology.
http://www.ncbi.nlm.nih.gov/pubmed/20930172
Zhou J, Wang Y, Xiong Y, Wang H, Feng Y, Chen J (2010) Delivery of TFPI-2 Using Ultrasound With a Microbubble Agent (Sonovue) Inhibits Intimal Hyperplasia after Balloon Injury in a Rabbit Carotid Artery Model. Ultrasound in Medicine and Biology.
http://www.ncbi.nlm.nih.gov/pubmed/20888684
__________________________________________________________
ABOUT TRIGGER
TRIGGER is edited by Jim Morrissey and Pierre Neuenschwander, with editorial assistance by Genie Morrissey. It includes Abstracts of Papers in Press, Meeting Announcements, Positions Sought/Available,or any other pertinent item that subscribers may want to share with their colleagues. To submit an item for publication in Trigger, e-mail us. To request or cancel a subscription,or for more information about TRIGGER or the biology of tissue factor and factor VII, visit our web site. You can also contact us by mail: J.H. Morrissey, University of Illinois College of Medicine, 417 Med Sci Bldg MC-714, 506 S. Mathews Ave., Urbana, IL 61801, USA.
DISCLAIMER: TRIGGER is provided "as is" for information purposes only and without warranty of any kind, express or implied. Users shall assume the entire risk as to the accuracy and usefulness of information in TRIGGER. Opinions expressed here are not necessarily those of the editors or their employers. You may share TRIGGER with your scientific colleagues but you are not permitted to use it or its contents for commercial purposes.
__________________________________________________________
Friday, October 1, 2010
Vol. 16, No. 19
TRIGGER
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 16, No. 19 October 1, 2010
(The next issue will be on October 15, 2010)
__________________________________________________________
TRIGGER is also available by RSS Feed:
http://feeds.feedburner.com/blogspot/glro
and BLOG:
http://trigger-tf7.blogspot.com/
__________________________________________________________
PAPERS IN PRESS
None submitted for this issue.
__________________________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI
Papers are culled from NLM MedLine (PubMed). Titles in square brackets indicate that the paper was not published in English. References that lack volume or page numbers are typically electronic pre-publications (E-pubs) ahead of the print publication; if so, the final citation with volume and page numbers may or may not appear in a future issue of Trigger.
THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1-S-FxgMhh7Dxk0J1ocxIid/
Campbell JE, Brummel-Ziedins KE, Butenas S, and Mann KG (2010) Cellular regulation of blood coagulation: A model for venous stasis. Blood
http://www.ncbi.nlm.nih.gov/pubmed/20864579
Castellino FJ, Donahue DL, Navari RM, Ploplis VA, and Walsh M (2010) An accompanying genetic severe deficiency of tissue factor protects mice with a protein C deficiency from lethal endotoxemia. Blood
http://www.ncbi.nlm.nih.gov/pubmed/20858853
Czuprynska MM, Wawrzynowicz-Syczewska M, Jureczko L, Andrzejewska J, Jarosz K, Trzebicki J, Pacholczyk M, Chmura A, and Wojcicki M (2010) Preemptive administration of recombinant factor VII (rVIIa) in patients transplanted due to fulminant Wilson's disease. Ann Transplant 15:7-10.
http://www.ncbi.nlm.nih.gov/pubmed/20877260
de Azeredo EL, Kubelka CF, Alburquerque LM, Barbosa LS, Damasco PV, Avila CA, Motta-Castro AR, da Cunha RV, and Monteiro RQ (2010) Tissue factor expression on monocytes from patients with severe dengue fever. Blood Cells Mol Dis
http://www.ncbi.nlm.nih.gov/pubmed/20846886
Debaugnies F, Azerad MA, Noubouossie D, Rozen L, Hemker HC, Corazza HF, Efira A, and Demulder A (2010) Evaluation of the procoagulant activity in the plasma of cancer patients using a thrombin generation assay. Thromb Res
http://www.ncbi.nlm.nih.gov/pubmed/20870277
Hauser CJ, Boffard K, Dutton R, Bernard GR, Croce MA, et al. (2010) Results of the CONTROL trial: Efficacy and safety of recombinant activated Factor VII in the management of refractory traumatic hemorrhage. J Trauma 69:489-500.
http://www.ncbi.nlm.nih.gov/pubmed/20838118
Kelly LA, O'Leary JJ, Seidlova-Wuttke D, Wuttke W, and Norris LA (2010) Genistein alters coagulation gene expression in ovariectomised rats treated with phytoestrogens. Thromb Haemost 104:
http://www.ncbi.nlm.nih.gov/pubmed/20838740
Lad SP, Hegen H, Gupta G, Deisenhammer F, and Steinberg GK (2010) Proteomic biomarker discovery in cerebrospinal fluid for cerebral vasospasm following subarachnoid hemorrhage. J Stroke Cerebrovasc Dis
http://www.ncbi.nlm.nih.gov/pubmed/20851633
Lindhoff-Last E, Samama MM, Ortel TL, Weitz JI, and Spiro TE (2010) Assays for measuring Rivaroxaban: Their suitability and limitations. Ther Drug Monit
http://www.ncbi.nlm.nih.gov/pubmed/20844464
Luan D, Szlam F, Tanaka KA, Barie PS, and Varner JD (2010) Ensembles of uncertain mathematical models can identify network response to therapeutic interventions. Mol Biosyst
http://www.ncbi.nlm.nih.gov/pubmed/20844798
Mosbaek CR, Nolan D, Persson E, Svergun DI, Bukrinski JT, and Vestergaard B (2010) Extensive small angle X-ray scattering studies of blood coagulation factor VIIa reveal interdomain flexibility. Biochemistry
http://www.ncbi.nlm.nih.gov/pubmed/20873866
Schaffner F, Versteeg HH, Schillert A, Yokota N, Petersen LC, Mueller BM, and Ruf W (2010) Cooperation of tissue factor cytoplasmic domain and PAR2 signaling in breast cancer development. Blood
http://www.ncbi.nlm.nih.gov/pubmed/20861457
Seested T, Appa RS, Jacobsen C, and Christensen EI (2010) Recombinant activated factor VII is reabsorbed in renal proximal tubules and is a ligand to megalin and cubilin. Nephron Exp Nephrol 117:e82-e92
http://www.ncbi.nlm.nih.gov/pubmed/20861656
Toschi V (2010) Blood-born tissue factor in cardiovascular disease: Where are we now? Intern Emerg Med
http://www.ncbi.nlm.nih.gov/pubmed/20853069
Wang H, Paton JX, Thorpe CX, Bonder CX, Sun WX, and Paton AX (2010) Tissue factor-dependent procoagulant activity of subtilase cytotoxin, a potent AB5 toxin produced by shiga toxigenic Escherichia coli. J Infect Dis
http://www.ncbi.nlm.nih.gov/pubmed/20874089
Xu C and Fu X (2010) [Advances of tissue factor in lung cancer]. Zhongguo Fei Ai Za Zhi 13:908-912.
http://www.ncbi.nlm.nih.gov/pubmed/20840822
Yatuv R, Robinson M, Dayan-Tarshish I, and Baru M (2010) The use of PEGylated liposomes in the development of drug delivery applications for the treatment of hemophilia. Int J Nanomedicine 5:581-591.
http://www.ncbi.nlm.nih.gov/pubmed/20856833
Zabczyk M, Butenas S, Palka I, Nessler J, and Undas A (2010) Active tissue factor and activated factor XI in circulating blood of patients with systolic heart failure due to ischemic cardiomyopathy. Pol Arch Med Wewn 120:334-340.
http://www.ncbi.nlm.nih.gov/pubmed/20864906
__________________________________________________________
ABOUT TRIGGER
TRIGGER is edited by Jim Morrissey and Pierre Neuenschwander, with editorial assistance by Genie Morrissey. It includes Abstracts of Papers in Press, Meeting Announcements, Positions Sought/Available,or any other pertinent item that subscribers may want to share with their colleagues. To submit an item for publication in Trigger, e-mail us. To request or cancel a subscription,or for more information about TRIGGER or the biology of tissue factor and factor VII, visit our web site. You can also contact us by mail: J.H. Morrissey, University of Illinois College of Medicine, 417 Med Sci Bldg MC-714, 506 S. Mathews Ave., Urbana, IL 61801, USA.
DISCLAIMER: TRIGGER is provided "as is" for information purposes only and without warranty of any kind, express or implied. Users shall assume the entire risk as to the accuracy and usefulness of information in TRIGGER. Opinions expressed here are not necessarily those of the editors or their employers. You may share TRIGGER with your scientific colleagues but you are not permitted to use it or its contents for commercial purposes.
__________________________________________________________
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 16, No. 19 October 1, 2010
(The next issue will be on October 15, 2010)
__________________________________________________________
TRIGGER is also available by RSS Feed:
http://feeds.feedburner.com/blogspot/glro
and BLOG:
http://trigger-tf7.blogspot.com/
__________________________________________________________
PAPERS IN PRESS
None submitted for this issue.
__________________________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI
Papers are culled from NLM MedLine (PubMed). Titles in square brackets indicate that the paper was not published in English. References that lack volume or page numbers are typically electronic pre-publications (E-pubs) ahead of the print publication; if so, the final citation with volume and page numbers may or may not appear in a future issue of Trigger.
THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1-S-FxgMhh7Dxk0J1ocxIid/
Campbell JE, Brummel-Ziedins KE, Butenas S, and Mann KG (2010) Cellular regulation of blood coagulation: A model for venous stasis. Blood
http://www.ncbi.nlm.nih.gov/pubmed/20864579
Castellino FJ, Donahue DL, Navari RM, Ploplis VA, and Walsh M (2010) An accompanying genetic severe deficiency of tissue factor protects mice with a protein C deficiency from lethal endotoxemia. Blood
http://www.ncbi.nlm.nih.gov/pubmed/20858853
Czuprynska MM, Wawrzynowicz-Syczewska M, Jureczko L, Andrzejewska J, Jarosz K, Trzebicki J, Pacholczyk M, Chmura A, and Wojcicki M (2010) Preemptive administration of recombinant factor VII (rVIIa) in patients transplanted due to fulminant Wilson's disease. Ann Transplant 15:7-10.
http://www.ncbi.nlm.nih.gov/pubmed/20877260
de Azeredo EL, Kubelka CF, Alburquerque LM, Barbosa LS, Damasco PV, Avila CA, Motta-Castro AR, da Cunha RV, and Monteiro RQ (2010) Tissue factor expression on monocytes from patients with severe dengue fever. Blood Cells Mol Dis
http://www.ncbi.nlm.nih.gov/pubmed/20846886
Debaugnies F, Azerad MA, Noubouossie D, Rozen L, Hemker HC, Corazza HF, Efira A, and Demulder A (2010) Evaluation of the procoagulant activity in the plasma of cancer patients using a thrombin generation assay. Thromb Res
http://www.ncbi.nlm.nih.gov/pubmed/20870277
Hauser CJ, Boffard K, Dutton R, Bernard GR, Croce MA, et al. (2010) Results of the CONTROL trial: Efficacy and safety of recombinant activated Factor VII in the management of refractory traumatic hemorrhage. J Trauma 69:489-500.
http://www.ncbi.nlm.nih.gov/pubmed/20838118
Kelly LA, O'Leary JJ, Seidlova-Wuttke D, Wuttke W, and Norris LA (2010) Genistein alters coagulation gene expression in ovariectomised rats treated with phytoestrogens. Thromb Haemost 104:
http://www.ncbi.nlm.nih.gov/pubmed/20838740
Lad SP, Hegen H, Gupta G, Deisenhammer F, and Steinberg GK (2010) Proteomic biomarker discovery in cerebrospinal fluid for cerebral vasospasm following subarachnoid hemorrhage. J Stroke Cerebrovasc Dis
http://www.ncbi.nlm.nih.gov/pubmed/20851633
Lindhoff-Last E, Samama MM, Ortel TL, Weitz JI, and Spiro TE (2010) Assays for measuring Rivaroxaban: Their suitability and limitations. Ther Drug Monit
http://www.ncbi.nlm.nih.gov/pubmed/20844464
Luan D, Szlam F, Tanaka KA, Barie PS, and Varner JD (2010) Ensembles of uncertain mathematical models can identify network response to therapeutic interventions. Mol Biosyst
http://www.ncbi.nlm.nih.gov/pubmed/20844798
Mosbaek CR, Nolan D, Persson E, Svergun DI, Bukrinski JT, and Vestergaard B (2010) Extensive small angle X-ray scattering studies of blood coagulation factor VIIa reveal interdomain flexibility. Biochemistry
http://www.ncbi.nlm.nih.gov/pubmed/20873866
Schaffner F, Versteeg HH, Schillert A, Yokota N, Petersen LC, Mueller BM, and Ruf W (2010) Cooperation of tissue factor cytoplasmic domain and PAR2 signaling in breast cancer development. Blood
http://www.ncbi.nlm.nih.gov/pubmed/20861457
Seested T, Appa RS, Jacobsen C, and Christensen EI (2010) Recombinant activated factor VII is reabsorbed in renal proximal tubules and is a ligand to megalin and cubilin. Nephron Exp Nephrol 117:e82-e92
http://www.ncbi.nlm.nih.gov/pubmed/20861656
Toschi V (2010) Blood-born tissue factor in cardiovascular disease: Where are we now? Intern Emerg Med
http://www.ncbi.nlm.nih.gov/pubmed/20853069
Wang H, Paton JX, Thorpe CX, Bonder CX, Sun WX, and Paton AX (2010) Tissue factor-dependent procoagulant activity of subtilase cytotoxin, a potent AB5 toxin produced by shiga toxigenic Escherichia coli. J Infect Dis
http://www.ncbi.nlm.nih.gov/pubmed/20874089
Xu C and Fu X (2010) [Advances of tissue factor in lung cancer]. Zhongguo Fei Ai Za Zhi 13:908-912.
http://www.ncbi.nlm.nih.gov/pubmed/20840822
Yatuv R, Robinson M, Dayan-Tarshish I, and Baru M (2010) The use of PEGylated liposomes in the development of drug delivery applications for the treatment of hemophilia. Int J Nanomedicine 5:581-591.
http://www.ncbi.nlm.nih.gov/pubmed/20856833
Zabczyk M, Butenas S, Palka I, Nessler J, and Undas A (2010) Active tissue factor and activated factor XI in circulating blood of patients with systolic heart failure due to ischemic cardiomyopathy. Pol Arch Med Wewn 120:334-340.
http://www.ncbi.nlm.nih.gov/pubmed/20864906
__________________________________________________________
ABOUT TRIGGER
TRIGGER is edited by Jim Morrissey and Pierre Neuenschwander, with editorial assistance by Genie Morrissey. It includes Abstracts of Papers in Press, Meeting Announcements, Positions Sought/Available,or any other pertinent item that subscribers may want to share with their colleagues. To submit an item for publication in Trigger, e-mail us. To request or cancel a subscription,or for more information about TRIGGER or the biology of tissue factor and factor VII, visit our web site. You can also contact us by mail: J.H. Morrissey, University of Illinois College of Medicine, 417 Med Sci Bldg MC-714, 506 S. Mathews Ave., Urbana, IL 61801, USA.
DISCLAIMER: TRIGGER is provided "as is" for information purposes only and without warranty of any kind, express or implied. Users shall assume the entire risk as to the accuracy and usefulness of information in TRIGGER. Opinions expressed here are not necessarily those of the editors or their employers. You may share TRIGGER with your scientific colleagues but you are not permitted to use it or its contents for commercial purposes.
__________________________________________________________
Wednesday, September 15, 2010
Vol. 16, No. 18
TRIGGER
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 16, No. 18 September 15, 2010
(The next issue will be on October 1, 2010)
__________________________________________________________
TRIGGER is also available by RSS Feed:
http://feeds.feedburner.com/blogspot/glro
and BLOG:
http://trigger-tf7.blogspot.com/
__________________________________________________________
ANNOUNCEMENTS
Some companies have asked us to include announcements of research products in TRIGGER that would be of interest to our subscribers. We have agreed to do this, free of charge, with ground rules that are available on the TRIGGER web site:
http://tf7.org/product_info.html
Please note that everything about TRIGGER (subscribing, placing product announcements, etc.) is free and that the editors receive no remuneration for any aspect of publishing TRIGGER.
__________________________________________________________
PRODUCT ANNOUNCEMENT
Haematologic Technologies, Inc. supplies a full range of purified proteins and antibodies for use in thrombosis research. These proteins include:
DISCLAIMER: Commercial product announcements appearing in TRIGGER are provided "as is" for informational purposes only. The editors of TRIGGER have not necessarily evaluated any materials from commercial suppliers described in this newsletter or on its web sites, and we certainly are not endorsing any specific suppliers or products. Furthermore, the editors receive no revenues from any source in the course of publishing TRIGGER.
__________________________________________________________
PAPERS IN PRESS
None submitted for this issue.
__________________________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI
Papers are culled from NLM MedLine (PubMed). Titles in square brackets indicate that the paper was not published in English. References that lack volume or page numbers are typically electronic pre-publications (E-pubs) ahead of the print publication; if so, the final citation with volume and page numbers may or may not appear in a future issue of Trigger.
THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1de12h8bJo256khgO-cbu6i/
Bae JS, Yang L, and Rezaie AR (2010) Factor X/Xa elicits protective signaling responses in endothelial cells directly via PAR-2 and indirectly via EPCR-dependent recruitment of PAR-1. J Biol Chem
http://www.ncbi.nlm.nih.gov/pubmed/20826780
Berntorp E, Collins P, D'Oiron R, Ewing N, Gringeri A, Negrier C, and Young G (2010) Identifying non-responsive bleeding episodes in patients with haemophilia and inhibitors: a consensus definition. Haemophilia
http://www.ncbi.nlm.nih.gov/pubmed/20825500
Criddle LM (2010) Recombinant factor VIIa and the patient with neurologic bleeding: separating fact from fiction. J Neurosci Nurs 42:229-234
http://www.ncbi.nlm.nih.gov/pubmed/20804119
Matevosyan K, Madden C, Barnett SL, Beshay JE, Rutherford C, and Sarode R (2010) Coagulation factor levels in neurosurgical patients with mild prolongation of prothrombin time: effect on plasma transfusion therapy. J Neurosurg
http://www.ncbi.nlm.nih.gov/pubmed/20815699
Michalska-Krzanowska G (2010) [Recombinant factor VIIa for treatment of postpartum hemorrhage due to uterine atony]. Ginekol Pol 81:544-548.
http://www.ncbi.nlm.nih.gov/pubmed/20825059
Mu E, Liu X, Chen S, Zhi L, Li X, Xu X, and Ma X (2010) Changes in factor VII-activating protease in a bleomycin-induced lung injury rat model and its influence on human pulmonary fibroblasts in vitro. Int J Mol Med 26:549-555.
http://www.ncbi.nlm.nih.gov/pubmed/20818495
Schwarz H, Stephan S, Sidelmann JJ, Fischer B, Althaus H, Hahn M, Kappel A, Ehm M, and Vitzthum F (2010) Qualitative detection of the Marburg I alloenzyme of factor VII-activating protease by an immunoassay and its comparison to PCR testing. Clin Chem Lab Med
http://www.ncbi.nlm.nih.gov/pubmed/20828365
Tetik S, Ak K, Sahin Y, Gulsoy O, Isbir S, Arsan S, and Yardimci T (2010) Postoperative statin therapy attenuates the intensity of systemic inflammation and increases fibrinolysis after coronary artery bypass grafting. Clin Appl Thromb Hemost
http://www.ncbi.nlm.nih.gov/pubmed/20805103
West KL, Adamson C, and Hoffman M (2010) Prophylactic correction of the international normalized ratio in neurosurgery: a brief review of a brief literature. J Neurosurg
http://www.ncbi.nlm.nih.gov/pubmed/20815695
__________________________________________________________
ABOUT TRIGGER
TRIGGER is edited by Jim Morrissey and Pierre Neuenschwander, with editorial assistance by Genie Morrissey. It includes Abstracts of Papers in Press, Meeting Announcements, Positions Sought/Available,or any other pertinent item that subscribers may want to share with their colleagues. To submit an item for publication in Trigger, e-mail us. To request or cancel a subscription,or for more information about TRIGGER or the biology of tissue factor and factor VII, visit our web site. You can also contact us by mail: J.H. Morrissey, University of Illinois College of Medicine, 417 Med Sci Bldg MC-714, 506 S. Mathews Ave., Urbana, IL 61801, USA.
DISCLAIMER: TRIGGER is provided "as is" for information purposes only and without warranty of any kind, express or implied. Users shall assume the entire risk as to the accuracy and usefulness of information in TRIGGER. Opinions expressed here are not necessarily those of the editors or their employers. You may share TRIGGER with your scientific colleagues but you are not permitted to use it or its contents for commercial purposes.
__________________________________________________________
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 16, No. 18 September 15, 2010
(The next issue will be on October 1, 2010)
__________________________________________________________
TRIGGER is also available by RSS Feed:
http://feeds.feedburner.com/blogspot/glro
and BLOG:
http://trigger-tf7.blogspot.com/
__________________________________________________________
ANNOUNCEMENTS
Some companies have asked us to include announcements of research products in TRIGGER that would be of interest to our subscribers. We have agreed to do this, free of charge, with ground rules that are available on the TRIGGER web site:
http://tf7.org/product_info.html
Please note that everything about TRIGGER (subscribing, placing product announcements, etc.) is free and that the editors receive no remuneration for any aspect of publishing TRIGGER.
