Tuesday, January 15, 2013

Vol. 19, No. 2

TRIGGER
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 19, No. 2 January 15, 2013
(The next issue will be on February 1, 2013)
__________________________________________________________
TRIGGER is also available by RSS Feed:
and BLOG:
http://trigger-tf7.blogspot.com/
__________________________________________________________
UPCOMING MEETINGS & EVENTS
The XXIV Congress of the ISTH will be held in Amsterdam, June 29 - July 4, 2013.  The abstract deadline is February 1.  For more information, go to:
http://www.isth2013.org/abstract-submission/

Please note -- scientists from developing countries are encouraged to apply for "Reach the World Grants" to help defray their travel expenses in attending this meeting.  The deadline for such applications is February 6. For more info:
http://www.isth2013.org/registration/reach-the-world-grants/

For general info on upcoming meetings:
http://tf7.org/meetings.htm
_________________________________________________________
POSITIONS AVAILABLE
Thomas RennĂ© at the Karolinska Institutet and University Hospital Solna, Stockholm, Sweden, has postdoctoral positions available.  For details,see the following online ad at Nature Jobs:
http://www.nature.com/naturejobs/science/jobs/299639-Postdoc-in-Cardiovascular-Medicine

or for more information, contact:
Thomas Renné, MD, PhD
Department of Molecular Medicine and Surgery
Karolinska Institutet and University Hospital Solna (L1:00)
SE-171 76 Stockholm, Sweden
E-mail:  Thomas DOT Renne AT ki DOT se
_________________________________________________________
PRODUCT ANNOUNCEMENT
Diagnostica Stago Offers Three Factor VII Detection Methods

June 15, 2012, Parsippany, NJ, USA - Diagnostica Stago, Inc. announces products to suit a variety of clinical research needs for factor VII (FVII).

Staclot® VIIa-rTF (catalog #00281) is a kit for plasma analysis of circulating FVIIa using a clotting method.  This unique product is a tool for research studies where the determination of FVIIa levels may be useful due to the fact that it reflects coagulation activation as a result of in vivo FVIIa production.

Asserachrom® VII:Ag (catalog #00241) is an enzyme-linked immunosorbent assay (ELISA) that determines the antigen level of factor VII in plasma samples.

Asserachrom® VIIa-AT (catalog #00491) is a new kit for the analysis of plasma circulating factor VIIa-Antithrombin (FVIIa-AT) complex levels by the ELISA method, and can be run on any plate reader reporting absorbance at 450 nm.  This first of its kind product is useful for examination of FVIIa-AT levels, which has been recognized in the literature as a surrogate marker for the extent of tissue factor (TF) exposure to plasma as a result of coagulation activation in prothrombotic disease states such as arterial and venous thrombosis.  Unlike the FVIIa-TFPI complex, which stays bound to the endothelium, FVIIa-AT is present in the blood upon physiological coagulation activation, making it a useful surrogate marker for this phenomenon.

All three methods described are for research use only (not for use in diagnostic procedures).

Contact:
Paul Riley, PhD, Manager, Research Use Products
Diagnostica Stago, Inc.
(973) 631-1200 x4238
paul DOT riley AT stago-us DOT com

Web links:
www.stago-us.com

http://www.stago-us.com/nc/products-services/catalog/research-products/selection/type-research-products/group/research-kits-2/

DISCLAIMER:  Commercial product announcements appearing in TRIGGER are provided "as is" for informational purposes only.  The editors of TRIGGER have not necessarily evaluated any materials from commercial suppliers described in this newsletter or on its web sites, and we certainly are not endorsing any specific suppliers or products.  Furthermore, the editors receive no revenues from any source in the course of publishing TRIGGER.
_________________________________________________________
PAPERS IN PRESS
None Submitted for this issue.
__________________________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI
Papers are culled from NLM MedLine (PubMed). Titles in square brackets indicate that the paper was not published in English. References that lack volume or page numbers are typically electronic pre-publications (E-pubs) ahead of the print publication; if so, the final citation with volume and page numbers may or may not appear in a future issue of Trigger.
THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1poRUtS1KzDOPNJ0qfQD3Wp/

Aditya S (2012) Oral and parenteral anticoagulants: New kids on the block. J Postgrad Med 58:275-285.
http://www.ncbi.nlm.nih.gov/pubmed/23298923

Alam SE, Singh RB, Gupta S, Dherange P, De Meester F, Wilczynska A, . . . Hungin P (2012) Nutritional aspects of epigenetic inheritance. Can J Physiol Pharmacol 90:989-994.
http://www.ncbi.nlm.nih.gov/pubmed/22803604

Barras CD, Tress BM, Christensen S, Collins M, Desmond PM, Skolnick BE, . . . Davis SM (2013) Quantitative CT Densitometry for Predicting Intracerebral Hemorrhage Growth. AJNR Am J Neuroradiol.
http://www.ncbi.nlm.nih.gov/pubmed/23306009

Basavaraj MG, Osterud B, Hansen JB (2012) Influence of different anticoagulants on monocyte procoagulant functions and monocyte-platelet aggregates formation. J Thromb Haemost 10:1698-1702.
http://www.ncbi.nlm.nih.gov/pubmed/22712695

Chen H, Jiao J, Cheung CP, Borra S (2012) Mysterious bruises. J Postgrad Med 58:221-224.
http://www.ncbi.nlm.nih.gov/pubmed/23023361

Cole M, Bromberg M (2013) Tissue Factor as a Novel Target for Treatment of Breast Cancer. Oncologist.
http://www.ncbi.nlm.nih.gov/pubmed/23287882

Cvirn G, Schlagenhauf A, Leschnik B, Koestenberger M, Roessler A, Jantscher A, . . . Goswami N (2012) Coagulation changes during presyncope and recovery. PLoS One 7:e42221.
http://www.ncbi.nlm.nih.gov/pubmed/22876309

Deanda A, Jr., Hymes K (2012) Thrombosis and recombinant factor VIIa: letter 1. Ann Thorac Surg 94:1783.
http://www.ncbi.nlm.nih.gov/pubmed/23098970

Dieri RA, Bloemen S, Kelchtermans H, Wagenvoord R, Hemker HC (2013) A new regulatory function of activated factor V; inhibition of the activation by tissue factor /factor VII(a) of factor X. J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/23294934

Gerotziafas GT, Galea V, Mbemba E, Khaterchi A, Sassi M, Baccouche H, . . . Elalamy I (2012) Tissue factor over-expression by human pancreatic cancer cells BXPC3 is related to higher prothrombotic potential as compared to breast cancer cells MCF7. Thromb Res 129:779-786.
http://www.ncbi.nlm.nih.gov/pubmed/21917301

Gorczyca ME, Nair SC, Jilma B, Priya S, Male C, Reitter S, . . . Srivastava A (2012) Inhibition of tissue factor pathway inhibitor by the aptamer BAX499 improves clotting of hemophilic blood and plasma. J Thromb Haemost 10:1581-1590.
http://www.ncbi.nlm.nih.gov/pubmed/22632032

Hoffman M, Dargaud Y (2012) Mechanisms and monitoring of bypassing agent therapy. J Thromb Haemost 10:1478-1485.
http://www.ncbi.nlm.nih.gov/pubmed/22632160

Hong H, Zhang Y, Nayak TR, Engle JW, Wong HC, Liu B, . . . Cai W (2012) Immuno-PET of tissue factor in pancreatic cancer. J Nucl Med 53:1748-1754.
http://www.ncbi.nlm.nih.gov/pubmed/22988057

Ji M, Yi S, Yu D, Wang W (2011) [siRNA-mediated tissue factor knockdown in porcine neonatal islet cell clusters in vitro]. Zhong Nan Da Xue Xue Bao Yi Xue Ban 36:1141-1146.
http://www.ncbi.nlm.nih.gov/pubmed/22246358

Krysiak R, Okopien B (2012) Hemostatic effects of omega-3 fatty acids in isolated hypertriglyceridemic patients treated with bezafibrate. Eur J Intern Med 23:e168-169.
http://www.ncbi.nlm.nih.gov/pubmed/22863446

Langer F, Spath B, Fischer C, Stolz M, Ayuk FA, Kroger N, . . . Ruf W (2013) Rapid activation of monocyte tissue factor by antithymocyte globulin is dependent on complement and protein disulfide isomerase. Blood.
http://www.ncbi.nlm.nih.gov/pubmed/23315166

Lauer S, Westphal M, Fischer LG, Meissner A, Van Aken H, Freise H (2011) Recombinant factor VIIa and factor VIII treatment for acquired factor VIII deficiency: a case of repeated thrombotic endotracheal occlusion in a mechanically ventilated patient. Crit Care 15:407.
http://www.ncbi.nlm.nih.gov/pubmed/21418550

Lavrentieva A (2013) Replacement of specific coagulation factors in patients with burn: A review. Burns.
http://www.ncbi.nlm.nih.gov/pubmed/23312909

Liang WL, Wei HY, Lin FQ, Zhou JL (2012) [Molecular analysis of two pedigrees with inherited coagulation factor VII deficiency]. Zhonghua Er Ke Za Zhi 50:817-820.
http://www.ncbi.nlm.nih.gov/pubmed/23302610

Mahmood I (2012) Allometric extrapolation of factors VII, VIII and IX clearance in children from adults. J Thromb Haemost 10:1609-1613.
http://www.ncbi.nlm.nih.gov/pubmed/22612736

Miyares MA, Davis K (2012) Newer oral anticoagulants: a review of laboratory monitoring options and reversal agents in the hemorrhagic patient. Am J Health Syst Pharm 69:1473-1484.
http://www.ncbi.nlm.nih.gov/pubmed/22899742

Moosdorf R (2012) Aortic valve thrombosis after treatment with recombinant factor VIIa: letter 2. Ann Thorac Surg 94:1783-1784; author reply 1784.
http://www.ncbi.nlm.nih.gov/pubmed/23098971

Napoleone E, Cutrone A, Cugino D, Amore C, Di Santo A, Iacoviello L, . . . Lorenzet R (2012) Inhibition of the renin-angiotensin system downregulates tissue factor and vascular endothelial growth factor in human breast carcinoma cells. Thromb Res 129:736-742.
http://www.ncbi.nlm.nih.gov/pubmed/22188725

Ogasawara S, Stokol T (2012) Interleukin-10 inhibits lipopolysaccharide-induced upregulation of tissue factor in canine peripheral blood monocytes. Vet Immunol Immunopathol 148:331-336.
http://www.ncbi.nlm.nih.gov/pubmed/22609246

Oishi K, Koyanagi S, Ohkura N (2013) The molecular clock regulates circadian transcription of tissue factor gene. Biochem Biophys Res Commun.
http://www.ncbi.nlm.nih.gov/pubmed/23291174

Okamoto Y, Ishii S, Croce K, Katsumata H, Fukushima M, Kihara S, . . . Minami S (2012) Adiponectin inhibits macrophage tissue factor, a key trigger of thrombosis in disrupted atherosclerotic plaques. Atherosclerosis.
http://www.ncbi.nlm.nih.gov/pubmed/23290299

Papareddy P, Kalle M, Sorensen OE, Lundqvist K, Morgelin M, Malmsten M, Schmidtchen A (2012) Tissue factor pathway inhibitor 2 is found in skin and its C-terminal region encodes for antibacterial activity. PLoS One 7:e52772.
http://www.ncbi.nlm.nih.gov/pubmed/23300768

Rad M, Burggraaf J, de Kam ML, Cohen AF, Kluft C (2012) Discriminant analysis of the metabolic effects of a new combined contraceptive vaginal ring containing Nestorone/EE vs. a second-generation oral contraceptive containing levonorgestrel/EE. Contraception 86:231-237.
http://www.ncbi.nlm.nih.gov/pubmed/22445437

Rico MC, Rough JJ, Manns JM, Del Carpio-Cano F, Safadi FF, Kunapuli SP, DeLa Cadena RA (2012) Assembly of the prothrombinase complex on the surface of human foreskin fibroblasts: Implications for connective tissue growth factor. Thromb Res 129:801-806.
http://www.ncbi.nlm.nih.gov/pubmed/21889790

Rybinnik I, Mullen MT, Messe S, Kasner SE, Cucchiara B (2013) Treatment of Acute Stroke in Patients on Dabigatran: A Survey of US Stroke Specialists. J Stroke Cerebrovasc Dis.
http://www.ncbi.nlm.nih.gov/pubmed/23313461

Solheim S, Seljeflot I, Lunde K, Bratseth V, Aakhus S, Forfang K, Arnesen H (2013) Prothrombotic markers in patients with acute myocardial infarction and left ventricular thrombus formation treated with pci and dual antiplatelet therapy. Thromb J 11:1.
http://www.ncbi.nlm.nih.gov/pubmed/23311309

Spiezia L, Campello E, Bon M, Gavasso S, Woodhams B, Simioni P (2012) Factor VIIa-antithrombin complexes plasma levels in cancer patients with and without thrombosis. Thromb Res 129:818-819.
http://www.ncbi.nlm.nih.gov/pubmed/22444156

Stephan F, Dienava-Verdoold I, Bulder I, Wouters D, Mast AE, Te Velthuis H, . . . Zeerleder S (2012) Tissue factor pathway inhibitor is an inhibitor of factor VII-activating protease. J Thromb Haemost 10:1165-1171.
http://www.ncbi.nlm.nih.gov/pubmed/22449009

Sullivan BP, Kopec AK, Joshi N, Cline H, Brown JA, Bishop SC, . . . Luyendyk JP (2013) Hepatocyte tissue factor activates the coagulation cascade in mice. Blood.
http://www.ncbi.nlm.nih.gov/pubmed/23305736

