TRIGGER current issue

http://trigger-tf7.blogspot.com/

and BLOG:

__________________________________________________________

PAPERS IN PRESS
None Submitted for this issue.

__________________________________________________________
UPCOMING MEETINGS EVENTS

General info on upcoming meetings of interest:

ISTH also maintains a list of upcoming meetings of interest:

http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1dSWKGLN7_jB7qag0acOYq9/

__________________________________________________________

RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI

Papers are culled from NLM MedLine (PubMed). Titles in square brackets indicate that the paper was not published in English. References that lack volume or page numbers are typically electronic pre-publications (E-pubs) ahead of the print publication; if so, the final citation with volume and page numbers may or may not appear in a future issue of Trigger.

THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":

(2013) [Lung tissue factor expression changes in relation to the stage of respiratory distress syndrome in the presence of pneumonia in A/H1N1 influenza]. Arkh Patol 75:16-21.

http://www.ncbi.nlm.nih.gov/pubmed/24624839

Acquazzino MA, Rush ET, Quiros Tejeira RE, Beck JC (2014) Liver transplant for congenital factor VII deficiency. Pediatr Blood Cancer.

http://www.ncbi.nlm.nih.gov/pubmed/24585521

Brandt KJ, Fickentscher C, Boehlen F, Kruithof EK, de Moerloose P (2014) NF-B is Activated from Endosomal Compartments in Antiphospholipid Antibodies-treated Human Monocytes. J Thromb Haemost.

http://www.ncbi.nlm.nih.gov/pubmed/24612386

Brummel-Ziedins KE, Lam PH, Gissel M, Gauthier E, Schneider DJ (2013) Depletion of systemic concentrations of coagulation factors in blood from patients with atherosclerotic vascular disease. Coron Artery Dis 24:468-474.

http://www.ncbi.nlm.nih.gov/pubmed/23787362

Buxhofer-Ausch V, Olcaydu D, Gisslinger B, Schalling M, Frantal S, Thiele J, . . . Gisslinger H (2014) Decanucleotide insertion polymorphism of F7 significantly influences the risk of thrombosis in patients with essential thrombocythemia. Eur J Haematol.

http://www.ncbi.nlm.nih.gov/pubmed/24617727

Cate HT, Meade T (2014) The Northwick Park Heart Study: Evidence from the Laboratory. J Thromb Haemost.

http://www.ncbi.nlm.nih.gov/pubmed/24593861

Choi Q, Kim JE, Hyun J, Han KS, Kim HK (2013) Contributions of procoagulants and anticoagulants to the international normalized ratio and thrombin generation assay in patients treated with warfarin: potential role of protein Z as a powerful determinant of coagulation assays. Thromb Res 132:e70-75.

http://www.ncbi.nlm.nih.gov/pubmed/23769659

D'Asti E, Magnus N, Meehan B, Garnier D, Rak J (2014) Genetic Basis of Thrombosis in Cancer. Semin Thromb Hemost.

http://www.ncbi.nlm.nih.gov/pubmed/24599437

De Robertis E, Kozek-Langenecker S, Tufano R, Romano GM, Piazza O, Zito Marinosci G (2014) Coagulopathy induced by acidosis, hypothermia and hypocalcaemia in severe bleeding. Minerva Anestesiol.

http://www.ncbi.nlm.nih.gov/pubmed/24608516

Ding Q, Shen Y, Yang L, Wang X, Rezaie AR (2013) The missense Thr211Pro mutation in the factor X activation peptide of a bleeding patient causes molecular defect in the clotting cascade. Thromb Haemost 110:53-61.

http://www.ncbi.nlm.nih.gov/pubmed/23677006

E Y, He N, Fan H (2013) The effect of short-term intra-arterial delivery of paclitaxel on neointimal hyperplasia and the local thrombotic environment after angioplasty. Cardiovasc Intervent Radiol 36:1086-1096.

http://www.ncbi.nlm.nih.gov/pubmed/23474915

Francischetti IM, Gordon E, Bizzarro B, Gera N, Andrade BB, Oliveira F, . . . Waisberg M (2014) Tempol, an intracellular antioxidant, inhibits tissue factor expression, attenuates dendritic cell function, and is partially protective in a murine model of cerebral malaria. PLoS One 9:e87140.

http://www.ncbi.nlm.nih.gov/pubmed/24586264

Fujii T, Saito S (2014) Hemostatic treatment for intractable traumatic hemorrhage using fibrinogen concentrates and recombinant activated factor VII. Rinsho Ketsueki 55:234-238.

http://www.ncbi.nlm.nih.gov/pubmed/24598191

Gleizes C, Constantinescu A, Abbas M, Zobairi F, Kessler L, Toti F (2014) Liraglutide protects Rin-m5f beta cells by reducing procoagulant tissue factor activity and apoptosis prompted by microparticles under conditions mimicking Instant Blood Mediated Inflammatory Reaction. Transpl Int.

http://www.ncbi.nlm.nih.gov/pubmed/24612163

Gomes M, Khorana AA (2014) Risk Assessment for Thrombosis in Cancer. Semin Thromb Hemost.

http://www.ncbi.nlm.nih.gov/pubmed/24599438

Guzzetta NA, Szlam F, Kiser AS, Fernandez JD, Szlam AD, Leong T, Tanaka KA (2014) Augmentation of thrombin generation in neonates undergoing cardiopulmonary bypass. Br J Anaesth 112:319-327.

http://www.ncbi.nlm.nih.gov/pubmed/24193321

Henn LW, Esmailian F (2013) Repair of a large main pulmonary artery aneurysm in a 71-year-old Jehovah's Witness patient. Tex Heart Inst J 40:350-352.