__________________________________________________________
PRODUCT ANNOUNCEMENT
- Purified human factor VIIa - purified from human plasma, and greater than 95% pure by SDS-PAGE. Anti-VIIa is also available. http://www.haemtech.com/Enzymes/Factor_VIIa.htm
- Recombinant human Tissue Factor - Fully functional, purified recombinant (Baculovirus) full-length tissue factor. Anti-TF is also available.
- Lactadherin - including fluorescent conjugates which are Phosphatidylserine specific. Useful for studying microparticles and protein/cell-membrane interactions. http://www.haemtech.com/Other/Lactadherin.htm
- Corn Trypsin Inhibitor - for use in thrombin generation assays and for the study of TF-dependent pathway of coagulation. http://www.haemtech.com/Inhibitors_Substrates/CTI.htm
DISCLAIMER: Commercial product announcements appearing in TRIGGER are provided "as is" for informational purposes only. The editors of TRIGGER have not necessarily evaluated any materials from commercial suppliers described in this newsletter or on its web sites, and we certainly are not endorsing any specific suppliers or products. Furthermore, the editors receive no revenues from any source in the course of publishing TRIGGER.
__________________________________________________________
PAPERS IN PRESS
None submitted for this issue.
__________________________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI
Papers are culled from NLM MedLine (PubMed). Titles in square brackets indicate that the paper was not published in English. References that lack volume or page numbers are typically electronic pre-publications (E-pubs) ahead of the print publication; if so, the final citation with volume and page numbers may or may not appear in a future issue of Trigger.
THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1de12h8bJo256khgO-cbu6i/
Bae JS, Yang L, and Rezaie AR (2010) Factor X/Xa elicits protective signaling responses in endothelial cells directly via PAR-2 and indirectly via EPCR-dependent recruitment of PAR-1. J Biol Chem
http://www.ncbi.nlm.nih.gov/pubmed/20826780
Berntorp E, Collins P, D'Oiron R, Ewing N, Gringeri A, Negrier C, and Young G (2010) Identifying non-responsive bleeding episodes in patients with haemophilia and inhibitors: a consensus definition. Haemophilia
http://www.ncbi.nlm.nih.gov/pubmed/20825500
Criddle LM (2010) Recombinant factor VIIa and the patient with neurologic bleeding: separating fact from fiction. J Neurosci Nurs 42:229-234
http://www.ncbi.nlm.nih.gov/pubmed/20804119
Matevosyan K, Madden C, Barnett SL, Beshay JE, Rutherford C, and Sarode R (2010) Coagulation factor levels in neurosurgical patients with mild prolongation of prothrombin time: effect on plasma transfusion therapy. J Neurosurg
http://www.ncbi.nlm.nih.gov/pubmed/20815699
Michalska-Krzanowska G (2010) [Recombinant factor VIIa for treatment of postpartum hemorrhage due to uterine atony]. Ginekol Pol 81:544-548.
http://www.ncbi.nlm.nih.gov/pubmed/20825059
Mu E, Liu X, Chen S, Zhi L, Li X, Xu X, and Ma X (2010) Changes in factor VII-activating protease in a bleomycin-induced lung injury rat model and its influence on human pulmonary fibroblasts in vitro. Int J Mol Med 26:549-555.
http://www.ncbi.nlm.nih.gov/pubmed/20818495
Schwarz H, Stephan S, Sidelmann JJ, Fischer B, Althaus H, Hahn M, Kappel A, Ehm M, and Vitzthum F (2010) Qualitative detection of the Marburg I alloenzyme of factor VII-activating protease by an immunoassay and its comparison to PCR testing. Clin Chem Lab Med
http://www.ncbi.nlm.nih.gov/pubmed/20828365
Tetik S, Ak K, Sahin Y, Gulsoy O, Isbir S, Arsan S, and Yardimci T (2010) Postoperative statin therapy attenuates the intensity of systemic inflammation and increases fibrinolysis after coronary artery bypass grafting. Clin Appl Thromb Hemost
http://www.ncbi.nlm.nih.gov/pubmed/20805103
West KL, Adamson C, and Hoffman M (2010) Prophylactic correction of the international normalized ratio in neurosurgery: a brief review of a brief literature. J Neurosurg
http://www.ncbi.nlm.nih.gov/pubmed/20815695
__________________________________________________________
ABOUT TRIGGER
TRIGGER is edited by Jim Morrissey and Pierre Neuenschwander, with editorial assistance by Genie Morrissey. It includes Abstracts of Papers in Press, Meeting Announcements, Positions Sought/Available,or any other pertinent item that subscribers may want to share with their colleagues. To submit an item for publication in Trigger, e-mail us. To request or cancel a subscription,or for more information about TRIGGER or the biology of tissue factor and factor VII, visit our web site. You can also contact us by mail: J.H. Morrissey, University of Illinois College of Medicine, 417 Med Sci Bldg MC-714, 506 S. Mathews Ave., Urbana, IL 61801, USA.
DISCLAIMER: TRIGGER is provided "as is" for information purposes only and without warranty of any kind, express or implied. Users shall assume the entire risk as to the accuracy and usefulness of information in TRIGGER. Opinions expressed here are not necessarily those of the editors or their employers. You may share TRIGGER with your scientific colleagues but you are not permitted to use it or its contents for commercial purposes.
__________________________________________________________
Thursday, September 2, 2010
Vol. 16, No. 17
TRIGGER
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 16, No. 17 September 1, 2010
(The next issue will be on September 15, 2010)
__________________________________________________________
TRIGGER is also available by RSS Feed:
http://feeds.feedburner.com/blogspot/glro
and BLOG:
http://trigger-tf7.blogspot.com/
__________________________________________________________
PAPERS IN PRESS
None submitted for this issue.
__________________________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI
Papers are culled from NLM MedLine (PubMed). Titles in square brackets indicate that the paper was not published in English. References that lack volume or page numbers are typically electronic pre-publications (E-pubs) ahead of the print publication; if so, the final citation with volume and page numbers may or may not appear in a future issue of Trigger.
THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1TyMfe4r978Jfx_w7gR2vGg/
Alkistis Frentzou G, Collier ME, Seymour AM, and Ettelaie C (2010) Differential induction of cellular proliferation, hypertrophy and apoptosis in H9c2 cardiomyocytes by exogenous tissue factor. Mol Cell Biochem
http://www.ncbi.nlm.nih.gov/pubmed/20730477
Basavaraj MG, Gruber FX, Sovershaev M, Appelbom HI, Osterud B, Petersen LC, and Hansen JB (2010) The role of TFPI in regulation of TF-induced thrombogenicity on the surface of human monocytes. Thromb Res
http://www.ncbi.nlm.nih.gov/pubmed/20723970
Breyne J, Juthier F, Corseaux D, Marechaux S, Zawadzki C, et al. (2010) Atherosclerotic-like process in aortic stenosis: Activation of the tissue factor-thrombin pathway and potential role through osteopontin alteration. Atherosclerosis
http://www.ncbi.nlm.nih.gov/pubmed/20732681
Del Fiorentino A, Cianchetti S, Celi A, and Pedrinelli R (2010) Aliskiren, a renin inhibitor, downregulates TNF-{alpha}-induced tissue factor expression in HUVECS. J Renin Angiotensin Aldosterone Syst
http://www.ncbi.nlm.nih.gov/pubmed/20798130
Demetz G, Seitz I, Stein A, Steppich B, Groha P, Brandl R, Schomig A, and Ott I (2010) Tissue Factor-Factor VIIa complex induces cytokine expression in coronary artery smooth muscle cells. Atherosclerosis
http://www.ncbi.nlm.nih.gov/pubmed/20708733
Evangelho JS, Casali KR, Campos C, De Angelis K, Veiga AB, and Rigatto K (2010) Hypercholesterolemia magnitude increases sympathetic modulation and coagulation in LDLr knockout mice. Auton Neurosci
http://www.ncbi.nlm.nih.gov/pubmed/20719578
Garcia Rodriguez P, Eikenboom HC, Tesselaar ME, Huisman MV, Nijkeuter M, Osanto S, and Bertina RM (2010) Plasma levels of microparticle-associated tissue factor activity in patients with clinically suspected pulmonary embolism. Thromb Res
http://www.ncbi.nlm.nih.gov/pubmed/20708219
Geiger A, Collange O, Samin J, Meyer A, Freys G, and Pottecher T (2010) [Efficiency and safety of recombinant activated factor VII in a case of severe postpartum hemorrhage.]. Ann Fr Anesth Reanim
http://www.ncbi.nlm.nih.gov/pubmed/20729029
Girolami A, Berti de Marinis G, and Bonamigo E (2010) Diagnosis of FVII Padua (Arg304Gln) by means of simple clotting tests. Clin Chim Acta
http://www.ncbi.nlm.nih.gov/pubmed/20713035
Gissel M, Undas A, Slowik A, Mann KG, and Brummel-Ziedins KE (2010) Plasma factor and inhibitor composition contributes to thrombin generation dynamics in patients with acute or previous cerebrovascular events. Thromb Res
http://www.ncbi.nlm.nih.gov/pubmed/20709367
Ken-Dror G, Drenos F, Humphries E, Talmud PJ, Hingorani AD, Kivimaki M, Kumari M, Bauer KA, Morrissey JH, and Ireland HA (2010) Haplotype and genotype effects of the F7 gene on circulating factor VII, coagulation activation markers and incident coronary heart disease in UK men. J Thromb Haemost
http://www.ncbi.nlm.nih.gov/pubmed/20735728
Mahon KP, Love KT, Whitehead KA, Qin J, Akinc A, Leshchiner E, Leshchiner I, Langer R, and Anderson DG (2010) Combinatorial approach to determine functional group effects on lipidoid-mediated siRNA delivery. Bioconjug Chem 21:1448-1454.
http://www.ncbi.nlm.nih.gov/pubmed/20715849
McEachron TA, Pawlinski R, Richards KL, Church FC, and Mackman N (2010) Protease-activated receptors mediate cross-talk between coagulation and fibrinolysis. Blood
http://www.ncbi.nlm.nih.gov/pubmed/20736455
Miller MA, Kandala NB, Kumari M, Marmot MG, and Cappuccio FP (2010) BAS/BSCR53 Relationships between sleep duration and von Willebrand factor, fibrinogen and factor VII: Whitehall II study. Heart 96:e28
http://www.ncbi.nlm.nih.gov/pubmed/20801846
Mita A, Ricordi C, Messinger S, Miki A, Misawa R, et al. (2010) Anti-proinflammatory effects of Iodixanol (OptiPrep)-based density gradient purification on human islet preparations. Cell Transplant
http://www.ncbi.nlm.nih.gov/pubmed/20719078
Mitra B, Phillips L, Cameron PA, Billah B, and Reid C (2010) The safety of recombinant factor VIIa in cardiac surgery. Anaesth Intensive Care 38:671-677.
