Friday, December 21, 2012

Vol. 18, No. 24

TRIGGER
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 18, No. 24  December 17, 2012
(The next issue will be on January 3, 2012)
__________________________________________________________
TRIGGER is also available by RSS Feed:
and BLOG:
http://trigger-tf7.blogspot.com/
__________________________________________________________
ANNOUNCEMENTS
To all our subscribers -- best wishes for the holiday season, and for 
a happy, healthy and prosperous New Year!
-Jim & Genie Morrissey and Pierre Neuenschwander
__________________________________________________________
PAPERS IN PRESS
None Submitted for this issue.
__________________________________________________________
UPCOMING MEETINGS & EVENTS
http://tf7.org/meetings.htm
__________________________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI
Papers are culled from NLM MedLine (PubMed). Titles in square brackets indicate that the paper was not published in English. References that lack volume or page numbers are typically electronic pre-publications (E-pubs) ahead of the print publication; if so, the final citation with volume and page numbers may or may not appear in a future issue of Trigger.
THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1low6aV3mjCpaCX5mZKGlAl/

Andreasen JJ (2012) Pharmacologic methods to reduce postoperative bleeding in adult cardiac surgery. A mini-review. Curr Pharm Des.
http://www.ncbi.nlm.nih.gov/pubmed/23228316

Augoustides JG (2012) Breakthroughs in anticoagulation: advent of the oral direct factor Xa inhibitors. J Cardiothorac Vasc Anesth 26:740-745.
http://www.ncbi.nlm.nih.gov/pubmed/22608466

Baumann Kreuziger LM, Morton CT, Dries DJ (2012) New anticoagulants: A concise review. J Trauma Acute Care Surg 73:983-992.
http://www.ncbi.nlm.nih.gov/pubmed/22976421

Bid HK, Oswald D, Li C, London CA, Lin J, Houghton PJ (2012) Anti-angiogenic activity of a small molecule STAT3 inhibitor LLL12. PLoS One 7:e35513.
http://www.ncbi.nlm.nih.gov/pubmed/22530037

Biswas I, Garg I, Singh B, Khan GA (2012) A key role of toll-like receptor 3 in tissue factor activation through extracellular signal regulated kinase 1/2 pathway in a murine hypoxia model. Blood Cells Mol Dis 49:92-101.
http://www.ncbi.nlm.nih.gov/pubmed/22647506

Chaari M, Bouhlel R, Kallel S, Aidi Z, Makni F, Gerotziafas G, . . . Kallel C (2012) Post partum acquired hemophilia A with fatal outcome: a case report. Ann Biol Clin (Paris) 70:741-746.
http://www.ncbi.nlm.nih.gov/pubmed/23207822

Chambers RC, Scotton CJ (2012) Coagulation cascade proteinases in lung injury and fibrosis. Proc Am Thorac Soc 9:96-101.
http://www.ncbi.nlm.nih.gov/pubmed/22802281

Chen J, Duan ZP, Bai L, Zhao J, Ding M, Tong XY, Cong YL (2012) [Changing characteristic of blood coagulation factors and their correlation with blood coagulation status in different hepatic diseases]. Zhonghua Gan Zang Bing Za Zhi 20:206-210.
http://www.ncbi.nlm.nih.gov/pubmed/22475141

Collins PW (2012) Therapeutic challenges in acquired factor VIII deficiency. Hematology Am Soc Hematol Educ Program 2012:369-374.
http://www.ncbi.nlm.nih.gov/pubmed/23233606

Darbousset R, Thomas GM, Mezouar S, Frere C, Bonier R, Mackman N, . . . Panicot-Dubois L (2012) Tissue factor-positive neutrophils bind to injured endothelial wall and initiate thrombus formation. Blood 120:2133-2143.
http://www.ncbi.nlm.nih.gov/pubmed/22837532

Dashkevich NM, Ovanesov MV, Balandina AN, Karamzin SS, Shestakov PI, Soshitova NP, . . . Ataullakhanov FI (2012) Thrombin activity propagates in space during blood coagulation as an excitation wave. Biophys J 103:2233-2240.
http://www.ncbi.nlm.nih.gov/pubmed/23200057

Date K, Hall J, Greenman J, Maraveyas A, Madden LA (2012) Tumour and microparticle tissue factor expression and cancer thrombosis. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/23237339

Dogra RK, Das R, Ahluwalia J, Kumar RM, Talwar KK (2012) Prothrombotic gene polymorphisms and plasma factors in young north Indian survivors of acute myocardial infarction. J Thromb Thrombolysis 34:276-282.
http://www.ncbi.nlm.nih.gov/pubmed/22535530

Ekser B, Lin CC, Long C, Echeverri GJ, Hara H, Ezzelarab M, . . . Gridelli B (2012) Potential factors influencing the development of thrombocytopenia and consumptive coagulopathy after genetically modified pig liver xenotransplantation. Transpl Int 25:882-896.
http://www.ncbi.nlm.nih.gov/pubmed/22642260

Faber DR, Kalkhoven E, Westerink J, Bouwman JJ, Monajemi HM, Visseren FL (2012) Conditioned media from (pre)adipocytes stimulate fibrinogen and PAI-1 production by HepG2 hepatoma cells. Nutr Diabetes 2:e52.
http://www.ncbi.nlm.nih.gov/pubmed/23208413

Fan LK, Wang ZW, Hua BL, Su W, Wang SJ, Zhao YQ (2009) [Comparison of modified Bethesda assay and Nijmegen assay in detecting FVII inhibitor in patients with hemophilia A]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao 31:551-554.
http://www.ncbi.nlm.nih.gov/pubmed/19968068

Fu Y, Zhao Y, Liu Y, Zhu Y, Chi J, Hu J, . . . Yin X (2012) Adenovirus-mediated tissue factor pathway inhibitor gene transfer induces apoptosis by blocking the phosphorylation of JAK-2/STAT-3 pathway in vascular smooth muscle cells. Cell Signal 24:1909-1917.
http://www.ncbi.nlm.nih.gov/pubmed/22709828

Ge HX, Zhang J, Chen L, Kou JP, Yu BY (2012) Chemical and microbial semi-synthesis of tetrahydroprotoberberines as inhibitors on tissue factor procoagulant activity. Bioorg Med Chem.
http://www.ncbi.nlm.nih.gov/pubmed/23199480

Godby RC, Van Den Berg YW, Srinivasan R, Sturm R, Hui DY, Konieczny SF, . . . Bogdanov VY (2012) Nonproteolytic properties of murine alternatively spliced tissue factor: implications for integrin-mediated signaling in murine models. Mol Med 18:771-779.
http://www.ncbi.nlm.nih.gov/pubmed/22481268

Guo DL, Zhou H, Wu Y, Zhou F, Zhang XM, Xu GY, Wen HP (2011) [Role of NF-kappaB in factor VIIa-induced proliferation and migration of colon cancer cell line SW620 cells]. Zhonghua Zhong Liu Za Zhi 33:649-653.
http://www.ncbi.nlm.nih.gov/pubmed/22340043

Hag AM, Pedersen SF, Christoffersen C, Binderup T, Jensen MM, Jorgensen JT, . . . Kjaer A (2012) (18)F-FDG PET Imaging of Murine Atherosclerosis: Association with Gene Expression of Key Molecular Markers. PLoS One 7:e50908.
http://www.ncbi.nlm.nih.gov/pubmed/23226424

Hajj-Chahine J, Jayle C, Tomasi J, Corbi P (2012) Recombinant factor VIIa while on extracorporeal membrane oxygenator support: a word of caution. Eur J Cardiothorac Surg 42:387-388.
http://www.ncbi.nlm.nih.gov/pubmed/22457149

Hvas AM, Boas TW, Jensen M, Lindskov C, Folkersen L, Ravn HB (2012) Change in hemostatic intervention after implementation of thromboelastometry. J Cardiothorac Vasc Anesth 26:227-231.
http://www.ncbi.nlm.nih.gov/pubmed/21924638

Khorana AA (2012) Cancer-associated thrombosis: updates and controversies. Hematology Am Soc Hematol Educ Program 2012:626-630.
http://www.ncbi.nlm.nih.gov/pubmed/23233644

Kotovshchikova EF, Buevich EI, Pen'kova EV, Kulikov VP, Chudimov VF, Siul'zhina EN, . . . Bochkarev AP (2012) [The mutation of genes of hemostasis system in patients with venous cerebral angiodystonia against the background of connective tissue dysplasia]. Klin Lab Diagn:33-36.
http://www.ncbi.nlm.nih.gov/pubmed/23097990

Kraiem I, Hadhri S, El Omri H, Sassi R, Chaabani W, Ennabli S, Skouri H (2012) Frequency of specific coagulation inhibitors and antiphospholipid antibodies in Tunisian haemophiliacs. Ann Biol Clin (Paris) 70:659-665.
http://www.ncbi.nlm.nih.gov/pubmed/23207810

Kubier A, O'Brien M (2012) Endogenous anticoagulants. Top Companion Anim Med 27:81-87.
http://www.ncbi.nlm.nih.gov/pubmed/23031460

Liu S, Sammons V, Fairhall J, Reddy R, Tu J, Duong TT, Stoodley M (2012) Molecular responses of brain endothelial cells to radiation in a mouse model. J Clin Neurosci 19:1154-1158.
http://www.ncbi.nlm.nih.gov/pubmed/22595350

Louw E, van der Merwe NA, Neitz AWH, Maritz-Olivier C (2012) Evolution of the tissue factor pathway inhibitor-like Kunitz domain-containing protein family in Rhipicephalus microplus. Int J Parasitol.
http://www.ncbi.nlm.nih.gov/pubmed/23220044

Marchetti M, Diani E, ten Cate H, Falanga A (2012) Characterization of the thrombin generation potential of leukemic and solid tumor cells by calibrated automated thrombography. Haematologica 97:1173-1180.
http://www.ncbi.nlm.nih.gov/pubmed/22419573

Mariani G, Napolitano M, Dolce A, Perez Garrido R, Batorova A, Karimi M, . . . Ruiz-Saez A (2012) Replacement therapy for bleeding episodes in factor VII deficiency. A prospective evaluation. Thromb Haemost 109.
http://www.ncbi.nlm.nih.gov/pubmed/23238632

Marlu R, Polack B (2012) Gla-domainless factor Xa: molecular bait to bypass a blocked tenase complex. Haematologica 97:1165-1172.
http://www.ncbi.nlm.nih.gov/pubmed/22491732

Matsubara S (2012) Spontaneous spinal epidural hematoma during pregnancy. Arq Neuropsiquiatr 70:81.
http://www.ncbi.nlm.nih.gov/pubmed/22218485

Milella RA, Antonacci D, Crupi P, Incampo F, Carrieri C, Semeraro N, Colucci M (2012) Skin extracts from 2 Italian table grapes (Italia and Palieri) inhibit tissue factor expression by human blood mononuclear cells. J Food Sci 77:H154-159.
http://www.ncbi.nlm.nih.gov/pubmed/22860586