http://www.ncbi.nlm.nih.gov/pubmed/23914038

Htun KT, McFadyen J, Tran HA (2014) The successful management of dabigatran-associated critical end-organ bleeding with recombinant factor VIIa. Ann Hematol.

http://www.ncbi.nlm.nih.gov/pubmed/24584995

Jo JT, Schiff D, Perry JR (2014) Thrombosis in Brain Tumors. Semin Thromb Hemost.

http://www.ncbi.nlm.nih.gov/pubmed/24599439

Kuroda H, Ishikawa K, Jomen W, Yoshida M, Yamada M, Abe T, . . . Kato J (2013) [Primary myelofibrosis complicated by acquired hemophilia A and subsequent development of acute myeloid leukemia]. Rinsho Ketsueki 54:2192-2198.

http://www.ncbi.nlm.nih.gov/pubmed/24452152

Kwaan HC (2014) The Unique Hemostatic Dysfunction in Acute Promyelocytic Leukemia. Semin Thromb Hemost.

http://www.ncbi.nlm.nih.gov/pubmed/24590422

Larcombe PJ, Kapur N, Fraser CJ, Coulthard MG, Schlapbach LJ (2014) Intrabronchial administration of activated recombinant factor VII in a young child with diffuse alveolar hemorrhage. Pediatr Blood Cancer 61:570-571.

http://www.ncbi.nlm.nih.gov/pubmed/24424793

Leers MP, Keuren JF, Frissen ME, Huts M, Kragten JA, Jie KS (2013) The pro- and anticoagulant role of blood-borne phagocytes in patients with acute coronary syndrome. Thromb Haemost 110:101-109.

http://www.ncbi.nlm.nih.gov/pubmed/23595567

Liu Q, Xu B, Xiao T, Su J, Zhong L (2013) Molecular cloning, characterization and expression analysis of coagulation factor VII gene in grass carp (Ctenopharyngodon idella). Fish Shellfish Immunol 35:618-622.

http://www.ncbi.nlm.nih.gov/pubmed/23727283

Mackman N, Luther T (2013) Platelet tissue factor: to be or not to be. Thromb Res 132:3-5.

http://www.ncbi.nlm.nih.gov/pubmed/23731564

Maier MA, Jayaraman M, Matsuda S, Liu J, Barros S, Querbes W, . . . Akinc A (2013) Biodegradable lipids enabling rapidly eliminated lipid nanoparticles for systemic delivery of RNAi therapeutics. Mol Ther 21:1570-1578.

http://www.ncbi.nlm.nih.gov/pubmed/23799535

Mazzeffi M, Szlam F, Jakubowski JA, Tanaka KA, Sugidachi A, Levy JH (2013) In vitro effects of recombinant activated factor VII on thrombin generation and coagulation following inhibition of platelet procoagulant activity by prasugrel. Thromb Res 132:106-111.

http://www.ncbi.nlm.nih.gov/pubmed/23664633

Omran N, Harrer J, Brtko M, Habal P, Turek Z, Pojar M, Brozik J (2013) Recombinant activated factor VII administration after pulmonary embolectomy: case report. Heart Surg Forum 16:E205-207.

http://www.ncbi.nlm.nih.gov/pubmed/23958532

Osterud B, Olsen JO (2013) Human platelets do not express tissue factor. Thromb Res 132:112-115.

http://www.ncbi.nlm.nih.gov/pubmed/23623171

Pamuk BO, Sari I, Selcuk S, Gokce G, Kozaci DL (2013) Evaluation of circulating endothelial biomarkers in familial Mediterranean fever.

Rheumatol Int 33:1967-1972.

http://www.ncbi.nlm.nih.gov/pubmed/23358733

Perzborn E, Gruber A, Tinel H, Marzec UM, Buetehorn U, Buchmueller A, . . . Laux V (2013) Reversal of rivaroxaban anticoagulation by haemostatic agents in rats and primates. Thromb Haemost 110:162-172.

http://www.ncbi.nlm.nih.gov/pubmed/23636219

Raja O, Imane S, Saadia F, Bouchra O (2013) [Lack of congenital factor VII]. Tunis Med 91:482-483.

http://www.ncbi.nlm.nih.gov/pubmed/24008890

Sbrana F, Coceani M, Panchetti L, Pasanisi EM, Rovai D, Del Corso A (2013) Factor VII deficiency, masked by warfarin therapy, as a cause of bleeding after cardiovascular intervention. Cardiovasc Intervent Radiol 36:1180-1183.

http://www.ncbi.nlm.nih.gov/pubmed/23188558

Shetty S, Shelar T, Mirgal D, Nawadkar V, Pinto P, Shabhag S, . . . Ghosh K (2014) Rare coagulation factor deficiencies: a countrywide screening data from India. Haemophilia.

http://www.ncbi.nlm.nih.gov/pubmed/24581247

Siboni SM, Biguzzi E, Pasta G, Mannucci PM, Mistretta C, Fantini NN, . . . Peyvandi F (2014) Management of orthopaedic surgery in rare bleeding disorders. Haemophilia.

http://www.ncbi.nlm.nih.gov/pubmed/24612427

Singh SP, Chauhan S, Choudhury M, Malik V, Choudhary SK (2014) Recombinant activated factor VII in cardiac surgery: single-center experience. Asian Cardiovasc Thorac Ann 22:148-154.

http://www.ncbi.nlm.nih.gov/pubmed/24585784

Stein P, Bosshart M, Brand B, Schlicker A, Spahn DR, Bettex D (2014) Dabigatran anticoagulation and Stanford type A aortic dissection: lethal coincidence: Case report with literature review. Acta Anaesthesiol Scand.