http://www.ncbi.nlm.nih.gov/pubmed/20715730
Poller L, Ibrahim S, Keown M, Pattison A, and Jespersen J (2010) Simplified method for International Normalized Ratio (INR) derivation based on the Prothrombin Time/INR line: An international study. Clin Chem
http://www.ncbi.nlm.nih.gov/pubmed/20798354
Smith SA, McMichael M, Galligan A, Gilor S, and Hoh CM (2010) Clot formation in canine whole blood as measured by rotational thromboelastometry is influenced by sample handling and coagulation activator. Blood Coagul Fibrinolysis
http://www.ncbi.nlm.nih.gov/pubmed/20739876
Smith SA, Choi SH, Davis-Harrison R, Huyck J, Boettcher J, Rienstra CM, and Morrissey JH (2010) Polyphosphate exerts differential effects on blood clotting, depending on polymer size. Blood
http://www.ncbi.nlm.nih.gov/pubmed/20709905
Soeda T, Nogami K, Matsumoto T, Ogiwara K, and Shima M (2010) Mechanisms of factor VIIa-catalyzed activation of factor VIII. J Thromb Haemost
http://www.ncbi.nlm.nih.gov/pubmed/20735721
Sorour Y, van Veen JJ, and Makris M (2010) Recombinant factor VIIa for unlicensed indications - a definite No or a cautious Maybe in selected patients? Int J Clin Pract
http://www.ncbi.nlm.nih.gov/pubmed/20722768
van Zaane B, Nur E, Squizzato A, Gerdes VE, Buller HR, Dekkers OM, and Brandjes DP (2010) Systematic review on the effect of glucocorticoid use on procoagulant, anticoagulant and fibrinolytic factors. J Thromb Haemost
http://www.ncbi.nlm.nih.gov/pubmed/20735729
__________________________________________________________
ABOUT TRIGGER
TRIGGER is edited by Jim Morrissey and Pierre Neuenschwander, with editorial assistance by Genie Morrissey. It includes Abstracts of Papers in Press, Meeting Announcements, Positions Sought/Available,or any other pertinent item that subscribers may want to share with their colleagues. To submit an item for publication in Trigger, e-mail us. To request or cancel a subscription,or for more information about TRIGGER or the biology of tissue factor and factor VII, visit our web site. You can also contact us by mail: J.H. Morrissey, University of Illinois College of Medicine, 417 Med Sci Bldg MC-714, 506 S. Mathews Ave., Urbana, IL 61801, USA.
DISCLAIMER: TRIGGER is provided "as is" for information purposes only and without warranty of any kind, express or implied. Users shall assume the entire risk as to the accuracy and usefulness of information in TRIGGER. Opinions expressed here are not necessarily those of the editors or their employers. You may share TRIGGER with your scientific colleagues but you are not permitted to use it or its contents for commercial purposes.
__________________________________________________________
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 16, No. 17 September 1, 2010
(The next issue will be on September 15, 2010)
__________________________________________________________
TRIGGER is also available by RSS Feed:
http://feeds.feedburner.com/blogspot/glro
and BLOG:
http://trigger-tf7.blogspot.com/
__________________________________________________________
PAPERS IN PRESS
None submitted for this issue.
__________________________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI
Papers are culled from NLM MedLine (PubMed). Titles in square brackets indicate that the paper was not published in English. References that lack volume or page numbers are typically electronic pre-publications (E-pubs) ahead of the print publication; if so, the final citation with volume and page numbers may or may not appear in a future issue of Trigger.
THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1TyMfe4r978Jfx_w7gR2vGg/
Alkistis Frentzou G, Collier ME, Seymour AM, and Ettelaie C (2010) Differential induction of cellular proliferation, hypertrophy and apoptosis in H9c2 cardiomyocytes by exogenous tissue factor. Mol Cell Biochem
http://www.ncbi.nlm.nih.gov/pubmed/20730477
Basavaraj MG, Gruber FX, Sovershaev M, Appelbom HI, Osterud B, Petersen LC, and Hansen JB (2010) The role of TFPI in regulation of TF-induced thrombogenicity on the surface of human monocytes. Thromb Res
http://www.ncbi.nlm.nih.gov/pubmed/20723970
Breyne J, Juthier F, Corseaux D, Marechaux S, Zawadzki C, et al. (2010) Atherosclerotic-like process in aortic stenosis: Activation of the tissue factor-thrombin pathway and potential role through osteopontin alteration. Atherosclerosis
http://www.ncbi.nlm.nih.gov/pubmed/20732681
Del Fiorentino A, Cianchetti S, Celi A, and Pedrinelli R (2010) Aliskiren, a renin inhibitor, downregulates TNF-{alpha}-induced tissue factor expression in HUVECS. J Renin Angiotensin Aldosterone Syst
http://www.ncbi.nlm.nih.gov/pubmed/20798130
Demetz G, Seitz I, Stein A, Steppich B, Groha P, Brandl R, Schomig A, and Ott I (2010) Tissue Factor-Factor VIIa complex induces cytokine expression in coronary artery smooth muscle cells. Atherosclerosis
http://www.ncbi.nlm.nih.gov/pubmed/20708733
Evangelho JS, Casali KR, Campos C, De Angelis K, Veiga AB, and Rigatto K (2010) Hypercholesterolemia magnitude increases sympathetic modulation and coagulation in LDLr knockout mice. Auton Neurosci
http://www.ncbi.nlm.nih.gov/pubmed/20719578
Garcia Rodriguez P, Eikenboom HC, Tesselaar ME, Huisman MV, Nijkeuter M, Osanto S, and Bertina RM (2010) Plasma levels of microparticle-associated tissue factor activity in patients with clinically suspected pulmonary embolism. Thromb Res
http://www.ncbi.nlm.nih.gov/pubmed/20708219
Geiger A, Collange O, Samin J, Meyer A, Freys G, and Pottecher T (2010) [Efficiency and safety of recombinant activated factor VII in a case of severe postpartum hemorrhage.]. Ann Fr Anesth Reanim
http://www.ncbi.nlm.nih.gov/pubmed/20729029
Girolami A, Berti de Marinis G, and Bonamigo E (2010) Diagnosis of FVII Padua (Arg304Gln) by means of simple clotting tests. Clin Chim Acta
http://www.ncbi.nlm.nih.gov/pubmed/20713035
Gissel M, Undas A, Slowik A, Mann KG, and Brummel-Ziedins KE (2010) Plasma factor and inhibitor composition contributes to thrombin generation dynamics in patients with acute or previous cerebrovascular events. Thromb Res
http://www.ncbi.nlm.nih.gov/pubmed/20709367
Ken-Dror G, Drenos F, Humphries E, Talmud PJ, Hingorani AD, Kivimaki M, Kumari M, Bauer KA, Morrissey JH, and Ireland HA (2010) Haplotype and genotype effects of the F7 gene on circulating factor VII, coagulation activation markers and incident coronary heart disease in UK men. J Thromb Haemost
http://www.ncbi.nlm.nih.gov/pubmed/20735728
Mahon KP, Love KT, Whitehead KA, Qin J, Akinc A, Leshchiner E, Leshchiner I, Langer R, and Anderson DG (2010) Combinatorial approach to determine functional group effects on lipidoid-mediated siRNA delivery. Bioconjug Chem 21:1448-1454.
http://www.ncbi.nlm.nih.gov/pubmed/20715849
McEachron TA, Pawlinski R, Richards KL, Church FC, and Mackman N (2010) Protease-activated receptors mediate cross-talk between coagulation and fibrinolysis. Blood
http://www.ncbi.nlm.nih.gov/pubmed/20736455
Miller MA, Kandala NB, Kumari M, Marmot MG, and Cappuccio FP (2010) BAS/BSCR53 Relationships between sleep duration and von Willebrand factor, fibrinogen and factor VII: Whitehall II study. Heart 96:e28
http://www.ncbi.nlm.nih.gov/pubmed/20801846
Mita A, Ricordi C, Messinger S, Miki A, Misawa R, et al. (2010) Anti-proinflammatory effects of Iodixanol (OptiPrep)-based density gradient purification on human islet preparations. Cell Transplant
http://www.ncbi.nlm.nih.gov/pubmed/20719078
Mitra B, Phillips L, Cameron PA, Billah B, and Reid C (2010) The safety of recombinant factor VIIa in cardiac surgery. Anaesth Intensive Care 38:671-677.
http://www.ncbi.nlm.nih.gov/pubmed/20715730
Poller L, Ibrahim S, Keown M, Pattison A, and Jespersen J (2010) Simplified method for International Normalized Ratio (INR) derivation based on the Prothrombin Time/INR line: An international study. Clin Chem
http://www.ncbi.nlm.nih.gov/pubmed/20798354
Smith SA, McMichael M, Galligan A, Gilor S, and Hoh CM (2010) Clot formation in canine whole blood as measured by rotational thromboelastometry is influenced by sample handling and coagulation activator. Blood Coagul Fibrinolysis
http://www.ncbi.nlm.nih.gov/pubmed/20739876
Smith SA, Choi SH, Davis-Harrison R, Huyck J, Boettcher J, Rienstra CM, and Morrissey JH (2010) Polyphosphate exerts differential effects on blood clotting, depending on polymer size. Blood
http://www.ncbi.nlm.nih.gov/pubmed/20709905
Soeda T, Nogami K, Matsumoto T, Ogiwara K, and Shima M (2010) Mechanisms of factor VIIa-catalyzed activation of factor VIII. J Thromb Haemost
http://www.ncbi.nlm.nih.gov/pubmed/20735721
Sorour Y, van Veen JJ, and Makris M (2010) Recombinant factor VIIa for unlicensed indications - a definite No or a cautious Maybe in selected patients? Int J Clin Pract
http://www.ncbi.nlm.nih.gov/pubmed/20722768
van Zaane B, Nur E, Squizzato A, Gerdes VE, Buller HR, Dekkers OM, and Brandjes DP (2010) Systematic review on the effect of glucocorticoid use on procoagulant, anticoagulant and fibrinolytic factors. J Thromb Haemost
http://www.ncbi.nlm.nih.gov/pubmed/20735729
__________________________________________________________
ABOUT TRIGGER
TRIGGER is edited by Jim Morrissey and Pierre Neuenschwander, with editorial assistance by Genie Morrissey. It includes Abstracts of Papers in Press, Meeting Announcements, Positions Sought/Available,or any other pertinent item that subscribers may want to share with their colleagues. To submit an item for publication in Trigger, e-mail us. To request or cancel a subscription,or for more information about TRIGGER or the biology of tissue factor and factor VII, visit our web site. You can also contact us by mail: J.H. Morrissey, University of Illinois College of Medicine, 417 Med Sci Bldg MC-714, 506 S. Mathews Ave., Urbana, IL 61801, USA.