Mitrovic M, Elezovic I, Suvajdzic-Vukovic N, Antic D (2012) Successful non-standard approaches to massive hemoptysis in invasive pulmonary aspergillosis. Srp Arh Celok Lek 140:505-507.
http://www.ncbi.nlm.nih.gov/pubmed/23092038

Narverud I, Iversen PO, Aukrust P, Halvorsen B, Ueland T, Johansen SG, . . . Holven KB (2012) Maternal familial hypercholesterolaemia (FH) confers altered haemostatic profile in offspring with and without FH. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/23199546

O'Brien M (2012) The reciprocal relationship between inflammation and coagulation. Top Companion Anim Med 27:46-52.
http://www.ncbi.nlm.nih.gov/pubmed/23031455

Park DW, Lyu JH, Kim JS, Chin H, Bae YS, Baek SH (2012) Role of JAK2-STAT3 in TLR2-mediated tissue factor expression. J Cell Biochem.
http://www.ncbi.nlm.nih.gov/pubmed/23238822

Perez-Ferrer A, Gredilla E, de Vicente J, Laporta Y (2012) Cardiac surgery without blood products in a Jehovah's Witness child with factor VII deficiency. J Cardiothorac Vasc Anesth 26:651-653.
http://www.ncbi.nlm.nih.gov/pubmed/21924639

Pisetsky DS, Ullal AJ, Gauley J, Ning TC (2012) Microparticles as mediators and biomarkers of rheumatic disease. Rheumatology (Oxford) 51:1737-1746.
http://www.ncbi.nlm.nih.gov/pubmed/22403183

Reid VL, Webster NR (2012) Role of microparticles in sepsis. Br J Anaesth 109:503-513.
http://www.ncbi.nlm.nih.gov/pubmed/22952169

Rigby M, Kamat P, Vats A, Heard M (2012) Controlling intrathoracic hemorrhage on ECMO: help from Factor VIIa and Virchow. Perfusion.
http://www.ncbi.nlm.nih.gov/pubmed/23201816

Rozental T, Shore-Lesserson L (2012) Pharmacologic management of coagulopathy in cardiac surgery: an update. J Cardiothorac Vasc Anesth 26:669-679.
http://www.ncbi.nlm.nih.gov/pubmed/22608465

Rubin O, Delobel J, Prudent M, Lion N, Kohl K, Tucker EI, . . . Angelillo-Scherrer A (2012) Red blood cell-derived microparticles isolated from blood units initiate and propagate thrombin generation. Transfusion.
http://www.ncbi.nlm.nih.gov/pubmed/23228139

Saeed D, Albert A, Kamiya H, Maxhera B, Westenfeld R, Lichtenberg A (2012) Five days of no anticoagulation or antiplatelet therapy and NovoSeven administration in a HeartWare HVAD patient. Artif Organs 36:751-753.
http://www.ncbi.nlm.nih.gov/pubmed/22607278

Schulman S (2012) Pharmacologic tools to reduce bleeding in surgery. Hematology Am Soc Hematol Educ Program 2012:517-521.
http://www.ncbi.nlm.nih.gov/pubmed/23233628

Sekiya A, Morishita E, Maruyama K, Asakura H, Nakao S, Ohtake S (2012) [Significant decrease in factor VII activity by tissue thromboplastin derived from rabbit brain in a patient with congenital factor VII deficiency (FVII Padua)]. Rinsho Ketsueki 53:357-360.
http://www.ncbi.nlm.nih.gov/pubmed/22499055

Silveira A, Scanavini D, Boquist S, Ericsson CG, Hellenius ML, Leander K, . . . Hamsten A (2012) Relationships of plasma factor VIIa-antithrombin complexes to manifest and future cardiovascular disease. Thromb Res 130:221-225.
http://www.ncbi.nlm.nih.gov/pubmed/21925715

Smejkal P, Bulikova A, Chlupova G, Zavrelova J (2012) [Acquired haemophilia A]. Vnitr Lek 58:571-578.
http://www.ncbi.nlm.nih.gov/pubmed/23067181

Stavenuiter F, Davis NF, Duan E, Gale AJ, Heeb MJ (2012) Platelet protein S directly inhibits procoagulant activity on platelets and microparticles. Thromb Haemost 109.
http://www.ncbi.nlm.nih.gov/pubmed/23238804

van der Meijden PE, Feijge MA, Swieringa F, Gilio K, Nergiz-Unal R, Hamulyak K, Heemskerk JW (2012) Key role of integrin alpha(IIb)beta (3) signaling to Syk kinase in tissue factor-induced thrombin generation. Cell Mol Life Sci 69:3481-3492.
http://www.ncbi.nlm.nih.gov/pubmed/22669259

Wang P, Wu Y, Li X, Ma X, Zhong L (2012) Thioredoxin and Thioredoxin Reductase Control Tissue Factor Activity by Thiol-Redox-Dependent Mechanism. J Biol Chem.
http://www.ncbi.nlm.nih.gov/pubmed/23223577

Woo CH, Patel N, Conell C, Rao VA, Faigeles BS, Patel MC, . . . Flint AC (2012) Rapid warfarin reversal in the setting of intracranial hemorrhage: a comparison of plasma, recombinant activated Factor VII, and prothrombin complex concentrate. World Neurosurg.
http://www.ncbi.nlm.nih.gov/pubmed/23220122

Wu B, Zhou H, Hu L, Mu Y, Wu Y (2012) Involvement of PKCalpha activation in TF/VIIa/PAR2-induced proliferation, migration, and survival of colon cancer cell SW620. Tumour Biol.
http://www.ncbi.nlm.nih.gov/pubmed/23233043

Wyckoff T, Reed EA, Desai ND, Augoustides JG (2012) Possible anaphylaxis due to recombinant factor VIIa administration during thoracic aortic surgery. J Cardiothorac Vasc Anesth 26:e15-17.
http://www.ncbi.nlm.nih.gov/pubmed/22155168

Xu Y, Zhang X, Zhao Y, Zhao L, Qiu H, Wu D (2012) Successful treatment of a patient with acquired haemophilia A with a combination of a low-dose rituximab and recombinant human FVIIa. Haemophilia.
http://www.ncbi.nlm.nih.gov/pubmed/23231056

Ye R, Ye C, Huang Y, Liu L, Wang S (2012) Circulating tissue factor positive microparticles in patients with acute recurrent deep venous thrombosis. Thromb Res 130:253-258.
http://www.ncbi.nlm.nih.gov/pubmed/22099707
__________________________________________________________
ABOUT TRIGGER
TRIGGER is edited by Jim Morrissey and Pierre Neuenschwander, with editorial assistance by Genie Morrissey. It includes Abstracts of Papers in Press, Meeting Announcements, Positions Sought/Available,or any other pertinent item that subscribers may want to share with their colleagues. To submit an item for publication in Trigger, e-mail us. To request or cancel a subscription,or for more information about TRIGGER or the biology of tissue factor and factor VII, visit our web site. You can also contact us by mail: J.H. Morrissey, University of Illinois College of Medicine, 417 Med Sci Bldg MC-714, 506 S. Mathews Ave., Urbana, IL 61801, USA.

DISCLAIMER: TRIGGER is provided "as is" for information purposes only and without warranty of any kind, express or implied. Users shall assume the entire risk as to the accuracy and usefulness of information in TRIGGER. Opinions expressed here are not necessarily those of the editors or their employers. You may share TRIGGER with your scientific colleagues but you are not permitted to use it or its contents for commercial purposes.
__________________________________________________________

Monday, December 3, 2012

Vol. 18, No. 23

TRIGGER
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 18, No. 23  December 3, 2012
(The next issue will be on December 17, 2012)
__________________________________________________________
TRIGGER is also available by RSS Feed:
and BLOG:
http://trigger-tf7.blogspot.com/
__________________________________________________________
PAPERS IN PRESS
None Submitted for this issue.
__________________________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI
Papers are culled from NLM MedLine (PubMed). Titles in square brackets indicate that the paper was not published in English. References that lack volume or page numbers are typically electronic pre-publications (E-pubs) ahead of the print publication; if so, the final citation with volume and page numbers may or may not appear in a future issue of Trigger.
THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1Dss3c2Bben9w8sffs6oqp3/

Brown SA, Barnes C, Curtin J, Dunkley S, Ockelford P, Phillips J, . . . Tran H (2012) How we use recombinant activated Factor VII in patients with haemophilia A or B complicated by inhibitors. Intern Med J 42:1243-1250.
http://www.ncbi.nlm.nih.gov/pubmed/23157518

Chen H, Qi X, He C, Yin Z, Fan D, Han G (2012) Coagulation imbalance may not contribute to the development of portal vein thrombosis in patients with cirrhosis. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/23157737

Davies J, Kadir RA (2012) Endometrial haemostasis and menstruation. Rev Endocr Metab Disord.
http://www.ncbi.nlm.nih.gov/pubmed/23180227

Deutschmann A, Schlagenhauf A, Leschnik B, Hoffmann KM, Hauer A, Muntean W (2012) Increased Procoagulant Function of Microparticles In Pediatric Inflammatory Bowel Disease: Role In Increased Thrombin Generation. J Pediatr Gastroenterol Nutr.
http://www.ncbi.nlm.nih.gov/pubmed/23164759

Ettelaie C, Elkeeb AM, Maraveyas A, Collier ME (2012) p38alpha phosphorylates serine 258 within the cytoplasmic domain of tissue factor and prevents its incorporation into cell-derived microparticles. Biochim Biophys Acta.
http://www.ncbi.nlm.nih.gov/pubmed/23195225

Geenen IL, Molin DG, van den Akker NM, Jeukens F, Spronk HM, Schurink GW, Post MJ (2012) Endothelial cells (ECs) for vascular tissue engineering: venous ECs are less thrombogenic than arterial ECs. J Tissue Eng Regen Med.
http://www.ncbi.nlm.nih.gov/pubmed/23166106

Girolami A, Scarparo P, Bonamigo E, Treleani M, Lombardi AM (2012) Homozygous FVII deficiencies with different reactivity towards tissue thromboplastins of different origin. Hematology 17:350-354.
http://www.ncbi.nlm.nih.gov/pubmed/23168073

Guo Y, Lip GY, Apostolakis S (2012) Inflammation in atrial fibrillation. J Am Coll Cardiol 60:2263-2270.
http://www.ncbi.nlm.nih.gov/pubmed/23194937

Harinstein LM, Morgan JW, Russo N (2012) Treatment of Dabigatran-Associated Bleeding: Case Report and Review of the Literature. J Pharm Pract.
http://www.ncbi.nlm.nih.gov/pubmed/23160864

He CL, Yi PF, Fan QJ, Shen HQ, Jiang XL, Qin QQ, . . . Fu BD (2012) Xiang-Qi-Tang and its active components exhibit anti-inflammatory and anticoagulant properties by inhibiting MAPK and NF-kappaB signaling pathways in LPS-treated rat cardiac microvascular endothelial cells. Immunopharmacol Immunotoxicol.
http://www.ncbi.nlm.nih.gov/pubmed/23171279

Kutcher ME, Xu J, Vilardi RF, Ho C, Esmon CT, Cohen MJ (2012) Extracellular histone release in response to traumatic injury: Implications for a compensatory role of activated protein C. J Trauma Acute Care Surg 73:1387-1392.
http://www.ncbi.nlm.nih.gov/pubmed/23188230