Tatsumi K, Ohashi K, Matsubara Y, Kohori A, Ohno T, Kakidachi H, . . . Okano T (2013) Tissue factor triggers procoagulation in transplanted mesenchymal stem cells leading to thromboembolism. Biochem Biophys Res Commun.
http://www.ncbi.nlm.nih.gov/pubmed/23313481

Tersteeg C, Roest M, Mak-Nienhuis EM, Ligtenberg E, Hoefer IE, de Groot PG, Pasterkamp G (2012) A fibronectin-fibrinogen-tropoelastin coating reduces smooth muscle cell growth but improves endothelial cell function. J Cell Mol Med 16:2117-2126.
http://www.ncbi.nlm.nih.gov/pubmed/22225866

Vakamudi M, Ravulapalli H, Karthikeyan R (2012) Recent advances in paediatric cardiac anaesthesia. Indian J Anaesth 56:485-490.
http://www.ncbi.nlm.nih.gov/pubmed/23293388

van der Poll T, Levi M (2012) Crosstalk between inflammation and coagulation: the lessons of sepsis. Curr Vasc Pharmacol 10:632-638.
http://www.ncbi.nlm.nih.gov/pubmed/22272914

Van Dreden P, Woodhams B, Rousseau A, Favier M, Favier R (2012) Comparative evaluation of Tissue factor and Thrombomodulin activity changes during normal and idiopathic early and late foetal loss: the cause of hypercoagulability? Thromb Res 129:787-792.
http://www.ncbi.nlm.nih.gov/pubmed/21880353

Von Kanel R, Vokt F, Biasiutti FD, Stauber S, Wuillemin WA, Lukas PS (2012) Relation of psychological distress to the international normalized ratio in patients with venous thromboembolism with and without oral anticoagulant therapy. J Thromb Haemost 10:1547-1555.
http://www.ncbi.nlm.nih.gov/pubmed/22646913

Wang Z, Zhao X, Lv M, Zhang J (2011) [Current status and trends in blood biologicals]. Sheng Wu Gong Cheng Xue Bao 27:730-746.
http://www.ncbi.nlm.nih.gov/pubmed/21845840

Woei AJFJ, De Kruif MD, Garcia Rodriguez P, Osanto S, Bertina RM (2012) Microparticles expressing tissue factor are concurrently released with markers of inflammation and coagulation during human endotoxemia. J Thromb Haemost 10:1185-1188.
http://www.ncbi.nlm.nih.gov/pubmed/22489893

Xie H, Zhou H, Wang H, Chen D, Xia L, Wang T, Yan J (2013) Anti-beta(2)GPI/beta(2)GPI induced TF and TNF-alpha expression in monocytes involving both TLR4/MyD88 and TLR4/TRIF signaling pathways. Mol Immunol 53:246-254.
http://www.ncbi.nlm.nih.gov/pubmed/22964479

Yamamoto Y, Morita T, Tanaka T, Ikeda K, Kikuchi H, Oguri G, . . . Nagai R (2013) Amiodarone inhibits tissue factor expression in monocytic THP-1 cells. Eur J Pharmacol.
http://www.ncbi.nlm.nih.gov/pubmed/23305835

Zhao X, Dong S, Wang J, Li F, Chen A, Li B (2012) A comparative study of antithrombotic and antiplatelet activities of different fucoidans from Laminaria japonica. Thromb Res 129:771-778.
http://www.ncbi.nlm.nih.gov/pubmed/21872298
__________________________________________________________
ABOUT TRIGGER
TRIGGER is edited by Jim Morrissey and Pierre Neuenschwander, with editorial assistance by Genie Morrissey. It includes Abstracts of Papers in Press, Meeting Announcements, Positions Sought/Available,or any other pertinent item that subscribers may want to share with their colleagues. To submit an item for publication in Trigger, e-mail us. To request or cancel a subscription,or for more information about TRIGGER or the biology of tissue factor and factor VII, visit our web site. You can also contact us by mail: J.H. Morrissey, University of Illinois College of Medicine, 417 Med Sci Bldg MC-714, 506 S. Mathews Ave., Urbana, IL 61801, USA.

DISCLAIMER: TRIGGER is provided "as is" for information purposes only and without warranty of any kind, express or implied. Users shall assume the entire risk as to the accuracy and usefulness of information in TRIGGER. Opinions expressed here are not necessarily those of the editors or their employers. You may share TRIGGER with your scientific colleagues but you are not permitted to use it or its contents for commercial purposes.
__________________________________________________________