http://www.ncbi.nlm.nih.gov/pubmed/24601892

Sugita C, Yamashita A, Matsuura Y, Iwakiri T, Okuyama N, Matsuda S, . . . Asada Y (2013) Elevated plasma factor VIII enhances venous thrombus formation in rabbits: contribution of factor XI, von Willebrand factor and tissue factor. Thromb Haemost 110:62-75.

http://www.ncbi.nlm.nih.gov/pubmed/23636277

van Geffen M, Mathijssen NC, Holme PA, Laros-van Gorkom BA, van Kraaij MG, Masereeuw R, . . . van Heerde WL (2013) Pharmacodynamics of recombinant activated factor VII and plasma-derived factor VII in a cohort of severe FVII deficient patients. Thromb Res 132:116-122.

http://www.ncbi.nlm.nih.gov/pubmed/23731565

Wang Z, Li J, Cao L, Yu Z, Bai X, Ruan C (2014) [Hypofibrinogenemia caused by long-term administration of hemocoagulase: three cases report and literature review]. Zhonghua Xue Ye Xue Za Zhi 35:50-52.

http://www.ncbi.nlm.nih.gov/pubmed/24602733

Wood JP, Ellery PE, Maroney SA, Mast AE (2014) Biology of tissue factor pathway inhibitor. Blood.

http://www.ncbi.nlm.nih.gov/pubmed/24620349

Xie H, Sheng L, Zhou H, Yan J (2014) The role of TLR4 in pathophysiology of antiphospholipid syndrome-associated thrombosis and pregnancy morbidity. Br J Haematol 164:165-176.

http://www.ncbi.nlm.nih.gov/pubmed/24180619

Zhang X, McGeoch SC, Megson IL, Macrury SM, Johnstone AM, Abraham P, . . . Lobley GE (2014) Oat-enriched diet reduces inflammatory status assessed by circulating cell-derived microparticle concentrations in type 2 diabetes. Mol Nutr Food Res.

http://www.ncbi.nlm.nih.gov/pubmed/24604886

Zhu B, Zhang P, Zeng P, Huang Z, Dong TF, Gui YK, Zhang GW (2013) Tissue factor pathway inhibitor-2 silencing promotes hepatocellular carcinoma cell invasion in vitro. Anat Rec (Hoboken) 296:1708-1716.

http://www.ncbi.nlm.nih.gov/pubmed/24591127

__________________________________________________________

ABOUT TRIGGER
TRIGGER is edited by Jim Morrissey and Pierre Neuenschwander, with editorial assistance by Genie Morrissey. It includes Abstracts of Papers in Press, Meeting Announcements, Positions Sought/Available,or any other pertinent item that subscribers may want to share with their colleagues. To submit an item for publication in Trigger, e-mail us. To request or cancel a subscription,or for more information about TRIGGER or the biology of tissue factor and factor VII, visit our web site. You can also contact us by mail: J.H. Morrissey, University of Illinois College of Medicine, 417 Med Sci Bldg MC-714, 506 S. Mathews Ave., Urbana, IL 61801, USA.

DISCLAIMER: TRIGGER is provided "as is" for information purposes only and without warranty of any kind, express or implied. Users shall assume the entire risk as to the accuracy and usefulness of information in TRIGGER. Opinions expressed here are not necessarily those of the editors or their employers. You may share TRIGGER with your scientific colleagues but you are not permitted to use it or its contents for commercial purposes.
__________________________________________________________

Monday, March 3, 2014

Vol. 20, No. 5

TRIGGER
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 20, No. 5 March 3, 2014

(The next issue will be on March 18, 2014)

__________________________________________________________
TRIGGER is also available by RSS Feed:

and BLOG:
http://trigger-tf7.blogspot.com/
__________________________________________________________

PAPERS IN PRESS
None Submitted for this issue.

__________________________________________________________
UPCOMING MEETINGS EVENTS

General info on upcoming meetings of interest:

ISTH also maintains a list of upcoming meetings of interest:

__________________________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI

THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":

http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1xmXzoKy-fPeqHzorDHfhaq/

Agerso H, Overgaard RV, Petersen MB, Hansen L, Hermit MB, Sorensen MH, . . . Hilden I (2014) Pharmacokinetics of an anti-TFPI monoclonal antibody (concizumab) blocking the TFPI interaction with the active site of FXa in Cynomolgus Monkeys after iv and sc administration. Eur J Pharm Sci.
http://www.ncbi.nlm.nih.gov/pubmed/24568891

Batorova A, Mariani G, Kavakli K, de Saez AR, Caliskan U, Karimi M, . . . Ingerslev J (2014) Inhibitors to factor VII in congenital factor VII deficiency. Haemophilia 20:e188-191.
http://www.ncbi.nlm.nih.gov/pubmed/24533960

Colace TV, Tormoen GW, McCarty OJ, Diamond SL (2013) Microfluidics and coagulation biology. Annu Rev Biomed Eng 15:283-303.
http://www.ncbi.nlm.nih.gov/pubmed/23642241

Cordazzo C, Neri T, Petrini S, Lombardi S, Balia C, Cianchetti S, . . . Celi A (2013) Angiotensin II induces the generation of procoagulant microparticles by human mononuclear cells via an angiotensin type 2 receptor-mediated pathway. Thromb Res 131:e168-174.
http://www.ncbi.nlm.nih.gov/pubmed/23414567

Ellery PE, Maroney SA, Martinez ND, Wickens MP, Mast AE (2014) Translation of human tissue factor pathway inhibitor-beta mRNA is controlled by alternative splicing within the 5' untranslated region. Arterioscler Thromb Vasc Biol 34:187-195.
http://www.ncbi.nlm.nih.gov/pubmed/24233486

Geddings JE, Mackman N (2014) New players in haemostasis and thrombosis. Thromb Haemost 111.
http://www.ncbi.nlm.nih.gov/pubmed/24573314

