TRIGGER
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 17, No. 3 February 1, 2011
(The next issue will be on February 15, 2011)
__________________________________________________________
TRIGGER is also available by RSS Feed:
http://feeds.feedburner.com/blogspot/glro
and BLOG:
http://trigger-tf7.blogspot.com/
__________________________________________________________
PAPERS IN PRESS
None submitted for this issue.
__________________________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI
Papers are culled from NLM MedLine (PubMed). Titles in square brackets indicate that the paper was not published in English. References that lack volume or page numbers are typically electronic pre-publications (E-pubs) ahead of the print publication; if so, the final citation with volume and page numbers may or may not appear in a future issue of Trigger.
THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/18GT3YuDrhe2hjYJgZwLnGz/
Abe R, Yamashita N, Rochier A, Nixon A, Madri JA, Sumpio BE (2011) Pulsatile To-fro Flow Induces Greater and Sustained Expression of Tissue Factor RNA in HUVEC than Unidirectional Laminar Flow. Am J Physiol Heart Circ Physiol.
http://www.ncbi.nlm.nih.gov/pubmed/21257914
Ando R, Kase S, Ohashi T, Dong Z, Fukuhara J, Kanda A, . . . Ishida S (2011) Tissue factor expression in human pterygium. Mol Vis 17:63-69.
http://www.ncbi.nlm.nih.gov/pubmed/21245964
Ayral Y, Rauch U, Goldin-Lang P, Eisenreich A, Pepke W, Deiner C, . . . Pels K (2011) Prolonged clopidogrel application reduces tissue factor expression after percutaneous coronary intervention in the porcine model. Cardiovasc Revasc Med 12:47-55.
http://www.ncbi.nlm.nih.gov/pubmed/21241972
Beausoleil MS, Schulze EB, Goodale D, Postenka CO, Allan AL (2011) Deletion of the thrombin cleavage domain of osteopontin mediates breast cancer cell adhesion, proteolytic activity, tumorgenicity, and metastasis. BMC Cancer 11:25.
http://www.ncbi.nlm.nih.gov/pubmed/21247495
Berckmans RJ, Sturk A, Schaap MC, Nieuwland R (2011) Cell-derived vesicles exposing coagulant tissue factor in saliva. Blood.
http://www.ncbi.nlm.nih.gov/pubmed/21248061
Brodin E, Vikan T, Hansen JB, Svartberg J (2011) Testosterone, hemostasis, and cardiovascular diseases in men. Semin Thromb Hemost 37:87-94.
http://www.ncbi.nlm.nih.gov/pubmed/21249606
Campello E, Spiezia L, Radu CM, Bulato C, Castelli M, Gavasso S, Simioni P (2011) Endothelial, platelet, and tissue factor-bearing microparticles in cancer patients with and without venous thromboembolism. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/21256535
Chen Z, Huo JR, Zhu HY (2011) Effect of ligustrazine on mice model of hepatic veno-occlusive disease induced by Sedum aizoon. J Gastroenterol Hepatol.
http://www.ncbi.nlm.nih.gov/pubmed/21251065
Cugno M, Castelli R, Mari D, Mozzi E, Zappa MA, Boscolo-Anzoletti M, . . . Mannucci PM (2011) Inflammatory and prothrombotic parameters in normotensive non-diabetic obese women: effect of weight loss obtained by gastric banding. Intern Emerg Med.
http://www.ncbi.nlm.nih.gov/pubmed/21249470
Dabar G, Harmouche C, Jammal M (2011) [Efficacy of recombinant activated factor VII in diffuse alveolar haemorrhage.]. Rev Mal Respir 28:106-111.
http://www.ncbi.nlm.nih.gov/pubmed/21277485
Deloughery EP, Lenfesty B, Deloughery TG (2011) A retrospective case control study of recombinant factor VIIa in patients with intracranial haemorrhage caused by trauma. Br J Haematol.