DISCLAIMER: TRIGGER is provided "as is" for information purposes only and without warranty of any kind, express or implied. Users shall assume the entire risk as to the accuracy and usefulness of information in TRIGGER. Opinions expressed here are not necessarily those of the editors or their employers. You may share TRIGGER with your scientific colleagues but you are not permitted to use it or its contents for commercial purposes.
__________________________________________________________
Monday, August 16, 2010
Vol.16, No. 16
TRIGGER
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 16, No. 16 August 16, 2010
(The next issue will be on September 1, 2010)
__________________________________________________________
TRIGGER is also available by RSS Feed:
http://feeds.feedburner.com/blogspot/glro
and BLOG:
http://trigger-tf7.blogspot.com/
__________________________________________________________
PAPERS IN PRESS
AUTHORS: Stephanie A. Smith, Sharon H. Choi, Rebecca Davis-Harrison, Jillian Huyck, John Boettcher, Chad M. Reinstra, and James H. Morrissey
TITLE: Polyphosphate exerts differential effects on blood clotting, depending on polymer size
JOURNAL: Blood
ABSTRACT: Polyphosphate, a linear polymer of inorganic phosphate, is secreted by activated platelets and accumulates in many infectious microorganisms. We recently showed that polyphosphate modulates the blood coagulation cascade at three steps: it triggers the contact pathway, it accelerates factor V activation, and it enhances fibrin polymerization. We now report that polyphosphate exerts differential effects on blood clotting depending on polymer length. Very long polymers (>500mers, such as those present in microorganisms) were required for optimal activation of the contact pathway, while shorter polymers (~100mers, similar to the polymer lengths released by platelets) were sufficient to accelerate factor V activation and abrogate the anticoagulant function of tissue factor pathway inhibitor. Optimal enhancement of fibrin clot turbidity by polyphosphate required >250mers. Pyrophosphate, which is also secreted by activated platelets, potently blocked polyphosphate-mediated enhancement of fibrin clot structure, suggesting that pyrophosphate is a novel regulator of fibrin function. In conclusion, polyphosphate of the size secreted by platelets is very efficient at accelerating blood clotting reactions but is less efficient at initiating them or at modulating clot structure. Microbial polyphosphate, which is highly procoagulant, may function in host responses to pathogens.
PREPRINT:
http://bloodjournal.hematologylibrary.org/cgi/content/abstract/blood-2010-01-266791v1
SUBMITTED BY: Jim Morrissey
__________________________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI
Papers are culled from NLM MedLine (PubMed). Titles in square brackets indicate that the paper was not published in English. References that lack volume or page numbers are typically electronic pre-publications (E-pubs) ahead of the print publication; if so, the final citation with volume and page numbers may or may not appear in a future issue of Trigger.
THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/10kih57W5b5iucWke6bPhfQ/
Al-Ruzzeh S and Navia JL (2010) Caution with the published database reviews analyzing the off-label use of recombinant activated factor VII (rFVIIa) in cardiac surgery. Transfus Apher Sci
http://www.ncbi.nlm.nih.gov/pubmed/20675193
Atkinson BT, Jasuja R, Chen V, Nandivada P, Furie B, and Furie BC (2010) Laser-induced endothelial cell activation supports fibrin formation. Blood
http://www.ncbi.nlm.nih.gov/pubmed/20675401
Biancofiore G, Bindi LM, Cioni R, Cicorelli A, and Filipponi F (2010) Recombinant activated factor VII for hemoperitoneum after transjugular intrahepatic portosystemic shunt. Blood Coagul Fibrinolysis 21:611
http://www.ncbi.nlm.nih.gov/pubmed/20703105
Bolliger D, Szlam F, Azran M, Koyama K, Levy JH, Molinaro RJ, and Tanaka KA (2010) The anticoagulant effect of protamine sulfate is attenuated in the presence of platelets or elevated factor VIII concentrations. Anesth Analg
http://www.ncbi.nlm.nih.gov/pubmed/20686004
Borissoff JI, Heeneman S, Kilinc E, Kassak P, Van Oerle R, et al. (2010) Early atherosclerosis exhibits an enhanced procoagulant state. Circulation
http://www.ncbi.nlm.nih.gov/pubmed/20697022
Bouchard BA, Mann KG, and Butenas S (2010) No evidence for tissue factor on platelets. Blood 116:854-855.
http://www.ncbi.nlm.nih.gov/pubmed/20688968
Christensen MC, Parr M, Tortella BJ, Malmgren J, Morris S, Rice T, and Holcomb JB (2010) Global differences in causes, management, and survival after severe trauma: The recombinant activated factor VII Phase 3 Trauma Trial. J Trauma 69:344-352.
http://www.ncbi.nlm.nih.gov/pubmed/20699743
Cocco E, Hu Z, Richter CE, Bellone S, Casagrande F, et al. (2010) hI-con1, a factor VII-IgGFc chimeric protein targeting tissue factor for immunotherapy of uterine serous papillary carcinoma. Br J Cancer
http://www.ncbi.nlm.nih.gov/pubmed/20700124
Economou M, Papadopoulou E, Vagianou I, Farmaki E, Gompakis N, and Athanassiou-Metaxa M (2010) Haematuria in a young patient with severe haemophilia and inhibitor presence receiving prophylactic treatment with recombinant factor VIIa. Blood Coagul Fibrinolysis 21:611-613.
http://www.ncbi.nlm.nih.gov/pubmed/20703104
Goto M, Imura T, Inagaki A, Ogawa N, Yamaya H, Fujimori K, Kurokawa Y, and Satomi S (2010) The impact of ischemic stress on the quality of isolated pancreatic islets. Transplant Proc 42:2040-2042.
http://www.ncbi.nlm.nih.gov/pubmed/20692402
Herrera RN, Amaya EI, Perez Aguilar RC, Joo Turoni C, Maranon R, Berman SG, Luciardi HL, Coviello A, and Bruno MP (2010) Inflammatory and prothrombotic activation with conserved endothelial function in patients with chronic, asymptomatic Chagas disease. Clin Appl Thromb Hemost
http://www.ncbi.nlm.nih.gov/pubmed/20699256
Iorio A, Matino D, D'Amico R, and Makris M (2010) Recombinant factor VIIa concentrate versus plasma derived concentrates for the treatment of acute bleeding episodes in people with haemophilia and inhibitors. Cochrane Database Syst Rev 8:CD004449
http://www.ncbi.nlm.nih.gov/pubmed/20687076
Johansson PI and Ostrowski SR (2010) Evidence supporting the use of recombinant activated factor VII in congenital bleeding disorders. Drug Des Devel Ther 4:107-116.
http://www.ncbi.nlm.nih.gov/pubmed/20689697
Kim JE, Kim KJ, Ahn W, Han KS, and Kim HK (2010) Local anesthetics inhibit tissue factor expression in activated monocytes via inhibition of tissue factor mRNA synthesis. Clin Appl Thromb Hemost
http://www.ncbi.nlm.nih.gov/pubmed/20699252
Manly DA, Boles J, and Mackman N (2010) Role of tissue factor in venous thrombosis. Annu Rev Physiol
http://www.ncbi.nlm.nih.gov/pubmed/20690821
Massberg S, Grahl L, von Bruehl ML, Manukyan D, Pfeiler S, et al. (2010) Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases. Nat Med 16:887-896.
http://www.ncbi.nlm.nih.gov/pubmed/20676107
McVey JH (2010) O tissue factor, where art thou? Blood 116:676-677.
http://www.ncbi.nlm.nih.gov/pubmed/20688964
Naumnik B, Rydzewska-Rosolowska A, and Mysliwiec M (2010) Different effects of enoxaparin, nadroparin, and dalteparin on plasma TFPI during hemodialysis: A prospective crossover randomized study. Clin Appl Thromb Hemost
http://www.ncbi.nlm.nih.gov/pubmed/20682597
Nishimura N, Takai M, Yamamoto E, and Hasumi K (2010) Purpurin as a specific inhibitor of spermidine-induced autoactivation of the protease plasma hyaluronan-binding protein. Biol Pharm Bull 33:1430-1433.
http://www.ncbi.nlm.nih.gov/pubmed/20686243
Puetz J (2010) Optimal use of recombinant factor VIIa in the control of bleeding episodes in hemophilic patients. Drug Des Devel Ther 4:127-137.
http://www.ncbi.nlm.nih.gov/pubmed/20689699
Stampfli SF, Akhmedov A, Gebhard C, Lohmann C, Holy EW, Rozenberg I, Spescha R, Shi Y, Luscher TF, Tanner FC, and Camici GG (2010) Aging induces endothelial dysfunction while sparing arterial thrombosis. Arterioscler Thromb Vasc Biol
http://www.ncbi.nlm.nih.gov/pubmed/20689076
van den Berg YW and Versteeg HH (2010) Alternatively spliced tissue factor. A crippled protein in coagulation or a key player in non-haemostatic processes? Hamostaseologie 30:144-149.
http://www.ncbi.nlm.nih.gov/pubmed/20680231
Wade CE, Eastridge BJ, Jones JA, West SA, Spinella PC, Perkins JG, Dubick MA, Blackbourne LH, and Holcomb JB (2010) Use of recombinant factor VIIa in US military casualties for a five-Year period. J Trauma 69:353-359.
http://www.ncbi.nlm.nih.gov/pubmed/20699744
Wang Y, Zhou J, Zhang Y, Wang X, and Chen J (2010) Delivery of TFPI-2 using SonoVue and adenovirus results in the suppression of thrombosis and arterial re-stenosis. Exp Biol Med (Maywood)
http://www.ncbi.nlm.nih.gov/pubmed/20682602
__________________________________________________________
ABOUT TRIGGER
TRIGGER is edited by Jim Morrissey and Pierre Neuenschwander, with editorial assistance by Genie Morrissey. It includes Abstracts of Papers in Press, Meeting Announcements, Positions Sought/Available,or any other pertinent item that subscribers may want to share with their colleagues. To submit an item for publication in Trigger, e-mail us. To request or cancel a subscription,or for more information about TRIGGER or the biology of tissue factor and factor VII, visit our web site. You can also contact us by mail: J.H. Morrissey, University of Illinois College of Medicine, 417 Med Sci Bldg MC-714, 506 S. Mathews Ave., Urbana, IL 61801, USA.