Ghinea N, Lipworth W, Kerridge I, Little M, Day RO (2014) Ethics and Evidence in Medical Debates: The Case of Recombinant Activated Factor VII. Hastings Cent Rep.
http://www.ncbi.nlm.nih.gov/pubmed/24532448

Iwase H, Ezzelarab MB, Ekser B, Cooper DK (2014) The role of platelets in coagulation dysfunction in xenotransplantation, and therapeutic options. Xenotransplantation.
http://www.ncbi.nlm.nih.gov/pubmed/24571124

Lin ZM, Zhao JX, Duan XN, Zhang LB, Ye JM, Xu L, Liu YH (2014) Effects of Tissue Factor, PAR-2 and MMP-9 Expression on Human Breast Cancer Cell Line MCF-7 Invasion. Asian Pac J Cancer Prev 15:643-646.
http://www.ncbi.nlm.nih.gov/pubmed/24568471

Parker RI (2014) Transfusion in critically ill children: indications, risks, and challenges. Crit Care Med 42:675-690.
http://www.ncbi.nlm.nih.gov/pubmed/24534955

Perzborn E, Heitmeier S, Laux V, Buchmuller A (2014) Reversal of rivaroxaban-induced anticoagulation with prothrombin complex concentrate, activated prothrombin complex concentrate and recombinant activated factor VII in vitro. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/24529498

Sakamoto T, Kudoh T, Sakamoto K, Matsui K, Ogawa H (2014) Antithrombotic effects of losartan in patients with hypertension complicated by atrial fibrillation: 4A (Angiotensin II Antagonist of platelet Aggregation in patients with Atrial fibrillation), a pilot study. Hypertens Res.
http://www.ncbi.nlm.nih.gov/pubmed/24572913

Sridharan V, Tripathi P, Sharma S, Corry PM, Moros EG, Singh A, . . . Boerma M (2013) Effects of late administration of pentoxifylline and tocotrienols in an image-guided rat model of localized heart irradiation. PLoS One 8:e68762.
http://www.ncbi.nlm.nih.gov/pubmed/23894340

Stephan F, Marsman G, Bakker LM, Bulder I, Stavenuiter F, Aarden LA, Zeerleder S (2014) Cooperation of Factor VII-Activating Protease and Serum DNase I in the Release of Nucleosomes From Necrotic Cells.
Arthritis Rheumatol 66:686-693.
http://www.ncbi.nlm.nih.gov/pubmed/24574229

Wood JP, Ellery PE, Maroney SA, Mast AE (2014) Protein S is a cofactor for platelet and endothelial tissue factor pathway inhibitor-alpha but not for cell surface-associated tissue factor pathway inhibitor. Arterioscler Thromb Vasc Biol 34:169-176.
http://www.ncbi.nlm.nih.gov/pubmed/24233490

Wu X, Du Z, Yu J, Sun Y, Pei B, Lu X, . . . Hu J (2014) Activity of factor VII in patients with isolated blunt traumatic brain injury: association with coagulopathy and progressive hemorrhagic injury. J Trauma Acute Care Surg 76:114-120.
http://www.ncbi.nlm.nih.gov/pubmed/24368365

Zhang B, Wang H, Liao Z, Wang Y, Hu Y, Yang J, . . . Jiang X (2014) EGFP-EGF1-conjugated nanoparticles for targeting both neovascular and glioma cells in therapy of brain glioma. Biomaterials.
http://www.ncbi.nlm.nih.gov/pubmed/24529623

__________________________________________________________

Wednesday, February 26, 2014

Vol. 20, No. 4

TRIGGER
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 20, No. 4 February 17, 2014

(The next issue will be on March 3, 2014)

__________________________________________________________
TRIGGER is also available by RSS Feed:

and BLOG:
http://trigger-tf7.blogspot.com/
__________________________________________________________

PAPERS IN PRESS
None Submitted for this issue.

__________________________________________________________
UPCOMING MEETINGS EVENTS

General info on upcoming meetings of interest:

ISTH also maintains a list of upcoming meetings of interest:

http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1xUxfj2qjSnKcWprx7A1izH/

__________________________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI

THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":

Ardillon L, Lefrancois A, Graveleau J, Fouassier M, Ternisien C, Sigaud M, . . . Trossaert M (2014) Management of bleeding in severe factor V deficiency with a factor V inhibitor. Vox Sang.

http://www.ncbi.nlm.nih.gov/pubmed/24517203

Backman S, Hiltunen L, Huoponen O, Vepsalainen K, Riikonen P (2014) Inaccuracy in factor VIII measurement due to administration of recombinant activated factor VII in vivo. Int J Lab Hematol.

http://www.ncbi.nlm.nih.gov/pubmed/24495303

Banov L, Pavanello M, Piattelli G, Disma N, Severino M, Dufour C, Molinari AC (2014) Successful urgent neurosugery management with rFVIIa mega doses in a child with haemophilia a and high titre inhibitor. Blood Coagul Fibrinolysis.

http://www.ncbi.nlm.nih.gov/pubmed/24509334

Brophy GM, Candeloro CL, Robles JR, Brophy DF (2013) Recombinant activated factor VII use in critically ill patients: clinical outcomes and thromboembolic events. Ann Pharmacother 47:447-454.

http://www.ncbi.nlm.nih.gov/pubmed/23535812

Cesarman-Maus G, Braggio E, Lome-Maldonado C, Morales-Leyte AL, Fonseca R (2014) Absence of tissue factor is characteristic of lymphoid malignancies of both T- and B-cell origin. Thromb Res.