Mancl EE, Crawford AN, Voils SA (2012) Contemporary Anticoagulation Reversal: Focus on Direct Thrombin Inhibitors and Factor Xa Inhibitors. J Pharm Pract.
http://www.ncbi.nlm.nih.gov/pubmed/23160865

Oszajca K, Wronski K, Janiszewska G, Bienkiewicz M, Panek M, Bartkowiak J, Szemraj J (2012) Association analysis of genetic polymorphisms of factor V, factor VII and fibrinogen beta chain genes with human abdominal aortic aneurysm. Exp Ther Med 4:514-518.
http://www.ncbi.nlm.nih.gov/pubmed/23181128

Sbrana F, Coceani M, Panchetti L, Pasanisi EM, Rovai D, Del Corso A (2012) Factor VII Deficiency, Masked by Warfarin Therapy, as a Cause of Bleeding After Cardiovascular Intervention. Cardiovasc Intervent Radiol.
http://www.ncbi.nlm.nih.gov/pubmed/23188558

Sharma SK, Kumar S, Seth T, Mishra P, Agrawal N, Singh G, . . . Saxena R (2012) Clinical profile of patients with rare inherited coagulation disorders: a retrospective analysis of 67 patients from northern India. Mediterr J Hematol Infect Dis 4:e2012057.
http://www.ncbi.nlm.nih.gov/pubmed/23170186

Wang GF, Zou XL (2012) Tissue factor with age-related macular degeneration. Int J Ophthalmol 5:609-613.
http://www.ncbi.nlm.nih.gov/pubmed/23166874

Wu Y, Zhang X, Zhou H, Chen D, Xie H, Mu Y, . . . Yan J (2012) Factor VIIa Regulates the Expression of Caspase-3, MMP-9, and CD44 in SW620 Colon Cancer Cells Involving PAR2/MAPKs/NF-kappaB Signaling Pathways. Cancer Invest.
http://www.ncbi.nlm.nih.gov/pubmed/23170789

Zhang Z, Yang Y, Hill MA, Wu J (2012) Does C-reactive protein contribute to atherothrombosis via oxidant-mediated release of pro-thrombotic factors and activation of platelets? Front Physiol 3:433.
http://www.ncbi.nlm.nih.gov/pubmed/23162475
__________________________________________________________
ABOUT TRIGGER
TRIGGER is edited by Jim Morrissey and Pierre Neuenschwander, with editorial assistance by Genie Morrissey. It includes Abstracts of Papers in Press, Meeting Announcements, Positions Sought/Available,or any other pertinent item that subscribers may want to share with their colleagues. To submit an item for publication in Trigger, e-mail us. To request or cancel a subscription,or for more information about TRIGGER or the biology of tissue factor and factor VII, visit our web site. You can also contact us by mail: J.H. Morrissey, University of Illinois College of Medicine, 417 Med Sci Bldg MC-714, 506 S. Mathews Ave., Urbana, IL 61801, USA.

DISCLAIMER: TRIGGER is provided "as is" for information purposes only and without warranty of any kind, express or implied. Users shall assume the entire risk as to the accuracy and usefulness of information in TRIGGER. Opinions expressed here are not necessarily those of the editors or their employers. You may share TRIGGER with your scientific colleagues but you are not permitted to use it or its contents for commercial purposes.
__________________________________________________________

Monday, November 19, 2012

Vol. 18, No. 22

TRIGGER
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 18, No. 22  November 15, 2012
(The next issue will be on December 3, 2012)
__________________________________________________________
TRIGGER is also available by RSS Feed:
and BLOG:
http://trigger-tf7.blogspot.com/

__________________________________________________________
PAPERS IN PRESS
None Submitted for this issue.
__________________________________________________________
POSITIONS SOUGHT/AVAILABLE
POSTDOCTORAL POSITION - The Children's Hospital of Philadelphia
We are seeking a highly qualified and motivated individual for one Postdoctoral Position in the Division of Hematology at The Children's Hospital of Philadelphia and The University of Pennsylvania.  This is a joint position available immediately in the laboratories of Dr. 
Katherine A. High and Dr. Paris Margaritis.  This position will be devoted to studying the biological and therapeutic effects of blood coagulation factor expression in vitro or in vivo in appropriate models. Applicants for this position should have a strong background in molecular biology and have experience working with transgenic/gene targeted mouse models.  Applicants with experience in coagulation protein biochemistry and tissue culture are strongly encouraged to apply.  Candidates should have successfully earned an advanced degree (M.D. or Ph.D.), have excellent communications skills and be willing to work on a multidisciplinary team.  Highly competitive salary and benefits are offered.  Curriculum vitae and three references should be sent to:  

Drs. Katherine A. High and Paris Margaritis, The Children's Hospital of Philadelphia, Division of Hematology, Colket Translational Research Building, Rm 5000, 3501 Civic Center Blvd., Philadelphia, PA 19104 USA.  
TEL: (215)-590-4521 (High), (267)-426-7262 (Margaritis).

The Children's Hospital of Philadelphia and the University of Pennsylvania are Equal Opportunity/Affirmative Action Employers.  Women and minorities are encouraged to apply.

(Note from the Editors: Please note that the email addresses above have been modified to prevent SPAM. When clicking on the links or typing them into your email program, please replace the "AT" with "@" and the "DOT" with "." and remove all spaces. Thank you.)

__________________________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI
Papers are culled from NLM MedLine (PubMed). Titles in square brackets indicate that the paper was not published in English. References that lack volume or page numbers are typically electronic pre-publications (E-pubs) ahead of the print publication; if so, the final citation with volume and page numbers may or may not appear in a future issue of Trigger.
THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1fI0EmmJEejxJSnxbik_Np3/

Anonymous (2012) [The mutation of genes of hemostasis system in patients with venous cerebral angiodystonia against the background of connective tissue dysplasia]. Klin Lab Diagn:33-36.
http://www.ncbi.nlm.nih.gov/pubmed/23097990

Ahmad S, Ahmad A, Rancourt RC, Neeves KB, Loader JE, Hendry-Hofer T, . . . White CW (2012) Tissue Factor Signals Airway Epithelial Basal Cell Survival via Coagulation and PAR1/2. Am J Respir Cell Mol Biol.
http://www.ncbi.nlm.nih.gov/pubmed/23065128

Ahnstrom J, Andersson HM, Hockey V, Meng Y, McKinnon TA, Hamuro T, . . . Lane DA (2012) Identification of functionally important residues in TFPI Kunitz domain 3 required for the enhancement of its activity by protein S. Blood.
http://www.ncbi.nlm.nih.gov/pubmed/23074276

Alioglu B, Ozsoy MH, Tapci E, Karamercan S, Agras PI, Dallar Y (2012) Successful use of recombinant factor VIIa in a child with Schoenlein-Henoch purpura presenting with compartment syndrome and severe factor XIII deficiency. Blood Coagul Fibrinolysis.
http://www.ncbi.nlm.nih.gov/pubmed/23103728

Arda-Pirincci P, Oztay F, Bayrak BB, Yanardag R, Bolkent S (2012) Teduglutide, a glucagon-like peptide 2 analogue: A novel protective agent with anti-apoptotic and anti-oxidant properties in mice with lung injury. Peptides.
http://www.ncbi.nlm.nih.gov/pubmed/23059393

Bolton-Maggs PH (2012) The rare inherited coagulation disorders. Pediatr Blood Cancer.
http://www.ncbi.nlm.nih.gov/pubmed/23109366

Boyle JJ, Christou I, Iqbal MB, Nguyen AT, Leung VW, Evans PC, . . . Haskard DO (2012) Solid-phase immunoglobulins IgG and IgM activate macrophages with solid-phase IgM acting via a novel scavenger receptor a pathway. Am J Pathol 181:347-361.
http://www.ncbi.nlm.nih.gov/pubmed/22658487

Breitenstein A, Sluka SH, Akhmedov A, Stivala S, Steffel J, Camici GG, . . . Tanner FC (2012) Dronedarone reduces arterial thrombus formation. Basic Res Cardiol 107:302.
http://www.ncbi.nlm.nih.gov/pubmed/23052639

Caballo C, Escolar G, Diaz-Ricart M, Lopez-Vilchez I, Lozano M, Cid J, . . . Galan AM (2012) Impact of experimental haemodilution on platelet function, thrombin generation and clot firmness: effects of different coagulation factor concentrates. Blood Transfus:1-10.
http://www.ncbi.nlm.nih.gov/pubmed/23058866

Cavallari N, Balestra D, Branchini A, Maestri I, Chuamsunrit A, Sasanakul W, . . . Pinotti M (2012) Activation of a cryptic splice site in a potentially lethal coagulation defect accounts for a functional protein variant. Biochim Biophys Acta 1822:1109-1113.
http://www.ncbi.nlm.nih.gov/pubmed/22426302

Cooper DK, Ekser B, Burlak C, Ezzelarab M, Hara H, Paris L, . . . Pierson RN, 3rd (2012) Clinical lung xenotransplantation--what donor genetic modifications may be necessary? Xenotransplantation 19:144-158.
http://www.ncbi.nlm.nih.gov/pubmed/22702466

Cugno M, Castelli R, Mari D, Mozzi E, Zappa MA, Boscolo-Anzoletti M, . . . Mannucci PM (2012) Inflammatory and prothrombotic parameters in normotensive non-diabetic obese women: effect of weight loss obtained by gastric banding. Intern Emerg Med 7:237-242.
http://www.ncbi.nlm.nih.gov/pubmed/21249470

Deanda A, Jr., Hymes K (2012) Thrombosis and Recombinant Factor VIIa: Letter 1. Ann Thorac Surg 94:1783.
http://www.ncbi.nlm.nih.gov/pubmed/23098970

Dudash LA, Kligman F, Sarett SM, Kottke-Marchant K, Marchant RE (2012) Endothelial cell attachment and shear response on biomimetic polymer-coated vascular grafts. J Biomed Mater Res A 100:2204-2210.
http://www.ncbi.nlm.nih.gov/pubmed/22623267

Dutra LA, Braga-Neto P, Pedroso JL, Barsottini OG (2012) Sneddon's syndrome: case report and review of its relationship with antiphospholipid syndrome. Einstein (Sao Paulo) 10:230-232.
http://www.ncbi.nlm.nih.gov/pubmed/23052460

Elden L, Reinders M, Witmer C (2012) Predictors of bleeding disorders in children with epistaxis: value of preoperative tests and clinical screening. Int J Pediatr Otorhinolaryngol 76:767-771.
http://www.ncbi.nlm.nih.gov/pubmed/22459034

Eleftheriou D, Ganesan V, Hong Y, Klein NJ, Brogan PA (2012) Endothelial injury in childhood stroke with cerebral arteriopathy: A cross-sectional study. Neurology.
http://www.ncbi.nlm.nih.gov/pubmed/23077025

Funderburg NT, Zidar DA, Shive C, Lioi A, Mudd J, Musselwhite LW, . . . Lederman MM (2012) Shared monocyte subset phenotypes in HIV-1 infection and in uninfected subjects with acute coronary syndromes. Blood.
http://www.ncbi.nlm.nih.gov/pubmed/23065151