http://www.ncbi.nlm.nih.gov/pubmed/21275948
Duntas LH, Biondi B (2011) New insights into subclinical hypothyroidism and cardiovascular risk. Semin Thromb Hemost 37:27-34.
http://www.ncbi.nlm.nih.gov/pubmed/21249602
Eckly A, Hechler B, Freund M, Zerr M, Cazenave JP, Lanza F, . . . Gachet C (2011) Mechanisms underlying FeCl(3) -induced arterial thrombosis. J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/21261806
Fedorov O, Huber K, Eisenreich A, Filippakopoulos P, King O, Bullock AN, . . . Knapp S (2011) Specific CLK Inhibitors from a Novel Chemotype for Regulation of Alternative Splicing. Chem Biol 18:67-76.
http://www.ncbi.nlm.nih.gov/pubmed/21276940
Fortenberry YM, Cook AB, Church FC (2011) Protein C inhibitor inhibits factor VIIa when bound to tissue factor. J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/21251198
Gerrits AJ, Koekman CA, van Haeften TW, Akkerman JW (2011) Increased tissue factor expression in diabetes mellitus type 2-monocytes caused by insulin resistance. J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/21251203
Girardi G (2011) Role of tissue factor in pregnancy complications: crosstalk between coagulation and inflammation. Thromb Res 127S3:S43-S46.
http://www.ncbi.nlm.nih.gov/pubmed/21262438
Hammad MA, Abdel-Bakky MS, Walker LA, Ashfaq MK (2011) Oxidized low-density lipoprotein and tissue factor are involved in monocrotaline/lipopolysaccharide-induced hepatotoxicity. Arch Toxicol.
http://www.ncbi.nlm.nih.gov/pubmed/21279329
Holzhauser E, Albrecht C, Zhou Q, Buttler A, Preusch MR, Blessing E, . . . Bea F (2011) Nicotinic acid has anti-atherogenic and anti-inflammatory properties on advanced atherosclerotic lesions independent of its lipid-modifying capabilities Holzhauser et al., Anti-atherogenic properties of nicotinic acid. J Cardiovasc Pharmacol.
http://www.ncbi.nlm.nih.gov/pubmed/21242806
Johansson L, Karpf DM, Hansen L, Pelzer H, Persson E (2011) Activation peptides prolong the murine plasma half-life of human factor VII. Blood.
http://www.ncbi.nlm.nih.gov/pubmed/21252090
Kamat P, Kunde S, Vos M, Vats A, Heffron T, Romero R, Fortenberry JD (2011) Invasive intracranial pressure monitoring is a useful adjunct in the management of severe hepatic encephalopathy associated with pediatric acute liver failure. Pediatr Crit Care Med.
http://www.ncbi.nlm.nih.gov/pubmed/21263362
Kozuma Y, Sawahata Y, Takei Y, Chiba S, Ninomiya H (2011) Procoagulant properties of microparticles released from red blood cells in paroxysmal nocturnal haemoglobinuria. Br J Haematol.
http://www.ncbi.nlm.nih.gov/pubmed/21241275
Krysiak R, Gdula-Dymek A, Okopien B (2010) Hemostatic effects of simvastatin in subjects with impaired fasting glucose. Pharmacol Rep 62:1090-1098.
http://www.ncbi.nlm.nih.gov/pubmed/21273666
Krysiak R, Handzlik G, Okopien B (2010) Hemostatic effects of fenofibrate in patients with mixed dyslipidemia and impaired fasting glucose. Pharmacol Rep 62:1099-1107.
http://www.ncbi.nlm.nih.gov/pubmed/21273667
Lin R, Roychowdhury-Saha M, Black C, Watt AT, Marcusson EG, Freier SM, Edgington TS (2011) Control of RNA processing by a large non-coding RNA over-expressed in carcinomas. FEBS Lett.