DISCLAIMER: TRIGGER is provided "as is" for information purposes only and without warranty of any kind, express or implied. Users shall assume the entire risk as to the accuracy and usefulness of information in TRIGGER. Opinions expressed here are not necessarily those of the editors or their employers. You may share TRIGGER with your scientific colleagues but you are not permitted to use it or its contents for commercial purposes.
__________________________________________________________
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 16, No. 16 August 16, 2010
(The next issue will be on September 1, 2010)
__________________________________________________________
TRIGGER is also available by RSS Feed:
http://feeds.feedburner.com/blogspot/glro
and BLOG:
http://trigger-tf7.blogspot.com/
__________________________________________________________
PAPERS IN PRESS
AUTHORS: Stephanie A. Smith, Sharon H. Choi, Rebecca Davis-Harrison, Jillian Huyck, John Boettcher, Chad M. Reinstra, and James H. Morrissey
TITLE: Polyphosphate exerts differential effects on blood clotting, depending on polymer size
JOURNAL: Blood
ABSTRACT: Polyphosphate, a linear polymer of inorganic phosphate, is secreted by activated platelets and accumulates in many infectious microorganisms. We recently showed that polyphosphate modulates the blood coagulation cascade at three steps: it triggers the contact pathway, it accelerates factor V activation, and it enhances fibrin polymerization. We now report that polyphosphate exerts differential effects on blood clotting depending on polymer length. Very long polymers (>500mers, such as those present in microorganisms) were required for optimal activation of the contact pathway, while shorter polymers (~100mers, similar to the polymer lengths released by platelets) were sufficient to accelerate factor V activation and abrogate the anticoagulant function of tissue factor pathway inhibitor. Optimal enhancement of fibrin clot turbidity by polyphosphate required >250mers. Pyrophosphate, which is also secreted by activated platelets, potently blocked polyphosphate-mediated enhancement of fibrin clot structure, suggesting that pyrophosphate is a novel regulator of fibrin function. In conclusion, polyphosphate of the size secreted by platelets is very efficient at accelerating blood clotting reactions but is less efficient at initiating them or at modulating clot structure. Microbial polyphosphate, which is highly procoagulant, may function in host responses to pathogens.
PREPRINT:
http://bloodjournal.hematologylibrary.org/cgi/content/abstract/blood-2010-01-266791v1
SUBMITTED BY: Jim Morrissey
__________________________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI
Papers are culled from NLM MedLine (PubMed). Titles in square brackets indicate that the paper was not published in English. References that lack volume or page numbers are typically electronic pre-publications (E-pubs) ahead of the print publication; if so, the final citation with volume and page numbers may or may not appear in a future issue of Trigger.
THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/10kih57W5b5iucWke6bPhfQ/
Al-Ruzzeh S and Navia JL (2010) Caution with the published database reviews analyzing the off-label use of recombinant activated factor VII (rFVIIa) in cardiac surgery. Transfus Apher Sci
http://www.ncbi.nlm.nih.gov/pubmed/20675193
Atkinson BT, Jasuja R, Chen V, Nandivada P, Furie B, and Furie BC (2010) Laser-induced endothelial cell activation supports fibrin formation. Blood
http://www.ncbi.nlm.nih.gov/pubmed/20675401
Biancofiore G, Bindi LM, Cioni R, Cicorelli A, and Filipponi F (2010) Recombinant activated factor VII for hemoperitoneum after transjugular intrahepatic portosystemic shunt. Blood Coagul Fibrinolysis 21:611
http://www.ncbi.nlm.nih.gov/pubmed/20703105
Bolliger D, Szlam F, Azran M, Koyama K, Levy JH, Molinaro RJ, and Tanaka KA (2010) The anticoagulant effect of protamine sulfate is attenuated in the presence of platelets or elevated factor VIII concentrations. Anesth Analg
http://www.ncbi.nlm.nih.gov/pubmed/20686004
Borissoff JI, Heeneman S, Kilinc E, Kassak P, Van Oerle R, et al. (2010) Early atherosclerosis exhibits an enhanced procoagulant state. Circulation
http://www.ncbi.nlm.nih.gov/pubmed/20697022
Bouchard BA, Mann KG, and Butenas S (2010) No evidence for tissue factor on platelets. Blood 116:854-855.
http://www.ncbi.nlm.nih.gov/pubmed/20688968
Christensen MC, Parr M, Tortella BJ, Malmgren J, Morris S, Rice T, and Holcomb JB (2010) Global differences in causes, management, and survival after severe trauma: The recombinant activated factor VII Phase 3 Trauma Trial. J Trauma 69:344-352.
http://www.ncbi.nlm.nih.gov/pubmed/20699743
Cocco E, Hu Z, Richter CE, Bellone S, Casagrande F, et al. (2010) hI-con1, a factor VII-IgGFc chimeric protein targeting tissue factor for immunotherapy of uterine serous papillary carcinoma. Br J Cancer
http://www.ncbi.nlm.nih.gov/pubmed/20700124
Economou M, Papadopoulou E, Vagianou I, Farmaki E, Gompakis N, and Athanassiou-Metaxa M (2010) Haematuria in a young patient with severe haemophilia and inhibitor presence receiving prophylactic treatment with recombinant factor VIIa. Blood Coagul Fibrinolysis 21:611-613.
http://www.ncbi.nlm.nih.gov/pubmed/20703104
Goto M, Imura T, Inagaki A, Ogawa N, Yamaya H, Fujimori K, Kurokawa Y, and Satomi S (2010) The impact of ischemic stress on the quality of isolated pancreatic islets. Transplant Proc 42:2040-2042.
http://www.ncbi.nlm.nih.gov/pubmed/20692402
Herrera RN, Amaya EI, Perez Aguilar RC, Joo Turoni C, Maranon R, Berman SG, Luciardi HL, Coviello A, and Bruno MP (2010) Inflammatory and prothrombotic activation with conserved endothelial function in patients with chronic, asymptomatic Chagas disease. Clin Appl Thromb Hemost
http://www.ncbi.nlm.nih.gov/pubmed/20699256
Iorio A, Matino D, D'Amico R, and Makris M (2010) Recombinant factor VIIa concentrate versus plasma derived concentrates for the treatment of acute bleeding episodes in people with haemophilia and inhibitors. Cochrane Database Syst Rev 8:CD004449
http://www.ncbi.nlm.nih.gov/pubmed/20687076
Johansson PI and Ostrowski SR (2010) Evidence supporting the use of recombinant activated factor VII in congenital bleeding disorders. Drug Des Devel Ther 4:107-116.
http://www.ncbi.nlm.nih.gov/pubmed/20689697
Kim JE, Kim KJ, Ahn W, Han KS, and Kim HK (2010) Local anesthetics inhibit tissue factor expression in activated monocytes via inhibition of tissue factor mRNA synthesis. Clin Appl Thromb Hemost
http://www.ncbi.nlm.nih.gov/pubmed/20699252
Manly DA, Boles J, and Mackman N (2010) Role of tissue factor in venous thrombosis. Annu Rev Physiol
http://www.ncbi.nlm.nih.gov/pubmed/20690821
Massberg S, Grahl L, von Bruehl ML, Manukyan D, Pfeiler S, et al. (2010) Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases. Nat Med 16:887-896.
http://www.ncbi.nlm.nih.gov/pubmed/20676107
McVey JH (2010) O tissue factor, where art thou? Blood 116:676-677.
http://www.ncbi.nlm.nih.gov/pubmed/20688964
Naumnik B, Rydzewska-Rosolowska A, and Mysliwiec M (2010) Different effects of enoxaparin, nadroparin, and dalteparin on plasma TFPI during hemodialysis: A prospective crossover randomized study. Clin Appl Thromb Hemost
http://www.ncbi.nlm.nih.gov/pubmed/20682597
Nishimura N, Takai M, Yamamoto E, and Hasumi K (2010) Purpurin as a specific inhibitor of spermidine-induced autoactivation of the protease plasma hyaluronan-binding protein. Biol Pharm Bull 33:1430-1433.
http://www.ncbi.nlm.nih.gov/pubmed/20686243
Puetz J (2010) Optimal use of recombinant factor VIIa in the control of bleeding episodes in hemophilic patients. Drug Des Devel Ther 4:127-137.
http://www.ncbi.nlm.nih.gov/pubmed/20689699
Stampfli SF, Akhmedov A, Gebhard C, Lohmann C, Holy EW, Rozenberg I, Spescha R, Shi Y, Luscher TF, Tanner FC, and Camici GG (2010) Aging induces endothelial dysfunction while sparing arterial thrombosis. Arterioscler Thromb Vasc Biol
http://www.ncbi.nlm.nih.gov/pubmed/20689076
van den Berg YW and Versteeg HH (2010) Alternatively spliced tissue factor. A crippled protein in coagulation or a key player in non-haemostatic processes? Hamostaseologie 30:144-149.
http://www.ncbi.nlm.nih.gov/pubmed/20680231
Wade CE, Eastridge BJ, Jones JA, West SA, Spinella PC, Perkins JG, Dubick MA, Blackbourne LH, and Holcomb JB (2010) Use of recombinant factor VIIa in US military casualties for a five-Year period. J Trauma 69:353-359.
http://www.ncbi.nlm.nih.gov/pubmed/20699744
Wang Y, Zhou J, Zhang Y, Wang X, and Chen J (2010) Delivery of TFPI-2 using SonoVue and adenovirus results in the suppression of thrombosis and arterial re-stenosis. Exp Biol Med (Maywood)
http://www.ncbi.nlm.nih.gov/pubmed/20682602
__________________________________________________________
ABOUT TRIGGER
TRIGGER is edited by Jim Morrissey and Pierre Neuenschwander, with editorial assistance by Genie Morrissey. It includes Abstracts of Papers in Press, Meeting Announcements, Positions Sought/Available,or any other pertinent item that subscribers may want to share with their colleagues. To submit an item for publication in Trigger, e-mail us. To request or cancel a subscription,or for more information about TRIGGER or the biology of tissue factor and factor VII, visit our web site. You can also contact us by mail: J.H. Morrissey, University of Illinois College of Medicine, 417 Med Sci Bldg MC-714, 506 S. Mathews Ave., Urbana, IL 61801, USA.
DISCLAIMER: TRIGGER is provided "as is" for information purposes only and without warranty of any kind, express or implied. Users shall assume the entire risk as to the accuracy and usefulness of information in TRIGGER. Opinions expressed here are not necessarily those of the editors or their employers. You may share TRIGGER with your scientific colleagues but you are not permitted to use it or its contents for commercial purposes.