Geiser F, Gessler K, Conrad R, Imbierowicz K, Albus C, Harbrecht U (2012) Can activation of coagulation and impairment of fibrinolysis in patients with anxiety and depression be reversed after improvement of psychiatric symptoms? Results of a pilot study. J Nerv Ment Dis 200:721-723.
http://www.ncbi.nlm.nih.gov/pubmed/22850309

Godoi LC, Gomes KB, Alpoim PN, Carvalho M, Lwaleed BA, Sant'Ana Dusse LM (2012) Preeclampsia: the role of tissue factor and tissue factor pathway inhibitor. J Thromb Thrombolysis 34:1-6.
http://www.ncbi.nlm.nih.gov/pubmed/22461171

Hall CL, Zaman FS (2012) A computational analysis of an in vitro vessel wall injury model. Ann Biomed Eng 40:1486-1494.
http://www.ncbi.nlm.nih.gov/pubmed/22290588

Hernandez Vera R, Vilahur G, Ferrer-Lorente R, Pena E, Badimon L (2012) Platelets derived from the bone marrow of diabetic animals show dysregulated endoplasmic reticulum stress proteins that contribute to increased thrombosis. Arterioscler Thromb Vasc Biol 32:2141-2148.
http://www.ncbi.nlm.nih.gov/pubmed/22837468

Ho KM, Litton E (2012) Cost-effectiveness of using recombinant activated factor VII as an off-label rescue treatment for critical bleeding requiring massive transfusion. Transfusion 52:1696-1702.
http://www.ncbi.nlm.nih.gov/pubmed/22211634

Jin YH, Wang MS, Zheng FX, Xie YS, Xie HX, Xu PF (2012) [Molecular genetics and clinical features of nine patients with inherited coagulation factor VII deficiency]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 29:404-407.
http://www.ncbi.nlm.nih.gov/pubmed/22875495

Katsuyama T, Sada KE, Katayama A, Hinamoto N, Wakabayashi H, Kawabata T, Makino H (2012) Acquired haemophilia in a patient with Castleman's disease: a case report. Haemophilia 18:e360-362.
http://www.ncbi.nlm.nih.gov/pubmed/22630343

Knight M, Fitzpatrick K, Kurinczuk JJ, Tuffnell D (2012) Use of recombinant factor VIIa in patients with amniotic fluid embolism. Anesthesiology 117:423; author reply 423-424.
http://www.ncbi.nlm.nih.gov/pubmed/22828419

Lee KG, Lee H, Ha JM, Lee YK, Kang HJ, Park CG, Kim SJ (2012) Increased human tumor necrosis factor-alpha levels induce procoagulant change in porcine endothelial cells in vitro. Xenotransplantation 19:186-195.
http://www.ncbi.nlm.nih.gov/pubmed/22702470

Lippi G, Favaloro EJ, Cervellin G (2012) Massive Posttraumatic Bleeding: Epidemiology, Causes, Clinical Features, and Therapeutic Management. Semin Thromb Hemost.
http://www.ncbi.nlm.nih.gov/pubmed/23086540

Lupu C, Herlea O, Tang H, Lijnen RH, Lupu F (2012) Plasmin-dependent proteolysis of Tissue Factor Pathway Inhibitor in a mouse model of endotoxemia. J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/23106863

Magnusson M, Fischler B, Svensson J, Petrini P, Schulman S, Nemeth A (2012) Bile acids and coagulation factors: paradoxical association in children with chronic liver disease. Eur J Gastroenterol Hepatol.
http://www.ncbi.nlm.nih.gov/pubmed/23075699

Mitrophanov AY, Rosendaal FR, Reifman J (2012) Therapeutic correction of thrombin generation in dilution-induced coagulopathy: computational analysis based on a data set of healthy subjects. J Trauma Acute Care Surg 73:S95-S102.
http://www.ncbi.nlm.nih.gov/pubmed/22847103

Mitrovic M, Elezovic I, Suvajdzic-Vukovic N, Antic D (2012) Successful non-standard approaches to massive hemoptysis in invasive pulmonary aspergillosis. Srp Arh Celok Lek 140:505-507.
http://www.ncbi.nlm.nih.gov/pubmed/23092038

Moosdorf R (2012) Aortic Valve Thrombosis After Treatment With Recombinant Factor VIIa: Letter 2. Ann Thorac Surg 94:1783-1784.
http://www.ncbi.nlm.nih.gov/pubmed/23098971

Neal MD, Marsh A, Marino R, Kautza B, Raval JS, Forsythe RM, . . . Sperry JL (2012) Massive transfusion: an evidence-based review of recent developments. Arch Surg 147:563-571.
http://www.ncbi.nlm.nih.gov/pubmed/22786545

Peled E, Davis M, Axelman E, Norman D, Nadir Y (2012) Heapranase role in the treatment of avascular necrosis of femur head. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/23063054

Perry JR (2012) Thromboembolic disease in patients with high-grade glioma. Neuro Oncol 14 Suppl 4:iv73-iv80.
http://www.ncbi.nlm.nih.gov/pubmed/23095833

Pircher J, Merkle M, Wornle M, Ribeiro A, Czermak T, Stampnik Y, . . . Krotz F (2012) Prothrombotic effects of tumor necrosis factor alpha in vivo are amplified by the absence of TNF-alpha receptor subtype 1 and require TNF-alpha receptor subtype 2. Arthritis Res Ther 14:R225.
http://www.ncbi.nlm.nih.gov/pubmed/23079185

Qi L, Li JM, Sun H, Huang XQ, Lin KQ, Chu JY, Yang ZQ (2012) [Association between gene polymorphisms and myocardial infarction in Han Chinese of Yunnan province]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 29:413-419.
http://www.ncbi.nlm.nih.gov/pubmed/22875497

Ro H, Lee EW, Hong JH, Han KH, Yeom HJ, Kim HJ, . . . Yang J (2012) Roles of Islet Toll-like Receptors in Pig to Mouse Islet Xenotransplantation. Cell Transplant.
http://www.ncbi.nlm.nih.gov/pubmed/23051007

Saja MF, Abdo AA, Sanai FM, Shaikh SA, Gader AG (2012) The coagulopathy of liver disease: does vitamin K help? Blood Coagul Fibrinolysis.
http://www.ncbi.nlm.nih.gov/pubmed/23080365

Sattler S, Schwartz A (2012) Does the use of recombinant factor VIIA reduce morbidity or mortality in nonhemophiliac patients? Ann Emerg Med 60:160-161.
http://www.ncbi.nlm.nih.gov/pubmed/22542308

Sauna ZE, Pandey GS, Jain N, Mahmood I, Kimchi-Sarfaty C, Golding B (2012) Plasma derivatives: new products and new approaches. Biologicals 40:191-195.
http://www.ncbi.nlm.nih.gov/pubmed/22239993

Singh A, Foster GD, Gunawardana J, McCoy TA, Nguyen T, Vander Veur S, . . . Rao AK (2012) Elevated circulating tissue factor procoagulant activity, factor VII, and plasminogen activator inhibitor-1 in childhood obesity: evidence of a procoagulant state. Br J Haematol 158:523-527.
http://www.ncbi.nlm.nih.gov/pubmed/22612792

Skeppholm M, Mobarrez F, Malmqvist K, Wallen H (2012) Platelet-derived microparticles during and after acute coronary syndrome. Thromb Haemost 107:1122-1129.
http://www.ncbi.nlm.nih.gov/pubmed/22371053

Smejkal P, Bulikova A, Chlupova G, Zavrelova J (2012) [Acquired haemophilia A]. Vnitr Lek 58:571-578.
http://www.ncbi.nlm.nih.gov/pubmed/23067181

Stavik B, Skretting G, Olstad OK, Sletten M, Dehli Vigeland M, Sandset PM, Iversen N (2012) TFPI Alpha and Beta Regulate mRNAs and microRNAs Involved in Cancer Biology and in the Immune System in Breast Cancer Cells. PLoS One 7:e47184.
http://www.ncbi.nlm.nih.gov/pubmed/23071754

Steward RG, Saleh OA, James AH, Shah AA, Price TM (2012) Management of gynecologic surgery in the patient with factor XI deficiency: a review of the literature. Obstet Gynecol Surv 67:291-297.
http://www.ncbi.nlm.nih.gov/pubmed/22624777

Suzuki A, Miyawaki Y, Okuyama E, Murata M, Ando Y, Kato I, . . . Kojima T (2012) Ribavirin-induced intracellular GTP depletion activates transcription elongation in coagulation factor VII gene expression. Biochem J.
http://www.ncbi.nlm.nih.gov/pubmed/23050902

Tardy-Poncet B, Piot M, Brunet D, Chapelle C, Bonardel M, Mismetti P, . . . Tardy B (2012) TFPI resistance related to inherited or acquired protein S deficiency. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/23079294

Thaler J, Preusser M, Ay C, Kaider A, Marosi C, Zielinski C, . . . Hainfellner JA (2012) Intratumoral tissue factor expression and risk of venous thromboembolism in brain tumor patients. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/23084660

Valentino LA, Walsh CE, Reding MT, Young GA, Levendoglu-Tugal O, Cooper DL (2012) Patient- and caregiver-reported bleeding symptoms and reasons for starting and stopping treatment with recombinant factor VIIa: analysis of the Dosing Observational Study in Haemophilia (DOSE). Haemophilia 18:554-560.
http://www.ncbi.nlm.nih.gov/pubmed/22348407

Van Dreden P, Woodhams B, Rousseau A, Dreyfus JF, Vasse M (2012) Contribution of procoagulant phospholipids, thrombomodulin activity and thrombin generation assays as prognostic factors in intensive care patients with septic and non-septic organ failure. Clin Chem Lab Med.
http://www.ncbi.nlm.nih.gov/pubmed/23096108

Van Geffen M, Menegatti M, Loof A, Lap P, Karimi M, Laros-van Gorkom BA, . . . Van Heerde WL (2012) Retrospective evaluation of bleeding tendency and simultaneous thrombin and plasmin generation in patients with rare bleeding disorders. Haemophilia 18:630-638.
http://www.ncbi.nlm.nih.gov/pubmed/22404435

Walenga JM, Jeske WP, Hoppensteadt D, Cunanan J, Khan H, Escalante V, . . . Bakhos M (2012) Comparative Studies on Branded Enoxaparin and a US Generic Version of Enoxaparin. Clin Appl Thromb Hemost.
http://www.ncbi.nlm.nih.gov/pubmed/23091283

Wunderink RG, Mandell L (2012) Adjunctive therapy in community-acquired pneumonia. Semin Respir Crit Care Med 33:311-318.
http://www.ncbi.nlm.nih.gov/pubmed/22718217

Zangari M, Berno T, Zhan F, Tricot G, Fink L (2012) Mechanisms of Thrombosis in Paraproteinemias: The Effects of Immunomodulatory Drugs. Semin Thromb Hemost.
http://www.ncbi.nlm.nih.gov/pubmed/23104518

Zderic TW, Hamilton MT (2012) Identification of hemostatic genes expressed in human and rat leg muscles and a novel gene (LPP1/PAP2A) suppressed during prolonged physical inactivity (sitting). Lipids Health Dis 11:137.
http://www.ncbi.nlm.nih.gov/pubmed/23061662


__________________________________________________________
ABOUT TRIGGER
TRIGGER is edited by Jim Morrissey and Pierre Neuenschwander, with editorial assistance by Genie Morrissey. It includes Abstracts of Papers in Press, Meeting Announcements, Positions Sought/Available,or any other pertinent item that subscribers may want to share with their colleagues. To submit an item for publication in Trigger, e-mail us. To request or cancel a subscription,or for more information about TRIGGER or the biology of tissue factor and factor VII, visit our web site. You can also contact us by mail: J.H. Morrissey, University of Illinois College of Medicine, 417 Med Sci Bldg MC-714, 506 S. Mathews Ave., Urbana, IL 61801, USA.