http://www.ncbi.nlm.nih.gov/pubmed/21266177
Mitterlechner T, Innerhofer P, Streif W, Lodl M, Danninger T, Klima G, . . . Fries D (2011) PCC, recombinant prothrombin alone or in combination with recombinant FX and FVIIa in dilutional coagulopathy: a porcine model. J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/21255250
Pierfranceschi MG, Imberti D, Orlando S, Vallisa D, Michieletti E (2010) Effectiveness of recombinant activated factor VII in haemorragic cancer-related disseminated intravascular coagulation: a case report. Blood Transfus.
http://www.ncbi.nlm.nih.gov/pubmed/21251460
Rondina MT, Schwertz H, Harris ES, Kraemer BF, Campbell RA, Mackman N, . . . Zimmerman GA (2011) The Septic Milieu Triggers Expression of Spliced Tissue Factor mRNA in Human Platelets. J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/21255247
Seested T, Appa RS, Christensen EI, Ioannou YA, Krogh TN, Karpf DM, Nielsen HM (2011) In vivo clearance and metabolism of recombinant activated factor VII (rFVIIa) and its complexes with plasma protease inhibitors in the liver. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/21262526
Sen P, Gopalakrishnan R, Kothari H, Keshava S, Clark CA, Esmon CT, . . . Rao LV (2011) Factor VIIa bound to endothelial cell protein C receptor activates protease activated receptor-1 and mediates cell signaling and barrier protection. Blood.
http://www.ncbi.nlm.nih.gov/pubmed/21252088
Solomon D, Kim B, Scultetus A, Arnaud F, Auker C, Freilich D, McCarron R (2011) The effect of rFVIIa on pro- and anti-inflamatory cytokines in serum and cerebrospinal fluid in a swine model of traumatic brain injury. Cytokine.
http://www.ncbi.nlm.nih.gov/pubmed/21251848
Trigg DE, Wood MG, Kouides PA, Kadir RA (2011) Hormonal influences on hemostasis in women. Semin Thromb Hemost 37:77-86.
http://www.ncbi.nlm.nih.gov/pubmed/21249605
van den Besselaar AM, Witteveen E, Tripodi A (2011) Calibration of Combined Thromboplastins with the International Standard for Thromboplastin, Rabbit, Plain. J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/21261807
Wang CH, Li F, Hiller S, Kim HS, Maeda N, Smithies O, Takahashi N (2011) A modest decrease in endothelial NOS in mice comparable to that associated with human NOS3 variants exacerbates diabetic nephropathy. Proc Natl Acad Sci U S A.
http://www.ncbi.nlm.nih.gov/pubmed/21245338
Yamashita A, Asada Y (2011) A rabbit model of thrombosis on atherosclerotic lesions. J Biomed Biotechnol 2011:424929.
http://www.ncbi.nlm.nih.gov/pubmed/21253503
Zwicker JI, Trenor CC, 3rd, Furie BC, Furie B (2011) Tissue Factor-Bearing Microparticles and Thrombus Formation. Arterioscler Thromb Vasc Biol.
http://www.ncbi.nlm.nih.gov/pubmed/21252066
__________________________________________________________
ABOUT TRIGGER
TRIGGER is edited by Jim Morrissey and Pierre Neuenschwander, with editorial assistance by Genie Morrissey. It includes Abstracts of Papers in Press, Meeting Announcements, Positions Sought/Available,or any other pertinent item that subscribers may want to share with their colleagues. To submit an item for publication in Trigger, e-mail us. To request or cancel a subscription,or for more information about TRIGGER or the biology of tissue factor and factor VII, visit our web site. You can also contact us by mail: J.H. Morrissey, University of Illinois College of Medicine, 417 Med Sci Bldg MC-714, 506 S. Mathews Ave., Urbana, IL 61801, USA.
DISCLAIMER: TRIGGER is provided "as is" for information purposes only and without warranty of any kind, express or implied. Users shall assume the entire risk as to the accuracy and usefulness of information in TRIGGER. Opinions expressed here are not necessarily those of the editors or their employers. You may share TRIGGER with your scientific colleagues but you are not permitted to use it or its contents for commercial purposes.
