Wednesday, February 26, 2014

Vol. 20, No. 4

TRIGGER
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 20, No. 4 February 17, 2014
(The next issue will be on March 3, 2014)
__________________________________________________________
TRIGGER is also available by RSS Feed:
and BLOG:
http://trigger-tf7.blogspot.com/
__________________________________________________________
PAPERS IN PRESS
None Submitted for this issue.
__________________________________________________________
UPCOMING MEETINGS EVENTS
General info on upcoming meetings of interest:
http://tf7.org/meetings.htm

ISTH also maintains a list of upcoming meetings of interest:
__________________________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI
Papers are culled from NLM MedLine (PubMed). Titles in square brackets indicate that the paper was not published in English. References that lack volume or page numbers are typically electronic pre-publications (E-pubs) ahead of the print publication; if so, the final citation with volume and page numbers may or may not appear in a future issue of Trigger.
THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":

Ardillon L, Lefrancois A, Graveleau J, Fouassier M, Ternisien C, Sigaud M, . . . Trossaert M (2014) Management of bleeding in severe factor V deficiency with a factor V inhibitor. Vox Sang.

Backman S, Hiltunen L, Huoponen O, Vepsalainen K, Riikonen P (2014) Inaccuracy in factor VIII measurement due to administration of recombinant activated factor VII in vivo. Int J Lab Hematol.

Banov L, Pavanello M, Piattelli G, Disma N, Severino M, Dufour C, Molinari AC (2014) Successful urgent neurosugery management with rFVIIa mega doses in a child with haemophilia a and high titre inhibitor. Blood Coagul Fibrinolysis.

Brophy GM, Candeloro CL, Robles JR, Brophy DF (2013) Recombinant activated factor VII use in critically ill patients: clinical outcomes and thromboembolic events. Ann Pharmacother 47:447-454.

Cesarman-Maus G, Braggio E, Lome-Maldonado C, Morales-Leyte AL, Fonseca R (2014) Absence of tissue factor is characteristic of lymphoid malignancies of both T- and B-cell origin. Thromb Res.

Dashty M, Motazacker MM, Levels J, Vries M, Mahmoudi M, Peppelenbosch MP, Rezaee F (2014) Proteome of human plasma very low-density lipoprotein and low-density lipoprotein exhibits a link with coagulation and lipid metabolism. Thromb Haemost 111.

Davies GF, Berg A, Postnikoff SD, Wilson HL, Arnason TG, Kusalik A, Harkness TA (2014) TFPI1 Mediates Resistance to Doxorubicin in Breast Cancer Cells by Inducing a Hypoxic-Like Response. PLoS One 9:e84611.

Gatt A, Chowdary P (2014) Does Balanced Haemostasis Equate to Normal Coagulation in Patients with Acute Liver Failure? Liver Int.

Geng Y, Verhamme IM, Sun MF, Bajaj SP, Emsley J, Gailani D (2013) Analysis of the factor XI variant Arg184Gly suggests a structural basis for factor IX binding to factor XIa. J Thromb Haemost 11:1374-1384.

Goel A, Nair SC, Viswabandya A, Masilamani VP, Rao SV, George A, . . . Chandy G (2013) Preliminary experience with use of recombinant activated factor VII to control postpartum hemorrhage in acute fatty liver of pregnancy and other pregnancy-related liver disorders.
Indian J Gastroenterol 32:268-271.

Grottke O, van Ryn J, Spronk HM, Rossaint R (2014) Prothrombin complex concentrates and a specific antidote to dabigatran are effective ex-vivo in reversing the effects of dabigatran in an anticoagulation/liver trauma experimental model. Crit Care 18:R27.

Hammad MA, Abdel-Bakky MS, Walker LA, Ashfaq MK (2013) Tissue factor antisense deoxyoligonucleotide prevents monocrotaline/LPS hepatotoxicity in mice. J Appl Toxicol 33:774-783.

Harinstein LM, Morgan JW, Russo N (2013) Treatment of dabigatran-associated bleeding: case report and review of the literature. J Pharm Pract 26:264-269.

Hot A, Lavocat F, Maggi L, Annunziato F, Miossec P (2014) A8.5 Comparison of the effects of TH17 and TH1 cells on endothelial cells and synoviocytes. Ann Rheum Dis 73 Suppl 1:A78.

Ishibazawa A, Nagaoka T, Yokota H, Ono S, Yoshida A (2013) Low shear stress up-regulation of proinflammatory gene expression in human retinal microvascular endothelial cells. Exp Eye Res 116:308-311.

Jiang P, Xue D, Zhang Y, Ye L, Liu Y, Makale M, . . . Liu C (2014) The extrinsic coagulation cascade and tissue factor pathway inhibitor in macrophages: A potential therapeutic opportunity for atherosclerotic thrombosis. Thromb Res.

Jin Y, Wang M, Wang Y, Yang X, Yang L, Xie Y, . . . Yu F (2014) [Phenotype and genotype analysis for a consanguineous pedigree with combined coagulation factor VII and X deficiency]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 31:16-20.

Kato M, Atsumi T, Oku K, Amengual O, Nakagawa H, Fujieda Y, . . .Koike T (2013) The involvement of CD36 in monocyte activation by antiphospholipid antibodies. Lupus 22:761-771.

Ke K, Yuan J, Morrissey JH (2014) Tissue factor residues that putatively interact with membrane phospholipids. PLoS One 9:e88675.

Keren-Politansky A, Breizman T, Brenner B, Sarig G, Drugan A (2014) The coagulation profile of preterm delivery. Thromb Res.

Kothari H, Pendurthi UR, Rao LV (2013) Analysis of tissue factor expression in various cell model systems: cryptic vs. active. J Thromb Haemost 11:1353-1363.

Lipets E, Vlasova O, Urnova E, Margolin O, Soloveva A, Ostapushchenko O, . . . Panteleev M (2014) Circulating Contact-Pathway-Activating Microparticles Together with Factors IXa and XIa Induce Spontaneous Clotting in Plasma of Hematology and Cardiologic Patients. PLoS One 9:e87692.

Ljung R, Karim FA, Saxena K, Suzuki T, Arkhammar P, Rosholm A, Giangrande P (2013) 40K glycoPEGylated, recombinant FVIIa: 3-month, double-blind, randomized trial of safety, pharmacokinetics and preliminary efficacy in hemophilia patients with inhibitors. J Thromb Haemost 11:1260-1268.

