TRIGGER
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 17, No. 10 May 16, 2011
(The next issue will be on June 1, 2011)
__________________________________________________________
TRIGGER is also available by RSS Feed:
http://feeds.feedburner.com/blogspot/glro
and BLOG:
http://trigger-tf7.blogspot.com/
__________________________________________________________
PAPERS IN PRESS
AUTHORS: Tavoosi N, Davis-Harrison RL, Pogorelov TV, Ohkubo YZ, Arcario MJ, Clay MC, Rienstra CM, Tajkhorshid E and Morrissey JH
TITLE: Molecular determinants of phospholipid synergy in blood clotting
JOURNAL: The Journal of Biological Chemistry
ABSTRACT: Many regulatory processes in biology involve reversible association of proteins with membranes. Clotting proteins bind to phosphatidylserine on cell surfaces, but a clear picture of this
interaction has yet to emerge. We present a novel explanation for membrane binding by GLA domains of clotting proteins, supported by biochemical studies, solid-state NMR analyses and molecular dynamics simulations. The model invokes a single "phospho-L-serine-specific" interaction and multiple "phosphate-specific" interactions. In the latter, the phosphates in phospholipids interact with tightly bound Ca2+ in GLA domains. We show that phospholipids with any headgroup other than choline strongly synergize with phosphatidylserine to enhance factor X activation. We propose that phosphatidylcholine and sphingomyelin (the major external phospholipids of healthy cells) are
anticoagulant primarily because their bulky choline headgroups sterically hinder access to their phosphates. Following cell damage or activation, exposed phosphatidylserine and
phosphatidylethanolamine collaborate to bind GLA domains, by providing phospho-L-serine-specific and phosphate-specific interactions, respectively.
PREPRINT: http://www.jbc.org/content/early/2011/05/11/jbc.M111.251769
SUBMITTED BY: Jim Morrissey: jhmorris AT illinois DOT edu
__________________________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI
Papers are culled from NLM MedLine (PubMed). Titles in square brackets indicate that the paper was not published in English. References that lack volume or page numbers are typically electronic pre-publications (E-pubs) ahead of the print publication; if so, the final citation with volume and page numbers may or may not appear in a future issue of Trigger.
THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1fsZsuNJhHORjzcAXyzPROE/
Bergrem A, Dahm AE, Jacobsen AF, Mowinckel MC, Sandvik L, Sandset PM (2011) Resistance to activated protein C is a risk factor for pregnancy-related venous thrombosis in the absence of the F5 rs6025 (factor V Leiden) polymorphism. Br J Haematol.
http://www.ncbi.nlm.nih.gov/pubmed/21564075
Ferrari L, Podda GM (2011) Off-label use of recombinant activated coagulation factor VII for bleeding may raise the risk of arterial thrombosis. Intern Emerg Med.
http://www.ncbi.nlm.nih.gov/pubmed/21541718
Gessler F, Voss V, Seifert V, Gerlach R, Kogel D (2011) Knockdown of TFPI-2 promotes migration and invasion of glioma cells. Neurosci Lett.
http://www.ncbi.nlm.nih.gov/pubmed/21530612
Gouni-Berthold I, Berthold HK (2011) Lipoprotein(a): Current Perspectives. Curr Vasc Pharmacol.
http://www.ncbi.nlm.nih.gov/pubmed/21529331
Gray LD, Hussey MA, Larson BM, Machlus KR, Campbell RA, Koch G, . . . Wolberg AS (2011) Recombinant factor VIIa analog NN1731 (V158D/E296V/M298Q-FVIIa) enhances fibrin formation, structure and stability in lipidated hemophilic plasma. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/21561645
Hacquard M, Durand M, Lecompte T, Boini S, Briancon S, Carteaux JP (2011) Off-label use of recombinant activated factor VII in intractable haemorrhage after cardiovascular surgery: an
observational study of practices in 23 French cardiac centres (2005-7). Eur J Cardiothorac Surg.