__________________________________________________________
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 17, No. 3 February 1, 2011
(The next issue will be on February 15, 2011)
__________________________________________________________
TRIGGER is also available by RSS Feed:
http://feeds.feedburner.com/blogspot/glro
and BLOG:
http://trigger-tf7.blogspot.com/
__________________________________________________________
PAPERS IN PRESS
None submitted for this issue.
__________________________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI
Papers are culled from NLM MedLine (PubMed). Titles in square brackets indicate that the paper was not published in English. References that lack volume or page numbers are typically electronic pre-publications (E-pubs) ahead of the print publication; if so, the final citation with volume and page numbers may or may not appear in a future issue of Trigger.
THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/18GT3YuDrhe2hjYJgZwLnGz/
Abe R, Yamashita N, Rochier A, Nixon A, Madri JA, Sumpio BE (2011) Pulsatile To-fro Flow Induces Greater and Sustained Expression of Tissue Factor RNA in HUVEC than Unidirectional Laminar Flow. Am J Physiol Heart Circ Physiol.
http://www.ncbi.nlm.nih.gov/pubmed/21257914
Ando R, Kase S, Ohashi T, Dong Z, Fukuhara J, Kanda A, . . . Ishida S (2011) Tissue factor expression in human pterygium. Mol Vis 17:63-69.
http://www.ncbi.nlm.nih.gov/pubmed/21245964
Ayral Y, Rauch U, Goldin-Lang P, Eisenreich A, Pepke W, Deiner C, . . . Pels K (2011) Prolonged clopidogrel application reduces tissue factor expression after percutaneous coronary intervention in the porcine model. Cardiovasc Revasc Med 12:47-55.
http://www.ncbi.nlm.nih.gov/pubmed/21241972
Beausoleil MS, Schulze EB, Goodale D, Postenka CO, Allan AL (2011) Deletion of the thrombin cleavage domain of osteopontin mediates breast cancer cell adhesion, proteolytic activity, tumorgenicity, and metastasis. BMC Cancer 11:25.
http://www.ncbi.nlm.nih.gov/pubmed/21247495
Berckmans RJ, Sturk A, Schaap MC, Nieuwland R (2011) Cell-derived vesicles exposing coagulant tissue factor in saliva. Blood.
http://www.ncbi.nlm.nih.gov/pubmed/21248061
Brodin E, Vikan T, Hansen JB, Svartberg J (2011) Testosterone, hemostasis, and cardiovascular diseases in men. Semin Thromb Hemost 37:87-94.
http://www.ncbi.nlm.nih.gov/pubmed/21249606
Campello E, Spiezia L, Radu CM, Bulato C, Castelli M, Gavasso S, Simioni P (2011) Endothelial, platelet, and tissue factor-bearing microparticles in cancer patients with and without venous thromboembolism. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/21256535
Chen Z, Huo JR, Zhu HY (2011) Effect of ligustrazine on mice model of hepatic veno-occlusive disease induced by Sedum aizoon. J Gastroenterol Hepatol.
http://www.ncbi.nlm.nih.gov/pubmed/21251065
Cugno M, Castelli R, Mari D, Mozzi E, Zappa MA, Boscolo-Anzoletti M, . . . Mannucci PM (2011) Inflammatory and prothrombotic parameters in normotensive non-diabetic obese women: effect of weight loss obtained by gastric banding. Intern Emerg Med.
http://www.ncbi.nlm.nih.gov/pubmed/21249470
Dabar G, Harmouche C, Jammal M (2011) [Efficacy of recombinant activated factor VII in diffuse alveolar haemorrhage.]. Rev Mal Respir 28:106-111.
http://www.ncbi.nlm.nih.gov/pubmed/21277485
Deloughery EP, Lenfesty B, Deloughery TG (2011) A retrospective case control study of recombinant factor VIIa in patients with intracranial haemorrhage caused by trauma. Br J Haematol.
http://www.ncbi.nlm.nih.gov/pubmed/21275948
Duntas LH, Biondi B (2011) New insights into subclinical hypothyroidism and cardiovascular risk. Semin Thromb Hemost 37:27-34.
http://www.ncbi.nlm.nih.gov/pubmed/21249602
Eckly A, Hechler B, Freund M, Zerr M, Cazenave JP, Lanza F, . . . Gachet C (2011) Mechanisms underlying FeCl(3) -induced arterial thrombosis. J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/21261806
Fedorov O, Huber K, Eisenreich A, Filippakopoulos P, King O, Bullock AN, . . . Knapp S (2011) Specific CLK Inhibitors from a Novel Chemotype for Regulation of Alternative Splicing. Chem Biol 18:67-76.
http://www.ncbi.nlm.nih.gov/pubmed/21276940
Fortenberry YM, Cook AB, Church FC (2011) Protein C inhibitor inhibits factor VIIa when bound to tissue factor. J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/21251198
Gerrits AJ, Koekman CA, van Haeften TW, Akkerman JW (2011) Increased tissue factor expression in diabetes mellitus type 2-monocytes caused by insulin resistance. J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/21251203
Girardi G (2011) Role of tissue factor in pregnancy complications: crosstalk between coagulation and inflammation. Thromb Res 127S3:S43-S46.
http://www.ncbi.nlm.nih.gov/pubmed/21262438
Hammad MA, Abdel-Bakky MS, Walker LA, Ashfaq MK (2011) Oxidized low-density lipoprotein and tissue factor are involved in monocrotaline/lipopolysaccharide-induced hepatotoxicity. Arch Toxicol.
http://www.ncbi.nlm.nih.gov/pubmed/21279329
Holzhauser E, Albrecht C, Zhou Q, Buttler A, Preusch MR, Blessing E, . . . Bea F (2011) Nicotinic acid has anti-atherogenic and anti-inflammatory properties on advanced atherosclerotic lesions independent of its lipid-modifying capabilities Holzhauser et al., Anti-atherogenic properties of nicotinic acid. J Cardiovasc Pharmacol.
http://www.ncbi.nlm.nih.gov/pubmed/21242806
Johansson L, Karpf DM, Hansen L, Pelzer H, Persson E (2011) Activation peptides prolong the murine plasma half-life of human factor VII. Blood.
http://www.ncbi.nlm.nih.gov/pubmed/21252090
Kamat P, Kunde S, Vos M, Vats A, Heffron T, Romero R, Fortenberry JD (2011) Invasive intracranial pressure monitoring is a useful adjunct in the management of severe hepatic encephalopathy associated with pediatric acute liver failure. Pediatr Crit Care Med.
http://www.ncbi.nlm.nih.gov/pubmed/21263362
Kozuma Y, Sawahata Y, Takei Y, Chiba S, Ninomiya H (2011) Procoagulant properties of microparticles released from red blood cells in paroxysmal nocturnal haemoglobinuria. Br J Haematol.
http://www.ncbi.nlm.nih.gov/pubmed/21241275
Krysiak R, Gdula-Dymek A, Okopien B (2010) Hemostatic effects of simvastatin in subjects with impaired fasting glucose. Pharmacol Rep 62:1090-1098.
http://www.ncbi.nlm.nih.gov/pubmed/21273666
Krysiak R, Handzlik G, Okopien B (2010) Hemostatic effects of fenofibrate in patients with mixed dyslipidemia and impaired fasting glucose. Pharmacol Rep 62:1099-1107.
http://www.ncbi.nlm.nih.gov/pubmed/21273667
Lin R, Roychowdhury-Saha M, Black C, Watt AT, Marcusson EG, Freier SM, Edgington TS (2011) Control of RNA processing by a large non-coding RNA over-expressed in carcinomas. FEBS Lett.
http://www.ncbi.nlm.nih.gov/pubmed/21266177
Mitterlechner T, Innerhofer P, Streif W, Lodl M, Danninger T, Klima G, . . . Fries D (2011) PCC, recombinant prothrombin alone or in combination with recombinant FX and FVIIa in dilutional coagulopathy: a porcine model. J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/21255250
Pierfranceschi MG, Imberti D, Orlando S, Vallisa D, Michieletti E (2010) Effectiveness of recombinant activated factor VII in haemorragic cancer-related disseminated intravascular coagulation: a case report. Blood Transfus.
http://www.ncbi.nlm.nih.gov/pubmed/21251460
Rondina MT, Schwertz H, Harris ES, Kraemer BF, Campbell RA, Mackman N, . . . Zimmerman GA (2011) The Septic Milieu Triggers Expression of Spliced Tissue Factor mRNA in Human Platelets. J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/21255247
Seested T, Appa RS, Christensen EI, Ioannou YA, Krogh TN, Karpf DM, Nielsen HM (2011) In vivo clearance and metabolism of recombinant activated factor VII (rFVIIa) and its complexes with plasma protease inhibitors in the liver. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/21262526
Sen P, Gopalakrishnan R, Kothari H, Keshava S, Clark CA, Esmon CT, . . . Rao LV (2011) Factor VIIa bound to endothelial cell protein C receptor activates protease activated receptor-1 and mediates cell signaling and barrier protection. Blood.
http://www.ncbi.nlm.nih.gov/pubmed/21252088
Solomon D, Kim B, Scultetus A, Arnaud F, Auker C, Freilich D, McCarron R (2011) The effect of rFVIIa on pro- and anti-inflamatory cytokines in serum and cerebrospinal fluid in a swine model of traumatic brain injury. Cytokine.
http://www.ncbi.nlm.nih.gov/pubmed/21251848
Trigg DE, Wood MG, Kouides PA, Kadir RA (2011) Hormonal influences on hemostasis in women. Semin Thromb Hemost 37:77-86.
http://www.ncbi.nlm.nih.gov/pubmed/21249605
van den Besselaar AM, Witteveen E, Tripodi A (2011) Calibration of Combined Thromboplastins with the International Standard for Thromboplastin, Rabbit, Plain. J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/21261807
Wang CH, Li F, Hiller S, Kim HS, Maeda N, Smithies O, Takahashi N (2011) A modest decrease in endothelial NOS in mice comparable to that associated with human NOS3 variants exacerbates diabetic nephropathy. Proc Natl Acad Sci U S A.
http://www.ncbi.nlm.nih.gov/pubmed/21245338
Yamashita A, Asada Y (2011) A rabbit model of thrombosis on atherosclerotic lesions. J Biomed Biotechnol 2011:424929.
http://www.ncbi.nlm.nih.gov/pubmed/21253503
Zwicker JI, Trenor CC, 3rd, Furie BC, Furie B (2011) Tissue Factor-Bearing Microparticles and Thrombus Formation. Arterioscler Thromb Vasc Biol.
http://www.ncbi.nlm.nih.gov/pubmed/21252066
__________________________________________________________
ABOUT TRIGGER
TRIGGER is edited by Jim Morrissey and Pierre Neuenschwander, with editorial assistance by Genie Morrissey. It includes Abstracts of Papers in Press, Meeting Announcements, Positions Sought/Available,or any other pertinent item that subscribers may want to share with their colleagues. To submit an item for publication in Trigger, e-mail us. To request or cancel a subscription,or for more information about TRIGGER or the biology of tissue factor and factor VII, visit our web site. You can also contact us by mail: J.H. Morrissey, University of Illinois College of Medicine, 417 Med Sci Bldg MC-714, 506 S. Mathews Ave., Urbana, IL 61801, USA.
DISCLAIMER: TRIGGER is provided "as is" for information purposes only and without warranty of any kind, express or implied. Users shall assume the entire risk as to the accuracy and usefulness of information in TRIGGER. Opinions expressed here are not necessarily those of the editors or their employers. You may share TRIGGER with your scientific colleagues but you are not permitted to use it or its contents for commercial purposes.
__________________________________________________________