DISCLAIMER: TRIGGER is provided "as is" for information purposes only and without warranty of any kind, express or implied. Users shall assume the entire risk as to the accuracy and usefulness of information in TRIGGER. Opinions expressed here are not necessarily those of the editors or their employers. You may share TRIGGER with your scientific colleagues but you are not permitted to use it or its contents for commercial purposes.
__________________________________________________________

Vol. 18, No. 21

TRIGGER
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 18, No. 21  November 1, 2012
(The next issue will be on November 15, 2012)
__________________________________________________________
TRIGGER is also available by RSS Feed:
and BLOG:
http://trigger-tf7.blogspot.com/
__________________________________________________________
PAPERS IN PRESS
None Submitted for this issue.
__________________________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI
Papers are culled from NLM MedLine (PubMed). Titles in square brackets indicate that the paper was not published in English. References that lack volume or page numbers are typically electronic pre-publications (E-pubs) ahead of the print publication; if so, the final citation with volume and page numbers may or may not appear in a future issue of Trigger.
THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1fI0EmmJEejxJSnxbik_Np3/

Anonymous (2012) [The mutation of genes of hemostasis system in patients with venous cerebral angiodystonia against the background of connective tissue dysplasia]. Klin Lab Diagn:33-36.
http://www.ncbi.nlm.nih.gov/pubmed/23097990

Ahmad S, Ahmad A, Rancourt RC, Neeves KB, Loader JE, Hendry-Hofer T, . . . White CW (2012) Tissue Factor Signals Airway Epithelial Basal Cell Survival via Coagulation and PAR1/2. Am J Respir Cell Mol Biol.
http://www.ncbi.nlm.nih.gov/pubmed/23065128

Ahnstrom J, Andersson HM, Hockey V, Meng Y, McKinnon TA, Hamuro T, . . . Lane DA (2012) Identification of functionally important residues in TFPI Kunitz domain 3 required for the enhancement of its activity by protein S. Blood.
http://www.ncbi.nlm.nih.gov/pubmed/23074276

Alioglu B, Ozsoy MH, Tapci E, Karamercan S, Agras PI, Dallar Y (2012) Successful use of recombinant factor VIIa in a child with Schoenlein-Henoch purpura presenting with compartment syndrome and severe factor XIII deficiency. Blood Coagul Fibrinolysis.
http://www.ncbi.nlm.nih.gov/pubmed/23103728

Arda-Pirincci P, Oztay F, Bayrak BB, Yanardag R, Bolkent S (2012) Teduglutide, a glucagon-like peptide 2 analogue: A novel protective agent with anti-apoptotic and anti-oxidant properties in mice with lung injury. Peptides.
http://www.ncbi.nlm.nih.gov/pubmed/23059393

Bolton-Maggs PH (2012) The rare inherited coagulation disorders. Pediatr Blood Cancer.
http://www.ncbi.nlm.nih.gov/pubmed/23109366

Boyle JJ, Christou I, Iqbal MB, Nguyen AT, Leung VW, Evans PC, . . . Haskard DO (2012) Solid-phase immunoglobulins IgG and IgM activate macrophages with solid-phase IgM acting via a novel scavenger receptor a pathway. Am J Pathol 181:347-361.
http://www.ncbi.nlm.nih.gov/pubmed/22658487

Breitenstein A, Sluka SH, Akhmedov A, Stivala S, Steffel J, Camici GG, . . . Tanner FC (2012) Dronedarone reduces arterial thrombus formation. Basic Res Cardiol 107:302.
http://www.ncbi.nlm.nih.gov/pubmed/23052639

Caballo C, Escolar G, Diaz-Ricart M, Lopez-Vilchez I, Lozano M, Cid J, . . . Galan AM (2012) Impact of experimental haemodilution on platelet function, thrombin generation and clot firmness: effects of different coagulation factor concentrates. Blood Transfus:1-10.
http://www.ncbi.nlm.nih.gov/pubmed/23058866

Cavallari N, Balestra D, Branchini A, Maestri I, Chuamsunrit A, Sasanakul W, . . . Pinotti M (2012) Activation of a cryptic splice site in a potentially lethal coagulation defect accounts for a functional protein variant. Biochim Biophys Acta 1822:1109-1113.
http://www.ncbi.nlm.nih.gov/pubmed/22426302

Cooper DK, Ekser B, Burlak C, Ezzelarab M, Hara H, Paris L, . . . Pierson RN, 3rd (2012) Clinical lung xenotransplantation--what donor genetic modifications may be necessary? Xenotransplantation 19:144-158.
http://www.ncbi.nlm.nih.gov/pubmed/22702466

Cugno M, Castelli R, Mari D, Mozzi E, Zappa MA, Boscolo-Anzoletti M, . . . Mannucci PM (2012) Inflammatory and prothrombotic parameters in normotensive non-diabetic obese women: effect of weight loss obtained by gastric banding. Intern Emerg Med 7:237-242.
http://www.ncbi.nlm.nih.gov/pubmed/21249470

Deanda A, Jr., Hymes K (2012) Thrombosis and Recombinant Factor VIIa: Letter 1. Ann Thorac Surg 94:1783.
http://www.ncbi.nlm.nih.gov/pubmed/23098970

Dudash LA, Kligman F, Sarett SM, Kottke-Marchant K, Marchant RE (2012) Endothelial cell attachment and shear response on biomimetic polymer-coated vascular grafts. J Biomed Mater Res A 100:2204-2210.
http://www.ncbi.nlm.nih.gov/pubmed/22623267

Dutra LA, Braga-Neto P, Pedroso JL, Barsottini OG (2012) Sneddon's syndrome: case report and review of its relationship with antiphospholipid syndrome. Einstein (Sao Paulo) 10:230-232.
http://www.ncbi.nlm.nih.gov/pubmed/23052460

Elden L, Reinders M, Witmer C (2012) Predictors of bleeding disorders in children with epistaxis: value of preoperative tests and clinical screening. Int J Pediatr Otorhinolaryngol 76:767-771.
http://www.ncbi.nlm.nih.gov/pubmed/22459034

Eleftheriou D, Ganesan V, Hong Y, Klein NJ, Brogan PA (2012) Endothelial injury in childhood stroke with cerebral arteriopathy: A cross-sectional study. Neurology.
http://www.ncbi.nlm.nih.gov/pubmed/23077025

Funderburg NT, Zidar DA, Shive C, Lioi A, Mudd J, Musselwhite LW, . . . Lederman MM (2012) Shared monocyte subset phenotypes in HIV-1 infection and in uninfected subjects with acute coronary syndromes. Blood.
http://www.ncbi.nlm.nih.gov/pubmed/23065151

Geiser F, Gessler K, Conrad R, Imbierowicz K, Albus C, Harbrecht U (2012) Can activation of coagulation and impairment of fibrinolysis in patients with anxiety and depression be reversed after improvement of psychiatric symptoms? Results of a pilot study. J Nerv Ment Dis 200:721-723.
http://www.ncbi.nlm.nih.gov/pubmed/22850309

Godoi LC, Gomes KB, Alpoim PN, Carvalho M, Lwaleed BA, Sant'Ana Dusse LM (2012) Preeclampsia: the role of tissue factor and tissue factor pathway inhibitor. J Thromb Thrombolysis 34:1-6.
http://www.ncbi.nlm.nih.gov/pubmed/22461171

Hall CL, Zaman FS (2012) A computational analysis of an in vitro vessel wall injury model. Ann Biomed Eng 40:1486-1494.
http://www.ncbi.nlm.nih.gov/pubmed/22290588

Hernandez Vera R, Vilahur G, Ferrer-Lorente R, Pena E, Badimon L (2012) Platelets derived from the bone marrow of diabetic animals show dysregulated endoplasmic reticulum stress proteins that contribute to increased thrombosis. Arterioscler Thromb Vasc Biol 32:2141-2148.
http://www.ncbi.nlm.nih.gov/pubmed/22837468

Ho KM, Litton E (2012) Cost-effectiveness of using recombinant activated factor VII as an off-label rescue treatment for critical bleeding requiring massive transfusion. Transfusion 52:1696-1702.
http://www.ncbi.nlm.nih.gov/pubmed/22211634

Jin YH, Wang MS, Zheng FX, Xie YS, Xie HX, Xu PF (2012) [Molecular genetics and clinical features of nine patients with inherited coagulation factor VII deficiency]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 29:404-407.
http://www.ncbi.nlm.nih.gov/pubmed/22875495

Katsuyama T, Sada KE, Katayama A, Hinamoto N, Wakabayashi H, Kawabata T, Makino H (2012) Acquired haemophilia in a patient with Castleman's disease: a case report. Haemophilia 18:e360-362.
http://www.ncbi.nlm.nih.gov/pubmed/22630343

Knight M, Fitzpatrick K, Kurinczuk JJ, Tuffnell D (2012) Use of recombinant factor VIIa in patients with amniotic fluid embolism. Anesthesiology 117:423; author reply 423-424.
http://www.ncbi.nlm.nih.gov/pubmed/22828419

Lee KG, Lee H, Ha JM, Lee YK, Kang HJ, Park CG, Kim SJ (2012) Increased human tumor necrosis factor-alpha levels induce procoagulant change in porcine endothelial cells in vitro. Xenotransplantation 19:186-195.
http://www.ncbi.nlm.nih.gov/pubmed/22702470

Lippi G, Favaloro EJ, Cervellin G (2012) Massive Posttraumatic Bleeding: Epidemiology, Causes, Clinical Features, and Therapeutic Management. Semin Thromb Hemost.
http://www.ncbi.nlm.nih.gov/pubmed/23086540

Lupu C, Herlea O, Tang H, Lijnen RH, Lupu F (2012) Plasmin-dependent proteolysis of Tissue Factor Pathway Inhibitor in a mouse model of endotoxemia. J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/23106863

Magnusson M, Fischler B, Svensson J, Petrini P, Schulman S, Nemeth A (2012) Bile acids and coagulation factors: paradoxical association in children with chronic liver disease. Eur J Gastroenterol Hepatol.
http://www.ncbi.nlm.nih.gov/pubmed/23075699

Mitrophanov AY, Rosendaal FR, Reifman J (2012) Therapeutic correction of thrombin generation in dilution-induced coagulopathy: computational analysis based on a data set of healthy subjects. J Trauma Acute Care Surg 73:S95-S102.
http://www.ncbi.nlm.nih.gov/pubmed/22847103

Mitrovic M, Elezovic I, Suvajdzic-Vukovic N, Antic D (2012) Successful non-standard approaches to massive hemoptysis in invasive pulmonary aspergillosis. Srp Arh Celok Lek 140:505-507.
http://www.ncbi.nlm.nih.gov/pubmed/23092038

Moosdorf R (2012) Aortic Valve Thrombosis After Treatment With Recombinant Factor VIIa: Letter 2. Ann Thorac Surg 94:1783-1784.
http://www.ncbi.nlm.nih.gov/pubmed/23098971

Neal MD, Marsh A, Marino R, Kautza B, Raval JS, Forsythe RM, . . . Sperry JL (2012) Massive transfusion: an evidence-based review of recent developments. Arch Surg 147:563-571.
http://www.ncbi.nlm.nih.gov/pubmed/22786545

Peled E, Davis M, Axelman E, Norman D, Nadir Y (2012) Heapranase role in the treatment of avascular necrosis of femur head. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/23063054

Perry JR (2012) Thromboembolic disease in patients with high-grade glioma. Neuro Oncol 14 Suppl 4:iv73-iv80.
http://www.ncbi.nlm.nih.gov/pubmed/23095833

Pircher J, Merkle M, Wornle M, Ribeiro A, Czermak T, Stampnik Y, . . . Krotz F (2012) Prothrombotic effects of tumor necrosis factor alpha in vivo are amplified by the absence of TNF-alpha receptor subtype 1 and require TNF-alpha receptor subtype 2. Arthritis Res Ther 14:R225.
http://www.ncbi.nlm.nih.gov/pubmed/23079185

Qi L, Li JM, Sun H, Huang XQ, Lin KQ, Chu JY, Yang ZQ (2012) [Association between gene polymorphisms and myocardial infarction in Han Chinese of Yunnan province]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 29:413-419.
http://www.ncbi.nlm.nih.gov/pubmed/22875497

Ro H, Lee EW, Hong JH, Han KH, Yeom HJ, Kim HJ, . . . Yang J (2012) Roles of Islet Toll-like Receptors in Pig to Mouse Islet Xenotransplantation. Cell Transplant.
http://www.ncbi.nlm.nih.gov/pubmed/23051007

Saja MF, Abdo AA, Sanai FM, Shaikh SA, Gader AG (2012) The coagulopathy of liver disease: does vitamin K help? Blood Coagul Fibrinolysis.
http://www.ncbi.nlm.nih.gov/pubmed/23080365

Sattler S, Schwartz A (2012) Does the use of recombinant factor VIIA reduce morbidity or mortality in nonhemophiliac patients? Ann Emerg Med 60:160-161.
http://www.ncbi.nlm.nih.gov/pubmed/22542308

Sauna ZE, Pandey GS, Jain N, Mahmood I, Kimchi-Sarfaty C, Golding B (2012) Plasma derivatives: new products and new approaches. Biologicals 40:191-195.
http://www.ncbi.nlm.nih.gov/pubmed/22239993

Singh A, Foster GD, Gunawardana J, McCoy TA, Nguyen T, Vander Veur S, . . . Rao AK (2012) Elevated circulating tissue factor procoagulant activity, factor VII, and plasminogen activator inhibitor-1 in childhood obesity: evidence of a procoagulant state. Br J Haematol 158:523-527.
http://www.ncbi.nlm.nih.gov/pubmed/22612792

Skeppholm M, Mobarrez F, Malmqvist K, Wallen H (2012) Platelet-derived microparticles during and after acute coronary syndrome. Thromb Haemost 107:1122-1129.
http://www.ncbi.nlm.nih.gov/pubmed/22371053

Smejkal P, Bulikova A, Chlupova G, Zavrelova J (2012) [Acquired haemophilia A]. Vnitr Lek 58:571-578.
http://www.ncbi.nlm.nih.gov/pubmed/23067181

Stavik B, Skretting G, Olstad OK, Sletten M, Dehli Vigeland M, Sandset PM, Iversen N (2012) TFPI Alpha and Beta Regulate mRNAs and microRNAs Involved in Cancer Biology and in the Immune System in Breast Cancer Cells. PLoS One 7:e47184.
http://www.ncbi.nlm.nih.gov/pubmed/23071754

Steward RG, Saleh OA, James AH, Shah AA, Price TM (2012) Management of gynecologic surgery in the patient with factor XI deficiency: a review of the literature. Obstet Gynecol Surv 67:291-297.
http://www.ncbi.nlm.nih.gov/pubmed/22624777

Suzuki A, Miyawaki Y, Okuyama E, Murata M, Ando Y, Kato I, . . . Kojima T (2012) Ribavirin-induced intracellular GTP depletion activates transcription elongation in coagulation factor VII gene expression. Biochem J.
http://www.ncbi.nlm.nih.gov/pubmed/23050902

Tardy-Poncet B, Piot M, Brunet D, Chapelle C, Bonardel M, Mismetti P, . . . Tardy B (2012) TFPI resistance related to inherited or acquired protein S deficiency. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/23079294

Thaler J, Preusser M, Ay C, Kaider A, Marosi C, Zielinski C, . . . Hainfellner JA (2012) Intratumoral tissue factor expression and risk of venous thromboembolism in brain tumor patients. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/23084660

Valentino LA, Walsh CE, Reding MT, Young GA, Levendoglu-Tugal O, Cooper DL (2012) Patient- and caregiver-reported bleeding symptoms and reasons for starting and stopping treatment with recombinant factor VIIa: analysis of the Dosing Observational Study in Haemophilia (DOSE). Haemophilia 18:554-560.
http://www.ncbi.nlm.nih.gov/pubmed/22348407

Van Dreden P, Woodhams B, Rousseau A, Dreyfus JF, Vasse M (2012) Contribution of procoagulant phospholipids, thrombomodulin activity and thrombin generation assays as prognostic factors in intensive care patients with septic and non-septic organ failure. Clin Chem Lab Med.
http://www.ncbi.nlm.nih.gov/pubmed/23096108

Van Geffen M, Menegatti M, Loof A, Lap P, Karimi M, Laros-van Gorkom BA, . . . Van Heerde WL (2012) Retrospective evaluation of bleeding tendency and simultaneous thrombin and plasmin generation in patients with rare bleeding disorders. Haemophilia 18:630-638.
http://www.ncbi.nlm.nih.gov/pubmed/22404435

Walenga JM, Jeske WP, Hoppensteadt D, Cunanan J, Khan H, Escalante V, . . . Bakhos M (2012) Comparative Studies on Branded Enoxaparin and a US Generic Version of Enoxaparin. Clin Appl Thromb Hemost.
http://www.ncbi.nlm.nih.gov/pubmed/23091283

Wunderink RG, Mandell L (2012) Adjunctive therapy in community-acquired pneumonia. Semin Respir Crit Care Med 33:311-318.
http://www.ncbi.nlm.nih.gov/pubmed/22718217

Zangari M, Berno T, Zhan F, Tricot G, Fink L (2012) Mechanisms of Thrombosis in Paraproteinemias: The Effects of Immunomodulatory Drugs. Semin Thromb Hemost.
http://www.ncbi.nlm.nih.gov/pubmed/23104518

Zderic TW, Hamilton MT (2012) Identification of hemostatic genes expressed in human and rat leg muscles and a novel gene (LPP1/PAP2A) suppressed during prolonged physical inactivity (sitting). Lipids Health Dis 11:137.
http://www.ncbi.nlm.nih.gov/pubmed/23061662


__________________________________________________________
ABOUT TRIGGER
TRIGGER is edited by Jim Morrissey and Pierre Neuenschwander, with editorial assistance by Genie Morrissey. It includes Abstracts of Papers in Press, Meeting Announcements, Positions Sought/Available,or any other pertinent item that subscribers may want to share with their colleagues. To submit an item for publication in Trigger, e-mail us. To request or cancel a subscription,or for more information about TRIGGER or the biology of tissue factor and factor VII, visit our web site. You can also contact us by mail: J.H. Morrissey, University of Illinois College of Medicine, 417 Med Sci Bldg MC-714, 506 S. Mathews Ave., Urbana, IL 61801, USA.

DISCLAIMER: TRIGGER is provided "as is" for information purposes only and without warranty of any kind, express or implied. Users shall assume the entire risk as to the accuracy and usefulness of information in TRIGGER. Opinions expressed here are not necessarily those of the editors or their employers. You may share TRIGGER with your scientific colleagues but you are not permitted to use it or its contents for commercial purposes.
__________________________________________________________

Monday, October 15, 2012

Vol. 18, No. 20

TRIGGER
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 18, No. 20  October 15, 2012
(The next issue will be on November 1, 2012)
__________________________________________________________
TRIGGER is also available by RSS Feed:
and BLOG:
http://trigger-tf7.blogspot.com/
__________________________________________________________
PAPERS IN PRESS
None Submitted for this issue.
__________________________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI
Papers are culled from NLM MedLine (PubMed). Titles in square brackets indicate that the paper was not published in English. References that lack volume or page numbers are typically electronic pre-publications (E-pubs) ahead of the print publication; if so, the final citation with volume and page numbers may or may not appear in a future issue of Trigger.
THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1FOX0jiy08bdn0oftutiDpz/

Agerso H, Tranholm M (2012) Pharmacokinetics and pharmacodynamics of rFVIIa and new improved bypassing agents for the treatment of haemophilia. Haemophilia 18 Suppl 5:6-10.
http://www.ncbi.nlm.nih.gov/pubmed/22757678

Astrup E, Lekva T, Davi G, Otterdal K, Santilli F, Oie E, . . . Aukrust P (2012) A Complex Interaction between Rickettsia conorii and Dickkopf-1 - Potential Role in Immune Evasion Mechanisms in Endothelial Cells. PLoS One 7:e43638.
http://www.ncbi.nlm.nih.gov/pubmed/23028464

Bastarache JA, Sebag SC, Clune JK, Grove BS, Lawson WE, Janz DR, . . . Ware LB (2012) Low levels of tissue factor lead to alveolar haemorrhage, potentiating murine acute lung injury and oxidative stress. Thorax.
http://www.ncbi.nlm.nih.gov/pubmed/23033361

Bonnet MP, Basso O (2012) Prohemostatic interventions in obstetric hemorrhage. Semin Thromb Hemost 38:259-264.
http://www.ncbi.nlm.nih.gov/pubmed/22510859

Caviglia H, Narayan P, Forsyth A, Giangrande P, Gilbert M, Goddard N, . . . Rahim S (2012) Musculoskeletal problems in persons with inhibitors: how do we treat? Haemophilia 18 Suppl 4:54-60.
http://www.ncbi.nlm.nih.gov/pubmed/22726084

Cesarman-Maus G, Braggio E, Maldonado H, Fonseca R (2012) Absence of tissue factor expression by neoplastic plasma cells in multiple myeloma. Leukemia 26:1671-1674.
http://www.ncbi.nlm.nih.gov/pubmed/22333877

Chantrathammachart P, Mackman N, Sparkenbaugh E, Wang JG, Parise LV, Kirchhofer D, . . . Pawlinski R (2012) Tissue factor promotes activation of coagulation and inflammation in a mouse model of sickle cell disease. Blood 120:636-646.
http://www.ncbi.nlm.nih.gov/pubmed/22661702

Chitlur M (2012) Challenges in the laboratory analyses of bleeding disorders. Thromb Res 130:1-6.
http://www.ncbi.nlm.nih.gov/pubmed/22483776

Dahm AE, Eilertsen AL, Goeman J, Olstad OK, Ovstebo R, Kierulf P, . . . Sandset PM (2012) A microarray study on the effect of four hormone therapy regimens on gene transcription in whole blood from healthy postmenopausal women. Thromb Res 130:45-51.
http://www.ncbi.nlm.nih.gov/pubmed/22217510

Guzzetta NA, Russell IA, Williams GD (2012) Review of the off-label use of recombinant activated factor VII in pediatric cardiac surgery patients. Anesth Analg 115:364-378.
http://www.ncbi.nlm.nih.gov/pubmed/22652310

Howard BM, Daley AT, Cohen MJ (2012) Prohemostatic interventions in trauma: resuscitation-associated coagulopathy, acute traumatic coagulopathy, hemostatic resuscitation, and other hemostatic interventions. Semin Thromb Hemost 38:250-258.
http://www.ncbi.nlm.nih.gov/pubmed/22467527

Huber AW, Raio L, Alberio L, Ghezzi F, Surbek DV (2011) Recombinant human factor VIIa prevents hysterectomy in severe postpartum hemorrhage: single center study. J Perinat Med 40:43-49.
http://www.ncbi.nlm.nih.gov/pubmed/22017328

Kambas K, Mitroulis I, Apostolidou E, Girod A, Chrysanthopoulou A, Pneumatikos I, . . . Ritis K (2012) Autophagy mediates the delivery of thrombogenic tissue factor to neutrophil extracellular traps in human sepsis. PLoS One 7:e45427.
http://www.ncbi.nlm.nih.gov/pubmed/23029002

Kandane-Rathnayake RK, Isbister JP, Zatta AJ, Aoki NJ, Cameron P, Phillips LE (2012) Use of recombinant activated factor VII in Jehovah's Witness patients with critical bleeding. ANZ J Surg.
http://www.ncbi.nlm.nih.gov/pubmed/23035873

Kim G, Kim H, Kim KN, Son JI, Kim SY, Tamura T, Chang N (2012) Relationship of Cognitive Function with B Vitamin Status, Homocysteine, and Tissue Factor Pathway Inhibitor in Cognitively Impaired Elderly: A Cross-Sectional Survey. J Alzheimers Dis.
http://www.ncbi.nlm.nih.gov/pubmed/23042212

Kim JE, Kim KJ, Ahn W, Han KS, Kim HK (2011) Local anesthetics inhibit tissue factor expression in activated monocytes via inhibition of tissue factor mRNA synthesis. Clin Appl Thromb Hemost 17:E4-9.
http://www.ncbi.nlm.nih.gov/pubmed/20699252

Kogiso N, Taki M, Takamiya O (2011) Factor VII deficiency due to compound heterozygosity for Leu-48Pro mutation and a novel Pro260Leu mutation. Clin Appl Thromb Hemost 17:E205-210.
http://www.ncbi.nlm.nih.gov/pubmed/21441234

Koizume S, Ito S, Miyagi E, Hirahara F, Nakamura Y, Sakuma Y, . . . Miyagi Y (2012) HIF2alpha-Sp1 interaction mediates a deacetylation-dependent FVII-gene activation under hypoxic conditions in ovarian cancer cells. Nucleic Acids Res 40:5389-5401.
http://www.ncbi.nlm.nih.gov/pubmed/22402494

Kothari H, Rao LV, Vankayalapati R, Pendurthi UR (2012) Mycobacterium tuberculosis Infection and Tissue Factor Expression in Macrophages. PLoS One 7:e45700.
http://www.ncbi.nlm.nih.gov/pubmed/23029190

Kubier A, O'Brien M (2012) Endogenous anticoagulants. Top Companion Anim Med 27:81-87.
http://www.ncbi.nlm.nih.gov/pubmed/23031460

Lee AM, Tormoen GW, Kanso E, McCarty OJ, Newton PK (2012) Modeling and Simulation of Procoagulant Circulating Tumor Cells in Flow. Front Oncol 2:108.
http://www.ncbi.nlm.nih.gov/pubmed/23050240

Levy JH, Sniecinski RM (2012) Prohemostatic treatment in cardiac surgery. Semin Thromb Hemost 38:237-243.
http://www.ncbi.nlm.nih.gov/pubmed/22510857

Monroe DM, Hoffman M (2012) The clotting system - a major player in wound healing. Haemophilia 18 Suppl 5:11-16.
http://www.ncbi.nlm.nih.gov/pubmed/22757679

O'Brien M (2012) The reciprocal relationship between inflammation and coagulation. Top Companion Anim Med 27:46-52.
http://www.ncbi.nlm.nih.gov/pubmed/23031455

Peled E, Rovitsky A, Axelman E, Norman D, Brenner B, Nadir Y (2012) Increased heparanase level and procoagulant activity in orthopedic surgery patients receiving prophylactic dose of enoxaparin. Thromb Res 130:129-134.
http://www.ncbi.nlm.nih.gov/pubmed/22154361

Persson E, Olsen OH, Bjorn SE, Ezban M (2012) Vatreptacog alfa from conception to clinical proof of concept. Semin Thromb Hemost 38:274-281.
http://www.ncbi.nlm.nih.gov/pubmed/22510860

Peyvandi F, Bolton-Maggs PH, Batorova A, De Moerloose P (2012) Rare bleeding disorders. Haemophilia 18 Suppl 4:148-153.
http://www.ncbi.nlm.nih.gov/pubmed/22726099

Ranucci M, Baryshnikova E, Colella D (2012) Monitoring prohemostatic treatment in bleeding patients. Semin Thromb Hemost 38:282-291.
http://www.ncbi.nlm.nih.gov/pubmed/22510861

Sanchez-Solana B, Motwani M, Li DQ, Eswaran J, Kumar R (2012) P21-activated kinase-1 signaling regulates transcription of tissue factor and tissue factor pathway inhibitor. J Biol Chem.
http://www.ncbi.nlm.nih.gov/pubmed/23038262

Seligsohn U (2012) Treatment of inherited platelet disorders. Haemophilia 18 Suppl 4:161-165.
http://www.ncbi.nlm.nih.gov/pubmed/22726101

Shibeko AM, Woodle SA, Lee TK, Ovanesov MV (2012) Unifying the mechanism of recombinant FVIIa action: dose dependence is regulated differently by tissue factor and phospholipids. Blood 120:891-899.
http://www.ncbi.nlm.nih.gov/pubmed/22563088

Stellingwerff M, Brandsma A, Lisman T, Porte RJ (2012) Prohemostatic interventions in liver surgery. Semin Thromb Hemost 38:244-249.
http://www.ncbi.nlm.nih.gov/pubmed/22510858

Stepien E, Kablak-Ziembicka A, Czyz J, Przewlocki T, Malecki M (2012) Microparticles, not only markers but also a therapeutic target in the early stage of diabetic retinopathy and vascular aging. Expert Opin Ther Targets 16:677-688.
http://www.ncbi.nlm.nih.gov/pubmed/22616736

Vadivel K, Bajaj SP (2012) Structural biology of factor VIIa/tissue factor initiated coagulation. Front Biosci 17:2476-2494.
http://www.ncbi.nlm.nih.gov/pubmed/22652793

Vaitkiene P, Skiriute D, Skauminas K, Tamasauskas A (2012) Associations Between TFPI-2 Methylation and Poor Prognosis in Glioblastomas. Medicina (Kaunas) 48:345-349.
http://www.ncbi.nlm.nih.gov/pubmed/23032906

Vanden Hoek AL, Talbot K, Carter IS, Vickars L, Carter CJ, Jackson SC, . . . Pryzdial EL (2012) Coagulation Factor X Arg386 specifically affects activation by the intrinsic pathway: A novel patient mutation. J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/23039000

von Kanel R, Natarajan L, Ancoli-Israel S, Mills PJ, Wolfson T, Gamst AC, . . . Dimsdale JE (2012) Effect of continuous positive airway pressure on day/night rhythm of prothrombotic markers in obstructive sleep apnea. Sleep Med.
http://www.ncbi.nlm.nih.gov/pubmed/23036264
__________________________________________________________
ABOUT TRIGGER
TRIGGER is edited by Jim Morrissey and Pierre Neuenschwander, with editorial assistance by Genie Morrissey. It includes Abstracts of Papers in Press, Meeting Announcements, Positions Sought/Available,or any other pertinent item that subscribers may want to share with their colleagues. To submit an item for publication in Trigger, e-mail us. To request or cancel a subscription,or for more information about TRIGGER or the biology of tissue factor and factor VII, visit our web site. You can also contact us by mail: J.H. Morrissey, University of Illinois College of Medicine, 417 Med Sci Bldg MC-714, 506 S. Mathews Ave., Urbana, IL 61801, USA.

DISCLAIMER: TRIGGER is provided "as is" for information purposes only and without warranty of any kind, express or implied. Users shall assume the entire risk as to the accuracy and usefulness of information in TRIGGER. Opinions expressed here are not necessarily those of the editors or their employers. You may share TRIGGER with your scientific colleagues but you are not permitted to use it or its contents for commercial purposes.
__________________________________________________________

Monday, October 1, 2012

Vol. 18, No. 19

TRIGGER
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 18, No. 19  October 1, 2012
(The next issue will be on October 15, 2012)
__________________________________________________________
TRIGGER is also available by RSS Feed:
and BLOG:
http://trigger-tf7.blogspot.com/
__________________________________________________________
PAPERS IN PRESS
None Submitted for this issue.
__________________________________________________________
UPCOMING MEETINGS & EVENTS
http://tf7.org/meetings.htm

The Arteriosclerosis, Thrombosis and Vascular Biology 2013 Scientific Sessions will be held May 1-3, 2013 at The Dolphin Hotel, Lake Buena Vista, FL.  2013 abstract submission opens October 16, 2012 and closes January 25, 2013; registration begins December 14, 2012.
For more information, visit:
http://my.americanheart.org/professional/Sessions/ATVB/ATVB_UCM_316902_SubHomePage.jsp
__________________________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI
Papers are culled from NLM MedLine (PubMed). Titles in square brackets indicate that the paper was not published in English. References that lack volume or page numbers are typically electronic pre-publications (E-pubs) ahead of the print publication; if so, the final citation with volume and page numbers may or may not appear in a future issue of Trigger.
THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1lyqvsHwCB_wn7Uubr_Le15/

Alioglu B, Kilic N, Simsek E, Dallar Y (2012) Increased thrombin-activatable fibrinolysis inhibitor and decreased tissue factor pathway inhibitor and thrombomodulin levels in children with hypothyroidism. J Clin Res Pediatr Endocrinol 4:146-150.
http://www.ncbi.nlm.nih.gov/pubmed/22985614

Bao Y, Jin Y, Chivukula P, Zhang J, Liu Y, Liu J, . . . Yu L (2012) Effect of PEGylation on Biodistribution and Gene Silencing of siRNA/Lipid Nanoparticle Complexes. Pharm Res.
http://www.ncbi.nlm.nih.gov/pubmed/22983644

Batty P, Platton S, Hart D, Pasi J (2012) An unusual cause of bleeding in an elderly patient. Clin Med 12:397-398.
http://www.ncbi.nlm.nih.gov/pubmed/22930895

Baudo F, Collins P, Huth-Kuhne A, Levesque H, Marco P, Nemes L, . . . Knoebl P (2012) Management of bleeding in acquired hemophilia A: results from the European Acquired Haemophilia (EACH2) Registry. Blood 120:39-46.
http://www.ncbi.nlm.nih.gov/pubmed/22618709

Bockeria LA, Kupryashov AA, Samsonova NN (2012) eComment. Recombinant activated factor VII in pediatric cardiac surgery: possibilities and limitations. Interact Cardiovasc Thorac Surg 15:694-695.
http://www.ncbi.nlm.nih.gov/pubmed/22991396

Borkham-Kamphorst E, Zimmermann HW, Gassler N, Bissels U, Bosio A, Tacke F, . . . Kanse SM (2012) Factor VII activating protease (FSAP) exerts anti-inflammatory and anti-fibrotic effects in liver fibrosis in mice and men. J Hepatol.
http://www.ncbi.nlm.nih.gov/pubmed/22989567

Brekke OL, Waage C, Christiansen D, Fure H, Qu H, Lambris JD, . . . Mollnes TE (2013) The Effects of Selective Complement and CD14 Inhibition on the E. coli-Induced Tissue Factor mRNA Upregulation, Monocyte Tissue Factor Expression, and Tissue Factor Functional Activity in Human Whole Blood. Adv Exp Med Biol 734:123-136.
http://www.ncbi.nlm.nih.gov/pubmed/22990699

Brosnan JF, Sheppard BL, Kelly LA, O'Leary JJ, Norris LA (2012) Norethisterone acetate alters coagulation gene expression in vitro in human cell culture. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/22999413

Butenas S, Krudysz-Amblo J (2012) Decryption of tissue factor. Thromb Res 129 Suppl 2:S18-20.
http://www.ncbi.nlm.nih.gov/pubmed/22401800

Caulfield AJ, Lathem WW (2012) Substrates of the plasminogen activator protease of Yersinia pestis. Adv Exp Med Biol 954:253-260.
http://www.ncbi.nlm.nih.gov/pubmed/22782771

Chantrathammachart P, Pawlinski R (2012) Tissue factor and thrombin in sickle cell anemia. Thromb Res 129 Suppl 2:S70-72.
http://www.ncbi.nlm.nih.gov/pubmed/22398014

Chuang TD, Luo X, Panda H, Chegini N (2012) miR-93/106b and their host gene, MCM7, are differentially expressed in leiomyomas and functionally target F3 and IL-8. Mol Endocrinol 26:1028-1042.
http://www.ncbi.nlm.nih.gov/pubmed/22556343

Dieterich M, Mann E, Wagner KF, Kramer-Steiner B, Reimer T, Gerber B, Stubert J (2011) Desmopressin-induced Moschcowitz-like syndrome after treatment of uterine atonic bleeding in a 28-year-old pregnant woman: case report and overview of the literature. Blood Coagul Fibrinolysis 22:749-751.
http://www.ncbi.nlm.nih.gov/pubmed/21921792

Egorina EM, Sovershaev MA, Bogdanov VY, Sovershaev TA, Fallon JT, Seredkina N, . . . Hansen JB (2011) Low thrombogenicity of calcified atherosclerotic plaques is associated with bone morphogenetic protein-2-dependent inhibition of tissue factor expression. Blood Coagul Fibrinolysis 22:642-650.
http://www.ncbi.nlm.nih.gov/pubmed/21897206

Garrido-Serrano A (2012) Management of severe sphincterotomy bleeding with recombinant activated factor VII. Gastrointest Endosc 76:925-926.
http://www.ncbi.nlm.nih.gov/pubmed/22985655

Girolami A, de Marinis GB, Bonamigo E, Lombardi AM (2012) Recombinant FVIIa concentrate-associated thrombotic events in congenital bleeding disorders other than hemophilias. Hematology.
http://www.ncbi.nlm.nih.gov/pubmed/22980722

Goodnough LT (2012) A reappraisal of plasma, prothrombin complex concentrates, and recombinant factor VIIa in patient blood management. Crit Care Clin 28:413-426, vi-vii.
http://www.ncbi.nlm.nih.gov/pubmed/22713615

Hao F, Wu DD, Xu X, Cui MZ (2012) Histamine induces activation of protein kinase D that mediates tissue factor expression and activity in human aortic smooth muscle cells. Am J Physiol Heart Circ Physiol.
http://www.ncbi.nlm.nih.gov/pubmed/23001835

Harenberg J, Marx S, Kramer R, Giese C, Weiss C (2011) Determination of an international sensitivity index of thromboplastin reagents using a WHO thromboplastin as calibrator for plasma spiked with rivaroxaban. Blood Coagul Fibrinolysis 22:637-641.
http://www.ncbi.nlm.nih.gov/pubmed/21986465

Hoffman M (2012) Hemostatic properties of the FVIIa analog NN1731. Thromb Res 129 Suppl 2:S49-50.
http://www.ncbi.nlm.nih.gov/pubmed/22446168

Hong H, Zhang Y, Nayak TR, Engle JW, Wong HC, Liu B, . . . Cai W (2012) Immuno-PET of Tissue Factor in Pancreatic Cancer. J Nucl Med.
http://www.ncbi.nlm.nih.gov/pubmed/22988057

Kaufner L, Schuster M, Vogt M, Kroncke TJ, von Heymann C (2012) [Case Report: Recurrent postpartum haemorrhage after emergency caesarean section - Clipping, embolization and haemostaseological therapy]. Anasthesiol Intensivmed Notfallmed Schmerzther 47:308-314.
http://www.ncbi.nlm.nih.gov/pubmed/22628026

Kushnir MM, Naessen T, Wanggren K, Rockwood AL, Crockett DK, Bergquist J (2012) Protein and Steroid Profiles in Follicular Fluid after Ovarian Hyperstimulation as Potential Biomarkers of IVF Outcome. J Proteome Res.
http://www.ncbi.nlm.nih.gov/pubmed/22988950

Lacroix R, Dignat-George F (2012) Microparticles as a circulating source of procoagulant and fibrinolytic activities in the circulation. Thromb Res 129 Suppl 2:S27-29.
http://www.ncbi.nlm.nih.gov/pubmed/22424856

Lad SP, Hegen H, Gupta G, Deisenhammer F, Steinberg GK (2012) Proteomic biomarker discovery in cerebrospinal fluid for cerebral vasospasm following subarachnoid hemorrhage. J Stroke Cerebrovasc Dis 21:30-41.
http://www.ncbi.nlm.nih.gov/pubmed/20851633

Levi M, van der Poll T (2012) Disseminated intravascular coagulation: a review for the internist. Intern Emerg Med.
http://www.ncbi.nlm.nih.gov/pubmed/23015284

Liu X, Xue Y, Ding T, Sun J (2012) Enhancement of proinflammatory and procoagulant responses to silica particles by monocyte-endothelial cell interactions. Part Fibre Toxicol 9:36.
http://www.ncbi.nlm.nih.gov/pubmed/22985792

Mann KG, Krudysz-Amblo J, Butenas S (2012) Tissue factor controversies. Thromb Res 129 Suppl 2:S5-7.
http://www.ncbi.nlm.nih.gov/pubmed/22401799

Maroney SA, Mast AE (2012) Platelet tissue factor pathway inhibitor modulates intravascular coagulation. Thromb Res 129 Suppl 2:S21-22.
http://www.ncbi.nlm.nih.gov/pubmed/22425319

McCarthy GC, Allen TK, Habib AS (2012) Pulmonary embolism after administration of recombinant activated Factor VII for major obstetric hemorrhage. J Clin Anesth 24:508-509.
http://www.ncbi.nlm.nih.gov/pubmed/22986324

Morrissey JH, Tajkhorshid E, Sligar SG, Rienstra CM (2012) Tissue factor/factor VIIa complex: role of the membrane surface. Thromb Res 129 Suppl 2:S8-10.
http://www.ncbi.nlm.nih.gov/pubmed/22417943

Natorska J, Wypasek E, Grudzien G, Sobczyk D, Marek G, Filip G, . . . Undas A (2012) Does diabetes accelerate the progression of aortic stenosis through enhanced inflammatory response within aortic valves? Inflammation 35:834-840.
http://www.ncbi.nlm.nih.gov/pubmed/21935671

Neri T, Cordazzo C, Carmazzi Y, Petrini S, Balia C, Stefanelli F, . . . Celi A (2012) Effects of peroxisome proliferator-activated receptor-gamma agonists on the generation of microparticles by monocytes/macrophages. Cardiovasc Res 94:537-544.
http://www.ncbi.nlm.nih.gov/pubmed/22425902

Olbrich P, Parrilla Parrilla J, Caballero Eraso C, Loscertales Abril M, Neth O (2012) Combined use of recombinant activated factor VII and ECMO in severe postoperative bleeding after cardiac surgery in a newborn: death due to ventricular dysfunction. Klin Padiatr 224:193-194.
http://www.ncbi.nlm.nih.gov/pubmed/22504771

Owens AP, 3rd, Mackman N (2012) Sources of tissue factor that contribute to thrombosis after rupture of an atherosclerotic plaque. Thromb Res 129 Suppl 2:S30-33.
http://www.ncbi.nlm.nih.gov/pubmed/22444158

Peraramelli S, Rosing J, Hackeng TM (2012) TFPI-dependent activities of protein S. Thromb Res 129 Suppl 2:S23-26.
http://www.ncbi.nlm.nih.gov/pubmed/22425215

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ABOUT TRIGGER
TRIGGER is edited by Jim Morrissey and Pierre Neuenschwander, with editorial assistance by Genie Morrissey. It includes Abstracts of Papers in Press, Meeting Announcements, Positions Sought/Available,or any other pertinent item that subscribers may want to share with their colleagues. To submit an item for publication in Trigger, e-mail us. To request or cancel a subscription,or for more information about TRIGGER or the biology of tissue factor and factor VII, visit our web site. You can also contact us by mail: J.H. Morrissey, University of Illinois College of Medicine, 417 Med Sci Bldg MC-714, 506 S. Mathews Ave., Urbana, IL 61801, USA.

DISCLAIMER: TRIGGER is provided "as is" for information purposes only and without warranty of any kind, express or implied. Users shall assume the entire risk as to the accuracy and usefulness of information in TRIGGER. Opinions expressed here are not necessarily those of the editors or their employers. You may share TRIGGER with your scientific colleagues but you are not permitted to use it or its contents for commercial purposes.
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