__________________________________________________________
Monday, August 2, 2010
Vol. 16, No. 15
TRIGGER
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 16, No. 15 August 2, 2010
(The next issue will be on August 16, 2010)
__________________________________________________________
TRIGGER is also available by RSS Feed:
http://feeds.feedburner.com/blogspot/glro
and BLOG:
http://trigger-tf7.blogspot.com/
__________________________________________________________
PAPERS IN PRESS
None submitted for this issue.
__________________________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI
Papers are culled from NLM MedLine (PubMed). Titles in square brackets indicate that the paper was not published in English. References that lack volume or page numbers are typically electronic pre-publications (E-pubs) ahead of the print publication; if so, the final citation with volume and page numbers may or may not appear in a future issue of Trigger.
THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1VEu7PlDIIjS77-P9GTNgy9/
Apostolopoulos J, Moussa L, and Tipping PG (2010) The cytoplasmic domain of tissue factor restricts physiological albuminuria and pathological proteinuria associated with glomerulonephritis in mice. Nephron Exp Nephrol 116:e72-e83
http://www.ncbi.nlm.nih.gov/pubmed/20664298
Ayer JG, Song C, Steinbeck K, Celermajer DS, and Freedman SB (2010) Increased tissue factor activity in monocytes from obese young adults. Clin Exp Pharmacol Physiol
http://www.ncbi.nlm.nih.gov/pubmed/20659134
Berthelsen LO, Kristensen AT, and Tranholm M (2010) Purified thromboplastin causes haemostatic abnormalities but not overt DIC in an experimental rabbit model. Thromb Res
http://www.ncbi.nlm.nih.gov/pubmed/20637496
Borawski J, Naumnik B, Dubowski M, and Mysliwiec M (2010) Full-length TFPI release by heparinoid sulodexide. Clin Appl Thromb Hemost 16:485-487.
http://www.ncbi.nlm.nih.gov/pubmed/20647229
Calabro P, Cirillo P, Limongelli G, Maddaloni V, Riegler L, et al. (2010) Tissue factor is induced by Resistin in human coronary artery endothelial cells by the NF-kB-dependent pathway. J Vasc Res 48:59-66.
http://www.ncbi.nlm.nih.gov/pubmed/20628259
Cheng Q, Tucker EI, Pine MS, Sisler I, Matafonov A, et al. (2010) A role for factor XIIa-mediated factor XI activation in thrombus formation in vivo. Blood
http://www.ncbi.nlm.nih.gov/pubmed/20634381
Dang CN, Katakam LI, Smith PB, Cotten CM, Goldberg RN, Chandler N, Thornburg CD, and Bidegain M (2010) Recombinant activated factor VIIa treatment for refractory hemorrhage in infants. J Perinatol
http://www.ncbi.nlm.nih.gov/pubmed/20671714
Evola G, Novo G, Amoroso G, Guttilla D, Lo Coco L, Guagliardo M, Lupo A, Averna MR, Giambanco V, Miller V, and Novo S (2010) Modification of the lipidic and coagulative pattern in postmenopause women: Effect of hormone replacement therapy. Int Angiol 29:355-361.
http://www.ncbi.nlm.nih.gov/pubmed/20671654
Fadeeva OA, Panteleev MA, Karamzin SS, Balandina AN, Smirnov IV, and Ataullakhanov FI (2010) Thromboplastin immobilized on polystyrene surface exhibits kinetic characteristics close to those for the native protein and activates in vitro blood coagulation similarly to thromboplastin on fibroblasts. Biochemistry (Mosc ) 75:734-743.
http://www.ncbi.nlm.nih.gov/pubmed/20636265
Fang W, Zhang Q, Peng Y, Chen M, Lin X, Wu J, Cai C, Mei Y, and Jin H (2010) Resistin level is positively correlated with thrombotic complications in southern Chinese metabolic syndrome patients. J Endocrinol Invest
http://www.ncbi.nlm.nih.gov/pubmed/20671416
Franchini M and Lippi G (2010) Recombinant activated factor VII: Mechanisms of action and current indications. Semin Thromb Hemost 36:485-492.
http://www.ncbi.nlm.nih.gov/pubmed/20632246
Hindy-Francois C, Bachelot-Loza C, Le Bonniec B, Grelac F, Dizier B, Godier A, Emmerich J, Gaussem P, and Samama CM (2010) Recombinant activated factor VII does not reduce bleeding in rabbits treated with aspirin and clopidogrel. Thromb Haemost 104:
http://www.ncbi.nlm.nih.gov/pubmed/20664889
Huang ZJ, Luo Q, Yan JH, and Wang SY (2010) [Arginine-glycine-aspartic polypeptide mediated truncated tissue factor therapy for colorectal carcinoma.]. Zhonghua Wai Ke Za Zhi 48:619-623.
http://www.ncbi.nlm.nih.gov/pubmed/20646482
Key NS, De Paepe A, Malfait F, and Shovlin CL (2010) Vascular haemostasis. Haemophilia 16 Suppl 5:146-151.
http://www.ncbi.nlm.nih.gov/pubmed/20590874
Kim J, Min JK, Park JA, Doh HJ, Choi YS, Rho J, Kim YM, and Kwon YG (2010) Receptor activator of nuclear factor {kappa}B ligand is a novel inducer of tissue factor in macrophages. Circ Res
http://www.ncbi.nlm.nih.gov/pubmed/20671239
Lee H, Lee B, Kim Y, Paik N, and Rho H (2010) Characterization of transgenic pigs that express human decay accelerating factor and cell membrane-tethered human tissue factor pathway inhibitor. Reprod Domest Anim
http://www.ncbi.nlm.nih.gov/pubmed/20626677
Levi M, Lowenberg E, and Meijers JC (2010) Recombinant anticoagulant factors for adjunctive treatment of sepsis. Semin Thromb Hemost 36:550-557.
http://www.ncbi.nlm.nih.gov/pubmed/20632252
Li F, Wang CH, Wang JG, Thai T, Boysen G, Xu L, Turner AL, Wolberg AS, Mackman N, Maeda N, and Takahashi N (2010) Elevated tissue factor expression contributes to exacerbated diabetic nephropathy in mice lacking eNOS fed a high fat diet. J Thromb Haemost
http://www.ncbi.nlm.nih.gov/pubmed/20626618
Lin CC, Ezzelarab M, Shapiro R, Ekser B, Long C, et al. (2010) Recipient tissue factor expression is associated with consumptive coagulopathy in pig-to-primate kidney xenotransplantation. Am J Transplant 10:1556-1568.
http://www.ncbi.nlm.nih.gov/pubmed/20642682
Lund T, Hermansen SE, Andreasen TV, Olsen JO, Osterud B, Myrmel T, and Ytrehus K (2010) Shear stress regulates inflammatory and thrombogenic gene transcripts in cultured human endothelial progenitor cells. Thromb Haemost 104:
http://www.ncbi.nlm.nih.gov/pubmed/20664910
Macey MG, Wolf SI, and Lawson C (2010) Microparticle formation after exposure of blood to activated endothelium under flow. Cytometry A 77:761-768.
http://www.ncbi.nlm.nih.gov/pubmed/20653016
Macey MG, Enniks N, and Bevan S (2010) Flow cytometric analysis of microparticle phenotype and their role in thrombin generation. Cytometry B Clin Cytom
http://www.ncbi.nlm.nih.gov/pubmed/20632415
Miller MA, Kandala NB, Kumari M, Marmot MG, and Cappuccio FP (2010) Relationships between sleep duration and von Willebrand factor, factor VII, and fibrinogen. Whitehall II Study. Arterioscler Thromb Vasc Biol
http://www.ncbi.nlm.nih.gov/pubmed/20651279
Nadir Y, Brenner B, Fux L, Shafat I, Attias J, and Vlodavsky I (2010) Heparanase enhances factor Xa generation in the presence of tissue-factor and factor VIIa. Haematologica
http://www.ncbi.nlm.nih.gov/pubmed/20634491
Picchiassi E, Coata G, Centra M, Pennacchi L, Bini V, and Di Renzo GC (2010) Identification of universal mRNA markers for noninvasive prenatal screening of trisomies. Prenat Diagn 30:764-770.
http://www.ncbi.nlm.nih.gov/pubmed/20661890
Ruf W and Versteeg HH (2010) Tissue factor mutated at the allosteric Cys186-Cys209 disulfide bond is severely impaired in decrypted procoagulant activity. Blood 116:500-501.
http://www.ncbi.nlm.nih.gov/pubmed/20651086
Scultetus A, Arnaud F, Kaplan L, Shander A, Philbin N, Rice J, McCarron R, and Freilich D (2010) Hemoglobin-based oxygen carrier (HBOC-201) and escalating doses of recombinant factor VIIa (rFVIIa) as a novel pre-hospital resuscitation fluid in a swine model of severe uncontrolled hemorrhage. Artif Cells Blood Substit Immobil Biotechnol
http://www.ncbi.nlm.nih.gov/pubmed/20645681
Sovershaev MA, Egorina EM, Bogdanov VY, Seredkina N, Fallon JT, Valkov AY, Osterud B, and Hansen JB (2010) Bone morphogenetic protein-7 increases thrombogenicity of lipid-rich atherosclerotic plaques via activation of tissue factor. Thromb Res
http://www.ncbi.nlm.nih.gov/pubmed/20656331
Tripodi A, Chantarangkul V, van den Besselaar AM, Witteveen E, and Hubbard AR (2010) International collaborative study for the calibration of a proposed international standard for thromboplastin, human, plain. J Thromb Haemost
http://www.ncbi.nlm.nih.gov/pubmed/20626621
Wilson HM (2010) Macrophages heterogeneity in atherosclerosis - implications for therapy. J Cell Mol Med
http://www.ncbi.nlm.nih.gov/pubmed/20629993
__________________________________________________________
ABOUT TRIGGER
TRIGGER is edited by Jim Morrissey and Pierre Neuenschwander, with editorial assistance by Genie Morrissey. It includes Abstracts of Papers in Press, Meeting Announcements, Positions Sought/Available,or any other pertinent item that subscribers may want to share with their colleagues. To submit an item for publication in Trigger, e-mail us. To request or cancel a subscription,or for more information about TRIGGER or the biology of tissue factor and factor VII, visit our web site. You can also contact us by mail: J.H. Morrissey, University of Illinois College of Medicine, 417 Med Sci Bldg MC-714, 506 S. Mathews Ave., Urbana, IL 61801, USA.
DISCLAIMER: TRIGGER is provided "as is" for information purposes only and without warranty of any kind, express or implied. Users shall assume the entire risk as to the accuracy and usefulness of information in TRIGGER. Opinions expressed here are not necessarily those of the editors or their employers. You may share TRIGGER with your scientific colleagues but you are not permitted to use it or its contents for commercial purposes.