http://www.ncbi.nlm.nih.gov/pubmed/24491425

Dashty M, Motazacker MM, Levels J, Vries M, Mahmoudi M, Peppelenbosch MP, Rezaee F (2014) Proteome of human plasma very low-density lipoprotein and low-density lipoprotein exhibits a link with coagulation and lipid metabolism. Thromb Haemost 111.

http://www.ncbi.nlm.nih.gov/pubmed/24500811

Davies GF, Berg A, Postnikoff SD, Wilson HL, Arnason TG, Kusalik A, Harkness TA (2014) TFPI1 Mediates Resistance to Doxorubicin in Breast Cancer Cells by Inducing a Hypoxic-Like Response. PLoS One 9:e84611.

http://www.ncbi.nlm.nih.gov/pubmed/24489651

Gatt A, Chowdary P (2014) Does Balanced Haemostasis Equate to Normal Coagulation in Patients with Acute Liver Failure? Liver Int.

http://www.ncbi.nlm.nih.gov/pubmed/24484179

Geng Y, Verhamme IM, Sun MF, Bajaj SP, Emsley J, Gailani D (2013) Analysis of the factor XI variant Arg184Gly suggests a structural basis for factor IX binding to factor XIa. J Thromb Haemost 11:1374-1384.

http://www.ncbi.nlm.nih.gov/pubmed/23617568

Goel A, Nair SC, Viswabandya A, Masilamani VP, Rao SV, George A, . . . Chandy G (2013) Preliminary experience with use of recombinant activated factor VII to control postpartum hemorrhage in acute fatty liver of pregnancy and other pregnancy-related liver disorders.

Indian J Gastroenterol 32:268-271.

http://www.ncbi.nlm.nih.gov/pubmed/23475547

Grottke O, van Ryn J, Spronk HM, Rossaint R (2014) Prothrombin complex concentrates and a specific antidote to dabigatran are effective ex-vivo in reversing the effects of dabigatran in an anticoagulation/liver trauma experimental model. Crit Care 18:R27.

http://www.ncbi.nlm.nih.gov/pubmed/24499559

Hammad MA, Abdel-Bakky MS, Walker LA, Ashfaq MK (2013) Tissue factor antisense deoxyoligonucleotide prevents monocrotaline/LPS hepatotoxicity in mice. J Appl Toxicol 33:774-783.

http://www.ncbi.nlm.nih.gov/pubmed/22407844

Harinstein LM, Morgan JW, Russo N (2013) Treatment of dabigatran-associated bleeding: case report and review of the literature. J Pharm Pract 26:264-269.

http://www.ncbi.nlm.nih.gov/pubmed/23160864

Hot A, Lavocat F, Maggi L, Annunziato F, Miossec P (2014) A8.5 Comparison of the effects of TH17 and TH1 cells on endothelial cells and synoviocytes. Ann Rheum Dis 73 Suppl 1:A78.

http://www.ncbi.nlm.nih.gov/pubmed/24489308

Ishibazawa A, Nagaoka T, Yokota H, Ono S, Yoshida A (2013) Low shear stress up-regulation of proinflammatory gene expression in human retinal microvascular endothelial cells. Exp Eye Res 116:308-311.

http://www.ncbi.nlm.nih.gov/pubmed/24128656

Jiang P, Xue D, Zhang Y, Ye L, Liu Y, Makale M, . . . Liu C (2014) The extrinsic coagulation cascade and tissue factor pathway inhibitor in macrophages: A potential therapeutic opportunity for atherosclerotic thrombosis. Thromb Res.

http://www.ncbi.nlm.nih.gov/pubmed/24485401

Jin Y, Wang M, Wang Y, Yang X, Yang L, Xie Y, . . . Yu F (2014) [Phenotype and genotype analysis for a consanguineous pedigree with combined coagulation factor VII and X deficiency]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 31:16-20.

http://www.ncbi.nlm.nih.gov/pubmed/24510554

Kato M, Atsumi T, Oku K, Amengual O, Nakagawa H, Fujieda Y, . . .Koike T (2013) The involvement of CD36 in monocyte activation by antiphospholipid antibodies. Lupus 22:761-771.

http://www.ncbi.nlm.nih.gov/pubmed/23817509

Ke K, Yuan J, Morrissey JH (2014) Tissue factor residues that putatively interact with membrane phospholipids. PLoS One 9:e88675.

http://www.ncbi.nlm.nih.gov/pubmed/24516673

Keren-Politansky A, Breizman T, Brenner B, Sarig G, Drugan A (2014) The coagulation profile of preterm delivery. Thromb Res.

http://www.ncbi.nlm.nih.gov/pubmed/24508451

Kothari H, Pendurthi UR, Rao LV (2013) Analysis of tissue factor expression in various cell model systems: cryptic vs. active. J Thromb Haemost 11:1353-1363.

http://www.ncbi.nlm.nih.gov/pubmed/23621622

Lipets E, Vlasova O, Urnova E, Margolin O, Soloveva A, Ostapushchenko O, . . . Panteleev M (2014) Circulating Contact-Pathway-Activating Microparticles Together with Factors IXa and XIa Induce Spontaneous Clotting in Plasma of Hematology and Cardiologic Patients. PLoS One 9:e87692.

http://www.ncbi.nlm.nih.gov/pubmed/24498168

Ljung R, Karim FA, Saxena K, Suzuki T, Arkhammar P, Rosholm A, Giangrande P (2013) 40K glycoPEGylated, recombinant FVIIa: 3-month, double-blind, randomized trial of safety, pharmacokinetics and preliminary efficacy in hemophilia patients with inhibitors. J Thromb Haemost 11:1260-1268.

