Monday, November 19, 2012

Vol. 18, No. 22

TRIGGER
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 18, No. 22  November 15, 2012
(The next issue will be on December 3, 2012)
__________________________________________________________
TRIGGER is also available by RSS Feed:
and BLOG:
http://trigger-tf7.blogspot.com/

__________________________________________________________
PAPERS IN PRESS
None Submitted for this issue.
__________________________________________________________
POSITIONS SOUGHT/AVAILABLE
POSTDOCTORAL POSITION - The Children's Hospital of Philadelphia
We are seeking a highly qualified and motivated individual for one Postdoctoral Position in the Division of Hematology at The Children's Hospital of Philadelphia and The University of Pennsylvania.  This is a joint position available immediately in the laboratories of Dr. 
Katherine A. High and Dr. Paris Margaritis.  This position will be devoted to studying the biological and therapeutic effects of blood coagulation factor expression in vitro or in vivo in appropriate models. Applicants for this position should have a strong background in molecular biology and have experience working with transgenic/gene targeted mouse models.  Applicants with experience in coagulation protein biochemistry and tissue culture are strongly encouraged to apply.  Candidates should have successfully earned an advanced degree (M.D. or Ph.D.), have excellent communications skills and be willing to work on a multidisciplinary team.  Highly competitive salary and benefits are offered.  Curriculum vitae and three references should be sent to:  

Drs. Katherine A. High and Paris Margaritis, The Children's Hospital of Philadelphia, Division of Hematology, Colket Translational Research Building, Rm 5000, 3501 Civic Center Blvd., Philadelphia, PA 19104 USA.  
TEL: (215)-590-4521 (High), (267)-426-7262 (Margaritis).

The Children's Hospital of Philadelphia and the University of Pennsylvania are Equal Opportunity/Affirmative Action Employers.  Women and minorities are encouraged to apply.

(Note from the Editors: Please note that the email addresses above have been modified to prevent SPAM. When clicking on the links or typing them into your email program, please replace the "AT" with "@" and the "DOT" with "." and remove all spaces. Thank you.)

__________________________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI
Papers are culled from NLM MedLine (PubMed). Titles in square brackets indicate that the paper was not published in English. References that lack volume or page numbers are typically electronic pre-publications (E-pubs) ahead of the print publication; if so, the final citation with volume and page numbers may or may not appear in a future issue of Trigger.
THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1fI0EmmJEejxJSnxbik_Np3/

Anonymous (2012) [The mutation of genes of hemostasis system in patients with venous cerebral angiodystonia against the background of connective tissue dysplasia]. Klin Lab Diagn:33-36.
http://www.ncbi.nlm.nih.gov/pubmed/23097990

Ahmad S, Ahmad A, Rancourt RC, Neeves KB, Loader JE, Hendry-Hofer T, . . . White CW (2012) Tissue Factor Signals Airway Epithelial Basal Cell Survival via Coagulation and PAR1/2. Am J Respir Cell Mol Biol.
http://www.ncbi.nlm.nih.gov/pubmed/23065128

Ahnstrom J, Andersson HM, Hockey V, Meng Y, McKinnon TA, Hamuro T, . . . Lane DA (2012) Identification of functionally important residues in TFPI Kunitz domain 3 required for the enhancement of its activity by protein S. Blood.
http://www.ncbi.nlm.nih.gov/pubmed/23074276

Alioglu B, Ozsoy MH, Tapci E, Karamercan S, Agras PI, Dallar Y (2012) Successful use of recombinant factor VIIa in a child with Schoenlein-Henoch purpura presenting with compartment syndrome and severe factor XIII deficiency. Blood Coagul Fibrinolysis.
http://www.ncbi.nlm.nih.gov/pubmed/23103728

Arda-Pirincci P, Oztay F, Bayrak BB, Yanardag R, Bolkent S (2012) Teduglutide, a glucagon-like peptide 2 analogue: A novel protective agent with anti-apoptotic and anti-oxidant properties in mice with lung injury. Peptides.
http://www.ncbi.nlm.nih.gov/pubmed/23059393

Bolton-Maggs PH (2012) The rare inherited coagulation disorders. Pediatr Blood Cancer.
http://www.ncbi.nlm.nih.gov/pubmed/23109366

Boyle JJ, Christou I, Iqbal MB, Nguyen AT, Leung VW, Evans PC, . . . Haskard DO (2012) Solid-phase immunoglobulins IgG and IgM activate macrophages with solid-phase IgM acting via a novel scavenger receptor a pathway. Am J Pathol 181:347-361.
http://www.ncbi.nlm.nih.gov/pubmed/22658487

Breitenstein A, Sluka SH, Akhmedov A, Stivala S, Steffel J, Camici GG, . . . Tanner FC (2012) Dronedarone reduces arterial thrombus formation. Basic Res Cardiol 107:302.
http://www.ncbi.nlm.nih.gov/pubmed/23052639

Caballo C, Escolar G, Diaz-Ricart M, Lopez-Vilchez I, Lozano M, Cid J, . . . Galan AM (2012) Impact of experimental haemodilution on platelet function, thrombin generation and clot firmness: effects of different coagulation factor concentrates. Blood Transfus:1-10.
http://www.ncbi.nlm.nih.gov/pubmed/23058866

Cavallari N, Balestra D, Branchini A, Maestri I, Chuamsunrit A, Sasanakul W, . . . Pinotti M (2012) Activation of a cryptic splice site in a potentially lethal coagulation defect accounts for a functional protein variant. Biochim Biophys Acta 1822:1109-1113.
http://www.ncbi.nlm.nih.gov/pubmed/22426302

Cooper DK, Ekser B, Burlak C, Ezzelarab M, Hara H, Paris L, . . . Pierson RN, 3rd (2012) Clinical lung xenotransplantation--what donor genetic modifications may be necessary? Xenotransplantation 19:144-158.
http://www.ncbi.nlm.nih.gov/pubmed/22702466

Cugno M, Castelli R, Mari D, Mozzi E, Zappa MA, Boscolo-Anzoletti M, . . . Mannucci PM (2012) Inflammatory and prothrombotic parameters in normotensive non-diabetic obese women: effect of weight loss obtained by gastric banding. Intern Emerg Med 7:237-242.
http://www.ncbi.nlm.nih.gov/pubmed/21249470

Deanda A, Jr., Hymes K (2012) Thrombosis and Recombinant Factor VIIa: Letter 1. Ann Thorac Surg 94:1783.
http://www.ncbi.nlm.nih.gov/pubmed/23098970

Dudash LA, Kligman F, Sarett SM, Kottke-Marchant K, Marchant RE (2012) Endothelial cell attachment and shear response on biomimetic polymer-coated vascular grafts. J Biomed Mater Res A 100:2204-2210.
http://www.ncbi.nlm.nih.gov/pubmed/22623267

Dutra LA, Braga-Neto P, Pedroso JL, Barsottini OG (2012) Sneddon's syndrome: case report and review of its relationship with antiphospholipid syndrome. Einstein (Sao Paulo) 10:230-232.
http://www.ncbi.nlm.nih.gov/pubmed/23052460

Elden L, Reinders M, Witmer C (2012) Predictors of bleeding disorders in children with epistaxis: value of preoperative tests and clinical screening. Int J Pediatr Otorhinolaryngol 76:767-771.
http://www.ncbi.nlm.nih.gov/pubmed/22459034

Eleftheriou D, Ganesan V, Hong Y, Klein NJ, Brogan PA (2012) Endothelial injury in childhood stroke with cerebral arteriopathy: A cross-sectional study. Neurology.
http://www.ncbi.nlm.nih.gov/pubmed/23077025

Funderburg NT, Zidar DA, Shive C, Lioi A, Mudd J, Musselwhite LW, . . . Lederman MM (2012) Shared monocyte subset phenotypes in HIV-1 infection and in uninfected subjects with acute coronary syndromes. Blood.
http://www.ncbi.nlm.nih.gov/pubmed/23065151

Geiser F, Gessler K, Conrad R, Imbierowicz K, Albus C, Harbrecht U (2012) Can activation of coagulation and impairment of fibrinolysis in patients with anxiety and depression be reversed after improvement of psychiatric symptoms? Results of a pilot study. J Nerv Ment Dis 200:721-723.
http://www.ncbi.nlm.nih.gov/pubmed/22850309

Godoi LC, Gomes KB, Alpoim PN, Carvalho M, Lwaleed BA, Sant'Ana Dusse LM (2012) Preeclampsia: the role of tissue factor and tissue factor pathway inhibitor. J Thromb Thrombolysis 34:1-6.
http://www.ncbi.nlm.nih.gov/pubmed/22461171

Hall CL, Zaman FS (2012) A computational analysis of an in vitro vessel wall injury model. Ann Biomed Eng 40:1486-1494.
http://www.ncbi.nlm.nih.gov/pubmed/22290588

Hernandez Vera R, Vilahur G, Ferrer-Lorente R, Pena E, Badimon L (2012) Platelets derived from the bone marrow of diabetic animals show dysregulated endoplasmic reticulum stress proteins that contribute to increased thrombosis. Arterioscler Thromb Vasc Biol 32:2141-2148.
http://www.ncbi.nlm.nih.gov/pubmed/22837468

Ho KM, Litton E (2012) Cost-effectiveness of using recombinant activated factor VII as an off-label rescue treatment for critical bleeding requiring massive transfusion. Transfusion 52:1696-1702.
http://www.ncbi.nlm.nih.gov/pubmed/22211634

Jin YH, Wang MS, Zheng FX, Xie YS, Xie HX, Xu PF (2012) [Molecular genetics and clinical features of nine patients with inherited coagulation factor VII deficiency]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 29:404-407.
http://www.ncbi.nlm.nih.gov/pubmed/22875495

Katsuyama T, Sada KE, Katayama A, Hinamoto N, Wakabayashi H, Kawabata T, Makino H (2012) Acquired haemophilia in a patient with Castleman's disease: a case report. Haemophilia 18:e360-362.
http://www.ncbi.nlm.nih.gov/pubmed/22630343

Knight M, Fitzpatrick K, Kurinczuk JJ, Tuffnell D (2012) Use of recombinant factor VIIa in patients with amniotic fluid embolism. Anesthesiology 117:423; author reply 423-424.
http://www.ncbi.nlm.nih.gov/pubmed/22828419

Lee KG, Lee H, Ha JM, Lee YK, Kang HJ, Park CG, Kim SJ (2012) Increased human tumor necrosis factor-alpha levels induce procoagulant change in porcine endothelial cells in vitro. Xenotransplantation 19:186-195.
http://www.ncbi.nlm.nih.gov/pubmed/22702470

Lippi G, Favaloro EJ, Cervellin G (2012) Massive Posttraumatic Bleeding: Epidemiology, Causes, Clinical Features, and Therapeutic Management. Semin Thromb Hemost.
http://www.ncbi.nlm.nih.gov/pubmed/23086540

Lupu C, Herlea O, Tang H, Lijnen RH, Lupu F (2012) Plasmin-dependent proteolysis of Tissue Factor Pathway Inhibitor in a mouse model of endotoxemia. J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/23106863

Magnusson M, Fischler B, Svensson J, Petrini P, Schulman S, Nemeth A (2012) Bile acids and coagulation factors: paradoxical association in children with chronic liver disease. Eur J Gastroenterol Hepatol.
http://www.ncbi.nlm.nih.gov/pubmed/23075699

Mitrophanov AY, Rosendaal FR, Reifman J (2012) Therapeutic correction of thrombin generation in dilution-induced coagulopathy: computational analysis based on a data set of healthy subjects. J Trauma Acute Care Surg 73:S95-S102.
http://www.ncbi.nlm.nih.gov/pubmed/22847103

Mitrovic M, Elezovic I, Suvajdzic-Vukovic N, Antic D (2012) Successful non-standard approaches to massive hemoptysis in invasive pulmonary aspergillosis. Srp Arh Celok Lek 140:505-507.
http://www.ncbi.nlm.nih.gov/pubmed/23092038

Moosdorf R (2012) Aortic Valve Thrombosis After Treatment With Recombinant Factor VIIa: Letter 2. Ann Thorac Surg 94:1783-1784.
http://www.ncbi.nlm.nih.gov/pubmed/23098971

Neal MD, Marsh A, Marino R, Kautza B, Raval JS, Forsythe RM, . . . Sperry JL (2012) Massive transfusion: an evidence-based review of recent developments. Arch Surg 147:563-571.
http://www.ncbi.nlm.nih.gov/pubmed/22786545

Peled E, Davis M, Axelman E, Norman D, Nadir Y (2012) Heapranase role in the treatment of avascular necrosis of femur head. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/23063054

Perry JR (2012) Thromboembolic disease in patients with high-grade glioma. Neuro Oncol 14 Suppl 4:iv73-iv80.
http://www.ncbi.nlm.nih.gov/pubmed/23095833

Pircher J, Merkle M, Wornle M, Ribeiro A, Czermak T, Stampnik Y, . . . Krotz F (2012) Prothrombotic effects of tumor necrosis factor alpha in vivo are amplified by the absence of TNF-alpha receptor subtype 1 and require TNF-alpha receptor subtype 2. Arthritis Res Ther 14:R225.
http://www.ncbi.nlm.nih.gov/pubmed/23079185

Qi L, Li JM, Sun H, Huang XQ, Lin KQ, Chu JY, Yang ZQ (2012) [Association between gene polymorphisms and myocardial infarction in Han Chinese of Yunnan province]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 29:413-419.
http://www.ncbi.nlm.nih.gov/pubmed/22875497

Ro H, Lee EW, Hong JH, Han KH, Yeom HJ, Kim HJ, . . . Yang J (2012) Roles of Islet Toll-like Receptors in Pig to Mouse Islet Xenotransplantation. Cell Transplant.
http://www.ncbi.nlm.nih.gov/pubmed/23051007

Saja MF, Abdo AA, Sanai FM, Shaikh SA, Gader AG (2012) The coagulopathy of liver disease: does vitamin K help? Blood Coagul Fibrinolysis.
http://www.ncbi.nlm.nih.gov/pubmed/23080365

Sattler S, Schwartz A (2012) Does the use of recombinant factor VIIA reduce morbidity or mortality in nonhemophiliac patients? Ann Emerg Med 60:160-161.
http://www.ncbi.nlm.nih.gov/pubmed/22542308

Sauna ZE, Pandey GS, Jain N, Mahmood I, Kimchi-Sarfaty C, Golding B (2012) Plasma derivatives: new products and new approaches. Biologicals 40:191-195.
http://www.ncbi.nlm.nih.gov/pubmed/22239993

Singh A, Foster GD, Gunawardana J, McCoy TA, Nguyen T, Vander Veur S, . . . Rao AK (2012) Elevated circulating tissue factor procoagulant activity, factor VII, and plasminogen activator inhibitor-1 in childhood obesity: evidence of a procoagulant state. Br J Haematol 158:523-527.
http://www.ncbi.nlm.nih.gov/pubmed/22612792

Skeppholm M, Mobarrez F, Malmqvist K, Wallen H (2012) Platelet-derived microparticles during and after acute coronary syndrome. Thromb Haemost 107:1122-1129.
http://www.ncbi.nlm.nih.gov/pubmed/22371053

Smejkal P, Bulikova A, Chlupova G, Zavrelova J (2012) [Acquired haemophilia A]. Vnitr Lek 58:571-578.
http://www.ncbi.nlm.nih.gov/pubmed/23067181

Stavik B, Skretting G, Olstad OK, Sletten M, Dehli Vigeland M, Sandset PM, Iversen N (2012) TFPI Alpha and Beta Regulate mRNAs and microRNAs Involved in Cancer Biology and in the Immune System in Breast Cancer Cells. PLoS One 7:e47184.
http://www.ncbi.nlm.nih.gov/pubmed/23071754

Steward RG, Saleh OA, James AH, Shah AA, Price TM (2012) Management of gynecologic surgery in the patient with factor XI deficiency: a review of the literature. Obstet Gynecol Surv 67:291-297.
http://www.ncbi.nlm.nih.gov/pubmed/22624777

Suzuki A, Miyawaki Y, Okuyama E, Murata M, Ando Y, Kato I, . . . Kojima T (2012) Ribavirin-induced intracellular GTP depletion activates transcription elongation in coagulation factor VII gene expression. Biochem J.
http://www.ncbi.nlm.nih.gov/pubmed/23050902

Tardy-Poncet B, Piot M, Brunet D, Chapelle C, Bonardel M, Mismetti P, . . . Tardy B (2012) TFPI resistance related to inherited or acquired protein S deficiency. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/23079294

Thaler J, Preusser M, Ay C, Kaider A, Marosi C, Zielinski C, . . . Hainfellner JA (2012) Intratumoral tissue factor expression and risk of venous thromboembolism in brain tumor patients. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/23084660

Valentino LA, Walsh CE, Reding MT, Young GA, Levendoglu-Tugal O, Cooper DL (2012) Patient- and caregiver-reported bleeding symptoms and reasons for starting and stopping treatment with recombinant factor VIIa: analysis of the Dosing Observational Study in Haemophilia (DOSE). Haemophilia 18:554-560.
http://www.ncbi.nlm.nih.gov/pubmed/22348407

Van Dreden P, Woodhams B, Rousseau A, Dreyfus JF, Vasse M (2012) Contribution of procoagulant phospholipids, thrombomodulin activity and thrombin generation assays as prognostic factors in intensive care patients with septic and non-septic organ failure. Clin Chem Lab Med.
http://www.ncbi.nlm.nih.gov/pubmed/23096108

Van Geffen M, Menegatti M, Loof A, Lap P, Karimi M, Laros-van Gorkom BA, . . . Van Heerde WL (2012) Retrospective evaluation of bleeding tendency and simultaneous thrombin and plasmin generation in patients with rare bleeding disorders. Haemophilia 18:630-638.
http://www.ncbi.nlm.nih.gov/pubmed/22404435

Walenga JM, Jeske WP, Hoppensteadt D, Cunanan J, Khan H, Escalante V, . . . Bakhos M (2012) Comparative Studies on Branded Enoxaparin and a US Generic Version of Enoxaparin. Clin Appl Thromb Hemost.
http://www.ncbi.nlm.nih.gov/pubmed/23091283

Wunderink RG, Mandell L (2012) Adjunctive therapy in community-acquired pneumonia. Semin Respir Crit Care Med 33:311-318.
http://www.ncbi.nlm.nih.gov/pubmed/22718217

Zangari M, Berno T, Zhan F, Tricot G, Fink L (2012) Mechanisms of Thrombosis in Paraproteinemias: The Effects of Immunomodulatory Drugs. Semin Thromb Hemost.
http://www.ncbi.nlm.nih.gov/pubmed/23104518

Zderic TW, Hamilton MT (2012) Identification of hemostatic genes expressed in human and rat leg muscles and a novel gene (LPP1/PAP2A) suppressed during prolonged physical inactivity (sitting). Lipids Health Dis 11:137.
http://www.ncbi.nlm.nih.gov/pubmed/23061662


__________________________________________________________
ABOUT TRIGGER
TRIGGER is edited by Jim Morrissey and Pierre Neuenschwander, with editorial assistance by Genie Morrissey. It includes Abstracts of Papers in Press, Meeting Announcements, Positions Sought/Available,or any other pertinent item that subscribers may want to share with their colleagues. To submit an item for publication in Trigger, e-mail us. To request or cancel a subscription,or for more information about TRIGGER or the biology of tissue factor and factor VII, visit our web site. You can also contact us by mail: J.H. Morrissey, University of Illinois College of Medicine, 417 Med Sci Bldg MC-714, 506 S. Mathews Ave., Urbana, IL 61801, USA.

DISCLAIMER: TRIGGER is provided "as is" for information purposes only and without warranty of any kind, express or implied. Users shall assume the entire risk as to the accuracy and usefulness of information in TRIGGER. Opinions expressed here are not necessarily those of the editors or their employers. You may share TRIGGER with your scientific colleagues but you are not permitted to use it or its contents for commercial purposes.
__________________________________________________________

Vol. 18, No. 21

TRIGGER
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 18, No. 21  November 1, 2012
(The next issue will be on November 15, 2012)
__________________________________________________________
TRIGGER is also available by RSS Feed:
and BLOG:
http://trigger-tf7.blogspot.com/
__________________________________________________________
PAPERS IN PRESS
None Submitted for this issue.
__________________________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI
Papers are culled from NLM MedLine (PubMed). Titles in square brackets indicate that the paper was not published in English. References that lack volume or page numbers are typically electronic pre-publications (E-pubs) ahead of the print publication; if so, the final citation with volume and page numbers may or may not appear in a future issue of Trigger.
THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1fI0EmmJEejxJSnxbik_Np3/

Anonymous (2012) [The mutation of genes of hemostasis system in patients with venous cerebral angiodystonia against the background of connective tissue dysplasia]. Klin Lab Diagn:33-36.
http://www.ncbi.nlm.nih.gov/pubmed/23097990

Ahmad S, Ahmad A, Rancourt RC, Neeves KB, Loader JE, Hendry-Hofer T, . . . White CW (2012) Tissue Factor Signals Airway Epithelial Basal Cell Survival via Coagulation and PAR1/2. Am J Respir Cell Mol Biol.
http://www.ncbi.nlm.nih.gov/pubmed/23065128

Ahnstrom J, Andersson HM, Hockey V, Meng Y, McKinnon TA, Hamuro T, . . . Lane DA (2012) Identification of functionally important residues in TFPI Kunitz domain 3 required for the enhancement of its activity by protein S. Blood.
http://www.ncbi.nlm.nih.gov/pubmed/23074276

Alioglu B, Ozsoy MH, Tapci E, Karamercan S, Agras PI, Dallar Y (2012) Successful use of recombinant factor VIIa in a child with Schoenlein-Henoch purpura presenting with compartment syndrome and severe factor XIII deficiency. Blood Coagul Fibrinolysis.
http://www.ncbi.nlm.nih.gov/pubmed/23103728

Arda-Pirincci P, Oztay F, Bayrak BB, Yanardag R, Bolkent S (2012) Teduglutide, a glucagon-like peptide 2 analogue: A novel protective agent with anti-apoptotic and anti-oxidant properties in mice with lung injury. Peptides.
http://www.ncbi.nlm.nih.gov/pubmed/23059393

Bolton-Maggs PH (2012) The rare inherited coagulation disorders. Pediatr Blood Cancer.
http://www.ncbi.nlm.nih.gov/pubmed/23109366

Boyle JJ, Christou I, Iqbal MB, Nguyen AT, Leung VW, Evans PC, . . . Haskard DO (2012) Solid-phase immunoglobulins IgG and IgM activate macrophages with solid-phase IgM acting via a novel scavenger receptor a pathway. Am J Pathol 181:347-361.
http://www.ncbi.nlm.nih.gov/pubmed/22658487

Breitenstein A, Sluka SH, Akhmedov A, Stivala S, Steffel J, Camici GG, . . . Tanner FC (2012) Dronedarone reduces arterial thrombus formation. Basic Res Cardiol 107:302.
http://www.ncbi.nlm.nih.gov/pubmed/23052639

Caballo C, Escolar G, Diaz-Ricart M, Lopez-Vilchez I, Lozano M, Cid J, . . . Galan AM (2012) Impact of experimental haemodilution on platelet function, thrombin generation and clot firmness: effects of different coagulation factor concentrates. Blood Transfus:1-10.
http://www.ncbi.nlm.nih.gov/pubmed/23058866

Cavallari N, Balestra D, Branchini A, Maestri I, Chuamsunrit A, Sasanakul W, . . . Pinotti M (2012) Activation of a cryptic splice site in a potentially lethal coagulation defect accounts for a functional protein variant. Biochim Biophys Acta 1822:1109-1113.
http://www.ncbi.nlm.nih.gov/pubmed/22426302

Cooper DK, Ekser B, Burlak C, Ezzelarab M, Hara H, Paris L, . . . Pierson RN, 3rd (2012) Clinical lung xenotransplantation--what donor genetic modifications may be necessary? Xenotransplantation 19:144-158.
http://www.ncbi.nlm.nih.gov/pubmed/22702466

Cugno M, Castelli R, Mari D, Mozzi E, Zappa MA, Boscolo-Anzoletti M, . . . Mannucci PM (2012) Inflammatory and prothrombotic parameters in normotensive non-diabetic obese women: effect of weight loss obtained by gastric banding. Intern Emerg Med 7:237-242.
http://www.ncbi.nlm.nih.gov/pubmed/21249470

Deanda A, Jr., Hymes K (2012) Thrombosis and Recombinant Factor VIIa: Letter 1. Ann Thorac Surg 94:1783.
http://www.ncbi.nlm.nih.gov/pubmed/23098970

Dudash LA, Kligman F, Sarett SM, Kottke-Marchant K, Marchant RE (2012) Endothelial cell attachment and shear response on biomimetic polymer-coated vascular grafts. J Biomed Mater Res A 100:2204-2210.
http://www.ncbi.nlm.nih.gov/pubmed/22623267

Dutra LA, Braga-Neto P, Pedroso JL, Barsottini OG (2012) Sneddon's syndrome: case report and review of its relationship with antiphospholipid syndrome. Einstein (Sao Paulo) 10:230-232.
http://www.ncbi.nlm.nih.gov/pubmed/23052460

Elden L, Reinders M, Witmer C (2012) Predictors of bleeding disorders in children with epistaxis: value of preoperative tests and clinical screening. Int J Pediatr Otorhinolaryngol 76:767-771.
http://www.ncbi.nlm.nih.gov/pubmed/22459034

Eleftheriou D, Ganesan V, Hong Y, Klein NJ, Brogan PA (2012) Endothelial injury in childhood stroke with cerebral arteriopathy: A cross-sectional study. Neurology.
http://www.ncbi.nlm.nih.gov/pubmed/23077025

Funderburg NT, Zidar DA, Shive C, Lioi A, Mudd J, Musselwhite LW, . . . Lederman MM (2012) Shared monocyte subset phenotypes in HIV-1 infection and in uninfected subjects with acute coronary syndromes. Blood.
http://www.ncbi.nlm.nih.gov/pubmed/23065151

Geiser F, Gessler K, Conrad R, Imbierowicz K, Albus C, Harbrecht U (2012) Can activation of coagulation and impairment of fibrinolysis in patients with anxiety and depression be reversed after improvement of psychiatric symptoms? Results of a pilot study. J Nerv Ment Dis 200:721-723.
http://www.ncbi.nlm.nih.gov/pubmed/22850309

Godoi LC, Gomes KB, Alpoim PN, Carvalho M, Lwaleed BA, Sant'Ana Dusse LM (2012) Preeclampsia: the role of tissue factor and tissue factor pathway inhibitor. J Thromb Thrombolysis 34:1-6.
http://www.ncbi.nlm.nih.gov/pubmed/22461171

Hall CL, Zaman FS (2012) A computational analysis of an in vitro vessel wall injury model. Ann Biomed Eng 40:1486-1494.
http://www.ncbi.nlm.nih.gov/pubmed/22290588

Hernandez Vera R, Vilahur G, Ferrer-Lorente R, Pena E, Badimon L (2012) Platelets derived from the bone marrow of diabetic animals show dysregulated endoplasmic reticulum stress proteins that contribute to increased thrombosis. Arterioscler Thromb Vasc Biol 32:2141-2148.
http://www.ncbi.nlm.nih.gov/pubmed/22837468

Ho KM, Litton E (2012) Cost-effectiveness of using recombinant activated factor VII as an off-label rescue treatment for critical bleeding requiring massive transfusion. Transfusion 52:1696-1702.
http://www.ncbi.nlm.nih.gov/pubmed/22211634

Jin YH, Wang MS, Zheng FX, Xie YS, Xie HX, Xu PF (2012) [Molecular genetics and clinical features of nine patients with inherited coagulation factor VII deficiency]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 29:404-407.
http://www.ncbi.nlm.nih.gov/pubmed/22875495

Katsuyama T, Sada KE, Katayama A, Hinamoto N, Wakabayashi H, Kawabata T, Makino H (2012) Acquired haemophilia in a patient with Castleman's disease: a case report. Haemophilia 18:e360-362.
http://www.ncbi.nlm.nih.gov/pubmed/22630343

Knight M, Fitzpatrick K, Kurinczuk JJ, Tuffnell D (2012) Use of recombinant factor VIIa in patients with amniotic fluid embolism. Anesthesiology 117:423; author reply 423-424.
http://www.ncbi.nlm.nih.gov/pubmed/22828419

Lee KG, Lee H, Ha JM, Lee YK, Kang HJ, Park CG, Kim SJ (2012) Increased human tumor necrosis factor-alpha levels induce procoagulant change in porcine endothelial cells in vitro. Xenotransplantation 19:186-195.
http://www.ncbi.nlm.nih.gov/pubmed/22702470

Lippi G, Favaloro EJ, Cervellin G (2012) Massive Posttraumatic Bleeding: Epidemiology, Causes, Clinical Features, and Therapeutic Management. Semin Thromb Hemost.
http://www.ncbi.nlm.nih.gov/pubmed/23086540

Lupu C, Herlea O, Tang H, Lijnen RH, Lupu F (2012) Plasmin-dependent proteolysis of Tissue Factor Pathway Inhibitor in a mouse model of endotoxemia. J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/23106863

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ABOUT TRIGGER
TRIGGER is edited by Jim Morrissey and Pierre Neuenschwander, with editorial assistance by Genie Morrissey. It includes Abstracts of Papers in Press, Meeting Announcements, Positions Sought/Available,or any other pertinent item that subscribers may want to share with their colleagues. To submit an item for publication in Trigger, e-mail us. To request or cancel a subscription,or for more information about TRIGGER or the biology of tissue factor and factor VII, visit our web site. You can also contact us by mail: J.H. Morrissey, University of Illinois College of Medicine, 417 Med Sci Bldg MC-714, 506 S. Mathews Ave., Urbana, IL 61801, USA.

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