http://www.ncbi.nlm.nih.gov/pubmed/21550261
Jiang MH, Wang ZY, Yu ZQ, Bai X, Cao LJ, Su J, . . . Ruan CG (2011) [Genotype and phenotype analysis of congenital coagulator factor VII deficiency in four Chinese pedigrees.]. Zhonghua Xue Ye Xue Za Zhi 32:147-152.
http://www.ncbi.nlm.nih.gov/pubmed/21535950
Kambas K, Chrysanthopoulou A, Kourtzelis I, Skordala M, Mitroulis I, Rafail S, . . . Ritis K (2011) Endothelin-1 Signaling Promotes Fibrosis In Vitro in a Bronchopulmonary Dysplasia Model by Activating the Extrinsic Coagulation Cascade. J Immunol.
http://www.ncbi.nlm.nih.gov/pubmed/21531894
Kopp CW, Gremmel T, Steiner S, Seidinger D, Minar E, Maurer G, Huber K (2011) Platelet-monocyte cross talk and tissue factor expression in stable angina vs. unstable angina/non ST-elevation myocardial infarction. Platelets.
http://www.ncbi.nlm.nih.gov/pubmed/21557685
Kothari H, Rao LV, Pendurthi R (2011) Glycosylation of tissue factor is not essential for its transport or functions. J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/21535396
Layland J, Ray MJ, Siresena T, Walters DL (2011) Increased expression of monocyte tissue factor and soluble CD40 ligand at mid-term follow-up following percutaneous coronary intervention. Blood Coagul Fibrinolysis 22:349-350.
http://www.ncbi.nlm.nih.gov/pubmed/21546798
Ma Z, Zhang T, Wang R, Cheng Z, Xu H, Li W, . . . Wang X (2011) Tissue Factor-Factor VIIa Complex Induces Epithelial Ovarian Cancer Cell Invasion and Metastasis Through a Monocytes-Dependent Mechanism. Int J Gynecol Cancer 21:616-624.
http://www.ncbi.nlm.nih.gov/pubmed/21543928
Monteiro RQ (2011) Tissue factor as a target for the treatment of disseminated intravascular coagulation. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/21531009
Opstad TB, Pettersen AA, Bratseth V, Arnesen H, Seljeflot I (2011) The Influence of Tissue Factor and Tissue Factor Pathway Inhibitor Polymorphisms on Thrombin Generation in Stable Coronary Artery Disease. Pathophysiol Haemost Thromb.
http://www.ncbi.nlm.nih.gov/pubmed/21555871
Owens AP, 3rd, Mackman N (2011) Microparticles in hemostasis and thrombosis. Circ Res 108:1284-1297.
http://www.ncbi.nlm.nih.gov/pubmed/21566224
Shirahata A, Fukutake K, Mimaya J, Takamatsu J, Shima M, Hanabusa H, . . . Saito H (2011) Clinical pharmacological study of a plasma-derived factor VIIa and factor X mixture (MC710) in haemophilia patients with inhibitors - Phase I trial. Haemophilia.
http://www.ncbi.nlm.nih.gov/pubmed/21535327
Siboni SM, Zanon E, Sottilotta G, Consonni D, Castaman G, Mikovic D, . . . Peyvandi F (2011) Central nervous system bleeding in patients with rare bleeding disorders. Haemophilia.
http://www.ncbi.nlm.nih.gov/pubmed/21539694
Szmurlo D, Derylo L, Rys P, Wladysiuk M (2011) [Health economics of inhibitor bypassing agents in haemophilia A-activated prothrombin complex concentrate (aPCC) and recombinant activated factor VIIa (rFVIIa)]. Pol Merkur Lekarski 30:202-207.
http://www.ncbi.nlm.nih.gov/pubmed/21544998
Tiede A, Rand JH, Budde U, Ganser A, Federici AB (2011) How I Treat acquired von Willebrand syndrome. Blood.
http://www.ncbi.nlm.nih.gov/pubmed/21540459
Xing ZF, Wang XF, Dai J, Lu YL, Xu GQ, Xi XD, Wang HL (2011) [Two novel mutations in one pedigree with here-ditary Factor VII deficiency.]. Zhonghua Xue Ye Xue Za Zhi 32:158-162.
http://www.ncbi.nlm.nih.gov/pubmed/21535952
Xu GY, Zhou H, Wen HP, Guo DL, Zhou F, Chen DD, Xie HX (2011) [Activation of tumor necrosis factor receptor-associated factor 6 in anti-beta(2);GPI/beta(2);GPI-induced tissue factor expression on
THP-1 cells.]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 27:487-490.
http://www.ncbi.nlm.nih.gov/pubmed/21557901
Zheng F, Jin Y, Wang M, Niu Z, Xu P, Xie H (2011) Congenital combined deficiency of factor VII and X in a patient due to accidental diphacinone intoxication. Thromb Haemost 106.
http://www.ncbi.nlm.nih.gov/pubmed/21544315
__________________________________________________________
ABOUT TRIGGER
TRIGGER is edited by Jim Morrissey and Pierre Neuenschwander, with editorial assistance by Genie Morrissey. It includes Abstracts of Papers in Press, Meeting Announcements, Positions Sought/Available,or any other pertinent item that subscribers may want to share with their colleagues. To submit an item for publication in Trigger, e-mail us. To request or cancel a subscription,or for more information about TRIGGER or the biology of tissue factor and factor VII, visit our web site. You can also contact us by mail: J.H. Morrissey, University of Illinois College of Medicine, 417 Med Sci Bldg MC-714, 506 S. Mathews Ave., Urbana, IL 61801, USA.
DISCLAIMER: TRIGGER is provided "as is" for information purposes only and without warranty of any kind, express or implied. Users shall assume the entire risk as to the accuracy and usefulness of information in TRIGGER. Opinions expressed here are not necessarily those of the editors or their employers. You may share TRIGGER with your scientific colleagues but you are not permitted to use it or its contents for commercial purposes.
__________________________________________________________
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 17, No. 10 May 16, 2011
(The next issue will be on June 1, 2011)
__________________________________________________________
TRIGGER is also available by RSS Feed:
http://feeds.feedburner.com/blogspot/glro
and BLOG:
http://trigger-tf7.blogspot.com/
__________________________________________________________
PAPERS IN PRESS
AUTHORS: Tavoosi N, Davis-Harrison RL, Pogorelov TV, Ohkubo YZ, Arcario MJ, Clay MC, Rienstra CM, Tajkhorshid E and Morrissey JH
TITLE: Molecular determinants of phospholipid synergy in blood clotting
JOURNAL: The Journal of Biological Chemistry
ABSTRACT: Many regulatory processes in biology involve reversible association of proteins with membranes. Clotting proteins bind to phosphatidylserine on cell surfaces, but a clear picture of this
interaction has yet to emerge. We present a novel explanation for membrane binding by GLA domains of clotting proteins, supported by biochemical studies, solid-state NMR analyses and molecular dynamics simulations. The model invokes a single "phospho-L-serine-specific" interaction and multiple "phosphate-specific" interactions. In the latter, the phosphates in phospholipids interact with tightly bound Ca2+ in GLA domains. We show that phospholipids with any headgroup other than choline strongly synergize with phosphatidylserine to enhance factor X activation. We propose that phosphatidylcholine and sphingomyelin (the major external phospholipids of healthy cells) are
anticoagulant primarily because their bulky choline headgroups sterically hinder access to their phosphates. Following cell damage or activation, exposed phosphatidylserine and
phosphatidylethanolamine collaborate to bind GLA domains, by providing phospho-L-serine-specific and phosphate-specific interactions, respectively.
PREPRINT: http://www.jbc.org/content/early/2011/05/11/jbc.M111.251769
SUBMITTED BY: Jim Morrissey: jhmorris AT illinois DOT edu
__________________________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI
Papers are culled from NLM MedLine (PubMed). Titles in square brackets indicate that the paper was not published in English. References that lack volume or page numbers are typically electronic pre-publications (E-pubs) ahead of the print publication; if so, the final citation with volume and page numbers may or may not appear in a future issue of Trigger.
THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1fsZsuNJhHORjzcAXyzPROE/
Bergrem A, Dahm AE, Jacobsen AF, Mowinckel MC, Sandvik L, Sandset PM (2011) Resistance to activated protein C is a risk factor for pregnancy-related venous thrombosis in the absence of the F5 rs6025 (factor V Leiden) polymorphism. Br J Haematol.
http://www.ncbi.nlm.nih.gov/pubmed/21564075
Ferrari L, Podda GM (2011) Off-label use of recombinant activated coagulation factor VII for bleeding may raise the risk of arterial thrombosis. Intern Emerg Med.
http://www.ncbi.nlm.nih.gov/pubmed/21541718
Gessler F, Voss V, Seifert V, Gerlach R, Kogel D (2011) Knockdown of TFPI-2 promotes migration and invasion of glioma cells. Neurosci Lett.
http://www.ncbi.nlm.nih.gov/pubmed/21530612
Gouni-Berthold I, Berthold HK (2011) Lipoprotein(a): Current Perspectives. Curr Vasc Pharmacol.
http://www.ncbi.nlm.nih.gov/pubmed/21529331
Gray LD, Hussey MA, Larson BM, Machlus KR, Campbell RA, Koch G, . . . Wolberg AS (2011) Recombinant factor VIIa analog NN1731 (V158D/E296V/M298Q-FVIIa) enhances fibrin formation, structure and stability in lipidated hemophilic plasma. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/21561645
Hacquard M, Durand M, Lecompte T, Boini S, Briancon S, Carteaux JP (2011) Off-label use of recombinant activated factor VII in intractable haemorrhage after cardiovascular surgery: an
observational study of practices in 23 French cardiac centres (2005-7). Eur J Cardiothorac Surg.
http://www.ncbi.nlm.nih.gov/pubmed/21550261
Jiang MH, Wang ZY, Yu ZQ, Bai X, Cao LJ, Su J, . . . Ruan CG (2011) [Genotype and phenotype analysis of congenital coagulator factor VII deficiency in four Chinese pedigrees.]. Zhonghua Xue Ye Xue Za Zhi 32:147-152.
http://www.ncbi.nlm.nih.gov/pubmed/21535950
Kambas K, Chrysanthopoulou A, Kourtzelis I, Skordala M, Mitroulis I, Rafail S, . . . Ritis K (2011) Endothelin-1 Signaling Promotes Fibrosis In Vitro in a Bronchopulmonary Dysplasia Model by Activating the Extrinsic Coagulation Cascade. J Immunol.
http://www.ncbi.nlm.nih.gov/pubmed/21531894
Kopp CW, Gremmel T, Steiner S, Seidinger D, Minar E, Maurer G, Huber K (2011) Platelet-monocyte cross talk and tissue factor expression in stable angina vs. unstable angina/non ST-elevation myocardial infarction. Platelets.
http://www.ncbi.nlm.nih.gov/pubmed/21557685
Kothari H, Rao LV, Pendurthi R (2011) Glycosylation of tissue factor is not essential for its transport or functions. J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/21535396
Layland J, Ray MJ, Siresena T, Walters DL (2011) Increased expression of monocyte tissue factor and soluble CD40 ligand at mid-term follow-up following percutaneous coronary intervention. Blood Coagul Fibrinolysis 22:349-350.
http://www.ncbi.nlm.nih.gov/pubmed/21546798
Ma Z, Zhang T, Wang R, Cheng Z, Xu H, Li W, . . . Wang X (2011) Tissue Factor-Factor VIIa Complex Induces Epithelial Ovarian Cancer Cell Invasion and Metastasis Through a Monocytes-Dependent Mechanism. Int J Gynecol Cancer 21:616-624.
http://www.ncbi.nlm.nih.gov/pubmed/21543928
Monteiro RQ (2011) Tissue factor as a target for the treatment of disseminated intravascular coagulation. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/21531009
Opstad TB, Pettersen AA, Bratseth V, Arnesen H, Seljeflot I (2011) The Influence of Tissue Factor and Tissue Factor Pathway Inhibitor Polymorphisms on Thrombin Generation in Stable Coronary Artery Disease. Pathophysiol Haemost Thromb.
http://www.ncbi.nlm.nih.gov/pubmed/21555871
Owens AP, 3rd, Mackman N (2011) Microparticles in hemostasis and thrombosis. Circ Res 108:1284-1297.
http://www.ncbi.nlm.nih.gov/pubmed/21566224
Shirahata A, Fukutake K, Mimaya J, Takamatsu J, Shima M, Hanabusa H, . . . Saito H (2011) Clinical pharmacological study of a plasma-derived factor VIIa and factor X mixture (MC710) in haemophilia patients with inhibitors - Phase I trial. Haemophilia.
http://www.ncbi.nlm.nih.gov/pubmed/21535327
Siboni SM, Zanon E, Sottilotta G, Consonni D, Castaman G, Mikovic D, . . . Peyvandi F (2011) Central nervous system bleeding in patients with rare bleeding disorders. Haemophilia.
http://www.ncbi.nlm.nih.gov/pubmed/21539694
Szmurlo D, Derylo L, Rys P, Wladysiuk M (2011) [Health economics of inhibitor bypassing agents in haemophilia A-activated prothrombin complex concentrate (aPCC) and recombinant activated factor VIIa (rFVIIa)]. Pol Merkur Lekarski 30:202-207.
http://www.ncbi.nlm.nih.gov/pubmed/21544998
Tiede A, Rand JH, Budde U, Ganser A, Federici AB (2011) How I Treat acquired von Willebrand syndrome. Blood.
http://www.ncbi.nlm.nih.gov/pubmed/21540459
Xing ZF, Wang XF, Dai J, Lu YL, Xu GQ, Xi XD, Wang HL (2011) [Two novel mutations in one pedigree with here-ditary Factor VII deficiency.]. Zhonghua Xue Ye Xue Za Zhi 32:158-162.
http://www.ncbi.nlm.nih.gov/pubmed/21535952
Xu GY, Zhou H, Wen HP, Guo DL, Zhou F, Chen DD, Xie HX (2011) [Activation of tumor necrosis factor receptor-associated factor 6 in anti-beta(2);GPI/beta(2);GPI-induced tissue factor expression on
THP-1 cells.]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 27:487-490.
http://www.ncbi.nlm.nih.gov/pubmed/21557901
Zheng F, Jin Y, Wang M, Niu Z, Xu P, Xie H (2011) Congenital combined deficiency of factor VII and X in a patient due to accidental diphacinone intoxication. Thromb Haemost 106.
http://www.ncbi.nlm.nih.gov/pubmed/21544315
__________________________________________________________
ABOUT TRIGGER
TRIGGER is edited by Jim Morrissey and Pierre Neuenschwander, with editorial assistance by Genie Morrissey. It includes Abstracts of Papers in Press, Meeting Announcements, Positions Sought/Available,or any other pertinent item that subscribers may want to share with their colleagues. To submit an item for publication in Trigger, e-mail us. To request or cancel a subscription,or for more information about TRIGGER or the biology of tissue factor and factor VII, visit our web site. You can also contact us by mail: J.H. Morrissey, University of Illinois College of Medicine, 417 Med Sci Bldg MC-714, 506 S. Mathews Ave., Urbana, IL 61801, USA.
DISCLAIMER: TRIGGER is provided "as is" for information purposes only and without warranty of any kind, express or implied. Users shall assume the entire risk as to the accuracy and usefulness of information in TRIGGER. Opinions expressed here are not necessarily those of the editors or their employers. You may share TRIGGER with your scientific colleagues but you are not permitted to use it or its contents for commercial purposes.
__________________________________________________________