Ma D, Mizurini DM, Assumpcao TC, Li Y, Qi Y, Kotsyfakis M, . . .Francischetti IM (2013) Desmolaris, a novel factor XIa anticoagulant from the salivary gland of the vampire bat (Desmodus rotundus) inhibits inflammation and thrombosis in vivo. Blood 122:4094-4106.

Magnus N, Garnier D, Meehan B, McGraw S, Lee TH, Caron M, . . . Rak J (2014) Tissue factor expression provokes escape from tumor dormancy and leads to genomic alterations. Proc Natl Acad Sci U S A.

Majoor CJ, van de Pol MA, Kamphuisen PW, Meijers JC, Molenkamp R, Wolthers KC, . . . van der Sluijs KF (2014) Evaluation of coagulation activation after Rhinovirus infection in patients with asthma and healthy control subjects: an observational study. Respir Res 15:14.

Martinez-Palacian A, Kanse SM, Weiskirchen R (2014) Factor seven activating protease (FSAP): A novel protective factor in liver fibrosis. Proteomics Clin Appl.

McCain S, Gull S, Ahmad J, Carey D (2014) Acquired hemophilia A as a cause of acute upper gastrointestinal hemorrhage. BMJ Case Rep 2014.

McElroy AK, Erickson BR, Flietstra TD, Rollin PE, Nichol ST, Towner JS, Spiropoulou CF (2014) Ebola hemorrhagic fever: novel biomarker correlates of clinical outcome. J Infect Dis.

Nielsen MH, Beck-Nielsen H, Andersen MN, Handberg A (2014) A flow cytometric method for characterization of circulating cell-derived microparticles in plasma. J Extracell Vesicles 3.

Pagano S, Virzi J, Satta N, Mannic T, Roux-Lombard P, Mach F, . . .Vuilleumier N (2014) A9.11 Anti-apolipoprotein A1 autoantibodies induce tissue factor activity and expression: a role in atherothrombosis. Ann Rheum Dis 73 Suppl 1:A96.

Pham HP, Shaz BH (2013) Update on massive transfusion. Br J Anaesth 111 Suppl 1:i71-82.

Priestley ES, De Lucca I, Zhou J, Zhou J, Saiah E, Stanton R, . . .Wexler RR (2013) Discovery and gram-scale synthesis of BMS-593214, a potent, selective FVIIa inhibitor. Bioorg Med Chem Lett 23:2432-2435.

Senchenkova EY, Russell J, Esmon CT, Granger DN (2014) Roles of coagulation and fibrinolysis in angiotensin II enhanced microvascular thrombosis. Microcirculation.

Sharma R, Dash SK, Chawla R, Kansal S, Agrawal DK, Dua H (2013) Acquired hemophilia complicated by cardiorenal syndrome type 3. Indian J Crit Care Med 17:378-381.

Strickland DK, Au DT, Cunfer P, Muratoglu SC (2014) Low-Density Lipoprotein Receptor-Related Protein-1: Role in the Regulation of Vascular Integrity. Arterioscler Thromb Vasc Biol.

Tian Y, Ma S, Lin B, Kou J, Yu B (2013) Anti-thrombotic activity of DT-13, a saponin isolated from the root tuber of Liriope muscari. Indian J Pharmacol 45:283-285.

Tseng JC, Chang LC, Jiang BY, Liu YC, Chen HJ, Yu CT, Hua CC (2014) Elevated circulating levels of tissue factor-positive microvesicles are associated with distant metastasis in lung cancer. J Cancer Res Clin Oncol 140:61-67.

Uruga H, Fujii T, Kurosaki A, Hanada S, Takaya H, Miyamoto A, . . .Kishi K (2013) Pulmonary tumor thrombotic microangiopathy: a clinical analysis of 30 autopsy cases. Intern Med 52:1317-1323.

van Veen JJ, Maclean RM, Hampton KK, Hamer A, Makris M (2014) Major surgery in severe haemophilia A with inhibitors using a recombinant factor VIIa and activated prothrombin complex concentrate hybrid regimen. Haemophilia.

Wang LL, Ma B, Qian D, Pang J, Yao YL (2013) [Correlation between polymorphisms in the coagulation factor VII gene hypervariable region 4 site and the risk of coronary heart disease in population with different ethnic backgrounds: a Meta-analysis]. Zhonghua Liu Xing Bing Xue Za Zhi 34:1250-1254.

Waters EK, Genga RM, Thomson HA, Kurz JC, Schaub RG, Scheiflinger F, McGinness KE (2013) Aptamer BAX 499 mediates inhibition of tissue factor pathway inhibitor via interaction with multiple domains of the protein. J Thromb Haemost 11:1137-1145.

Williams L, Deana A, Romero A, Molina A, Lunello P (2014) High-level production of active human TFPI-2 Kunitz domain in plant. Protein Expr Purif.

Yau JW, Liao P, Fredenburgh JC, Stafford A, Revenko AS, Monia BP, Weitz JI (2014) Selective depletion of factor XI or factor XII with antisense oligonucleotides attenuates catheter thrombosis in rabbits. Blood.

Yu G, Li H, Wang X, Wu T, Zhu J, Huang S, . . . Tang J (2013) MicroRNA-19a targets tissue factor to inhibit colon cancer cells migration and invasion. Mol Cell Biochem 380:239-247.
__________________________________________________________
ABOUT TRIGGER
TRIGGER is edited by Jim Morrissey and Pierre Neuenschwander, with editorial assistance by Genie Morrissey. It includes Abstracts of Papers in Press, Meeting Announcements, Positions Sought/Available,or any other pertinent item that subscribers may want to share with their colleagues. To submit an item for publication in Trigger, e-mail us. To request or cancel a subscription,or for more information about TRIGGER or the biology of tissue factor and factor VII, visit our web site. You can also contact us by mail: J.H. Morrissey, University of Illinois College of Medicine, 417 Med Sci Bldg MC-714, 506 S. Mathews Ave., Urbana, IL 61801, USA.