__________________________________________________________
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 16, No. 15 August 2, 2010
(The next issue will be on August 16, 2010)
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TRIGGER is also available by RSS Feed:
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and BLOG:
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PAPERS IN PRESS
None submitted for this issue.
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RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI
Papers are culled from NLM MedLine (PubMed). Titles in square brackets indicate that the paper was not published in English. References that lack volume or page numbers are typically electronic pre-publications (E-pubs) ahead of the print publication; if so, the final citation with volume and page numbers may or may not appear in a future issue of Trigger.
THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1VEu7PlDIIjS77-P9GTNgy9/
Apostolopoulos J, Moussa L, and Tipping PG (2010) The cytoplasmic domain of tissue factor restricts physiological albuminuria and pathological proteinuria associated with glomerulonephritis in mice. Nephron Exp Nephrol 116:e72-e83
http://www.ncbi.nlm.nih.gov/pubmed/20664298
Ayer JG, Song C, Steinbeck K, Celermajer DS, and Freedman SB (2010) Increased tissue factor activity in monocytes from obese young adults. Clin Exp Pharmacol Physiol
http://www.ncbi.nlm.nih.gov/pubmed/20659134
Berthelsen LO, Kristensen AT, and Tranholm M (2010) Purified thromboplastin causes haemostatic abnormalities but not overt DIC in an experimental rabbit model. Thromb Res
http://www.ncbi.nlm.nih.gov/pubmed/20637496
Borawski J, Naumnik B, Dubowski M, and Mysliwiec M (2010) Full-length TFPI release by heparinoid sulodexide. Clin Appl Thromb Hemost 16:485-487.
http://www.ncbi.nlm.nih.gov/pubmed/20647229
Calabro P, Cirillo P, Limongelli G, Maddaloni V, Riegler L, et al. (2010) Tissue factor is induced by Resistin in human coronary artery endothelial cells by the NF-kB-dependent pathway. J Vasc Res 48:59-66.
http://www.ncbi.nlm.nih.gov/pubmed/20628259
Cheng Q, Tucker EI, Pine MS, Sisler I, Matafonov A, et al. (2010) A role for factor XIIa-mediated factor XI activation in thrombus formation in vivo. Blood
http://www.ncbi.nlm.nih.gov/pubmed/20634381
Dang CN, Katakam LI, Smith PB, Cotten CM, Goldberg RN, Chandler N, Thornburg CD, and Bidegain M (2010) Recombinant activated factor VIIa treatment for refractory hemorrhage in infants. J Perinatol
http://www.ncbi.nlm.nih.gov/pubmed/20671714
Evola G, Novo G, Amoroso G, Guttilla D, Lo Coco L, Guagliardo M, Lupo A, Averna MR, Giambanco V, Miller V, and Novo S (2010) Modification of the lipidic and coagulative pattern in postmenopause women: Effect of hormone replacement therapy. Int Angiol 29:355-361.
http://www.ncbi.nlm.nih.gov/pubmed/20671654
Fadeeva OA, Panteleev MA, Karamzin SS, Balandina AN, Smirnov IV, and Ataullakhanov FI (2010) Thromboplastin immobilized on polystyrene surface exhibits kinetic characteristics close to those for the native protein and activates in vitro blood coagulation similarly to thromboplastin on fibroblasts. Biochemistry (Mosc ) 75:734-743.
http://www.ncbi.nlm.nih.gov/pubmed/20636265
Fang W, Zhang Q, Peng Y, Chen M, Lin X, Wu J, Cai C, Mei Y, and Jin H (2010) Resistin level is positively correlated with thrombotic complications in southern Chinese metabolic syndrome patients. J Endocrinol Invest
http://www.ncbi.nlm.nih.gov/pubmed/20671416
Franchini M and Lippi G (2010) Recombinant activated factor VII: Mechanisms of action and current indications. Semin Thromb Hemost 36:485-492.
http://www.ncbi.nlm.nih.gov/pubmed/20632246
Hindy-Francois C, Bachelot-Loza C, Le Bonniec B, Grelac F, Dizier B, Godier A, Emmerich J, Gaussem P, and Samama CM (2010) Recombinant activated factor VII does not reduce bleeding in rabbits treated with aspirin and clopidogrel. Thromb Haemost 104:
http://www.ncbi.nlm.nih.gov/pubmed/20664889
Huang ZJ, Luo Q, Yan JH, and Wang SY (2010) [Arginine-glycine-aspartic polypeptide mediated truncated tissue factor therapy for colorectal carcinoma.]. Zhonghua Wai Ke Za Zhi 48:619-623.
http://www.ncbi.nlm.nih.gov/pubmed/20646482
Key NS, De Paepe A, Malfait F, and Shovlin CL (2010) Vascular haemostasis. Haemophilia 16 Suppl 5:146-151.
http://www.ncbi.nlm.nih.gov/pubmed/20590874
Kim J, Min JK, Park JA, Doh HJ, Choi YS, Rho J, Kim YM, and Kwon YG (2010) Receptor activator of nuclear factor {kappa}B ligand is a novel inducer of tissue factor in macrophages. Circ Res
http://www.ncbi.nlm.nih.gov/pubmed/20671239
Lee H, Lee B, Kim Y, Paik N, and Rho H (2010) Characterization of transgenic pigs that express human decay accelerating factor and cell membrane-tethered human tissue factor pathway inhibitor. Reprod Domest Anim
http://www.ncbi.nlm.nih.gov/pubmed/20626677
Levi M, Lowenberg E, and Meijers JC (2010) Recombinant anticoagulant factors for adjunctive treatment of sepsis. Semin Thromb Hemost 36:550-557.
http://www.ncbi.nlm.nih.gov/pubmed/20632252
Li F, Wang CH, Wang JG, Thai T, Boysen G, Xu L, Turner AL, Wolberg AS, Mackman N, Maeda N, and Takahashi N (2010) Elevated tissue factor expression contributes to exacerbated diabetic nephropathy in mice lacking eNOS fed a high fat diet. J Thromb Haemost
http://www.ncbi.nlm.nih.gov/pubmed/20626618
Lin CC, Ezzelarab M, Shapiro R, Ekser B, Long C, et al. (2010) Recipient tissue factor expression is associated with consumptive coagulopathy in pig-to-primate kidney xenotransplantation. Am J Transplant 10:1556-1568.
http://www.ncbi.nlm.nih.gov/pubmed/20642682
Lund T, Hermansen SE, Andreasen TV, Olsen JO, Osterud B, Myrmel T, and Ytrehus K (2010) Shear stress regulates inflammatory and thrombogenic gene transcripts in cultured human endothelial progenitor cells. Thromb Haemost 104:
http://www.ncbi.nlm.nih.gov/pubmed/20664910
Macey MG, Wolf SI, and Lawson C (2010) Microparticle formation after exposure of blood to activated endothelium under flow. Cytometry A 77:761-768.
http://www.ncbi.nlm.nih.gov/pubmed/20653016
Macey MG, Enniks N, and Bevan S (2010) Flow cytometric analysis of microparticle phenotype and their role in thrombin generation. Cytometry B Clin Cytom
http://www.ncbi.nlm.nih.gov/pubmed/20632415
Miller MA, Kandala NB, Kumari M, Marmot MG, and Cappuccio FP (2010) Relationships between sleep duration and von Willebrand factor, factor VII, and fibrinogen. Whitehall II Study. Arterioscler Thromb Vasc Biol
http://www.ncbi.nlm.nih.gov/pubmed/20651279
Nadir Y, Brenner B, Fux L, Shafat I, Attias J, and Vlodavsky I (2010) Heparanase enhances factor Xa generation in the presence of tissue-factor and factor VIIa. Haematologica
http://www.ncbi.nlm.nih.gov/pubmed/20634491
Picchiassi E, Coata G, Centra M, Pennacchi L, Bini V, and Di Renzo GC (2010) Identification of universal mRNA markers for noninvasive prenatal screening of trisomies. Prenat Diagn 30:764-770.
http://www.ncbi.nlm.nih.gov/pubmed/20661890
Ruf W and Versteeg HH (2010) Tissue factor mutated at the allosteric Cys186-Cys209 disulfide bond is severely impaired in decrypted procoagulant activity. Blood 116:500-501.
http://www.ncbi.nlm.nih.gov/pubmed/20651086
Scultetus A, Arnaud F, Kaplan L, Shander A, Philbin N, Rice J, McCarron R, and Freilich D (2010) Hemoglobin-based oxygen carrier (HBOC-201) and escalating doses of recombinant factor VIIa (rFVIIa) as a novel pre-hospital resuscitation fluid in a swine model of severe uncontrolled hemorrhage. Artif Cells Blood Substit Immobil Biotechnol
http://www.ncbi.nlm.nih.gov/pubmed/20645681
Sovershaev MA, Egorina EM, Bogdanov VY, Seredkina N, Fallon JT, Valkov AY, Osterud B, and Hansen JB (2010) Bone morphogenetic protein-7 increases thrombogenicity of lipid-rich atherosclerotic plaques via activation of tissue factor. Thromb Res
http://www.ncbi.nlm.nih.gov/pubmed/20656331
Tripodi A, Chantarangkul V, van den Besselaar AM, Witteveen E, and Hubbard AR (2010) International collaborative study for the calibration of a proposed international standard for thromboplastin, human, plain. J Thromb Haemost
http://www.ncbi.nlm.nih.gov/pubmed/20626621
Wilson HM (2010) Macrophages heterogeneity in atherosclerosis - implications for therapy. J Cell Mol Med
http://www.ncbi.nlm.nih.gov/pubmed/20629993
__________________________________________________________
ABOUT TRIGGER
TRIGGER is edited by Jim Morrissey and Pierre Neuenschwander, with editorial assistance by Genie Morrissey. It includes Abstracts of Papers in Press, Meeting Announcements, Positions Sought/Available,or any other pertinent item that subscribers may want to share with their colleagues. To submit an item for publication in Trigger, e-mail us. To request or cancel a subscription,or for more information about TRIGGER or the biology of tissue factor and factor VII, visit our web site. You can also contact us by mail: J.H. Morrissey, University of Illinois College of Medicine, 417 Med Sci Bldg MC-714, 506 S. Mathews Ave., Urbana, IL 61801, USA.
DISCLAIMER: TRIGGER is provided "as is" for information purposes only and without warranty of any kind, express or implied. Users shall assume the entire risk as to the accuracy and usefulness of information in TRIGGER. Opinions expressed here are not necessarily those of the editors or their employers. You may share TRIGGER with your scientific colleagues but you are not permitted to use it or its contents for commercial purposes.
__________________________________________________________
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