TRIGGER
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 17, No. 13 July 5, 2011
(The next issue will be on July 15, 2011)
__________________________________________________________
TRIGGER is also available by RSS Feed:
http://feeds.feedburner.com/blogspot/glro
and BLOG:
http://trigger-tf7.blogspot.com/
__________________________________________________________
PAPERS IN PRESS
None submitted for this issue.
__________________________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI
Papers are culled from NLM MedLine (PubMed). Titles in square brackets indicate that the paper was not published in English. References that lack volume or page numbers are typically electronic pre-publications (E-pubs) ahead of the print publication; if so, the final citation with volume and page numbers may or may not appear in a future issue of Trigger.
THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1X7DvXj4huqJh61LhqsJ9Vf/
Ben-Hadj-Khalifa S, Hezard N, Almawi WY, Lakbakbi S, Mace C, Cornillet-Lefebvre P, . . . Nguyen P (2011) IL-10 modulates fondaparinux inhibition of monocyte-induced thrombin generation. J Thromb Thrombolysis.
http://www.ncbi.nlm.nih.gov/pubmed/21725623
Brophy DF, Martin EJ, Barrett JC, Nolte ME, Kuhn JG, Hedner U, Ezban M (2011) Overcoming delayed in-vitro response to rFVIIa: effects of rFVIIa and rFVIIa analogue (vatreptacog alfa) concentration escalation in whole blood assays. Blood Coagul Fibrinolysis.
http://www.ncbi.nlm.nih.gov/pubmed/21681082
Carvalhal AV, Santos SS, Carrondo MJ (2011) Extracellular purine and pyrimidine catabolism in cell culture. Biotechnol Prog.
http://www.ncbi.nlm.nih.gov/pubmed/21695809
Cocco E, Varughese J, Buza N, Bellone S, Glasgow M, Bellone M, . . . Santin AD (2011) Expression of Tissue factor in Adenocarcinoma and Squamous Cell Carcinoma of the Uterine Cervix: Implications for immunotherapy with hI-con1, a factor VII-IgGFc chimeric protein targeting tissue factor. BMC Cancer 11:263.
http://www.ncbi.nlm.nih.gov/pubmed/21693061
Cocco E, Varughese J, Buza N, Bellone S, Lin KY, Bellone M, . . . Santin AD (2011) Tissue factor expression in ovarian cancer: implications for immunotherapy with hI-con1, a factor VII-IgGF(c) chimeric protein targeting tissue factor. Clin Exp Metastasis.
http://www.ncbi.nlm.nih.gov/pubmed/21725665
De Rop C, Stadler M, Buchholz S, Eisert R, Ganser A, Trummer A (2011) Evaluation of Tissue Factor Bearing Microparticles as Biomarkers in Allogeneic Stem-Cell Transplantation. Transplantation.
http://www.ncbi.nlm.nih.gov/pubmed/21681142
Girolami A, Bertozzi I, Rigoni I, Muzzolon R, Vettore S (2011) Congenital FVII deficiency and thrombotic events after replacement therapy. J Thromb Thrombolysis.
http://www.ncbi.nlm.nih.gov/pubmed/21681394
Girolami A, de Marinis GB, Bonamigo E, Vettore S (2011) Similarities and Discrepancies in Homozygous Factor VII Defects due to Mutations in the Region of Residues Met298 to Cys310 (Exon 8) in the Catalytic Domain of Factor VII. Lab Hematol 17:17-21.
http://www.ncbi.nlm.nih.gov/pubmed/21705315
Hay JW, Zhou ZY (2011) Systematic literature review of economics analysis on treatment of mild-to-moderate bleeds with aPCC versus rFVIIa. J Med Econ.
http://www.ncbi.nlm.nih.gov/pubmed/21699366
Houghton-Trivino N, Martin K, Giaya K, Rodriguez JA, Bosch I, Castellanos JE (2010) [Comparison of the transcriptional profiles of patients with dengue fever and dengue hemorrhagic fever reveals differences in the immune response and clues in immunopathogenesis.]. Biomedica 30:587-597.
http://www.ncbi.nlm.nih.gov/pubmed/21713363
Kalina M, Tinkoff G, Fulda G (2011) Massive postpartum hemorrhage: recombinant factor VIIa use is safe but not effective. Del Med J 83:109-113.
http://www.ncbi.nlm.nih.gov/pubmed/21675158
Khorana AA (2011) Risk Assessment and Prophylaxis for VTE in Cancer Patients. J Natl Compr Canc Netw 9:789-797.
http://www.ncbi.nlm.nih.gov/pubmed/21715725
Leighton BL, Wall MH, Lockhart EM, Phillips LE, Zatta AJ (2011) Use of Recombinant Factor VIIa in Patients with Amniotic Fluid Embolism: A Systematic Review of Case Reports. Anesthesiology.
http://www.ncbi.nlm.nih.gov/pubmed/21720243
Li P, Yang Y, Liu M (2011) Xuezhikang, extract of red yeast rice, inhibited Tissue Factor and Hypercoagulable state through suppressing NADPH oxidase and ERK activation. J Cardiovasc Pharmacol.
http://www.ncbi.nlm.nih.gov/pubmed/21697731
Lijnen HR, Van Hul M, Hemmeryckx B (2011) Caloric restriction improves coagulation and inflammation profile in obese mice. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/21689844
Luo D, Szaba FM, Kummer LW, Plow EF, Mackman N, Gailani D, Smiley ST (2011) Protective Roles for Fibrin, Tissue Factor, Plasminogen Activator Inhibitor-1, and Thrombin Activatable Fibrinolysis Inhibitor, but Not Factor XI, during Defense against the Gram-Negative Bacterium Yersinia enterocolitica. J Immunol.
http://www.ncbi.nlm.nih.gov/pubmed/21724997
Matejovic M, Chvojka J, Sykora R, Krouzecky A, Radej J, Parizkova R, . . . Cerny V (2011) A 24-h Work Shift in Intensive Care Personnel: Biological Pathways between Work Stress and Ill Health. J Int Med Res 39:629-636.
http://www.ncbi.nlm.nih.gov/pubmed/21672368
Morrissey JH (2011) Low-carb tissue factor? J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/21679295
Noto D, Cefalu AB, Barbagallo CM, Falletta A, Ganci A, Sapienza M, . . . Averna MR (2011) Prediction of incident type 2 diabetes mellitus based on a twenty-year follow-up of the Ventimiglia heart study. Acta Diabetol.
http://www.ncbi.nlm.nih.gov/pubmed/21698484
Oswanski MF, Shaik I, Nazzal M, Calkins K, Stombaugh H, Lowe S (2011) Activated Recombinant Factor VIIa and Uncontrolled Gastrointestinal Bleeding. Am Surg 77:59-61.
http://www.ncbi.nlm.nih.gov/pubmed/21679534
Parunov LA, Fadeeva OA, Balandina AN, Soshitova NP, Kopylov KG, Kumskova MA, . . . Panteleev MA (2011) Improvement of spatial fibrin formation by the anti-TFPI aptamer BAX499: changing clot size by targeting extrinsic pathway initiation. J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/21696535
Phillippe M, Diamond AK, Sweet LM, Oppenheimer KH, Bradley DF (2011) Expression of Coagulation-Related Protein Genes During LPS-Induced Preterm Delivery in the Pregnant Mouse. Reprod Sci.
http://www.ncbi.nlm.nih.gov/pubmed/21693778
Picarelli A, Di Tola M, Sabbatella L, Mercuri V, Pietrobono D, Bassotti G, . . . Gargiulo P (2011) Type 1 diabetes mellitus and celiac disease: endothelial dysfunction. Acta Diabetol.
http://www.ncbi.nlm.nih.gov/pubmed/21691748
Queiroz KC, Van 't Veer C, Van Den Berg Y, Duitman J, Versteeg HH, Aberson HL, . . . Spek CA (2011) Tissue factor-dependent chemokine production aggravates experimental colitis. Mol Med.
http://www.ncbi.nlm.nih.gov/pubmed/21717035
Quinn TJ, Gallacher J, Deary IJ, Lowe GD, Fenton C, Stott DJ (2011) Association between circulating haemostatic measures and dementia or cognitive impairment - systematic review and meta-analyses. J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/21676170
Semeraro F, Ammollo CT, Morrissey JH, Dale GL, Friese P, Esmon NL, Esmon CT (2011) Extracellular histones promote thrombin generation through platelet-dependent mechanisms: involvement of platelet TLR2 and 4. Blood.
http://www.ncbi.nlm.nih.gov/pubmed/21673343
Spiezia L, Campello E, Gentilomo C, Gavasso S, Woodhams B, Laverda AM, Simioni P (2011) Factor VIIa-antithrombin complexes in children with ischemic stroke. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/21708400
Tavoosi N, Davis-Harrison RL, Pogorelov TV, Ohkubo YZ, Arcario MJ, Clay MC, . . . Morrissey JH (2011) Molecular determinants of phospholipid synergy in blood clotting. J Biol Chem 286:23247-23253.
http://www.ncbi.nlm.nih.gov/pubmed/21561861
Taylor KC, Lange LA, Zabaneh D, Lange E, Keating BJ, Tang W, . . . Reiner AP (2011) A gene-centric association scan for Coagulation Factor VII levels in European and African Americans: the Candidate Gene Association Resource (CARe) Consortium. Hum Mol Genet.
http://www.ncbi.nlm.nih.gov/pubmed/21676895
Tran HT, Tjonnfjord GE, Paus A, Holme PA (2011) rFVIIa administered by continuous infusion during surgery in patients with severe congenital FVII deficiency. Haemophilia.
http://www.ncbi.nlm.nih.gov/pubmed/21707871
Tsimerman G, Roguin A, Bachar A, Melamed E, Brenner B, Aharon A (2011) Involvement of microparticles in diabetic vascular complications. Thromb Haemost 106.
http://www.ncbi.nlm.nih.gov/pubmed/21713319
Undas A, Slowik A, Gissel M, Mann KG, Butenas S (2011) Active tissue factor and activated factor XI in patients with acute ischemic cerebrovascular events. Eur J Clin Invest.
http://www.ncbi.nlm.nih.gov/pubmed/21707613
Wang R, Zhang SF, Ma YT, Chen D, Ma J, Zhou YM, Wen BZ (2011) [Expression of tissue factor in monocytes and plasma during acute phase and recovery stage of patients with myocardial infarction.]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 23:372-373.
http://www.ncbi.nlm.nih.gov/pubmed/21672391
Yu X, Zheng L, Xiong SL, Cai Z, Wang Q (2011) [Effect of simulated microgravity on human monocytic cell proliferation and tissue factor mRNA expression.]. Nan Fang Yi Ke Da Xue Xue Bao 31:1020-1022.
http://www.ncbi.nlm.nih.gov/pubmed/21690060
__________________________________________________________
ABOUT TRIGGER
TRIGGER is edited by Jim Morrissey and Pierre Neuenschwander, with editorial assistance by Genie Morrissey. It includes Abstracts of Papers in Press, Meeting Announcements, Positions Sought/Available,or any other pertinent item that subscribers may want to share with their colleagues. To submit an item for publication in Trigger, e-mail us. To request or cancel a subscription,or for more information about TRIGGER or the biology of tissue factor and factor VII, visit our web site. You can also contact us by mail: J.H. Morrissey, University of Illinois College of Medicine, 417 Med Sci Bldg MC-714, 506 S. Mathews Ave., Urbana, IL 61801, USA.
DISCLAIMER: TRIGGER is provided "as is" for information purposes only and without warranty of any kind, express or implied. Users shall assume the entire risk as to the accuracy and usefulness of information in TRIGGER. Opinions expressed here are not necessarily those of the editors or their employers. You may share TRIGGER with your scientific colleagues but you are not permitted to use it or its contents for commercial purposes.
__________________________________________________________
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 17, No. 13 July 5, 2011
(The next issue will be on July 15, 2011)
__________________________________________________________
TRIGGER is also available by RSS Feed:
http://feeds.feedburner.com/blogspot/glro
and BLOG:
http://trigger-tf7.blogspot.com/
__________________________________________________________
PAPERS IN PRESS
None submitted for this issue.
__________________________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI
Papers are culled from NLM MedLine (PubMed). Titles in square brackets indicate that the paper was not published in English. References that lack volume or page numbers are typically electronic pre-publications (E-pubs) ahead of the print publication; if so, the final citation with volume and page numbers may or may not appear in a future issue of Trigger.
THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1X7DvXj4huqJh61LhqsJ9Vf/
Ben-Hadj-Khalifa S, Hezard N, Almawi WY, Lakbakbi S, Mace C, Cornillet-Lefebvre P, . . . Nguyen P (2011) IL-10 modulates fondaparinux inhibition of monocyte-induced thrombin generation. J Thromb Thrombolysis.
http://www.ncbi.nlm.nih.gov/pubmed/21725623
Brophy DF, Martin EJ, Barrett JC, Nolte ME, Kuhn JG, Hedner U, Ezban M (2011) Overcoming delayed in-vitro response to rFVIIa: effects of rFVIIa and rFVIIa analogue (vatreptacog alfa) concentration escalation in whole blood assays. Blood Coagul Fibrinolysis.
http://www.ncbi.nlm.nih.gov/pubmed/21681082
Carvalhal AV, Santos SS, Carrondo MJ (2011) Extracellular purine and pyrimidine catabolism in cell culture. Biotechnol Prog.
http://www.ncbi.nlm.nih.gov/pubmed/21695809
Cocco E, Varughese J, Buza N, Bellone S, Glasgow M, Bellone M, . . . Santin AD (2011) Expression of Tissue factor in Adenocarcinoma and Squamous Cell Carcinoma of the Uterine Cervix: Implications for immunotherapy with hI-con1, a factor VII-IgGFc chimeric protein targeting tissue factor. BMC Cancer 11:263.
http://www.ncbi.nlm.nih.gov/pubmed/21693061
Cocco E, Varughese J, Buza N, Bellone S, Lin KY, Bellone M, . . . Santin AD (2011) Tissue factor expression in ovarian cancer: implications for immunotherapy with hI-con1, a factor VII-IgGF(c) chimeric protein targeting tissue factor. Clin Exp Metastasis.
http://www.ncbi.nlm.nih.gov/pubmed/21725665
De Rop C, Stadler M, Buchholz S, Eisert R, Ganser A, Trummer A (2011) Evaluation of Tissue Factor Bearing Microparticles as Biomarkers in Allogeneic Stem-Cell Transplantation. Transplantation.
http://www.ncbi.nlm.nih.gov/pubmed/21681142
Girolami A, Bertozzi I, Rigoni I, Muzzolon R, Vettore S (2011) Congenital FVII deficiency and thrombotic events after replacement therapy. J Thromb Thrombolysis.
http://www.ncbi.nlm.nih.gov/pubmed/21681394
Girolami A, de Marinis GB, Bonamigo E, Vettore S (2011) Similarities and Discrepancies in Homozygous Factor VII Defects due to Mutations in the Region of Residues Met298 to Cys310 (Exon 8) in the Catalytic Domain of Factor VII. Lab Hematol 17:17-21.
http://www.ncbi.nlm.nih.gov/pubmed/21705315
Hay JW, Zhou ZY (2011) Systematic literature review of economics analysis on treatment of mild-to-moderate bleeds with aPCC versus rFVIIa. J Med Econ.
http://www.ncbi.nlm.nih.gov/pubmed/21699366
Houghton-Trivino N, Martin K, Giaya K, Rodriguez JA, Bosch I, Castellanos JE (2010) [Comparison of the transcriptional profiles of patients with dengue fever and dengue hemorrhagic fever reveals differences in the immune response and clues in immunopathogenesis.]. Biomedica 30:587-597.
http://www.ncbi.nlm.nih.gov/pubmed/21713363
Kalina M, Tinkoff G, Fulda G (2011) Massive postpartum hemorrhage: recombinant factor VIIa use is safe but not effective. Del Med J 83:109-113.
http://www.ncbi.nlm.nih.gov/pubmed/21675158
Khorana AA (2011) Risk Assessment and Prophylaxis for VTE in Cancer Patients. J Natl Compr Canc Netw 9:789-797.
http://www.ncbi.nlm.nih.gov/pubmed/21715725
Leighton BL, Wall MH, Lockhart EM, Phillips LE, Zatta AJ (2011) Use of Recombinant Factor VIIa in Patients with Amniotic Fluid Embolism: A Systematic Review of Case Reports. Anesthesiology.
http://www.ncbi.nlm.nih.gov/pubmed/21720243
Li P, Yang Y, Liu M (2011) Xuezhikang, extract of red yeast rice, inhibited Tissue Factor and Hypercoagulable state through suppressing NADPH oxidase and ERK activation. J Cardiovasc Pharmacol.
http://www.ncbi.nlm.nih.gov/pubmed/21697731
Lijnen HR, Van Hul M, Hemmeryckx B (2011) Caloric restriction improves coagulation and inflammation profile in obese mice. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/21689844
Luo D, Szaba FM, Kummer LW, Plow EF, Mackman N, Gailani D, Smiley ST (2011) Protective Roles for Fibrin, Tissue Factor, Plasminogen Activator Inhibitor-1, and Thrombin Activatable Fibrinolysis Inhibitor, but Not Factor XI, during Defense against the Gram-Negative Bacterium Yersinia enterocolitica. J Immunol.
http://www.ncbi.nlm.nih.gov/pubmed/21724997
Matejovic M, Chvojka J, Sykora R, Krouzecky A, Radej J, Parizkova R, . . . Cerny V (2011) A 24-h Work Shift in Intensive Care Personnel: Biological Pathways between Work Stress and Ill Health. J Int Med Res 39:629-636.
http://www.ncbi.nlm.nih.gov/pubmed/21672368
Morrissey JH (2011) Low-carb tissue factor? J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/21679295
Noto D, Cefalu AB, Barbagallo CM, Falletta A, Ganci A, Sapienza M, . . . Averna MR (2011) Prediction of incident type 2 diabetes mellitus based on a twenty-year follow-up of the Ventimiglia heart study. Acta Diabetol.
http://www.ncbi.nlm.nih.gov/pubmed/21698484
Oswanski MF, Shaik I, Nazzal M, Calkins K, Stombaugh H, Lowe S (2011) Activated Recombinant Factor VIIa and Uncontrolled Gastrointestinal Bleeding. Am Surg 77:59-61.
http://www.ncbi.nlm.nih.gov/pubmed/21679534
Parunov LA, Fadeeva OA, Balandina AN, Soshitova NP, Kopylov KG, Kumskova MA, . . . Panteleev MA (2011) Improvement of spatial fibrin formation by the anti-TFPI aptamer BAX499: changing clot size by targeting extrinsic pathway initiation. J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/21696535
Phillippe M, Diamond AK, Sweet LM, Oppenheimer KH, Bradley DF (2011) Expression of Coagulation-Related Protein Genes During LPS-Induced Preterm Delivery in the Pregnant Mouse. Reprod Sci.
http://www.ncbi.nlm.nih.gov/pubmed/21693778
Picarelli A, Di Tola M, Sabbatella L, Mercuri V, Pietrobono D, Bassotti G, . . . Gargiulo P (2011) Type 1 diabetes mellitus and celiac disease: endothelial dysfunction. Acta Diabetol.
http://www.ncbi.nlm.nih.gov/pubmed/21691748
Queiroz KC, Van 't Veer C, Van Den Berg Y, Duitman J, Versteeg HH, Aberson HL, . . . Spek CA (2011) Tissue factor-dependent chemokine production aggravates experimental colitis. Mol Med.
http://www.ncbi.nlm.nih.gov/pubmed/21717035
Quinn TJ, Gallacher J, Deary IJ, Lowe GD, Fenton C, Stott DJ (2011) Association between circulating haemostatic measures and dementia or cognitive impairment - systematic review and meta-analyses. J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/21676170
Semeraro F, Ammollo CT, Morrissey JH, Dale GL, Friese P, Esmon NL, Esmon CT (2011) Extracellular histones promote thrombin generation through platelet-dependent mechanisms: involvement of platelet TLR2 and 4. Blood.
http://www.ncbi.nlm.nih.gov/pubmed/21673343
Spiezia L, Campello E, Gentilomo C, Gavasso S, Woodhams B, Laverda AM, Simioni P (2011) Factor VIIa-antithrombin complexes in children with ischemic stroke. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/21708400
Tavoosi N, Davis-Harrison RL, Pogorelov TV, Ohkubo YZ, Arcario MJ, Clay MC, . . . Morrissey JH (2011) Molecular determinants of phospholipid synergy in blood clotting. J Biol Chem 286:23247-23253.
http://www.ncbi.nlm.nih.gov/pubmed/21561861
Taylor KC, Lange LA, Zabaneh D, Lange E, Keating BJ, Tang W, . . . Reiner AP (2011) A gene-centric association scan for Coagulation Factor VII levels in European and African Americans: the Candidate Gene Association Resource (CARe) Consortium. Hum Mol Genet.
http://www.ncbi.nlm.nih.gov/pubmed/21676895
Tran HT, Tjonnfjord GE, Paus A, Holme PA (2011) rFVIIa administered by continuous infusion during surgery in patients with severe congenital FVII deficiency. Haemophilia.
http://www.ncbi.nlm.nih.gov/pubmed/21707871
Tsimerman G, Roguin A, Bachar A, Melamed E, Brenner B, Aharon A (2011) Involvement of microparticles in diabetic vascular complications. Thromb Haemost 106.
http://www.ncbi.nlm.nih.gov/pubmed/21713319
Undas A, Slowik A, Gissel M, Mann KG, Butenas S (2011) Active tissue factor and activated factor XI in patients with acute ischemic cerebrovascular events. Eur J Clin Invest.
http://www.ncbi.nlm.nih.gov/pubmed/21707613
Wang R, Zhang SF, Ma YT, Chen D, Ma J, Zhou YM, Wen BZ (2011) [Expression of tissue factor in monocytes and plasma during acute phase and recovery stage of patients with myocardial infarction.]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 23:372-373.
http://www.ncbi.nlm.nih.gov/pubmed/21672391
Yu X, Zheng L, Xiong SL, Cai Z, Wang Q (2011) [Effect of simulated microgravity on human monocytic cell proliferation and tissue factor mRNA expression.]. Nan Fang Yi Ke Da Xue Xue Bao 31:1020-1022.
http://www.ncbi.nlm.nih.gov/pubmed/21690060
__________________________________________________________
ABOUT TRIGGER
TRIGGER is edited by Jim Morrissey and Pierre Neuenschwander, with editorial assistance by Genie Morrissey. It includes Abstracts of Papers in Press, Meeting Announcements, Positions Sought/Available,or any other pertinent item that subscribers may want to share with their colleagues. To submit an item for publication in Trigger, e-mail us. To request or cancel a subscription,or for more information about TRIGGER or the biology of tissue factor and factor VII, visit our web site. You can also contact us by mail: J.H. Morrissey, University of Illinois College of Medicine, 417 Med Sci Bldg MC-714, 506 S. Mathews Ave., Urbana, IL 61801, USA.
DISCLAIMER: TRIGGER is provided "as is" for information purposes only and without warranty of any kind, express or implied. Users shall assume the entire risk as to the accuracy and usefulness of information in TRIGGER. Opinions expressed here are not necessarily those of the editors or their employers. You may share TRIGGER with your scientific colleagues but you are not permitted to use it or its contents for commercial purposes.
__________________________________________________________