http://www.ncbi.nlm.nih.gov/pubmed/23578227

Ma D, Mizurini DM, Assumpcao TC, Li Y, Qi Y, Kotsyfakis M, . . .Francischetti IM (2013) Desmolaris, a novel factor XIa anticoagulant from the salivary gland of the vampire bat (Desmodus rotundus) inhibits inflammation and thrombosis in vivo. Blood 122:4094-4106.

http://www.ncbi.nlm.nih.gov/pubmed/24159172

Magnus N, Garnier D, Meehan B, McGraw S, Lee TH, Caron M, . . . Rak J (2014) Tissue factor expression provokes escape from tumor dormancy and leads to genomic alterations. Proc Natl Acad Sci U S A.

http://www.ncbi.nlm.nih.gov/pubmed/24520174

Majoor CJ, van de Pol MA, Kamphuisen PW, Meijers JC, Molenkamp R, Wolthers KC, . . . van der Sluijs KF (2014) Evaluation of coagulation activation after Rhinovirus infection in patients with asthma and healthy control subjects: an observational study. Respir Res 15:14.

http://www.ncbi.nlm.nih.gov/pubmed/24502801

Martinez-Palacian A, Kanse SM, Weiskirchen R (2014) Factor seven activating protease (FSAP): A novel protective factor in liver fibrosis. Proteomics Clin Appl.

http://www.ncbi.nlm.nih.gov/pubmed/24497464

McCain S, Gull S, Ahmad J, Carey D (2014) Acquired hemophilia A as a cause of acute upper gastrointestinal hemorrhage. BMJ Case Rep 2014.

http://www.ncbi.nlm.nih.gov/pubmed/24501339

McElroy AK, Erickson BR, Flietstra TD, Rollin PE, Nichol ST, Towner JS, Spiropoulou CF (2014) Ebola hemorrhagic fever: novel biomarker correlates of clinical outcome. J Infect Dis.

http://www.ncbi.nlm.nih.gov/pubmed/24526742

Nielsen MH, Beck-Nielsen H, Andersen MN, Handberg A (2014) A flow cytometric method for characterization of circulating cell-derived microparticles in plasma. J Extracell Vesicles 3.

http://www.ncbi.nlm.nih.gov/pubmed/24511371

Pagano S, Virzi J, Satta N, Mannic T, Roux-Lombard P, Mach F, . . .Vuilleumier N (2014) A9.11 Anti-apolipoprotein A1 autoantibodies induce tissue factor activity and expression: a role in atherothrombosis. Ann Rheum Dis 73 Suppl 1:A96.

http://www.ncbi.nlm.nih.gov/pubmed/24489357

Pham HP, Shaz BH (2013) Update on massive transfusion. Br J Anaesth 111 Suppl 1:i71-82.

http://www.ncbi.nlm.nih.gov/pubmed/24335401

Priestley ES, De Lucca I, Zhou J, Zhou J, Saiah E, Stanton R, . . .Wexler RR (2013) Discovery and gram-scale synthesis of BMS-593214, a potent, selective FVIIa inhibitor. Bioorg Med Chem Lett 23:2432-2435.

http://www.ncbi.nlm.nih.gov/pubmed/23478148

Senchenkova EY, Russell J, Esmon CT, Granger DN (2014) Roles of coagulation and fibrinolysis in angiotensin II enhanced microvascular thrombosis. Microcirculation.

http://www.ncbi.nlm.nih.gov/pubmed/24495184

Sharma R, Dash SK, Chawla R, Kansal S, Agrawal DK, Dua H (2013) Acquired hemophilia complicated by cardiorenal syndrome type 3. Indian J Crit Care Med 17:378-381.

http://www.ncbi.nlm.nih.gov/pubmed/24501492

Strickland DK, Au DT, Cunfer P, Muratoglu SC (2014) Low-Density Lipoprotein Receptor-Related Protein-1: Role in the Regulation of Vascular Integrity. Arterioscler Thromb Vasc Biol.

http://www.ncbi.nlm.nih.gov/pubmed/24504736

Tian Y, Ma S, Lin B, Kou J, Yu B (2013) Anti-thrombotic activity of DT-13, a saponin isolated from the root tuber of Liriope muscari. Indian J Pharmacol 45:283-285.

http://www.ncbi.nlm.nih.gov/pubmed/23833374

Tseng JC, Chang LC, Jiang BY, Liu YC, Chen HJ, Yu CT, Hua CC (2014) Elevated circulating levels of tissue factor-positive microvesicles are associated with distant metastasis in lung cancer. J Cancer Res Clin Oncol 140:61-67.

http://www.ncbi.nlm.nih.gov/pubmed/24169761

Uruga H, Fujii T, Kurosaki A, Hanada S, Takaya H, Miyamoto A, . . .Kishi K (2013) Pulmonary tumor thrombotic microangiopathy: a clinical analysis of 30 autopsy cases. Intern Med 52:1317-1323.

http://www.ncbi.nlm.nih.gov/pubmed/23774540

van Veen JJ, Maclean RM, Hampton KK, Hamer A, Makris M (2014) Major surgery in severe haemophilia A with inhibitors using a recombinant factor VIIa and activated prothrombin complex concentrate hybrid regimen. Haemophilia.

http://www.ncbi.nlm.nih.gov/pubmed/24517157

Wang LL, Ma B, Qian D, Pang J, Yao YL (2013) [Correlation between polymorphisms in the coagulation factor VII gene hypervariable region 4 site and the risk of coronary heart disease in population with different ethnic backgrounds: a Meta-analysis]. Zhonghua Liu Xing Bing Xue Za Zhi 34:1250-1254.

http://www.ncbi.nlm.nih.gov/pubmed/24518031

Waters EK, Genga RM, Thomson HA, Kurz JC, Schaub RG, Scheiflinger F, McGinness KE (2013) Aptamer BAX 499 mediates inhibition of tissue factor pathway inhibitor via interaction with multiple domains of the protein. J Thromb Haemost 11:1137-1145.