DISCLAIMER: TRIGGER is provided "as is" for information purposes only and without warranty of any kind, express or implied. Users shall assume the entire risk as to the accuracy and usefulness of information in TRIGGER. Opinions expressed here are not necessarily those of the editors or their employers. You may share TRIGGER with your scientific colleagues but you are not permitted to use it or its contents for commercial purposes.
__________________________________________________________

Vol. 20, No. 2

TRIGGER
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 20, No. 2 January 15, 2014
(The next issue will be on February 3, 2014)
__________________________________________________________
TRIGGER is also available by RSS Feed:
and BLOG:
http://trigger-tf7.blogspot.com/
__________________________________________________________
ANNOUNCEMENTS
As we have done for the past few years, the individual PubMed "collections" of the papers appearing in each issue of TRIGGER for 2013 have now been consolidated into a single collection.  (The individual PubMed collections for each TRIGGER issue in 2013 have, accordingly, been deleted.)  Here are the links to the consolidated collections for the past five years:

2009 (301 references):

2010 (531 references):

2011 (612 references):

2012 (976 references):

2013 (848 references):
__________________________________________________________
PAPERS IN PRESS
None Submitted for this issue.
__________________________________________________________
UPCOMING MEETINGS EVENTS
7th Symposium on Hemostasis: Old System, New Players, New Directions May 15-17, 2014 at the Carolina Inn, Chapel Hill, NC, USA The focus will include the latest findings related to tissue factor, coagulation proteases and their role in hemostasis and thrombosis, as well as interplay between coagulation and inflammation. Important new research on novel approaches for treating bleeding in hemophilia and trauma induced coagulopathy, animal models of bleeding and thrombosis and activation of coagulation in disease will also be presented.

Invited faculty are the world's formost basic scientists and clinicians working in the field of tissue factor biology, coagulation and hemostasis. 
Registration is now OPEN:

    ***   ***   ***   ***   ***
General info on upcoming meetings of interest:
http://tf7.org/meetings.htm

ISTH also maintains a list of upcoming meetings of interest:
__________________________________________________________
POSITIONS SOUGHT/AVAILABLE 
A postdoctoral position is offered as part of the Novo Nordisk R&D STAR Programme (Science, Talent, Attraction and Recruitment). This program supports the brightest graduate students in biotechnology, life, medical and engineering sciences, who want to pursue a career in pharmaceutical R&D.

About the department:  Translational Haemophilia Pharmacology is offering an international Postdoc fellowship to a highly motivated and ambitious candidate. Translational Haemophilia Pharmacology is a research unit focusing on research and development of drug candidates for the treatment of haemophilia; we support the Novo Nordisk haemophilia portfolio with knowledge generated in animal models of haemophilia.

The Job:  The project will first focus on optimizing and validating a thrombin generation assay for use with samples from dogs, prior to and after therapeutic intervention. Subsequently the assay will be used to predicting the bleeding phenotype and response to treatment in dogs with haemophilia A and B as a model for human haemophilia. The project is conducted in close collaboration with leading researchers from the University of North Carolina at Chapel Hill.

The starting date is February 1, 2014 or later, and the position is on a temporary contract. Part of the PostDoc project will take place at Translational Haemophilia Pharmacology in Måløv, Denmark and the other part in the lab of Dr. Tim Nichols in close collaboration with Dr. Alisa Wolberg at the University of North Carolina, Chapel Hill. Travel expenses between the US and Denmark will be reimbursed by Novo Nordisk.

The candidate will become part of two laboratories located in high impact centers of excellence within haemophilia and thus exposed to world class science and in addition serve as a liaison between the University of Chapel Hill and Novo Nordisk A/S.

Qualifications:  You hold a PhD in medicine, veterinary medicine, pharmacology, biology or related disciplines. Solid knowledge on in vivo research in general and haemostasis research in particular is desirable. Experience with haemophilia research is considered an advantage. We require very good communication skills in English.

At Novo Nordisk your skills, dedication, and ambition help us change lives for the better. In exchange we offer you an opportunity to work with extraordinary talent and benefit from a range of possibilities for professional and personal development.

For further information, please call Bo Wiinberg on +45 3075 3030.
__________________________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI
Papers are culled from NLM MedLine (PubMed). Titles in square brackets indicate that the paper was not published in English. References that lack volume or page numbers are typically electronic pre-publications (E-pubs) ahead of the print publication; if so, the final citation with volume and page numbers may or may not appear in a future issue of Trigger.
THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":

Blatny J, Mathew P, Monagle P, Ovesna P, Fiamoli V (2014) Safety and efficacy of recombinant activated factor VII in nonhemophilia children with severe or life-threatening bleeding: a report from the SeveNBleeP registry. Blood Coagul Fibrinolysis.

Boknas N, Faxalv L, Lindahl TL, Ramstrom S (2014) Contact activation - important to consider when measuring the contribution of tissue factor-bearing microparticles to thrombin generation using phospholipid-containing reagents. J Thromb Haemost.

Bosch YP, Al Dieri R, Ten Cate H, Nelemans PJ, Bloemen S, de Laat B, . . . Mochtar B (2013) Measurement of thrombin generation intra-operatively and its association with bleeding tendency after cardiac surgery. Thromb Res.

Gebhard C, Stahli BE, Largiader S, Holy EW, Akhmedov A, Camici GG, . . . Tanner FC (2013) Caffeic acid phenethyl ester inhibits endothelial tissue factor expression. Biol Pharm Bull 36:1032-1035.

Hansen L, Petersen LC, Lauritzen B, Clausen JT, Grell SN, Agerso H, . . . Almholt K (2013) Target-mediated clearance and bio-distribution of a monoclonal antibody against the Kunitz-type protease inhibitor 2 domain of Tissue Factor Pathway Inhibitor. Thromb Res.

Hilbert P, Hofmann GO, Teichmann J, Struck MF, Stuttmann R (2013) The "coagulation box" and a new hemoglobin-driven algorithm for bleeding control in patients with severe multiple traumas. Arch Trauma Res 2:3-10.

Holley AB, Petteys S, Mitchell JD, Holley PR, Collen JF (2013) Thromboprophylaxis and VTE rates in soldiers wounded in Operation Enduring Freedom and Operation Iraqi Freedom. Chest 144:966-973.

Kiessling AH, Nitsch J, Strouhal U, Kornberger A, Zierer A, Moritz A (2013) Associated risk of recombinant activated factor VIIa application. Heart Surg Forum 16:E132-136.

Magon N, Babu KM, Kapur K, Chopra S, Joneja GS (2013) Recombinant activated factor VII in post partum haemorrhage. Niger Med J 54:289-294.

Menegatti M, Vangone A, Palla R, Milano G, Cavallo L, Oliva R, . . . Peyvandi F (2013) A recurrent Gly43Asp substitution in coagulation Factor X rigidifies its catalytic pocket and impairs catalytic activity and intracellular trafficking. Thromb Res.

Osterud B, Olsen JO (2013) Pro- and anti-inflammatory effects of histamine on tissue factor and TNFalpha expression in monocytes of human blood. Thromb Res.

Saeki N, Mochizuki S, Fujii T, Kawamoto M (2014) Postsurgical coagulopathy in a hemophilia A patient with inhibitors: efficacy of recombinant factor VIIa. J Anesth.

Wang GJ, Wang YB, Li DN, Li C, Deng BB (2014) Expression of tissue factor pathway inhibitor-2 in gastric stromal tumor and its clinical significance. Exp Ther Med 7:513-517.

Wood JP, Bunce MW, Maroney SA, Tracy PB, Camire RM, Mast AE (2013) Tissue factor pathway inhibitor-alpha inhibits prothrombinase during the initiation of blood coagulation. Proc Natl Acad Sci U S A 110:17838-17843.

Xiao W, Li CQ, Xiao XP, Lin FZ (2013) Expression and fast preparation of biologically active recombinant human coagulation factor VII in CHO-K1 cells. Genet Mol Res 12:6813-6824.

Yu YH, Wu DS, Huang FF, Zhang Z, Liu LX, Zhang J, . . . Chen FP (2013) MicroRNA-20b and ERK1/2 pathway independently regulate the expression of tissue factor in hematopoietic and trophoblastic differentiation of human embryonic stem cells. Stem Cell Res Ther 4:121.

Zelaya H, Tsukida K, Chiba E, Marranzino G, Alvarez S, Kitazawa H, . . . Villena J (2014) Immunobiotic lactobacilli reduce viral-associated pulmonary damage through the modulation of inflammation-coagulation interactions. Int Immunopharmacol.

Zerrouqi A, Pyrzynska B, Brat DJ, Van Meir EG (2014) p14ARF suppresses tumor-induced thrombosis by regulating the tissue factor pathway. Cancer Res.

__________________________________________________________
ABOUT TRIGGER
TRIGGER is edited by Jim Morrissey and Pierre Neuenschwander, with editorial assistance by Genie Morrissey. It includes Abstracts of Papers in Press, Meeting Announcements, Positions Sought/Available,or any other pertinent item that subscribers may want to share with their colleagues. To submit an item for publication in Trigger, e-mail us. To request or cancel a subscription,or for more information about TRIGGER or the biology of tissue factor and factor VII, visit our web site. You can also contact us by mail: J.H. Morrissey, University of Illinois College of Medicine, 417 Med Sci Bldg MC-714, 506 S. Mathews Ave., Urbana, IL 61801, USA.

DISCLAIMER: TRIGGER is provided "as is" for information purposes only and without warranty of any kind, express or implied. Users shall assume the entire risk as to the accuracy and usefulness of information in TRIGGER. Opinions expressed here are not necessarily those of the editors or their employers. You may share TRIGGER with your scientific colleagues but you are not permitted to use it or its contents for commercial purposes.
__________________________________________________________

Vol. 20, No. 1

TRIGGER
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 20, No. 1 January 2, 2014
(The next issue will be on January 15, 2014)
__________________________________________________________
TRIGGER is also available by RSS Feed:
and BLOG:
http://trigger-tf7.blogspot.com/
__________________________________________________________
PAPERS IN PRESS
None Submitted for this issue.
__________________________________________________________
UPCOMING MEETINGS EVENTS
General info on upcoming meetings of interest:
http://tf7.org/meetings.htm

ISTH also maintains a list of upcoming meetings of interest:
__________________________________________________________
POSITIONS SOUGHT/AVAILABLE 
We are seeking a highly qualified and motivated individual for one Postdoctoral Position in the Division of Hematology at The Children's Hospital of Philadelphia in the laboratory of Dr. Paris Margaritis.

The research will be devoted to studying the biological and therapeutic effects of blood coagulation factor expression in vitro or in vivo in appropriate models. Applicants should have a strong background in molecular biology and have experience working with transgenic/gene targeted mouse and rat models. Those with experience in coagulation protein biochemistry and tissue culture are strongly encouraged to apply. Candidates should have successfully earned an advanced degree (M.D. or Ph.D.), have excellent communications skills and are willing to work on a multidisciplinary team. Highly competitive salary and benefits are offered. Curriculum vitae and the names of three referees should be sent to: Dr. Paris Margaritis, The Children's Hospital of Philadelphia, Division of Hematology, Colket Translational Research Building, Rm 5024, 3501 Civic Center Blvd., Philadelphia, PA 19104 U.S.A. Email: margaritis AT email DOT chop DOT edu

The Children's Hospital of Philadelphia in an Equal Opportunity/Affirmative Action Employer. Women and minorities are encouraged to apply.
__________________________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI
Papers are culled from NLM MedLine (PubMed). Titles in square brackets indicate that the paper was not published in English. References that lack volume or page numbers are typically electronic pre-publications (E-pubs) ahead of the print publication; if so, the final citation with volume and page numbers may or may not appear in a future issue of Trigger.
THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":

Aberg M, Eriksson O, Mokhtari D, Siegbahn A (2013) Tissue factor/factor VIIa induces cell survival and gene transcription by transactivation of the insulin-like growth factor 1 receptor. Thromb Haemost 111.

Aberg M, Siegbahn A (2013) Tissue factor non-coagulant signaling - molecular mechanisms and biological consequences with a focus on cell migration and apoptosis. J Thromb Haemost 11:817-825.

Agarwal V, Okonta KE, Lal PS (2012) Recombinant-activated factor VII in the paediatric cardiac surgery: single unit experience. Afr J Paediatr Surg 9:193-197.

Ankeny RF, Hinds MT, Nerem RM (2013) Dynamic shear stress regulation of inflammatory and thrombotic pathways in baboon endothelial outgrowth cells. Tissue Eng Part A 19:1573-1582.

Bind MA, Lepeule J, Zanobetti A, Gasparini A, Baccarelli A, Coull BA, . . . Schwartz J (2014) Air pollution and gene-specific methylation in the Normative Aging Study: Association, effect modification, and mediation analysis. Epigenetics 9.

Bladbjerg EM, Larsen TM, Due A, Jespersen J, Stender S, Astrup A (2013) Postprandial coagulation activation in overweight individuals after weight loss: Acute and long-term effects of a high-monounsaturated fat diet and a low-fat diet. Thromb Res.

Bouchard BA, Gissel MT, Whelihan MF, Mann KG, Butenas S (2013) Platelets do not express the oxidized or reduced forms of tissue factor. Biochim Biophys Acta.

Breij EC, de Goeij BE, Verploegen S, Schuurhuis DH, Amirkhosravi A, Francis JL, . . . Parren PW (2013) An antibody-drug conjugate that targets tissue factor exhibits potent therapeutic activity against a broad range of solid tumors. Cancer Res.

Brouwers HB, Greenberg SM (2013) Hematoma expansion following acute intracerebral hemorrhage. Cerebrovasc Dis 35:195-201.

Broze GJ, Jr., Girard TJ (2013) Factor V, tissue factor pathway inhibitor, and east Texas bleeding disorder. J Clin Invest 123:3710-3712.

Buzby JS, Williams SA, Imfeld KL, Kunicki TJ, Nugent DJ (2014) Tissue factor inflammatory response regulated by promoter genotype and p38 MAPK in neonatal vs. adult microvascular endothelial cells. Inflamm Res.

Cao Y, Zhang Z, Xu J, Yuan W, Wang J, Huang X, . . . Du J (2013) The association of idiopathic recurrent pregnancy loss with polymorphisms in hemostasis-related genes. Gene 530:248-252.

Carrieri C, Milella RA, Incampo F, Crupi P, Antonacci D, Semeraro N, Colucci M (2013) Antithrombotic activity of 12 table grape varieties. Relationship with polyphenolic profile. Food Chem 140:647-653.

Chen C, Liao D, Wang J, Liang Z, Yao Q (2013) Anti-human protein S antibody induces tissue factor expression through a direct interaction with platelet phosphofructokinase. Thromb Res.

Chen D, Ma L, Tham EL, Maresh S, Lechler RI, McVey JH, Dorling A (2013) Fibrocytes mediate intimal hyperplasia post-vascular injury and are regulated by two tissue factor-dependent mechanisms. J Thromb Haemost 11:963-974.

Chen J, Zhang B, Pan C, Ren L, Chen Y (2013) [Effects of monocyte chemotactic protein-3 on ICAM-1, VCAM-1, TF, and TFPI expression and apoptosis in human umbilical vein endothelial cells]. Nan Fang Yi Ke Da Xue Xue Bao 33:86-92.

Chung YM, Goyette J, Tedla N, Hsu K, Geczy CL (2013) S100A12 suppresses pro-inflammatory, but not pro-thrombotic functions of serum amyloid A. PLoS One 8:e62372.

Clark KB, Kon ND, Hammon JW, Jr., MacGregor DA, Kincaid EH, Reichert MG (2013) Factor IX complex for the treatment of severe bleeding after cardiac surgery. J Cardiovasc Pharmacol 62:67-71.

Coppola A, Tagliaferri A, Calizzani G, Candura F, Franchini M, Ruosi C, . . . Di Minno G (2013) Clinical use and the Italian demand for activated prothrombin complex and activated recombinant factor VII concentrates. Blood Transfus 11 Suppl 4:s101-109.

Cornet AD, Hofstra JJ, Vlaar AP, Tuinman PR, Levi M, Girbes AR, . . .Beishuizen A (2013) Activated protein C attenuates pulmonary coagulopathy in patients with acute respiratory distress syndrome. J Thromb Haemost 11:894-901.

Demissie A, Shahani L, Khan A, Desai M (2013) Acquired haemophilia A initially diagnosed as angioedema. BMJ Case Rep 2013.

Dutra LA, Braga-Neto P, Pedroso JL, Barsottini OG (2012) Sneddon's syndrome: case report and review of its relationship with antiphospholipid syndrome. Einstein (Sao Paulo) 10:230-232.

Ebo DG, Faber M, Sabato V, Leysen J, Gadisseur A, Bridts CH, De Clerck LS (2013) Sensitization to the mammalian oligosaccharide galactose-alpha-1,3-galactose (alpha-gal): experience in a Flemish case series. Acta Clin Belg 68:206-209.

El Makarem MA, Eslam M, Sayed D, Shawkat M, Idriss NK, Soliman EM, . . . Elheney S (2013) Diabetes worsening of hepatitis C cirrhosis: Are alterations in monocytic tissue factor (CD 142) is the cause? Ann Hepatol 13:27-37.

Engelbrecht S, Wood EM, Cole-Sinclair MF (2013) Clinical transfusion practice update: haemovigilance, complications, patient blood management and national standards. Med J Aust 199:397-401.

Fisher MJ (2013) Brain regulation of thrombosis and hemostasis: from theory to practice. Stroke 44:3275-3285.

Francischetti IM, Assumpcao TC, Ma D, Li Y, Vicente EC, Uieda W, Ribeiro JM (2013) The "Vampirome": Transcriptome and proteome analysis of the principal and accessory submaxillary glands of the vampire bat Desmodus rotundus, a vector of human rabies. J Proteomics 82:288-319.

Franz C, Boing AN, Hau CM, Montag M, Strowitzki T, Nieuwland R, Toth B (2013) Procoagulant tissue factor-exposing vesicles in human seminal fluid. J Reprod Immunol 98:45-51.

Girolami A, Sambado L, Bonamigo E, Ferrari S, Lombardi AM (2013) Pathogenetic Role of Factor VII Deficiency and Thrombosis in Cross-Reactive Material Positive Patients. Lab Hematol 19:17-21.

Grabowski EF, Kushak RI, Liu B, Ingelfinger JR (2013) Shiga toxin downregulates tissue factor pathway inhibitor, modulating an increase in the expression of functional tissue factor on endothelium. Thromb Res 131:521-528.

Haku J, Nogami K, Matsumoto T, Ogiwara K, Shima M (2013) Optimal monitoring of bypass-therapy in hemophilia A patients with inhibitor using clot waveform analysis. J Thromb Haemost.

Han J, Gerstenhaber JA, Lazarovici P, Lelkes PI (2013) Tissue factor activity and ECM-related gene expression in human aortic endothelial cells grown on electrospun biohybrid scaffolds. Biomacromolecules 14:1338-1348.

Hayakawa M, Gando S, Ieko M, Honma Y, Homma T, Yanagida Y, . . .Asakura H (2013) Massive amounts of tissue factor induce fibrinogenolysis without tissue hypoperfusion in rats. Shock 39:514-519.

Herrmann R, Thom J, Wood A, Phillips M, Muhammad S, Baker R (2013) Thrombin generation using the calibrated automated thrombinoscope to assess reversibility of dabigatran and rivaroxaban. Thromb Haemost 111.

Hill AM, Stewart PW, Fung MK, Kris-Etherton PM, Ginsberg HN, Tracy RP, . . . Ershow AG (2014) Monthly hemostatic factor variability in women and men. Eur J Clin Invest.

Holster IL, Hunfeld NG, Kuipers EJ, Kruip MJ, Tjwa ET (2013) On the treatment of new oral anticoagulant-associated gastrointestinal hemorrhage. J Gastrointestin Liver Dis 22:229-231.

Holy EW, Jakob P, Eickner T, Camici GG, Beer JH, Akhmedov A, . . .Tanner FC (2013) PI3K/p110alpha inhibition selectively interferes with arterial thrombosis and neointima formation, but not re-endothelialization: potential implications for drug-eluting stent design. Eur Heart J.

Hu L, Xia L, Zhou H, Wu B, Mu Y, Wu Y, Yan J (2013) TF/FVIIa/PAR2 promotes cell proliferation and migration via PKCalpha and ERK-dependent c-Jun/AP-1 pathway in colon cancer cell line SW620. Tumour Biol 34:2573-2581.

Hus I, Sokolowska B, Walter-Croneck A, Chrapko M, Nowaczynska A, Dmoszynska A (2013) Assessment of plasma prothrombotic factors in patients with Buerger's disease. Blood Coagul Fibrinolysis 24:133-139.

Irons EE, Flatt JW, Doronin K, Fox TL, Acchione M, Stewart PL, Shayakhmetov DM (2013) Coagulation factor binding orientation and dimerization may influence infectivity of adenovirus-coagulation factor complexes. J Virol 87:9610-9619.

Isozumi Y, Arai R, Fujimoto K, Koyama T (2013) Activation of coagulation by lenalidomide-based regimens for the treatment of multiple myeloma. PLoS One 8:e64369.

Jakubowski JA, Zhou C, Jurcevic S, Winters KJ, Lachno DR, Frelinger AL, 3rd, . . . Mant TG (2013) A phase 1 study of prasugrel in patients with sickle cell disease: Effects on biomarkers of platelet activation and coagulation. Thromb Res.

Jialal I, Kaur H, Devaraj S (2013) Human C-reactive protein accentuates macrophage activity in biobreeding diabetic rats. J Diabetes Complications 27:23-28.

Kalus JS (2013) Pharmacologic interventions for reversing the effects of oral anticoagulants. Am J Health Syst Pharm 70:S12-21.

Kim MS, Park SH, Han SY, Kim YH, Lee EJ, Yoon Park JH, Kang YH (2013) Phloretin suppresses thrombin-mediated leukocyte-platelet-endothelial interactions. Mol Nutr Food Res.

Klein OL, Okwuosa T, Chan C, Schreiner P, Kanaya AM, Liu K, Green D (2013) Changes in procoagulants track longitudinally with insulin resistance: findings from the Coronary Artery Risk Development in Young Adults (CARDIA) study. Diabet Med.

Kohoutova D, Pecka M, Cihak M, Cyrany J, Maly J, Bures J (2013) Prevalence of hypercoagulable disorders in inflammatory bowel disease. Scand J Gastroenterol.

Korhonen TK, Haiko J, Laakkonen L, Jarvinen HM, Westerlund-Wikstrom B (2013) Fibrinolytic and coagulative activities of Yersinia pestis. Front Cell Infect Microbiol 3:35.

Kumar Y, Vadivel K, Schmidt AE, Ogueli GI, Ponnuraj SM, Rannulu NS, . . . Bajaj SP (2014) Decoy Plasminogen Receptor Containing a Selective Kunitz-Inhibitory Domain. Biochemistry.

Kyaw TZ, Jayaranee S, Bee PC, Chin EF (2013) Acquired Factor VIII Inhibitors: Three Cases. Turk J Haematol 30:76-80.

Laurance S, Aghourian MN, Jiva Lila Z, Lemarie CA, Blostein MD (2013) Gas6-induced tissue factor expression in endothelial cells is mediated through caveolin-1-enriched microdomains. J Thromb Haemost.

Levi M, van der Poll T (2013) Disseminated intravascular coagulation: a review for the internist. Intern Emerg Med 8:23-32.

Li B, Chen M, Liu X, Guo SW (2013) Constitutive and tumor necrosis factor-alpha-induced activation of nuclear factor-kappaB in adenomyosis and its inhibition by andrographolide. Fertil Steril 100:568-577.

Li M, Zheng F, Jin Y, Wang M, Zhu L, Yang L (2013) Double heterozygous mutations Gln100Leu and His348Gln of the F7 gene in a patient with factor VII deficiency. Blood Coagul Fibrinolysis 24:199-201.

Maroney SA, Ellery PE, Wood JP, Ferrel JP, Martinez ND, Mast AE (2013) Comparison of the inhibitory activities of human tissue factor pathway inhibitor (TFPI)alpha and TFPIbeta. J Thromb Haemost 11:911-918.

Mathieu C, Chevrier A, Lascau-Coman V, Rivard GE, Hoemann CD (2013) Stereological analysis of subchondral angiogenesis induced by chitosan and coagulation factors in microdrilled articular cartilage defects. Osteoarthritis Cartilage 21:849-859.

Moriguchi T, Sumpio BE (2013) PECAM-1 phosphorylation and tissue factor expression in HUVECs exposed to uniform and disturbed pulsatile flow and chemical stimuli. J Vasc Surg.

Nagao A, Hanabusa H, Takedani H (2014) Continuous infusion of rFVIIa during surgery in a FVII-deficient patient: a case report from Japan. Haemophilia 20:e110-112.

Napolitano M, Giansily-Blaizot M, Dolce A, Schved JF, Auerswald G, Ingerslev J, . . . Mariani G (2013) Prophylaxis in congenital factor VII deficiency: indications, efficacy and safety. Results from the Seven Treatment Evaluation Registry (STER). Haematologica 98:538-544.

Ng HJ, Chee YL, Ponnudurai K, Lim LC, Tan D, Tay JC, . . . Lee LH (2013) Consensus recommendations for preventing and managing bleeding complications associated with novel oral anticoagulants in singapore. Ann Acad Med Singapore 42:593-602.

Onasoga-Jarvis AA, Puls TJ, O'Brien SK, Kuang L, Liang HJ, Neeves KB (2013) Thrombin generation and fibrin formation under flow on biomimetic tissue factor rich surfaces. J Thromb Haemost.

Palmerini T, Tomasi L, Barozzi C, Della Riva D, Mariani A, Taglieri N, . . . Ahamed J (2013) Detection of Tissue Factor Antigen and Coagulation Activity in Coronary Artery Thrombi Isolated from Patients with ST-Segment Elevation Acute Myocardial Infarction. PLoS One 8:e81501.

Palojarvi A, Andersson S, Langstrom S, Petaja J (2013) Coordinated release of tissue factor and tissue factor pathway inhibitor in VLBW infants. Acta Paediatr 102:584-589.

Papalexopoulou N, Attia RQ, Bapat VN (2013) Successful surgical repair of acute type A aortic dissection without the use of blood products. Ann R Coll Surg Engl 95:127-129.

Papareddy P, Kalle M, Sorensen OE, Malmsten M, Morgelin M, Schmidtchen A (2013) The TFPI-2 Derived Peptide EDC34 Improves Outcome of Gram-Negative Sepsis. PLoS Pathog 9:e1003803.

Pasqualoto KF, Balan A, Barreto SA, Simons SM, Chudzinski-Tavassi AM (2013) Structural Findings and Molecular Modeling Approach of a Tfpi-Like Inhibitor. Protein Pept Lett.

Pham HP, Shaz BH (2013) Update on massive transfusion. Br J Anaesth 111 Suppl 1:i71-i82.

Rao AK (2013) Inherited platelet function disorders: overview and disorders of granules, secretion, and signal transduction. Hematol Oncol Clin North Am 27:585-611.

Romagnuolo I, Sticchi E, Fedi S, Cellai AP, Lami D, Alessandrello A, . . . Fatini C (2013) Is tissue factor pathway inhibitor a marker of procoagulable status in healthy infertile women undergoing ovarian stimulation for assisted reproduction? Blood Coagul Fibrinolysis.

Ross B, Miller MA, Ditch K, Tran M (2014) Clinical Experience of Life-Threatening Dabigatran-Related Bleeding at a Large, Tertiary Care, Academic Medical Center: a Case Series. J Med Toxicol.

Salge-Bartels U, Heiden M, Gross N, Seitz R (2013) Significance of platelet and monocyte activation for therapeutic immunoglobulin-induced thromboembolism. Thromb Res.

Scheffert JL, Taber DJ, Pilch NA, McGillicuddy JW, Baliga PK, Chavin KD (2013) Timing of factor VIIa in liver transplantation impacts cost and clinical outcomes. Pharmacotherapy 33:483-488.

Schulte S (2013) Challenges for new haemophilia products from a manufacturer's perspective. Thromb Res.

Shah K, Bayoumi R, Banerjee Y (2013) Protein anticoagulants targeting factor VIIa-tissue factor complex: a comprehensive review. Hematology 18:1-7.

Shapiro AD, Neufeld EJ, Blanchette V, Salaj P, Gut RZ, Cooper DL (2014) Safety of recombinant activated factor VII (rFVIIa) in patients with congenital haemophilia with inhibitors: overall rFVIIa exposure and intervals following high (>240 mug kg(-1) ) rFVIIa doses across clinical trials and registries. Haemophilia 20:e23-31.

Siegal DM, Garcia DA, Crowther MA (2014) How I treat: target specific oral anticoagulant associated bleeding. Blood.

Sui L, Liu GH, Izpisua Belmonte JC (2013) hESC-derived pancreatic progenitors. Cell Res 23:592-594.

Tavoosi N, Smith SA, Davis-Harrison RL, Morrissey JH (2013) Factor VII and protein C are phosphatidic acid-binding proteins. Biochemistry 52:5545-5552.

Trummer A, Werwitzke S, Wermes C, Ganser A, Birschmann I, Budde U, Tiede A (2013) Addition of in-vitro generated endothelial microparticles to von-Willebrand plasma improves primary and secondary hemostasis. Thromb Res.

Unruh D, Turner K, Srinivasan R, Kocaturk B, Qi X, Chu Z, . . .Bogdanov VY (2014) Alternatively spliced tissue factor contributes to tumor spread and activation of coagulation in pancreatic ductal adenocarcinoma. Int J Cancer 134:9-20.

Vincent LM, Tran S, Livaja R, Bensend TA, Milewicz DM, Dahlback B (2013) Coagulation factor V(A2440G) causes east Texas bleeding disorder via TFPIalpha. J Clin Invest 123:3777-3787.

Wafaisade A, Lefering R, Maegele M, Helm P, Braun M, Paffrath T, Bouillon B (2013) [Recombinant factor VIIa for the treatment of exsanguinating trauma patients: a matched-pair analysis from the Trauma Registry of the German Society for Trauma Surgery]. Unfallchirurg 116:524-530.

Walenga JM, Jeske WP, Hoppensteadt D, Cunanan J, Khan H, Escalante V, . . . Bakhos M (2013) Comparative studies on branded enoxaparin and a US generic version of enoxaparin. Clin Appl Thromb Hemost 19:261-267.

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Yada K, Nogami K, Ogiwara K, Shima M (2013) Activated prothrombin complex concentrate (APCC)-mediated activation of factor (F)VIII in mixtures of FVIII and APCC enhances hemostatic effectiveness. J Thromb Haemost 11:902-910.

Yamada Y, Fujimoto-Ibusuki K, Morikawa-Kubota K (2013) Perioperative management of factor XI deficiency in a patient undergoing hip arthroplasty. J Anesth.

Yang HP, Yue L, Jiang WW, Liu Q, Kou JP, Yu BY (2013) Diosgenin inhibits tumor necrosis factor-induced tissue factor activity and expression in THP-1 cells via down-regulation of the NF-kappaB, Akt, and MAPK signaling pathways. Chin J Nat Med 11:608-615.

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ABOUT TRIGGER
TRIGGER is edited by Jim Morrissey and Pierre Neuenschwander, with editorial assistance by Genie Morrissey. It includes Abstracts of Papers in Press, Meeting Announcements, Positions Sought/Available,or any other pertinent item that subscribers may want to share with their colleagues. To submit an item for publication in Trigger, e-mail us. To request or cancel a subscription,or for more information about TRIGGER or the biology of tissue factor and factor VII, visit our web site. You can also contact us by mail: J.H. Morrissey, University of Illinois College of Medicine, 417 Med Sci Bldg MC-714, 506 S. Mathews Ave., Urbana, IL 61801, USA.

DISCLAIMER: TRIGGER is provided "as is" for information purposes only and without warranty of any kind, express or implied. Users shall assume the entire risk as to the accuracy and usefulness of information in TRIGGER. Opinions expressed here are not necessarily those of the editors or their employers. You may share TRIGGER with your scientific colleagues but you are not permitted to use it or its contents for commercial purposes.
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Vol. 19, No. 24

TRIGGER
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 19, No. 24 December 15, 2013
(The next issue will be on January 2, 2014)
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TRIGGER is also available by RSS Feed:
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ANNOUNCEMENTS
To all our subscribers -- we wish you the best for the holiday season, and a very happy New Year!

-Jim & Genie Morrissey and Pierre Neuenschwander 
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PAPERS IN PRESS
None Submitted for this issue.
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UPCOMING MEETINGS & EVENTS
General info on upcoming meetings of interest:
http://tf7.org/meetings.htm

ISTH also maintains a list of upcoming meetings of interest:
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RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI
Papers are culled from NLM MedLine (PubMed). Titles in square brackets indicate that the paper was not published in English. References that lack volume or page numbers are typically electronic pre-publications (E-pubs) ahead of the print publication; if so, the final citation with volume and page numbers may or may not appear in a future issue of Trigger.
THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":

Alam MM, Moiz B, Rehman KA, Jethwani P, Fadoo Z (2013) Congenital Factor VII Deficiency in Children at Tertiary Health Care Facility in Pakistan. Clin Appl Thromb Hemost.

Bilgir O, Bilgir F, Bozkaya G, Calan M (2013) Changes in the levels of endothelium-derived coagulation parameters in nonalcoholic fatty liver disease. Blood Coagul Fibrinolysis.

Brophy DF, Carl DE, Mohammed BM, Song J, Martin EJ, Bostic JL, Gehr TW (2013) DIFFERENCES IN COAGULATION BETWEEN HEMODIALYSIS AND PERITONEAL DIALYSIS. Perit Dial Int.

Carneiro-Lobo TC, Lima MT, Mariano-Oliveira A, Dutra-Oliveira A, Oba-Shinjo SM, Marie SK, . . . Monteiro RQ (2013) Expression of tissue factor signaling pathway elements correlates with the production of vascular endothelial growth factor and interleukin-8 in human astrocytoma patients. Oncol Rep.

Davila M, Robles-Carrillo L, Unruh D, Huo Q, Gardiner C, Sargent IL, . . . Amirkhosravi A (2013) Microparticle association and heterogeneity of tumor-derived tissue factor in plasma: is it important for coagulation activation? J Thromb Haemost.

Gheldof D, Mullier F, Bailly N, Devalet B, Dogne JM, Chatelain B, Chatelain C (2013) Microparticle bearing tissue factor: A link between promyelocytic cells and hypercoagulable state. Thromb Res.

Ragni MV (2013) The old and new: PCCs, VIIa, and long-lasting clotting factors for hemophilia and other bleeding disorders. Hematology Am Soc Hematol Educ Program 2013:44-51.

Salaj P, Kubes R, Cetkovsky P, Capova I, Penka M, Ovesna P, . . .Lindgren P (2013) Economic evaluation of rFVIIa high initial dose compared to rFVIIa standard initial dose in patients with haemophilia with inhibitors using the Czech HemoRec registry. Thromb Res.

Scepansky E, Othman M, Smith H (2013) Acquired von Willebrand Syndrome with a Type 2B Phenotype: Diagnostic and Therapeutic Dilemmas. Acta Haematol 131:213-217.

Tu J, Hu Z, Chen Z (2013) A combination of radiosurgery and soluble tissue factor enhances vascular targeting for experimental glioblastoma. Biomed Res Int 2013:390714.

Yu H, Liu Q, Wang H, Wang D, Hu L, Sun X, Liu J (2013) The role of tissue factor pathway inhibitor-2 in malignant transformation of sinonasal inverted papilloma. Eur Arch Otorhinolaryngol.
__________________________________________________________
ABOUT TRIGGER
TRIGGER is edited by Jim Morrissey and Pierre Neuenschwander, with editorial assistance by Genie Morrissey. It includes Abstracts of Papers in Press, Meeting Announcements, Positions Sought/Available,or any other pertinent item that subscribers may want to share with their colleagues. To submit an item for publication in Trigger, e-mail us. To request or cancel a subscription,or for more information about TRIGGER or the biology of tissue factor and factor VII, visit our web site. You can also contact us by mail: J.H. Morrissey, University of Illinois College of Medicine, 417 Med Sci Bldg MC-714, 506 S. Mathews Ave., Urbana, IL 61801, USA.

DISCLAIMER: TRIGGER is provided "as is" for information purposes only and without warranty of any kind, express or implied. Users shall assume the entire risk as to the accuracy and usefulness of information in TRIGGER. Opinions expressed here are not necessarily those of the editors or their employers. You may share TRIGGER with your scientific colleagues but you are not permitted to use it or its contents for commercial purposes.
__________________________________________________________