http://www.ncbi.nlm.nih.gov/pubmed/23528042

Williams L, Deana A, Romero A, Molina A, Lunello P (2014) High-level production of active human TFPI-2 Kunitz domain in plant. Protein Expr Purif.

http://www.ncbi.nlm.nih.gov/pubmed/24486814

Yau JW, Liao P, Fredenburgh JC, Stafford A, Revenko AS, Monia BP, Weitz JI (2014) Selective depletion of factor XI or factor XII with antisense oligonucleotides attenuates catheter thrombosis in rabbits. Blood.

http://www.ncbi.nlm.nih.gov/pubmed/24501216

Yu G, Li H, Wang X, Wu T, Zhu J, Huang S, . . . Tang J (2013) MicroRNA-19a targets tissue factor to inhibit colon cancer cells migration and invasion. Mol Cell Biochem 380:239-247.

http://www.ncbi.nlm.nih.gov/pubmed/23666757

__________________________________________________________

Vol. 20, No. 2

TRIGGER
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 20, No. 2 January 15, 2014

(The next issue will be on February 3, 2014)

__________________________________________________________
TRIGGER is also available by RSS Feed:

http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1z_kd2hNzEEY8Wpxz8t1rph/

and BLOG:
http://trigger-tf7.blogspot.com/
__________________________________________________________

ANNOUNCEMENTS

As we have done for the past few years, the individual PubMed "collections" of the papers appearing in each issue of TRIGGER for 2013 have now been consolidated into a single collection. (The individual PubMed collections for each TRIGGER issue in 2013 have, accordingly, been deleted.) Here are the links to the consolidated collections for the past five years:

2009 (301 references):

2010 (531 references):

http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1-cH907gHdg5lzzYz_yPkW5/

2011 (612 references):

http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1bOQXIskFcJPXOjjcawlCfD/

2012 (976 references):

http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/10m9tjGWs19M9UbjsWSGxO5/

2013 (848 references):

http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1xi2SytqpQABqWbF_4p8sae/

__________________________________________________________

PAPERS IN PRESS
None Submitted for this issue.

__________________________________________________________
UPCOMING MEETINGS EVENTS

7th Symposium on Hemostasis: Old System, New Players, New Directions May 15-17, 2014 at the Carolina Inn, Chapel Hill, NC, USA The focus will include the latest findings related to tissue factor, coagulation proteases and their role in hemostasis and thrombosis, as well as interplay between coagulation and inflammation. Important new research on novel approaches for treating bleeding in hemophilia and trauma induced coagulopathy, animal models of bleeding and thrombosis and activation of coagulation in disease will also be presented.

Invited faculty are the world's formost basic scientists and clinicians working in the field of tissue factor biology, coagulation and hemostasis.

Registration is now OPEN:

https://www.med.unc.edu/hemonc/TF2014

*** *** *** *** ***
General info on upcoming meetings of interest:

ISTH also maintains a list of upcoming meetings of interest:

http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1bWsnnWsxD55LyxFvhZvYxB/

__________________________________________________________

POSITIONS SOUGHT/AVAILABLE

A postdoctoral position is offered as part of the Novo Nordisk R&D STAR Programme (Science, Talent, Attraction and Recruitment). This program supports the brightest graduate students in biotechnology, life, medical and engineering sciences, who want to pursue a career in pharmaceutical R&D.

About the department: Translational Haemophilia Pharmacology is offering an international Postdoc fellowship to a highly motivated and ambitious candidate. Translational Haemophilia Pharmacology is a research unit focusing on research and development of drug candidates for the treatment of haemophilia; we support the Novo Nordisk haemophilia portfolio with knowledge generated in animal models of haemophilia.

The Job: The project will first focus on optimizing and validating a thrombin generation assay for use with samples from dogs, prior to and after therapeutic intervention. Subsequently the assay will be used to predicting the bleeding phenotype and response to treatment in dogs with haemophilia A and B as a model for human haemophilia. The project is conducted in close collaboration with leading researchers from the University of North Carolina at Chapel Hill.

The starting date is February 1, 2014 or later, and the position is on a temporary contract. Part of the PostDoc project will take place at Translational Haemophilia Pharmacology in Måløv, Denmark and the other part in the lab of Dr. Tim Nichols in close collaboration with Dr. Alisa Wolberg at the University of North Carolina, Chapel Hill. Travel expenses between the US and Denmark will be reimbursed by Novo Nordisk.

The candidate will become part of two laboratories located in high impact centers of excellence within haemophilia and thus exposed to world class science and in addition serve as a liaison between the University of Chapel Hill and Novo Nordisk A/S.

Qualifications: You hold a PhD in medicine, veterinary medicine, pharmacology, biology or related disciplines. Solid knowledge on in vivo research in general and haemostasis research in particular is desirable. Experience with haemophilia research is considered an advantage. We require very good communication skills in English.

At Novo Nordisk your skills, dedication, and ambition help us change lives for the better. In exchange we offer you an opportunity to work with extraordinary talent and benefit from a range of possibilities for professional and personal development.

For further information, please call Bo Wiinberg on +45 3075 3030.

__________________________________________________________

RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI

THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":

Blatny J, Mathew P, Monagle P, Ovesna P, Fiamoli V (2014) Safety and efficacy of recombinant activated factor VII in nonhemophilia children with severe or life-threatening bleeding: a report from the SeveNBleeP registry. Blood Coagul Fibrinolysis.

http://www.ncbi.nlm.nih.gov/pubmed/24389586

Boknas N, Faxalv L, Lindahl TL, Ramstrom S (2014) Contact activation - important to consider when measuring the contribution of tissue factor-bearing microparticles to thrombin generation using phospholipid-containing reagents. J Thromb Haemost.

http://www.ncbi.nlm.nih.gov/pubmed/24405583

Bosch YP, Al Dieri R, Ten Cate H, Nelemans PJ, Bloemen S, de Laat B, . . . Mochtar B (2013) Measurement of thrombin generation intra-operatively and its association with bleeding tendency after cardiac surgery. Thromb Res.

http://www.ncbi.nlm.nih.gov/pubmed/24388571

Gebhard C, Stahli BE, Largiader S, Holy EW, Akhmedov A, Camici GG, . . . Tanner FC (2013) Caffeic acid phenethyl ester inhibits endothelial tissue factor expression. Biol Pharm Bull 36:1032-1035.

http://www.ncbi.nlm.nih.gov/pubmed/23727925

Hansen L, Petersen LC, Lauritzen B, Clausen JT, Grell SN, Agerso H, . . . Almholt K (2013) Target-mediated clearance and bio-distribution of a monoclonal antibody against the Kunitz-type protease inhibitor 2 domain of Tissue Factor Pathway Inhibitor. Thromb Res.

http://www.ncbi.nlm.nih.gov/pubmed/24393663

Hilbert P, Hofmann GO, Teichmann J, Struck MF, Stuttmann R (2013) The "coagulation box" and a new hemoglobin-driven algorithm for bleeding control in patients with severe multiple traumas. Arch Trauma Res 2:3-10.

http://www.ncbi.nlm.nih.gov/pubmed/24396782

Holley AB, Petteys S, Mitchell JD, Holley PR, Collen JF (2013) Thromboprophylaxis and VTE rates in soldiers wounded in Operation Enduring Freedom and Operation Iraqi Freedom. Chest 144:966-973.

http://www.ncbi.nlm.nih.gov/pubmed/23539197

Kiessling AH, Nitsch J, Strouhal U, Kornberger A, Zierer A, Moritz A (2013) Associated risk of recombinant activated factor VIIa application. Heart Surg Forum 16:E132-136.

http://www.ncbi.nlm.nih.gov/pubmed/23803235

Magon N, Babu KM, Kapur K, Chopra S, Joneja GS (2013) Recombinant activated factor VII in post partum haemorrhage. Niger Med J 54:289-294.

http://www.ncbi.nlm.nih.gov/pubmed/24403703

Menegatti M, Vangone A, Palla R, Milano G, Cavallo L, Oliva R, . . . Peyvandi F (2013) A recurrent Gly43Asp substitution in coagulation Factor X rigidifies its catalytic pocket and impairs catalytic activity and intracellular trafficking. Thromb Res.

http://www.ncbi.nlm.nih.gov/pubmed/24393662

Osterud B, Olsen JO (2013) Pro- and anti-inflammatory effects of histamine on tissue factor and TNFalpha expression in monocytes of human blood. Thromb Res.

http://www.ncbi.nlm.nih.gov/pubmed/24393660

Saeki N, Mochizuki S, Fujii T, Kawamoto M (2014) Postsurgical coagulopathy in a hemophilia A patient with inhibitors: efficacy of recombinant factor VIIa. J Anesth.

http://www.ncbi.nlm.nih.gov/pubmed/24389884

Wang GJ, Wang YB, Li DN, Li C, Deng BB (2014) Expression of tissue factor pathway inhibitor-2 in gastric stromal tumor and its clinical significance. Exp Ther Med 7:513-517.

http://www.ncbi.nlm.nih.gov/pubmed/24396436

Wood JP, Bunce MW, Maroney SA, Tracy PB, Camire RM, Mast AE (2013) Tissue factor pathway inhibitor-alpha inhibits prothrombinase during the initiation of blood coagulation. Proc Natl Acad Sci U S A 110:17838-17843.

http://www.ncbi.nlm.nih.gov/pubmed/24127605

Xiao W, Li CQ, Xiao XP, Lin FZ (2013) Expression and fast preparation of biologically active recombinant human coagulation factor VII in CHO-K1 cells. Genet Mol Res 12:6813-6824.

http://www.ncbi.nlm.nih.gov/pubmed/24391029

Yu YH, Wu DS, Huang FF, Zhang Z, Liu LX, Zhang J, . . . Chen FP (2013) MicroRNA-20b and ERK1/2 pathway independently regulate the expression of tissue factor in hematopoietic and trophoblastic differentiation of human embryonic stem cells. Stem Cell Res Ther 4:121.

http://www.ncbi.nlm.nih.gov/pubmed/24405935

Zelaya H, Tsukida K, Chiba E, Marranzino G, Alvarez S, Kitazawa H, . . . Villena J (2014) Immunobiotic lactobacilli reduce viral-associated pulmonary damage through the modulation of inflammation-coagulation interactions. Int Immunopharmacol.

http://www.ncbi.nlm.nih.gov/pubmed/24394565

Zerrouqi A, Pyrzynska B, Brat DJ, Van Meir EG (2014) p14ARF suppresses tumor-induced thrombosis by regulating the tissue factor pathway. Cancer Res.

http://www.ncbi.nlm.nih.gov/pubmed/24398474

__________________________________________________________

Vol. 20, No. 1

TRIGGER
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 20, No. 1 January 2, 2014

(The next issue will be on January 15, 2014)

__________________________________________________________
TRIGGER is also available by RSS Feed:

and BLOG:
http://trigger-tf7.blogspot.com/
__________________________________________________________

PAPERS IN PRESS
None Submitted for this issue.

__________________________________________________________
UPCOMING MEETINGS EVENTS

General info on upcoming meetings of interest:

ISTH also maintains a list of upcoming meetings of interest: